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Ldha
Gene Detail
Symbol

Name
ID
Ldha
lactate dehydrogenase A
MGI:96759
STS
Synonyms
l7R2, lactate dehydrogenase-A, Ldh1, Ldh-1, LDH-A
Feature Type
protein coding gene
Genetic Map
Chromosome 7
30.60 cM
Detailed Genetic Map ± 1 cM


Mapping data(19)
Sequence Map
Chr7:46841475-46855627 bp, + strand
From VEGA annotation of GRCm38

  14153 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56495  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: L-lactate/malate dehydrogenase
Gene Tree: Ldha

Human
homologs
Human Homolog LDHA, lactate dehydrogenase A
NCBI Gene ID 3939
neXtProt AC  NX_P00338
Human Synonyms  GSD11, HEL-S-133P, LDH1, LDHM
Human Chr (Location)  11p15.4; chr11:18394389-18408218 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human LDHA
Mutations,
alleles, and
phenotypes
All mutations/alleles(35) : Chemically induced (ENU)(7) Chemically induced (other)(2) Gene trapped(21) Radiation induced(3) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for one chemically induced mutation exhibit severe hemolytic anemia with pronounced reticulocytosis and hyperbilirubinemia. Another mutation results in prenatal lethality in homozygotes.
 
Interactions
Ldha interacts with 104 markers (Mir17, Mir20b, Mir22, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process carbohydrate metabolic process, cellular carbohydrate metabolic process, ...
Component cytoplasm, cytosol, ...
Function catalytic activity, L-lactate dehydrogenase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (121)    Tissues (119)    Images (21)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 119
RT-PCR 2
cDNA source data(1176)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(1193) Genomic(12) cDNA(1177) Primer pair(4)
Microarray probesets(3)
Other database
links
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016500 VEGA Gene Model | MGI Sequence Detail 14153 C57BL/6J ±  kb
transcript OTTMUST00000039850 VEGA | MGI Sequence Detail 1766 Not Applicable 
polypeptide OTTMUSP00000017775 VEGA | MGI Sequence Detail 361 Not Applicable 

For the selected sequences
All sequences(145) RefSeq(5) UniProt(12)
Polymorphisms
All PCR and RFLP(3) : PCR(2) RFLP(1) SNPs within 2kb(98 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR015955 Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal
InterPro IPR022383 Lactate/malate dehydrogenase, C-terminal
InterPro IPR001236 Lactate/malate dehydrogenase, N-terminal
InterPro IPR011304 L-lactate dehydrogenase
InterPro IPR018177 L-lactate dehydrogenase, active site
InterPro IPR001557 L-lactate/malate dehydrogenase
InterPro IPR016040 NAD(P)-binding domain
Protein Ontology PR:000009739 L-lactate dehydrogenase A chain
References
(Earliest) J:5105 Ruddle FH, et al., Allelically-determined isozyme polymorphisms in laboratory populations of mice. Ann N Y Acad Sci. 1968 Jun 14;151(1):531-9
(Latest) J:193996 Chauvin T, et al., A systematic analysis of a deep mouse epididymal sperm proteome. Biol Reprod. 2012;87(6):141
All references(97)
Other
accession IDs
MGD-MRK-11762, MGD-MRK-11768, MGI:1890511

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory