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Lck Gene Detail
Summary
  • Symbol
    Lck
  • Name
    lymphocyte protein tyrosine kinase
  • Synonyms
    Hck-3, p56lck
  • Feature Type
    protein coding gene
  • IDs
    MGI:96756
    NCBI Gene: 16818
  • Gene Overview
    MyGene.info: LCK
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr4:129548349-129573641 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      25293 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 63.26 cM, cytoband distal
  • Mapping Data
    60 experiments
  • Sequence Tag
    D4Nds20
Homology
more
  • Human Ortholog
    LCK, LCK proto-oncogene, Src family tyrosine kinase
  • Vertebrate Orthologs
    9
  • Human Ortholog
    LCK, LCK proto-oncogene, Src family tyrosine kinase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    IMD22, LSK, p56lck, pp58lck, YT16
  • Links
    NCBI Gene ID: 3932
    neXtProt AC: NX_P06239
    UniProt: P06239

  • Chr Location
    1p35.2; chr1:32251239-32286167 (+)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    43 phenotypes from 10 alleles in 9 genetic backgrounds
    35 phenotypes from multigenic genotypes
    97 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for mutations of this gene exhibit thymic atrophy with reduced numbers of peripheral T cells. Null mutants have few double positive and no mature single positive (SP) thymocytes. A hypomorph has decreased expression of CD3epsilon chain onSP thymocytes, whose numbers are reduced.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    86
  • GO References
    38
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    23
  • Tissues
    20
  • cDNA Data
    26
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000009667 VEGA Gene Model | MGI Sequence Detail 25293 C57BL/6J ±  kb
    transcript OTTMUST00000022308 VEGA | MGI Sequence Detail 2185 Not Applicable  
    polypeptide OTTMUSP00000010179 VEGA | MGI Sequence Detail 509 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      320 from dbSNP Build 142
    • PCR
      4
    • RFLP
      14
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 43
      Genomic 8
      cDNA 30
      Primer pair 4
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-10669, MGD-MRK-11758
    References
    more
    • Summaries
      All 275
      Developmental Gene Expression 3
      Gene Ontology 38
      Phenotypes 97
    • Earliest
      J:8130 Marth JD, et al., A lymphocyte-specific protein-tyrosine kinase gene is rearranged and overexpressed in the murine T cell lymphoma LSTRA. Cell. 1985 Dec;43(2 Pt 1):393-404
    • Latest
      J:251940 Courtney AH, et al., A Phosphosite within the SH2 Domain of Lck Regulates Its Activation by CD45. Mol Cell. 2017 Aug 3;67(3):498-511.e6
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    07/10/2018
    MGI 6.12     		The Jackson Laboratory