Lamb1
Gene Detail

Symbol Name ID

Lamb1 laminin B1 MGI:96743

Synonyms

C80098, C81607, D130003D08Rik, Lamb-1

Feature Type

protein coding gene

Genetic Map

Chromosome 12

13.39 cM
Detailed Genetic Map ± 1 cM


Mapping data(25)

Sequence Map

Chr12:31265234-31329644 bp, + strand From VEGA annotation of GRCm38   64411 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1722  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Lamb1

Human homologs

Human Homolog		LAMB1, laminin, beta 1
NCBI Gene ID		3912
neXtProt AC		NX_P07942
Human Synonyms		CLM, LIS5
Human Chr (Location)		7q22; chr7:107564246-107643804 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human LAMB1

Alleles and phenotypes

All alleles(21) : Targeted(3) Gene trapped(18)
 

Embryos homozygous for a gene trapped allele lack basement membranes and fail to survive past E5.5. The mutant embryonic region shows no signs of cavitation, the mural trophectoderm and parietal endoderm appear disorganized, and trophoblast invasion is greatly reduced.

 

Gene Ontology (GO) classifications

All GO classifications: (33 annotations)

Process	cell adhesion, cell migration, ...
Component	basal lamina, basement membrane, ...
Function	enzyme binding, extracellular matrix structural constituent, ...

External Resources: FuncBase

Expression

Literature Summary: (77 records)
Data Summary: Results (375)    Tissues (145)    Images (51)
Theiler Stages: 1, 2, 3, 4, 11, 17, 18, 20, 23, 24, 26, 28

Assay Type	Results
Immunohistochemistry	25
RNA in situ	305
Northern blot	23
Western blot	2
RT-PCR	20

cDNA source data(203)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(215) Genomic(1) cDNA(206) Primer pair(4) Other(4)
Microarray probesets(7)

Other database links

VEGA Gene Model	OTTMUSG00000035464 (Evidence)
Ensembl Gene Model	ENSMUSG00000002900 (Evidence)
Entrez Gene	16777 (Evidence)
UniGene	172674
DFCI	TC1574286, TC1609950, TC1702592
DoTS	DT.102544272, DT.40151935, DT.40160372, DT.495296, DT.94360950, DT.94382624, DT.97332613
PDB	4AQS
Consensus CDS Project	CCDS25862.1
International Mouse Knockout Project Status	Lamb1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000035464	VEGA Gene Model | MGI Sequence Detail	64411	C57BL/6J
transcript	OTTMUST00000090763	VEGA | MGI Sequence Detail	5784	Not Applicable
polypeptide	OTTMUSP00000049841	VEGA | MGI Sequence Detail	1834	Not Applicable

All sequences(73) RefSeq(2) UniProt(11)

Polymorphisms

All PCR and RFLP(4) : PCR(2) RFLP(2) SNPs(407 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002049	EGF-like, laminin
InterPro	IPR013015	Laminin IV
InterPro	IPR008211	Laminin, N-terminal
InterPro	IPR009053	Prefoldin
Protein Ontology	PR:000029583	laminin subunit beta-1

References

(Earliest) J:24442 Kurkinen M, et al., In vitro synthesis of laminin and entactin polypeptides. J Biol Chem. 1983 May 25;258(10):6543-8
(Latest) J:191082 Clavel C, et al., Sox2 in the dermal papilla niche controls hair growth by fine-tuning BMP signaling in differentiating hair shaft progenitors. Dev Cell. 2012 Nov 13;23(5):981-94
All references(163)

Other accession IDs

MGD-MRK-11734, MGD-MRK-11737, MGI:2145087, MGI:2145103, MGI:2145114