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Lcn2
Gene Detail
 Symbol
Name
ID
Lcn2
lipocalin 2
MGI:96757
Synonyms 24p3, NGAL
Feature Type protein coding gene
Genetic Map
Chromosome 2
22.09 cM, cytoband A3
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr2:32384633-32387797 bp, - strand
From VEGA annotation of GRCm38

  3165 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4064  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: lipocalin
Gene Tree: Lcn2

Human
homologs
Human Homolog LCN2, lipocalin 2
NCBI Gene ID 3934
neXtProt AC  NX_P80188
Human Synonyms  24p3, MSFI, NGAL
Human Chr (Location)  9q34; chr9:128149453-128153455 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutants are more susceptible to infection with bacteria that utilize enterochelin-type siderophores to acquire iron. Mice homozygous for another knock-out allele exhibit apoptotic defects in hematopoietic cells.
 
Interactions
Lcn2 interacts with 32 markers (Mir22, Mir92-2, Mir122, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (29 annotations)
Process apoptotic process, cellular response to hydrogen peroxide, ...
Component cell, cytosol, ...
Function iron ion binding, protease binding, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (65)    Tissues (16)    Images (29)
Theiler Stages: 18, 23, 26, 27, 28
Assay TypeResults
RNA in situ 25
Northern blot 36
Western blot 4
cDNA source data(542)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(544) cDNA(542) Other(2)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000012958 (Evidence)
Ensembl Gene ModelENSMUSG00000026822 (Evidence)
Entrez Gene16819 (Evidence)
UniGene9537
DFCITC1573315, TC1720586
DoTSDT.101247074, DT.55100399, DT.94379620
NIA Mouse Gene IndexU022503
PDB3U9P, 3S26
Consensus CDS ProjectCCDS15913.1
International Mouse Knockout Project StatusLcn2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000012958 VEGA Gene Model | MGI Sequence Detail 3165 C57BL/6J ±  kb
transcript OTTMUST00000031183 VEGA | MGI Sequence Detail 915 Not Applicable 
polypeptide OTTMUSP00000013951 VEGA | MGI Sequence Detail 200 Not Applicable 

For the selected sequences
All sequences(34) RefSeq(2) UniProt(1)
Polymorphisms RFLP(1) : SNPs within 2kb(15 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR012674 Calycin
InterPro IPR011038 Calycin-like
InterPro IPR002345 Lipocalin
InterPro IPR022272 Lipocalin conserved site
InterPro IPR000566 Lipocalin/cytosolic fatty-acid binding protein domain
InterPro IPR003087 Neutrophil gelatinase-associated lipocalin
Protein Ontology PR:000009725 neutrophil gelatinase-associated lipocalin
References (Earliest) J:20468 Hraba-Renevey S, et al., SV40-induced expression of mouse gene 24p3 involves a post-transcriptional mechanism. Oncogene. 1989 May;4(5):601-8
(Latest) J:209285 Ferreira MC, et al., Interleukin-17-induced protein lipocalin 2 is dispensable for immunity to oral candidiasis. Infect Immun. 2014 Mar;82(3):1030-5
All references(99)
Other
accession IDs
MGD-MRK-11759, MGI:2139327

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory