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Lhb
Gene Detail
Symbol

Name
ID
Lhb
luteinizing hormone beta
MGI:96782
Synonyms
leutropin, LH
Feature Type
protein coding gene
Genetic Map
Chromosome 7
29.30 cM
Detailed Genetic Map ± 1 cM


Mapping data(10)
Sequence Map
Chr7:45418166-45421855 bp, + strand
From NCBI annotation of GRCm38

  3690 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:81806  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: LHB
Protein SuperFamily: pituitary glycoprotein hormone beta chain

Human
homologs
LHB, luteinizing hormone beta polypeptide
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 3972
neXtProt AC: NX_P01229

Human Synonyms: CGB4, HH23, hLHB, LSH-B

Human Chr (Location): 19q13.32; chr19:49015980-49017090 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human LHB

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(4) Targeted(2) Transgenic(1)
 
Homozygous null mice display male and female infertility, hypogonadism, azoospermia, absent corpora lutea, degenerating oocytes, and reduced serum levels of estradiol, progesterone, and testosterone.
 
Interactions
Lhb interacts with 1 marker (Mir1892)
Gene Ontology
(GO)
classifications
All GO classifications: (6 annotations)
Process regulation of cGMP metabolic process
Component extracellular exosome, extracellular region
Function hormone activity
External Resources: FuncBase
Expression
Literature Summary: (72 records)
Data Summary: Results (77)    Tissues (61)    Images (7)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 14
RNA in situ 15
RT-PCR 48
cDNA source data(7)
Other mouse links: GEO   Expression Atlas
Other vertebrate links: Xenbase lhb    NEW 
Molecular
reagents
All nucleic(16) Genomic(3) cDNA(10) Primer pair(2) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000023868 (Evidence), OTTMUSG00000045085 (Evidence)
Ensembl Gene Model ENSMUSG00000038194 (Evidence), ENSMUSG00000100916 (Evidence)
Entrez Gene 16866 (Evidence)
UniGene 57061
NIA Mouse Gene Index U042807
Consensus CDS Project CCDS21242.1
International Mouse Phenotyping Consortium Status Lhb
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 16866 NCBI Gene Model | MGI Sequence Detail 3690 C57BL/6J ±  kb
transcript NM_008497 RefSeq | MGI Sequence Detail 509 C57BL/6 
polypeptide O09108 UniProt | EBI | MGI Sequence Detail 141 Not Applicable 

For the selected sequences
All sequences(35) RefSeq(12) UniProt(3)
Polymorphisms
RFLP(2) : SNPs within 2kb(11 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006208 Cystine knot
InterPro IPR001545 Gonadotropin, beta subunit
InterPro IPR018245 Gonadotropin, beta subunit, conserved site
Protein Ontology PR:000009783 lutropin subunit beta
Graphical View of Protein Domain Structure
References
(Earliest) J:7285 Naylor SL, et al., Chromosome assignment of genes encoding the alpha and beta subunits of glycoprotein hormones in man and mouse. Somatic Cell Genet. 1983 Nov;9(6):757-70
(Latest) J:218295 Mortensen AH, et al., Deletion of OTX2 in neural ectoderm delays anterior pituitary development. Hum Mol Genet. 2015 Feb 15;24(4):939-53
All references(131)
Other
accession IDs
MGD-MRK-11802

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory