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Ldhc
Gene Detail
 Symbol
Name
ID
Ldhc
lactate dehydrogenase C
MGI:96764
Synonyms Ldh3, Ldh-3, Ldhc4
Feature Type protein coding gene
Genetic Map
Chromosome 7
30.60 cM
Detailed Genetic Map ± 1 cM


Mapping data(25)
Sequence Map
Chr7:46861203-46878142 bp, + strand
From VEGA annotation of GRCm38

  16940 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:22767  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: L-lactate/malate dehydrogenase
Gene Tree: Ldhc

Human
homologs
Human Homolog LDHC, lactate dehydrogenase C
NCBI Gene ID 3948
neXtProt AC  NX_P07864
Human Synonyms  CT32, LDH3, LDHX
Human Chr (Location)  11p15.1; chr11:18412304-18451246 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(1) Targeted(3)
 
Homozygous male mice are infertile. Spermatogenesis appears normal, but sperm motility decreases rapidly after their release from the epididymus. In vitro fertilization is blocked unless the zona pellucida is removed; even then, the rate of sperm penetration is lower than for wild-type sperm.
 
Interactions
Ldhc interacts with 77 markers (Mir10a, Mir10b, Mir20a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process ATP biosynthetic process, carbohydrate metabolic process, ...
Component cilium, cytoplasm, ...
Function catalytic activity, L-lactate dehydrogenase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (189)    Tissues (139)    Images (16)
Theiler Stages: 22, 23, 28
Assay TypeResults
RNA in situ 94
RT-PCR 95
cDNA source data(146)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(154) Genomic(4) cDNA(146) Primer pair(4)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000027259 (Evidence)
Ensembl Gene ModelENSMUSG00000030851 (Evidence)
Entrez Gene16833 (Evidence)
UniGene16563
DFCITC1573080
DoTSDT.530011
NIA Mouse Gene IndexU116329
EC1.1.1.27
PDB2LDX
Consensus CDS ProjectCCDS21290.1
International Mouse Knockout Project StatusLdhc
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027259 VEGA Gene Model | MGI Sequence Detail 16940 C57BL/6J ±  kb
transcript OTTMUST00000067400 VEGA | MGI Sequence Detail 1370 Not Applicable 
polypeptide OTTMUSP00000033907 VEGA | MGI Sequence Detail 332 Not Applicable 

For the selected sequences
All sequences(44) RefSeq(8) UniProt(7)
Polymorphisms All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(69 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR015955 Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal
InterPro IPR022383 Lactate/malate dehydrogenase, C-terminal
InterPro IPR001236 Lactate/malate dehydrogenase, N-terminal
InterPro IPR011304 L-lactate dehydrogenase
InterPro IPR018177 L-lactate dehydrogenase, active site
InterPro IPR001557 L-lactate/malate dehydrogenase
InterPro IPR016040 NAD(P)-binding domain
Protein Ontology PR:000009743 L-lactate dehydrogenase C chain
References (Earliest) J:4448 Sakai I, et al., Molecular cloning and nucleotide sequence of the cDNA for sperm-specific lactate dehydrogenase-C from mouse. Biochem J. 1987 Mar 1;242(2):619-22
(Latest) J:202073 Tang H, et al., Human lactate dehydrogenase A (LDHA) rescues mouse Ldhc-null sperm function. Biol Reprod. 2013 Apr;88(4):96
All references(77)
Other
accession IDs
MGD-MRK-11767, MGD-MRK-11773

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory