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Lhb
Gene Detail
 Symbol
Name
ID
Lhb
luteinizing hormone beta
MGI:96782
Synonyms leutropin, LH
Feature Type protein coding gene
Genetic Map
Chromosome 7
29.30 cM
Detailed Genetic Map ± 1 cM


Mapping data(10)
Sequence Map
Chr7:45418353-45421854 bp, + strand
From VEGA annotation of GRCm38

  3502 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
Protein SuperFamily: pituitary glycoprotein hormone beta chain
Gene Tree: Lhb
Alleles
and
phenotypes
All alleles(6) : Targeted(2) Gene trapped(4)
 
Homozygous null mice display male and female infertility, hypogonadism, azoospermia, absent corpora lutea, degenerating oocytes, and reduced serum levels of estradiol, progesterone, and testosterone.
 
Gene Ontology
(GO)
classifications
All GO classifications: (3 annotations)
Process regulation of cGMP metabolic process
Component extracellular region
Function hormone activity
External Resources: FuncBase
Expression
Literature Summary: (67 records)
Data Summary: Results (71)    Tissues (57)    Images (7)
Theiler Stages: 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 8
RNA in situ 15
RT-PCR 48
cDNA source data(3)
External Resources: ArrayExpress
Molecular
reagents
All nucleic(12) Genomic(3) cDNA(6) Primer pair(2) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000023868 (Evidence)
Ensembl Gene ModelENSMUSG00000038194 (Evidence)
Entrez Gene16866, 100862214
NIA Mouse Gene IndexU042807
Consensus CDS ProjectCCDS21242.1
International Mouse Knockout Project StatusLhb
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023868 VEGA Gene Model | MGI Sequence Detail 3502 C57BL/6J ±  kb
transcript OTTMUST00000058302 VEGA | MGI Sequence Detail 569 Not Applicable 
polypeptide OTTMUSP00000028226 VEGA | MGI Sequence Detail 141 Not Applicable 

For the selected sequences
All sequences(19) UniProt(2)
Polymorphisms RFLP(2) : SNPs within 2kb(11 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006208 Cystine knot
InterPro IPR001545 Gonadotropin, beta subunit
InterPro IPR018245 Gonadotropin, beta subunit, conserved site
Protein Ontology PR:000009783 lutropin subunit beta
References (Earliest) J:7285 Naylor SL, et al., Chromosome assignment of genes encoding the alpha and beta subunits of glycoprotein hormones in man and mouse. Somatic Cell Genet. 1983 Nov;9(6):757-70
(Latest) J:201428 Oury F, et al., Osteocalcin regulates murine and human fertility through a pancreas-bone-testis axis. J Clin Invest. 2013 Jun 3;123(6):2421-33
All references(123)
Other
accession IDs
MGD-MRK-11802

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory