Lck MGI Mouse Gene Detail - MGI:96756 - lymphocyte protein tyrosine kinase

Symbol

Lck
Name

lymphocyte protein tyrosine kinase
Synonyms

Hck-3, p56^lck

Feature Type

protein coding gene
IDs

MGI:96756
NCBI Gene: 16818
Gene Overview

MyGene.info: LCK
Alliance

gene page
Transcription Start Sites

12 TSS

Sequence Map

Chr4:129548344-129573641 bp, - strand
From NCBI annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 63.26 cM, cytoband distal
Mapping Data

60 experiments
Sequence Tag

D4Nds20

SNPs within 2kb

320 from dbSNP Build 142
Strain Annotations

18
PCR

4
RFLP

14

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_96756	protein coding gene	Chr4:129548344-129573641 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0028828	protein coding gene	Chr4:131479407-131510796 (-)
A/J	MGP_AJ_G0028787	protein coding gene	Chr4:126225864-126251421 (-)
AKR/J	MGP_AKRJ_G0028740	protein coding gene	Chr4:129746086-129773420 (-)
BALB/cJ	MGP_BALBcJ_G0028810	protein coding gene	Chr4:126829849-126858493 (-)
C3H/HeJ	MGP_C3HHeJ_G0028524	protein coding gene	Chr4:129796665-129824989 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0029252	protein coding gene	Chr4:136426404-136451032 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026524	protein coding gene	Chr4:119356594-119380153 (-)
CAST/EiJ	MGP_CASTEiJ_G0027956	protein coding gene	Chr4:127982134-128011048 (-)
CBA/J	MGP_CBAJ_G0028490	protein coding gene	Chr4:139801893-139843113 (-)
DBA/2J	MGP_DBA2J_G0028639	protein coding gene	Chr4:126660025-126686742 (-)
FVB/NJ	MGP_FVBNJ_G0028606	protein coding gene	Chr4:125418087-125443651 (-)
LP/J	MGP_LPJ_G0028740	protein coding gene	Chr4:131756787-131787457 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028632	protein coding gene	Chr4:144629300-144656931 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029290	protein coding gene	Chr4:130114117-130141019 (-)
PWK/PhJ	MGP_PWKPhJ_G0027678	protein coding gene	Chr4:123262862-123288361 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0027504	protein coding gene	Chr4:125977347-126007300 (-)
WSB/EiJ	MGP_WSBEiJ_G0028037	protein coding gene	Chr4:130236359-130267511 (-)

Human Ortholog

LCK, LCK proto-oncogene, Src family tyrosine kinase

Vertebrate Orthologs

9

Human Ortholog

LCK, LCK proto-oncogene, Src family tyrosine kinase
Orthology source: HomoloGene, HGNC
Synonyms

IMD22, LSK, p56lck, pp58lck, YT16
Links

HGNC:6524

NCBI Gene ID: 3932

neXtProt AC: NX_P06239

UniProt: P06239
Chr Location

1p35.2; chr1:32251239-32286167 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 3911
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
HCOP

human homology predictions: LCK
Protein SuperFamily

tyrosine-protein kinase, proto-oncogene SRC type
Gene Tree

Lck

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Phenotype Summary

43 phenotypes from 10 alleles in 9 genetic backgrounds
35 phenotypes from multigenic genotypes
99 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

37
Chemically induced (ENU)

3
Chemically induced (other)

2
Gene trapped

15
Radiation induced

1
Targeted

8
Transgenic

8
Genomic Mutations

4 involving Lck
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

89 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

1

Mice homozygous for mutations of this gene exhibit thymic atrophy with reduced numbers of peripheral T cells. Null mutants have few double positive and no mature single positive (SP) thymocytes. A hypomorph has decreased expression of CD3epsilon chain onSP thymocytes, whose numbers are reduced.

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All GO Annotations

89
GO References

35

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

23
Tissues

20
cDNA Data

26
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN lck

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Lck interacts with 91 markers (Mir15a, Mir18, Mir20a, ...) View All

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All Sequences

64
RefSeq

8
UniProt

4
CCDS

CCDS18697.1, CCDS51306.1

Ensembl

ENSMUSG00000000409 (Evidence)
NCBI Gene

16818 (Evidence)

			Length	Strain/Species	Flank
genomic	16818	NCBI Gene Model \| MGI Sequence Detail	25298	C57BL/6J	± kb
transcript	NM_010693	RefSeq \| MGI Sequence Detail	2171	C57BL/6
polypeptide	P06240	UniProt \| EBI \| MGI Sequence Detail	509	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000002998 tyrosine-protein kinase Lck

(term hierarchy)
EC

2.7.10.2
InterPro Domains

IPR035749 Lck, SH3 domain

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain

IPR000980 SH2 domain

IPR036860 SH2 domain superfamily

IPR001452 SH3 domain

IPR036028 SH3-like domain superfamily

IPR008266 Tyrosine-protein kinase, active site

IPR020635 Tyrosine-protein kinase, catalytic domain

IPR035850 Tyrosine-protein kinase Lck, SH2 domain

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All nucleic 43

Genomic 8

cDNA 30

Primer pair 4

Other 1

Microarray probesets 6

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MGD-MRK-10669, MGD-MRK-11758

Summaries

All 276

Developmental Gene Expression 3

Gene Ontology 35

Phenotypes 99
Earliest

J:8130 Marth JD, et al., A lymphocyte-specific protein-tyrosine kinase gene is rearranged and overexpressed in the murine T cell lymphoma LSTRA. Cell. 1985 Dec;43(2 Pt 1):393-404
Latest

J:251940 Courtney AH, et al., A Phosphosite within the SH2 Domain of Lck Regulates Its Activation by CD45. Mol Cell. 2017 Aug 3;67(3):498-511.e6

TSS for Lck:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr43527	Chr4:129573637-129573652 (-)	-4 bp
Tssr43526	Chr4:129573599-129573629 (-)	27 bp
Tssr43522	Chr4:129558830-129558841 (-)	14,805 bp
Tssr43521	Chr4:129558808-129558821 (-)	14,826 bp
Tssr43520	Chr4:129558776-129558792 (-)	14,857 bp
Tssr43519	Chr4:129558749-129558760 (-)	14,886 bp
Tssr43518	Chr4:129558387-129558398 (-)	15,248 bp
Tssr43517	Chr4:129558355-129558378 (-)	15,274 bp
Tssr43516	Chr4:129558334-129558345 (-)	15,301 bp
Tssr43515	Chr4:129558253-129558258 (-)	15,385 bp
Tssr43514	Chr4:129556475-129556549 (-)	17,129 bp
Tssr43513	Chr4:129555784-129555815 (-)	17,841 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 06/11/2019 MGI 6.14