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Lhb Gene Detail
Summary
  • Symbol
    Lhb
  • Name
    luteinizing hormone beta
  • Synonyms
    Gm29035, leutropin, LH
  • Feature Type
    protein coding gene
  • IDs
    MGI:96782
    NCBI Gene: 16866
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr7:45420820-45421897 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      1078 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 29.30 cM
  • Mapping Data
    11 experiments
Homology
more
  • Human Ortholog
    LHB, luteinizing hormone beta polypeptide
  • Vertebrate Orthologs
    9
  • Human Ortholog
    LHB, luteinizing hormone beta polypeptide
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CGB4, HH23, LSH-B, LSH-beta
  • Links
    NCBI Gene ID: 3972
    neXtProt AC: NX_P01229
    UniProt: P01229

  • Chr Location
    19q13.33; chr19:49015980-49017090 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human LHB associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    33 phenotypes from 1 allele in 1 genetic background
    17 phenotypes from multigenic genotypes
    33 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display male and female infertility, hypogonadism, azoospermia, absent corpora lutea, degenerating oocytes, and reduced serum levels of estradiol, progesterone, and testosterone.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000023868 VEGA Gene Model | MGI Sequence Detail 1078 C57BL/6J ±  kb
    transcript OTTMUST00000058302 VEGA | MGI Sequence Detail 678 Not Applicable  
    polypeptide OTTMUSP00000028226 VEGA | MGI Sequence Detail 141 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      9 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • InterPro Domains
      IPR029034 Cystine-knot cytokine
      IPR006208 Glycoprotein hormone subunit beta
      IPR001545 Gonadotropin, beta subunit
      IPR018245 Gonadotropin, beta subunit, conserved site
    Molecular
    Reagents
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    • All nucleic 16
      Genomic 3
      cDNA 10
      Primer pair 2
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-11802, MGI:5579741
    References
    more
    • Summaries
      All 176
      Developmental Gene Expression 90
      Gene Ontology 5
      Phenotypes 33
    • Earliest
      J:7285 Naylor SL, et al., Chromosome assignment of genes encoding the alpha and beta subunits of glycoprotein hormones in man and mouse. Somatic Cell Genet. 1983 Nov;9(6):757-70
    • Latest
      J:249002 Cheung LYM, et al., Sox21 deletion in mice causes postnatal growth deficiency without physiological disruption of hypothalamic-pituitary endocrine axes. Mol Cell Endocrinol. 2017 Jan 5;439(None):213-223

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory