About   Help   FAQ
Lamb1
Gene Detail
 Symbol
Name
ID
Lamb1
laminin B1
MGI:96743
Synonyms C80098, C81607, D130003D08Rik, Lamb-1
Feature Type protein coding gene
Genetic Map
Chromosome 12
13.39 cM
Detailed Genetic Map ± 1 cM


Mapping data(25)
Sequence Map
Chr12:31265234-31329644 bp, + strand
From VEGA annotation of GRCm38

  64411 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1722  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Lamb1

Human
homologs
Human Homolog LAMB1, laminin, beta 1
NCBI Gene ID 3912
neXtProt AC  NX_P07942
Human Synonyms  CLM, LIS5
Human Chr (Location)  7q22; chr7:107923801-108003359 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human LAMB1
Mutations,
alleles, and
phenotypes
All mutations/alleles(21) : Gene trapped(18) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Embryos homozygous for a gene trapped allele lack basement membranes and fail to survive past E5.5. The mutant embryonic region shows no signs of cavitation, the mural trophectoderm and parietal endoderm appear disorganized, and trophoblast invasion is greatly reduced.
 
Interactions
Lamb1 interacts with 107 markers (Mir10b, Mir15a, Mir15b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (37 annotations)
Process cell adhesion, cell migration, ...
Component basal lamina, basement membrane, ...
Function enzyme binding, extracellular matrix structural constituent, ...
External Resources: FuncBase
Expression
Literature Summary: (83 records)
Data Summary: Results (386)    Tissues (164)    Images (52)
Theiler Stages: 1, 2, 3, 4, 5, 11, 17, 18, 20, 23, 24, 26, 28
Assay TypeResults
Immunohistochemistry 25
RNA in situ 326
Northern blot 20
Western blot 2
RT-PCR 13
cDNA source data(23)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(35) Genomic(1) cDNA(26) Primer pair(4) Other(4)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000035464 (Evidence)
Ensembl Gene ModelENSMUSG00000002900 (Evidence)
Entrez Gene16777 (Evidence)
DFCITC1574286, TC1609950, TC1702592
DoTSDT.102544272, DT.40151935, DT.40160372, DT.495296, DT.94360950, DT.94382624, DT.97332613
PDB4AQS
Consensus CDS ProjectCCDS25862.1
International Mouse Knockout Project StatusLamb1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035464 VEGA Gene Model | MGI Sequence Detail 64411 C57BL/6J ±  kb
transcript OTTMUST00000090763 VEGA | MGI Sequence Detail 5784 Not Applicable 
polypeptide OTTMUSP00000049841 VEGA | MGI Sequence Detail 1834 Not Applicable 

For the selected sequences
All sequences(77) RefSeq(6) UniProt(11)
Polymorphisms All PCR and RFLP(4) : PCR(2) RFLP(2) SNPs within 2kb(508 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002049 EGF-like, laminin
InterPro IPR013015 Laminin IV
InterPro IPR008211 Laminin, N-terminal
InterPro IPR009053 Prefoldin
Protein Ontology PR:000029583 laminin subunit beta-1
References (Earliest) J:24442 Kurkinen M, et al., In vitro synthesis of laminin and entactin polypeptides. J Biol Chem. 1983 May 25;258(10):6543-8
(Latest) J:208341 Seth A, et al., Prox1 ablation in hepatic progenitors causes defective hepatocyte specification and increases biliary cell commitment. Development. 2014 Feb;141(3):538-47
All references(170)
Other
accession IDs
MGD-MRK-11734, MGD-MRK-11737, MGI:2145087, MGI:2145103, MGI:2145114

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/09/2014
MGI 5.19
The Jackson Laboratory