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Ldha Gene Detail
Summary
  • Symbol
    Ldha
  • Name
    lactate dehydrogenase A
  • Synonyms
    l7R2, lactate dehydrogenase-A, Ldh1, Ldh-1, LDH-A
  • Feature Type
    protein coding gene
  • IDs
    MGI:96759
    NCBI Gene: 16828
  • Gene Overview
    MyGene.info: LDHA
Location & Maps
more
  • Sequence Map
    Chr7:46841475-46855627 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      14153 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 30.60 cM
  • Mapping Data
    19 experiments
  • Sequence Tag
Homology
more
  • Human Ortholog
    LDHA, lactate dehydrogenase A
  • Vertebrate Orthologs
    9
  • Human Ortholog
    LDHA, lactate dehydrogenase A
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GSD11, HEL-S-133P, LDHM, PIG19
  • Links
    NCBI Gene ID: 3939
    neXtProt AC: NX_P00338

  • Chr Location
    11p15.1; chr11:18394389-18408218 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human LDHA associations

Human Disease Mouse Models
       Glycogen Storage Disease XI; GSD11   OMIM: 612933
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    30 phenotypes from 13 alleles in 13 genetic backgrounds
    1 phenotype from multigenic genotypes
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    36
  • Chemically induced (ENU)
    7
  • Chemically induced (other)
    2
  • Gene trapped
    21
  • Radiation induced
    3
  • Targeted
    3
  • Incidental Mutations
Mice homozygous for one chemically induced mutation exhibit severe hemolytic anemia with pronounced reticulocytosis and hyperbilirubinemia. Another mutation results in prenatal lethality in homozygotes.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016500 VEGA Gene Model | MGI Sequence Detail 14153 C57BL/6J ±  kb
transcript OTTMUST00000039849 VEGA | MGI Sequence Detail 1588 Not Applicable  
polypeptide OTTMUSP00000017774 VEGA | MGI Sequence Detail 332 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    98 from dbSNP Build 142
  • PCR
  • RFLP
Protein
Information
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  • UniProt
    19 Sequences
  • EC
  • InterPro Domains
    IPR015955 Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal
    IPR022383 Lactate/malate dehydrogenase, C-terminal
    IPR001236 Lactate/malate dehydrogenase, N-terminal
    IPR011304 L-lactate dehydrogenase
    IPR018177 L-lactate dehydrogenase, active site
    IPR001557 L-lactate/malate dehydrogenase
    IPR016040 NAD(P)-binding domain
Molecular
Reagents
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  • All nucleic 1193
    Genomic 12
    cDNA 1177
    Primer pair 4

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-11762, MGD-MRK-11768, MGI:1890511
References
more
  • Summaries
    All 86
    Developmental Gene Expression 10
    Gene Ontology 11
    Phenotypes 26
  • Earliest
    J:5105 Ruddle FH, et al., Allelically-determined isozyme polymorphisms in laboratory populations of mice. Ann N Y Acad Sci. 1968 Jun 14;151(1):531-9
  • Latest
    J:234630 Bonney S, et al., Diverse Functions of Retinoic Acid in Brain Vascular Development. J Neurosci. 2016 Jul 20;36(29):7786-801

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory