About   Help   FAQ
Lcn2
Gene Detail
Symbol

Name
ID
Lcn2
lipocalin 2
MGI:96757
Synonyms
24p3, NGAL
Feature Type
protein coding gene
Genetic Map
Chromosome 2
22.09 cM, cytoband A3
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr2:32384633-32388252 bp, - strand
From VEGA annotation of GRCm38

  3620 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4064  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: LCN2
Protein SuperFamily: lipocalin
Gene Tree: Lcn2

Human
homologs
LCN2, lipocalin 2
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 3934
neXtProt AC: NX_P80188

Human Synonyms: 24p3, MSFI, NGAL

Human Chr (Location): 9q34; chr9:128149453-128153455 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Gene trapped(1) Targeted(8)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutants are more susceptible to infection with bacteria that utilize enterochelin-type siderophores to acquire iron. Mice homozygous for another knock-out allele exhibit apoptotic defects in hematopoietic cells.
 
Interactions
Lcn2 interacts with 32 markers (Mir22, Mir92-2, Mir122, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (29 annotations)
Process apoptotic process, cellular response to hydrogen peroxide, ...
Component cell, cytosol, ...
Function iron ion binding, protease binding, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (65)    Tissues (16)    Images (29)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 25
Northern blot 36
Western blot 4
cDNA source data(542)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(544) cDNA(542) Other(2)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000012958 (Evidence)
Ensembl Gene Model ENSMUSG00000026822 (Evidence)
Entrez Gene 16819 (Evidence)
UniGene 9537
DFCI TC1573315, TC1720586
DoTS DT.101247074, DT.55100399, DT.94379620
NIA Mouse Gene Index U022503
PDB 3U9P, 3S26
Consensus CDS Project CCDS15913.1
International Mouse Phenotyping Consortium Status Lcn2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000012958 VEGA Gene Model | MGI Sequence Detail 3620 C57BL/6J ±  kb
transcript OTTMUST00000129539 VEGA | MGI Sequence Detail 908 Not Applicable 
polypeptide OTTMUSP00000069578 VEGA | MGI Sequence Detail 271 Not Applicable 

For the selected sequences
All sequences(39) RefSeq(2) UniProt(2)
Polymorphisms
RFLP(1) : SNPs within 2kb(16 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR012674 Calycin
InterPro IPR011038 Calycin-like
InterPro IPR002345 Lipocalin
InterPro IPR022272 Lipocalin conserved site
InterPro IPR000566 Lipocalin/cytosolic fatty-acid binding protein domain
InterPro IPR003087 Neutrophil gelatinase-associated lipocalin
Protein Ontology PR:000009725 neutrophil gelatinase-associated lipocalin
References
(Earliest) J:20468 Hraba-Renevey S, et al., SV40-induced expression of mouse gene 24p3 involves a post-transcriptional mechanism. Oncogene. 1989 May;4(5):601-8
(Latest) J:220909 Watanabe H, et al., Lipocalin 2 binds to membrane phosphatidylethanolamine to induce lipid raft movement in a PKA-dependent manner and modulates sperm maturation. Development. 2014 May;141(10):2157-64
All references(107)
Other
accession IDs
MGD-MRK-11759, MGI:2139327

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/21/2015
MGI 5.22
The Jackson Laboratory