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Ldhc Gene Detail
Summary
  • Symbol
    Ldhc
  • Name
    lactate dehydrogenase C
  • Synonyms
    Ldh3, Ldh-3, Ldhc4
  • Feature Type
    protein coding gene
  • IDs
    MGI:96764
    NCBI Gene: 16833
Location & Maps
more
  • Sequence Map
    Chr7:46861203-46878142 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      16940 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 30.60 cM
  • Mapping Data
    25 experiments
Homology
more
  • Human Ortholog
    LDHC, lactate dehydrogenase C
  • Vertebrate Orthologs
    7
  • Human Ortholog
    LDHC, lactate dehydrogenase C
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CT32, LDH3, LDHX
  • Links
    NCBI Gene ID: 3948
    neXtProt AC: NX_P07864

  • Chr Location
    11p15.1; chr11:18412306-18451246 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    4
  • Gene trapped
    1
  • Targeted
    3
Homozygous male mice are infertile. Spermatogenesis appears normal, but sperm motility decreases rapidly after their release from the epididymus. In vitro fertilization is blocked unless the zona pellucida is removed; even then, the rate of sperm penetration is lower than for wild-type sperm.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027259 VEGA Gene Model | MGI Sequence Detail 16940 C57BL/6J ±  kb
transcript OTTMUST00000067400 VEGA | MGI Sequence Detail 1370 Not Applicable  
polypeptide OTTMUSP00000033907 VEGA | MGI Sequence Detail 332 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    69 from dbSNP Build 142
  • PCR
  • RFLP
Protein
Information
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Molecular
Reagents
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  • All nucleic 154
    Genomic 4
    cDNA 146
    Primer pair 4

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-11767, MGD-MRK-11773
References
more
  • Summaries
    All 72
    Developmental Gene Expression 9
    Gene Ontology 6
    Phenotypes 7
  • Earliest
    J:4448 Sakai I, et al., Molecular cloning and nucleotide sequence of the cDNA for sperm-specific lactate dehydrogenase-C from mouse. Biochem J. 1987 Mar 1;242(2):619-22
  • Latest
    J:234504 Shum EY, et al., The Antagonistic Gene Paralogs Upf3a and Upf3b Govern Nonsense-Mediated RNA Decay. Cell. 2016 Apr 7;165(2):382-95

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory