Lhb
Gene Detail

Symbol Name ID

Lhb luteinizing hormone beta MGI:96782

Synonyms

leutropin, LH

Feature Type

protein coding gene

Genetic Map

Chromosome 7

29.30 cM
Detailed Genetic Map ± 1 cM


Mapping data(10)

Sequence Map

Chr7:45418353-45421854 bp, + strand From VEGA annotation of GRCm38   3502 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

Protein SuperFamily: pituitary glycoprotein hormone beta chain
Gene Tree: Lhb

Alleles and phenotypes

All alleles(6) : Targeted(2) Gene trapped(4)
 

Homozygous null mice display male and female infertility, hypogonadism, azoospermia, absent corpora lutea, degenerating oocytes, and reduced serum levels of estradiol, progesterone, and testosterone.

 

Gene Ontology (GO) classifications

All GO classifications: (3 annotations)

Process	regulation of cGMP metabolic process
Component	extracellular region
Function	hormone activity

External Resources: FuncBase

Expression

Literature Summary: (65 records)
Data Summary: Results (71)    Tissues (57)    Images (7)
Theiler Stages: 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	8
RNA in situ	15
RT-PCR	48

cDNA source data(3)
External Resources: ArrayExpress

Molecular reagents

All nucleic(12) Genomic(3) cDNA(6) Primer pair(2) Other(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000023868 (Evidence)
Ensembl Gene Model	ENSMUSG00000038194 (Evidence)
Entrez Gene	16866, 100862214
NIA Mouse Gene Index	U042807
Consensus CDS Project	CCDS21242.1
International Mouse Knockout Project Status	Lhb

Sequences

Length	Strain/Species
genomic	OTTMUSG00000023868	VEGA Gene Model | MGI Sequence Detail	3502	C57BL/6J
transcript	OTTMUST00000058302	VEGA | MGI Sequence Detail	569	Not Applicable
polypeptide	OTTMUSP00000028226	VEGA | MGI Sequence Detail	141	Not Applicable

All sequences(19) UniProt(2)

Polymorphisms

RFLP(2) : SNPs(2 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR006208	Cystine knot
InterPro	IPR001545	Gonadotropin, beta subunit
InterPro	IPR018245	Gonadotropin, beta subunit, conserved site
Protein Ontology	PR:000009783	lutropin subunit beta

References

(Earliest) J:7285 Naylor SL, et al., Chromosome assignment of genes encoding the alpha and beta subunits of glycoprotein hormones in man and mouse. Somatic Cell Genet. 1983 Nov;9(6):757-70
(Latest) J:195620 Gumbel JH, et al., The forkhead transcription factor, Foxd1, is necessary for pituitary luteinizing hormone expression in mice. PLoS One. 2012;7(12):e52156
All references(119)

Other accession IDs

MGD-MRK-11802