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Lamb1 Gene Detail
Summary
  • Symbol
    Lamb1
  • Name
    laminin B1
  • Synonyms
    C80098, C81607, D130003D08Rik, Lamb-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:96743
    NCBI Gene: 16777
Location & Maps
more
  • Sequence Map
    Chr12:31265234-31329644 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      64411 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 13.39 cM
  • Detailed Genetic Map ± 1 cM
  • Mapping Data
    25 experiments
Homology
more
  • Human Ortholog
    LAMB1, laminin subunit beta 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    LAMB1, laminin subunit beta 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CLM, LIS5
  • Links
    NCBI Gene ID: 3912
    neXtProt AC: NX_P07942

  • Chr Location
    7q22; chr7:107923801-108003359 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 1722
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: LAMB1
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human LAMB1 associations

Human Disease Mouse Models
       Lissencephaly 5; LIS5   OMIM: 615191
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
Embryos homozygous for a gene trapped allele lack basement membranes and fail to survive past E5.5. The mutant embryonic region shows no signs of cavitation, the mural trophectoderm and parietal endoderm appear disorganized, and trophoblast invasion is greatly reduced.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035464 VEGA Gene Model | MGI Sequence Detail 64411 C57BL/6J ±  kb
transcript OTTMUST00000090763 VEGA | MGI Sequence Detail 5784 Not Applicable  
polypeptide OTTMUSP00000049841 VEGA | MGI Sequence Detail 1834 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    510 from dbSNP Build 142
  • PCR
  • RFLP
Protein
Information
less
Molecular
Reagents
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  • All nucleic 36
    Genomic 1
    cDNA 26
    Primer pair 5
    Other 4

    Microarray probesets 7
Other
Accession IDs
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MGD-MRK-11734, MGD-MRK-11737, MGI:2145087, MGI:2145103, MGI:2145114
References
more
  • Summaries
    All 170
    Developmental Gene Expression 86
    Gene Ontology 24
    Phenotypes 10
  • Earliest
    J:24442 Kurkinen M, et al., In vitro synthesis of laminin and entactin polypeptides. J Biol Chem. 1983 May 25;258(10):6543-8
  • Latest
    J:215166 Ayala de la Pena F, et al., Specific activation of K-RasG12D allele in the bladder urothelium results in lung alveolar and vascular defects. PLoS One. 2014;9(4):e95888

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory