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Ldhc
Gene Detail
Symbol

Name
ID
Ldhc
lactate dehydrogenase C
MGI:96764
Synonyms
Ldh3, Ldh-3, Ldhc4
Feature Type
protein coding gene
Genetic Map
Chromosome 7
30.60 cM
Detailed Genetic Map ± 1 cM


Mapping data(25)
Sequence Map
Chr7:46861203-46878142 bp, + strand
From VEGA annotation of GRCm38

  16940 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:22767  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: LDHC
Protein SuperFamily: L-lactate/malate dehydrogenase
Gene Tree: Ldhc

Human
homologs
LDHC, lactate dehydrogenase C
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 3948
neXtProt AC: NX_P07864

Human Synonyms: CT32, LDH3, LDHX

Human Chr (Location): 11p15.1; chr11:18412306-18451246 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(1) Targeted(3)
 
Homozygous male mice are infertile. Spermatogenesis appears normal, but sperm motility decreases rapidly after their release from the epididymus. In vitro fertilization is blocked unless the zona pellucida is removed; even then, the rate of sperm penetration is lower than for wild-type sperm.
 
Interactions
Ldhc interacts with 77 markers (Mir10a, Mir10b, Mir20a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process ATP biosynthetic process, carbohydrate metabolic process, ...
Component cilium, cytoplasm, ...
Function catalytic activity, L-lactate dehydrogenase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (189)    Tissues (139)    Images (16)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
RT-PCR 95
cDNA source data(146)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(154) Genomic(4) cDNA(146) Primer pair(4)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000027259 (Evidence)
Ensembl Gene Model ENSMUSG00000030851 (Evidence)
Entrez Gene 16833 (Evidence)
UniGene 16563
DFCI TC1573080
DoTS DT.530011
NIA Mouse Gene Index U116329
EC 1.1.1.27
PDB 2LDX
Consensus CDS Project CCDS21290.1
International Mouse Phenotyping Consortium Status Ldhc
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027259 VEGA Gene Model | MGI Sequence Detail 16940 C57BL/6J ±  kb
transcript OTTMUST00000067400 VEGA | MGI Sequence Detail 1370 Not Applicable 
polypeptide OTTMUSP00000033907 VEGA | MGI Sequence Detail 332 Not Applicable 

For the selected sequences
All sequences(45) RefSeq(8) UniProt(7)
Polymorphisms
All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(69 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR015955 Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal
InterPro IPR022383 Lactate/malate dehydrogenase, C-terminal
InterPro IPR001236 Lactate/malate dehydrogenase, N-terminal
InterPro IPR011304 L-lactate dehydrogenase
InterPro IPR018177 L-lactate dehydrogenase, active site
InterPro IPR001557 L-lactate/malate dehydrogenase
InterPro IPR016040 NAD(P)-binding domain
Protein Ontology PR:000009743 L-lactate dehydrogenase C chain
References
(Earliest) J:4448 Sakai I, et al., Molecular cloning and nucleotide sequence of the cDNA for sperm-specific lactate dehydrogenase-C from mouse. Biochem J. 1987 Mar 1;242(2):619-22
(Latest) J:202073 Tang H, et al., Human lactate dehydrogenase A (LDHA) rescues mouse Ldhc-null sperm function. Biol Reprod. 2013 Apr;88(4):96
All references(73)
Other
accession IDs
MGD-MRK-11767, MGD-MRK-11773

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory