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Ldha Gene Detail
Summary
  • Symbol
    Ldha
  • Name
    lactate dehydrogenase A
  • Synonyms
    l7R2, lactate dehydrogenase-A, Ldh1, Ldh-1, LDH-A
  • Feature Type
    protein coding gene
  • IDs
    MGI:96759
    NCBI Gene: 16828
  • Gene Overview
    MyGene.info: LDHA
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr7:46841475-46855627 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      14153 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 30.60 cM
  • Mapping Data
    19 experiments
  • Sequence Tag
    D7Mit29
Homology
more
  • Human Ortholog
    LDHA, lactate dehydrogenase A
  • Vertebrate Orthologs
    9
  • Human Ortholog
    LDHA, lactate dehydrogenase A
    Orthology source: HGNC, HomoloGene
  • Synonyms
    GSD11, HEL-S-133P, LDHM, PIG19
  • Links
    NCBI Gene ID: 3939
    neXtProt AC: NX_P00338
    UniProt: P00338

  • Chr Location
    11p15.1; chr11:18394389-18408218 (+)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    30 phenotypes from 13 alleles in 13 genetic backgrounds
    1 phenotype from multigenic genotypes
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for one chemically induced mutation exhibit severe hemolytic anemia with pronounced reticulocytosis and hyperbilirubinemia. Another mutation results in prenatal lethality in homozygotes.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    121
  • Tissues
    119
  • cDNA Data
    1177
  • Literature Summary
    14
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000016500 VEGA Gene Model | MGI Sequence Detail 14153 C57BL/6J ±  kb
    transcript OTTMUST00000039849 VEGA | MGI Sequence Detail 1588 Not Applicable  
    polypeptide OTTMUSP00000017774 VEGA | MGI Sequence Detail 332 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      98 from dbSNP Build 142
    • PCR
      2
    • RFLP
      1
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 1194
      Genomic 12
      cDNA 1178
      Primer pair 4

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-11762, MGD-MRK-11768, MGI:1890511
    References
    more
    • Summaries
      All 107
      Developmental Gene Expression 14
      Gene Ontology 11
      Phenotypes 29
    • Earliest
      J:5105 Ruddle FH, et al., Allelically-determined isozyme polymorphisms in laboratory populations of mice. Ann N Y Acad Sci. 1968 Jun 14;151(1):531-9
    • Latest
      J:256958 Chinchore Y, et al., Glycolytic reliance promotes anabolism in photoreceptors. Elife. 2017 Jun 9;6
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/11/2018
    MGI 6.12     		The Jackson Laboratory