Ldha
Gene Detail

Symbol

Name
ID

Ldha
lactate dehydrogenase A
MGI:96759

STS

D7Mit29

Synonyms

l7R2, lactate dehydrogenase-A, Ldh1, Ldh-1, LDH-A

Feature Type

protein coding gene

Genetic Map

Chromosome 7
30.60 cM
Detailed Genetic Map ± 1 cM


Mapping data(19)

Sequence Map

Chr7:46841475-46855627 bp, + strand From VEGA annotation of GRCm38   14153 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:56495  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: L-lactate/malate dehydrogenase
Gene Tree: Ldha

Human
homologs

Human Homolog		LDHA, lactate dehydrogenase A
NCBI Gene ID		3939
neXtProt AC		NX_P00338
Human Synonyms		GSD11, HEL-S-133P, LDH1, LDHM, PIG19
Human Chr (Location)		11p15.4; chr11:18394389-18408218 (+)  GRCh38
Disease Associations		(1) Diseases Associated with Human LDHA

Mutations,
alleles, and
phenotypes

All mutations/alleles(35) : Chemically induced (ENU)(7) Chemically induced (other)(2) Gene trapped(21) Radiation induced(3) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 

Mice homozygous for one chemically induced mutation exhibit severe hemolytic anemia with pronounced reticulocytosis and hyperbilirubinemia. Another mutation results in prenatal lethality in homozygotes.

 

Interactions

Ldha interacts with 104 markers (Mir17, Mir20b, Mir22, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (20 annotations)

Process	carbohydrate metabolic process, carboxylic acid metabolic process, ...
Component	cytoplasm, cytosol, ...
Function	catalytic activity, L-lactate dehydrogenase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (8 records)

Data Summary: Results (121)    Tissues (119)    Images (21)    Tissue x Stage Matrix (view)

Assay Type	Results
RNA in situ	119
RT-PCR	2

cDNA source data(1176)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(1193) Genomic(12) cDNA(1177) Primer pair(4)
Microarray probesets(3)

Other database
links

VEGA Gene Model	OTTMUSG00000016500 (Evidence)
Ensembl Gene Model	ENSMUSG00000063229 (Evidence)
Entrez Gene	16828 (Evidence)
UniGene	29324
DFCI	TC1573644, TC1595419, TC1700642
DoTS	DT.91306915, DT.101138883, DT.103574198, DT.110760323, DT.111003070, DT.111003077, DT.97377399, DT.97382448, DT.97386496, DT.99872367, DT.99872381
NIA Mouse Gene Index	U008111, U017987, U054859, U068119, U085237, U106424, U278427, U299692, U300515, U330200, U338599, U364657, U380204
EC	1.1.1.27
Consensus CDS Project	CCDS21289.1, CCDS52255.1
International Mouse Knockout Project Status	Ldha

Sequences

Length	Strain/Species
genomic	OTTMUSG00000016500	VEGA Gene Model | MGI Sequence Detail	14153	C57BL/6J
transcript	OTTMUST00000039850	VEGA | MGI Sequence Detail	1766	Not Applicable
polypeptide	OTTMUSP00000017775	VEGA | MGI Sequence Detail	361	Not Applicable

All sequences(145) RefSeq(5) UniProt(12)

Polymorphisms

All PCR and RFLP(3) : PCR(2) RFLP(1) SNPs within 2kb(98 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR015955	Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal
InterPro	IPR022383	Lactate/malate dehydrogenase, C-terminal
InterPro	IPR001236	Lactate/malate dehydrogenase, N-terminal
InterPro	IPR011304	L-lactate dehydrogenase
InterPro	IPR018177	L-lactate dehydrogenase, active site
InterPro	IPR001557	L-lactate/malate dehydrogenase
InterPro	IPR016040	NAD(P)-binding domain
Protein Ontology	PR:000009739	L-lactate dehydrogenase A chain

References

(Earliest) J:5105 Ruddle FH, et al., Allelically-determined isozyme polymorphisms in laboratory populations of mice. Ann N Y Acad Sci. 1968 Jun 14;151(1):531-9
(Latest) J:214948 Wang YH, et al., Cell-state-specific metabolic dependency in hematopoiesis and leukemogenesis. Cell. 2014 Sep 11;158(6):1309-23
All references(98)

Other
accession IDs

MGD-MRK-11762, MGD-MRK-11768, MGI:1890511