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Lhb Gene Detail
Summary
  • Symbol
    Lhb
  • Name
    luteinizing hormone beta
  • Synonyms
    leutropin, LH
  • Feature Type
    protein coding gene
  • IDs
    MGI:96782
    NCBI Gene: 16866
Location & Maps
more
  • Sequence Map
    Chr7:45420946-45421854 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      909 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 29.30 cM
  • Detailed Genetic Map ± 1 cM
  • Mapping Data
    10 experiments
Homology
more
  • Human Ortholog
    LHB, luteinizing hormone beta polypeptide
  • Vertebrate Orthologs
    9
  • Human Ortholog
    LHB, luteinizing hormone beta polypeptide
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CGB4, HH23, LSH-B, LSH-beta
  • Links
    NCBI Gene ID: 3972
    neXtProt AC: NX_P01229

  • Chr Location
    19q13.32; chr19:49015980-49017090 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human LHB associations

Human Disease Mouse Models
       Hypogonadotropic Hypogonadism 23 without Anosmia; HH23   OMIM: 228300
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    33 phenotypes from 1 allele in 1 genetic background
    17 phenotypes from multigenic genotypes
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    4
  • Gene trapped
    1
  • Targeted
    2
  • Transgenic
    1
Homozygous null mice display male and female infertility, hypogonadism, azoospermia, absent corpora lutea, degenerating oocytes, and reduced serum levels of estradiol, progesterone, and testosterone.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000100916 Ensembl Gene Model | MGI Sequence Detail 909 C57BL/6J ±  kb
transcript ENSMUST00000072453 Ensembl | MGI Sequence Detail 509 Not Applicable  
polypeptide ENSMUSP00000072276 Ensembl | MGI Sequence Detail 141 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    9 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000009783 lutropin subunit beta
  • InterPro Domains
    IPR029034 Cystine-knot cytokine
    IPR006208 Glycoprotein hormone subunit beta, cystine knot
    IPR001545 Gonadotropin, beta subunit
    IPR018245 Gonadotropin, beta subunit, conserved site
Molecular
Reagents
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  • All nucleic 16
    Genomic 3
    cDNA 10
    Primer pair 2
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-11802
References
more
  • Summaries
    All 131
    Developmental Gene Expression 74
    Gene Ontology 5
    Phenotypes 32
  • Earliest
    J:7285 Naylor SL, et al., Chromosome assignment of genes encoding the alpha and beta subunits of glycoprotein hormones in man and mouse. Somatic Cell Genet. 1983 Nov;9(6):757-70
  • Latest
    J:223814 Aujla PK, et al., Persistent expression of activated notch in the developing hypothalamus affects survival of pituitary progenitors and alters pituitary structure. Dev Dyn. 2015 Aug;244(8):921-34

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory