Ldha MGI Mouse Gene Detail - MGI:96759 - lactate dehydrogenase A

Ldha Gene Detail

Symbol

Ldha
Name

lactate dehydrogenase A
Synonyms

l7R2, lactate dehydrogenase-A, Ldh1, Ldh-1, LDH-A

Feature Type

protein coding gene
IDs

MGI:96759
NCBI Gene: 16828
Gene Overview

MyGene.info: LDHA

Sequence Map

Chr7:46841475-46855627 bp, + strand
From VEGA annotation of GRCm38

Mouse Genome Browser
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Sequence

14153 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 30.60 cM
Mapping Data

19 experiments
Sequence Tag

D7Mit29

Human Ortholog

LDHA, lactate dehydrogenase A

Vertebrate Orthologs

9

Human Ortholog

LDHA, lactate dehydrogenase A
Orthology source: HomoloGene, HGNC
Synonyms

GSD11, HEL-S-133P, LDHM, PIG19
Links

HGNC:6535

NCBI Gene ID: 3939

neXtProt AC: NX_P00338

UniProt: P00338
Chr Location

11p15.1; chr11:18394389-18408218 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 56495
1 human;1 mouse;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: LDHA
Protein SuperFamily

L-lactate/malate dehydrogenase
Gene Tree

Ldha

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Phenotype Summary

30 phenotypes from 13 alleles in 13 genetic backgrounds
1 phenotype from multigenic genotypes
27 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

36
Chemically induced (ENU)

7
Chemically induced (other)

2
Gene trapped

21
Radiation induced

3
Targeted

3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

20 strains or lines available

Mice homozygous for one chemically induced mutation exhibit severe hemolytic anemia with pronounced reticulocytosis and hyperbilirubinemia. Another mutation results in prenatal lethality in homozygotes.

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All GO Annotations

25
GO References

11

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

121
Tissues

119
cDNA Data

1176
Literature Summary

13

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA LDHA

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Ldha interacts with 104 markers (Mir17, Mir20b, Mir22, ...) View All

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All Sequences

177
RefSeq

5
UniProt

19
CCDS

CCDS21289.1, CCDS52255.1
UniGene

29324

			Length	Strain/Species	Flank
genomic	OTTMUSG00000016500	VEGA Gene Model \| MGI Sequence Detail	14153	C57BL/6J	± kb
transcript	OTTMUST00000039849	VEGA \| MGI Sequence Detail	1588	Not Applicable
polypeptide	OTTMUSP00000017774	VEGA \| MGI Sequence Detail	332	Not Applicable

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SNPs within 2kb

98 from dbSNP Build 142

PCR

2
RFLP

1

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UniProt

19 Sequences
Protein Ontology

PR:000009739 L-lactate dehydrogenase A chain

(term hierarchy)
EC

1.1.1.27
InterPro Domains

IPR015955 Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal

IPR022383 Lactate/malate dehydrogenase, C-terminal

IPR001236 Lactate/malate dehydrogenase, N-terminal

IPR011304 L-lactate dehydrogenase

IPR018177 L-lactate dehydrogenase, active site

IPR001557 L-lactate/malate dehydrogenase

IPR016040 NAD(P)-binding domain

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All nucleic 1193

Genomic 12

cDNA 1177

Primer pair 4

Microarray probesets 3

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MGD-MRK-11762, MGD-MRK-11768, MGI:1890511

Summaries

All 93

Developmental Gene Expression 13

Gene Ontology 11

Phenotypes 27
Earliest

J:5105 Ruddle FH, et al., Allelically-determined isozyme polymorphisms in laboratory populations of mice. Ann N Y Acad Sci. 1968 Jun 14;151(1):531-9
Latest

J:240028 Bulusu V, et al., Spatiotemporal Analysis of a Glycolytic Activity Gradient Linked to Mouse Embryo Mesoderm Development. Dev Cell. 2017 Feb 27;40(4):331-341.e4

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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