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Ldha
Gene Detail
 Symbol
Name
ID
Ldha
lactate dehydrogenase A
MGI:96759
STS D7Mit29
Synonyms l7R2, lactate dehydrogenase-A, Ldh1, Ldh-1, LDH-A
Feature Type protein coding gene
Genetic Map
Chromosome 7
30.60 cM
Detailed Genetic Map ± 1 cM


Mapping data(19)
Sequence Map
Chr7:46841475-46855627 bp, + strand
From VEGA annotation of GRCm38

  14153 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56495  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: L-lactate/malate dehydrogenase
Gene Tree: Ldha

Human
homologs
Human Homolog LDHA, lactate dehydrogenase A
NCBI Gene ID 3939
neXtProt AC  NX_P00338
Human Synonyms  GSD11, HEL-S-133P, LDH1, LDHM
Human Chr (Location)  11p15.4; chr11:18394389-18408218 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human LDHA
Alleles
and
phenotypes
All alleles(35) : Targeted(2) Gene trapped(21) Chemically induced(9) Radiation induced(3)
 
Mice homozygous for one chemically induced mutation exhibit severe hemolytic anemia with pronounced reticulocytosis and hyperbilirubinemia. Another mutation results in prenatal lethality in homozygotes.
 
Gene Ontology
(GO)
classifications
All GO classifications: (26 annotations)
Process carbohydrate metabolic process, cellular carbohydrate metabolic process, ...
Component cytoplasm, cytosol, ...
Function catalytic activity, identical protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (121)    Tissues (119)    Images (21)
Theiler Stages: 22, 26, 28
Assay TypeResults
RNA in situ 119
RT-PCR 2
cDNA source data(1176)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(1193) Genomic(12) cDNA(1177) Primer pair(4)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000016500 (Evidence)
Ensembl Gene ModelENSMUSG00000063229 (Evidence)
Entrez Gene16828 (Evidence)
UniGene29324
DFCITC1573644, TC1595419, TC1700642
DoTSDT.101138883, DT.103574198, DT.110760323, DT.111003070, DT.111003077, DT.91306915, DT.97377399, DT.97382448, DT.97386496, DT.99872367, DT.99872381
NIA Mouse Gene IndexU008111, U017987, U054859, U068119, U085237, U106424, U278427, U299692, U300515, U330200, U338599, U364657, U380204
EC1.1.1.27
Consensus CDS ProjectCCDS21289.1, CCDS52255.1
International Mouse Knockout Project StatusLdha
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016500 VEGA Gene Model | MGI Sequence Detail 14153 C57BL/6J ±  kb
transcript OTTMUST00000039850 VEGA | MGI Sequence Detail 1766 Not Applicable 
polypeptide OTTMUSP00000017775 VEGA | MGI Sequence Detail 361 Not Applicable 

For the selected sequences
All sequences(146) RefSeq(5) UniProt(13)
Polymorphisms All PCR and RFLP(3) : PCR(2) RFLP(1) SNPs within 2kb(98 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR015955 Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal
InterPro IPR022383 Lactate/malate dehydrogenase, C-terminal
InterPro IPR001236 Lactate/malate dehydrogenase, N-terminal
InterPro IPR011304 L-lactate dehydrogenase
InterPro IPR018177 L-lactate dehydrogenase, active site
InterPro IPR001557 L-lactate/malate dehydrogenase
InterPro IPR016040 NAD(P)-binding domain
Protein Ontology PR:000009739 L-lactate dehydrogenase A chain
References (Earliest) J:5105 Ruddle FH, et al., Allelically-determined isozyme polymorphisms in laboratory populations of mice. Ann N Y Acad Sci. 1968 Jun 14;151(1):531-9
(Latest) J:193996 Chauvin T, et al., A systematic analysis of a deep mouse epididymal sperm proteome. Biol Reprod. 2012;87(6):141
All references(98)
Other
accession IDs
MGD-MRK-11762, MGD-MRK-11768, MGI:1890511

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory