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Lcn2 Gene Detail
Summary
  • Symbol
    Lcn2
  • Name
    lipocalin 2
  • Synonyms
    24p3, neu-related lipocalin, NGAL, NRL
  • Feature Type
    protein coding gene
  • IDs
    MGI:96757
    NCBI Gene: 16819
  • Gene Overview
    MyGene.info: LCN2
  • Alliance
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:32384637-32387739 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 22.09 cM, cytoband A3
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    15 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96757
protein coding gene Chr2:32384633-32388252 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025605
protein coding gene Chr2:30834645-30838264 (-)
A/J MGP_AJ_G0025582
protein coding gene Chr2:29528910-29532536 (-)
AKR/J MGP_AKRJ_G0025552
protein coding gene Chr2:30584916-30588535 (-)
BALB/cJ MGP_BALBcJ_G0025579
protein coding gene Chr2:29654709-29658328 (-)
C3H/HeJ MGP_C3HHeJ_G0025339
protein coding gene Chr2:30476303-30479922 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026023
protein coding gene Chr2:31776703-31780907 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023432
protein coding gene Chr2:28255098-28258824 (-)
CAST/EiJ MGP_CASTEiJ_G0024801
protein coding gene Chr2:30412247-30415875 (-)
CBA/J MGP_CBAJ_G0025317
protein coding gene Chr2:32973173-32976792 (-)
DBA/2J MGP_DBA2J_G0025450
protein coding gene Chr2:29297847-29301466 (-)
FVB/NJ MGP_FVBNJ_G0025412
protein coding gene Chr2:29174219-29177838 (-)
LP/J MGP_LPJ_G0025536
protein coding gene Chr2:30712616-30716235 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025443
protein coding gene Chr2:32633991-32637617 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026081
protein coding gene Chr2:30466228-30470913 (-)
PWK/PhJ MGP_PWKPhJ_G0024549
protein coding gene Chr2:29201079-29204811 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024349
protein coding gene Chr2:30623027-30628233 (-)
WSB/EiJ MGP_WSBEiJ_G0024870
protein coding gene Chr2:30639062-30642681 (-)



Homology
more
  • Human Ortholog
    LCN2, lipocalin 2
  • Vertebrate Orthologs
    7
  • Human Ortholog
    LCN2, lipocalin 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    24p3, MSFI, NGAL, p25
  • Links
    NCBI Gene ID: 3934
    neXtProt AC: NX_P80188
    UniProt: P80188

  • Chr Location
    9q34.11; chr9:128149430-128153455 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    48 phenotypes from 4 alleles in 7 genetic backgrounds
    77 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutants are more susceptible to infection with bacteria that utilize enterochelin-type siderophores to acquire iron and impaired thermogenesis. Mice homozygous for another knock-out allele exhibit apoptotic defects in hematopoietic cells.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16819 NCBI Gene Model | MGI Sequence Detail 3103 C57BL/6J ±  kb
    transcript NM_008491 RefSeq | MGI Sequence Detail 853 Swiss  
    polypeptide P11672 UniProt | EBI | MGI Sequence Detail 200 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 545
      cDNA 543
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-11759, MGI:2139327
    References
    more
    • Summaries
      All 154
      Developmental Gene Expression 10
      Gene Ontology 11
      Phenotypes 77
    • Earliest
      J:20468 Hraba-Renevey S, et al., SV40-induced expression of mouse gene 24p3 involves a post-transcriptional mechanism. Oncogene. 1989 May;4(5):601-8
    • Latest
      J:272266 Rebalka IA, et al., Loss of the adipokine lipocalin-2 impairs satellite cell activation and skeletal muscle regeneration. Am J Physiol Cell Physiol. 2018 Nov 1;315(5):C714-C721

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    last database update
    10/08/2019
    MGI 6.14
    The Jackson Laboratory