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Lamb1
Gene Detail
Symbol

Name
ID
Lamb1
laminin B1
MGI:96743
Synonyms
C80098, C81607, D130003D08Rik, Lamb-1
Feature Type
protein coding gene
Genetic Map
Chromosome 12
13.39 cM
Detailed Genetic Map ± 1 cM


Mapping data(25)
Sequence Map
Chr12:31265234-31329644 bp, + strand
From VEGA annotation of GRCm38

  64411 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1722  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: LAMB1
Gene Tree: Lamb1

Human
homologs
LAMB1, laminin, beta 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 3912
neXtProt AC: NX_P07942

Human Synonyms: CLM, LIS5

Human Chr (Location): 7q22; chr7:107923801-108003359 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human LAMB1

Mutations,
alleles, and
phenotypes
All mutations/alleles(21) : Gene trapped(18) Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Embryos homozygous for a gene trapped allele lack basement membranes and fail to survive past E5.5. The mutant embryonic region shows no signs of cavitation, the mural trophectoderm and parietal endoderm appear disorganized, and trophoblast invasion is greatly reduced.
 
Interactions
Lamb1 interacts with 106 markers (Mir10b, Mir15a, Mir15b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (37 annotations)
Process cell adhesion, cell migration, ...
Component basal lamina, basement membrane, ...
Function enzyme binding, extracellular matrix structural constituent, ...
External Resources: FuncBase
Expression
Literature Summary: (86 records)
Data Summary: Results (387)    Tissues (163)    Images (53)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 24
RNA in situ 326
Northern blot 20
Western blot 2
RT-PCR 15
cDNA source data(23)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA LAMB1 ; Xenbase lamb1 ; ZFIN lamb1a, lamb1b    NEW 
Molecular
reagents
All nucleic(36) Genomic(1) cDNA(26) Primer pair(5) Other(4)
Microarray probesets(7)
Other database
links
VEGA Gene Model OTTMUSG00000035464 (Evidence)
Ensembl Gene Model ENSMUSG00000002900 (Evidence)
Entrez Gene 16777 (Evidence)
DFCI TC1574286, TC1609950, TC1702592
DoTS DT.102544272, DT.40151935, DT.40160372, DT.495296, DT.94360950, DT.94382624, DT.97332613
NIA Mouse Gene Index U013837
PDB 4AQS
Consensus CDS Project CCDS25862.1
International Mouse Phenotyping Consortium Status Lamb1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035464 VEGA Gene Model | MGI Sequence Detail 64411 C57BL/6J ±  kb
transcript OTTMUST00000090763 VEGA | MGI Sequence Detail 5784 Not Applicable 
polypeptide OTTMUSP00000049841 VEGA | MGI Sequence Detail 1834 Not Applicable 

For the selected sequences
All sequences(78) RefSeq(6) UniProt(11)
Polymorphisms
All PCR and RFLP(4) : PCR(2) RFLP(2) SNPs within 2kb(508 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002049 EGF-like, laminin
InterPro IPR013015 Laminin IV
InterPro IPR008211 Laminin, N-terminal
InterPro IPR009053 Prefoldin
Protein Ontology PR:000029583 laminin subunit beta-1
References
(Earliest) J:24442 Kurkinen M, et al., In vitro synthesis of laminin and entactin polypeptides. J Biol Chem. 1983 May 25;258(10):6543-8
(Latest) J:215166 Ayala de la Pena F, et al., Specific activation of K-RasG12D allele in the bladder urothelium results in lung alveolar and vascular defects. PLoS One. 2014;9(4):e95888
All references(172)
Other
accession IDs
MGD-MRK-11734, MGD-MRK-11737, MGI:2145087, MGI:2145103, MGI:2145114

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory