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Ldhc Gene Detail
Summary
  • Symbol
    Ldhc
  • Name
    lactate dehydrogenase C
  • Synonyms
    Ldh3, Ldh-3, Ldhc4
  • Feature Type
    protein coding gene
  • IDs
    MGI:96764
    NCBI Gene: 16833
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:46861263-46878147 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 30.60 cM
  • Mapping Data
    25 experiments
Strain
Comparison
more
  • SNPs within 2kb
    69 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96764
protein coding gene Chr7:46861203-46878142 (+)
129S1/SvImJ MGP_129S1SvImJ_G0032275
protein coding gene Chr7:47264651-47281577 (+)
A/J MGP_AJ_G0032254
protein coding gene Chr7:46286162-46303084 (+)
AKR/J MGP_AKRJ_G0032190
protein coding gene Chr7:47598102-47619732 (+)
BALB/cJ MGP_BALBcJ_G0032266
protein coding gene Chr7:46288382-46306041 (+)
C3H/HeJ MGP_C3HHeJ_G0031979
protein coding gene Chr7:48072585-48089408 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032756
protein coding gene Chr7:49531594-49553079 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029772
protein coding gene Chr7:48825695-48842937 (+)
CAST/EiJ MGP_CASTEiJ_G0031307
protein coding gene Chr7:39542271-39560615 (+)
CBA/J MGP_CBAJ_G0031944
protein coding gene Chr7:51197565-51215842 (+)
DBA/2J MGP_DBA2J_G0032101
protein coding gene Chr7:45963080-45979969 (+)
FVB/NJ MGP_FVBNJ_G0032055
protein coding gene Chr7:45773320-45795800 (+)
LP/J MGP_LPJ_G0032182
protein coding gene Chr7:47975349-47996600 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032092
protein coding gene Chr7:49816298-49834744 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032773
protein coding gene Chr7:46799092-46817627 (+)
PWK/PhJ MGP_PWKPhJ_G0031030
protein coding gene Chr7:39344803-39360674 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030870
protein coding gene Chr7:34821814-34842873 (+)
WSB/EiJ MGP_WSBEiJ_G0031427
protein coding gene Chr7:47321117-47339251 (+)



Homology
more
  • Human Ortholog
    LDHC, lactate dehydrogenase C
  • Vertebrate Orthologs
    7
  • Human Ortholog
    LDHC, lactate dehydrogenase C
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CT32, LDH3, LDHX
  • Links
    NCBI Gene ID: 3948
    neXtProt AC: NX_P07864
    UniProt: P07864

  • Chr Location
    11p15.1; chr11:18412298-18451246 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous male mice are infertile. Spermatogenesis appears normal, but sperm motility decreases rapidly after their release from the epididymus. In vitro fertilization is blocked unless the zona pellucida is removed; even then, the rate of sperm penetration is lower than for wild-type sperm.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16833 NCBI Gene Model | MGI Sequence Detail 16885 C57BL/6J ±  kb
    transcript NM_001368361 RefSeq | MGI Sequence Detail 1390 C57BL/6  
    polypeptide P00342 UniProt | EBI | MGI Sequence Detail 332 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 155
      Genomic 4
      cDNA 147
      Primer pair 4

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-11767, MGD-MRK-11773
    References
    more
    • Summaries
      All 75
      Developmental Gene Expression 10
      Gene Ontology 5
      Phenotypes 8
    • Earliest
      J:4448 Sakai I, et al., Molecular cloning and nucleotide sequence of the cDNA for sperm-specific lactate dehydrogenase-C from mouse. Biochem J. 1987 Mar 1;242(2):619-22
    • Latest
      J:242920 Tung KS, et al., Egress of sperm autoantigen from seminiferous tubules maintains systemic tolerance. J Clin Invest. 2017 Mar 01;127(3):1046-1060

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    last database update
    11/05/2019
    MGI 6.14
    The Jackson Laboratory