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Lck Gene Detail
Summary
  • Symbol
    Lck
  • Name
    lymphocyte protein tyrosine kinase
  • Synonyms
    Hck-3, p56lck
  • Feature Type
    protein coding gene
  • IDs
    MGI:96756
    NCBI Gene: 16818
  • Gene Overview
    MyGene.info: LCK
Location & Maps
more
  • Sequence Map
    Chr4:129548349-129573641 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      25293 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 63.26 cM, cytoband distal
  • Mapping Data
    60 experiments
  • Sequence Tag
    D4Nds20
Homology
more
  • Human Ortholog
    LCK, LCK proto-oncogene, Src family tyrosine kinase
  • Vertebrate Orthologs
    9
  • Human Ortholog
    LCK, LCK proto-oncogene, Src family tyrosine kinase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    IMD22, LSK, p56lck, pp58lck, YT16
  • Links
    NCBI Gene ID: 3932
    neXtProt AC: NX_P06239

  • Chr Location
    1p34.3; chr1:32251239-32286170 (+)  GRCh38.p2
Human Diseases
more
  • Diseases
    1 with human LCK associations

Human Disease Mouse Models
       Immunodeficiency 22; IMD22   OMIM: 615758
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    43 phenotypes from 10 alleles in 9 genetic backgrounds
    35 phenotypes from multigenic genotypes
    96 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    37
  • Chemically induced (ENU)
    3
  • Chemically induced (other)
    2
  • Gene trapped
    15
  • Radiation induced
    1
  • Targeted
    8
  • Transgenic
    8
  • Genomic Mutations
    4 involving Lck
  • Incidental Mutations
    Mutagenetix , APF , CvDC
Mice homozygous for mutations of this gene exhibit thymic atrophy with reduced numbers of peripheral T cells. Null mutants have few double positive and no mature single positive (SP) thymocytes. A hypomorph has decreased expression of CD3epsilon chain onSP thymocytes, whose numbers are reduced.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    75
  • GO References
    25
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    23
  • Tissues
    20
  • cDNA Data
    25
  • Literature Summary
    3
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000009667 VEGA Gene Model | MGI Sequence Detail 25293 C57BL/6J ±  kb
transcript OTTMUST00000022307 VEGA | MGI Sequence Detail 2111 Not Applicable  
polypeptide OTTMUSP00000010178 VEGA | MGI Sequence Detail 509 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    320 from dbSNP Build 142
  • PCR
    4
  • RFLP
    14
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 42
    Genomic 8
    cDNA 29
    Primer pair 4
    Other 1

    Microarray probesets 6
Other
Accession IDs
less
MGD-MRK-10669, MGD-MRK-11758
References
more
  • Summaries
    All 223
    Developmental Gene Expression 3
    Gene Ontology 25
    Phenotypes 96
  • Earliest
    J:8130 Marth JD, et al., A lymphocyte-specific protein-tyrosine kinase gene is rearranged and overexpressed in the murine T cell lymphoma LSTRA. Cell. 1985 Dec;43(2 Pt 1):393-404
  • Latest
    J:233828 De Cunto G, et al., Severe Reduction in Number and Function of Peripheral T Cells Does Not Afford Protection toward Emphysema and Bronchial Remodeling Induced in Mice by Cigarette Smoke. Am J Pathol. 2016 Jul;186(7):1814-24
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/27/2016
MGI 6.05 		The Jackson Laboratory