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Hikeshi Gene Detail
Summary
  • Symbol
    Hikeshi
  • Name
    heat shock protein nuclear import factor
  • Synonyms
    0610007P06Rik, 1110002N09Rik, Hikeshi, l(7)6Rn, l7Rn6
  • Feature Type
    protein coding gene
  • IDs
    MGI:96738
    NCBI Gene: 67669
  • Gene Overview
    MyGene.info: HIKESHI
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:89917529-89941204 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 50.40 cM, cytoband E1
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    148 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96738
protein coding gene Chr7:89917529-89941223 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032500
protein coding gene Chr7:92308391-92341255 (-)
A/J MGP_AJ_G0032474
protein coding gene Chr7:90095143-90121639 (-)
AKR/J MGP_AKRJ_G0032410
protein coding gene Chr7:92186765-92216796 (-)
BALB/cJ MGP_BALBcJ_G0032485
protein coding gene Chr7:89736526-89767814 (-)
C3H/HeJ MGP_C3HHeJ_G0032200
protein coding gene Chr7:92585341-92614051 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032983
protein coding gene Chr7:95905474-95931042 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029978
protein coding gene Chr7:92995797-93018421 (-)
CAST/EiJ MGP_CASTEiJ_G0031527
protein coding gene Chr7:84024478-84053484 (-)
CBA/J MGP_CBAJ_G0032167
protein coding gene Chr7:99101561-99130198 (-)
DBA/2J MGP_DBA2J_G0032319
protein coding gene Chr7:88521413-88546743 (-)
FVB/NJ MGP_FVBNJ_G0032275
protein coding gene Chr7:88394965-88417190 (-)
LP/J MGP_LPJ_G0032408
protein coding gene Chr7:93553599-93580071 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032309
protein coding gene Chr7:100110105-100136951 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033005
protein coding gene Chr7:91482506-91507999 (-)
PWK/PhJ MGP_PWKPhJ_G0031245
protein coding gene Chr7:81554367-81582233 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031088
protein coding gene Chr7:78805960-78831335 (-)
WSB/EiJ MGP_WSBEiJ_G0031644
protein coding gene Chr7:92140090-92166908 (-)



Homology
more
  • Human Ortholog
    HIKESHI, Hikeshi, heat shock protein nuclear import factor
  • Vertebrate Orthologs
    10
  • Human Ortholog
    HIKESHI, Hikeshi, heat shock protein nuclear import factor
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C11orf73, HLD13, HSPC138, HSPC179, L7RN6, OPI10
  • Links
    NCBI Gene ID: 51501
    neXtProt AC: NX_Q53FT3
    UniProt: Q53FT3

  • Chr Location
    11q14.2; chr11:86302211-86345943 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human HIKESHI associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 2 alleles in 2 genetic backgrounds
    35 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for an ENU-induced mutation die prenatally or neonatally, and exhibit cyanoisis with a significant emphysematous phenotype at birth. The secretory apparatus in Clara cells is also affected.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000062797 Ensembl Gene Model | MGI Sequence Detail 23676 C57BL/6J ±  kb
    transcript ENSMUST00000153470 Ensembl | MGI Sequence Detail 2224 Not Applicable  
    polypeptide ENSMUSP00000119806 Ensembl | MGI Sequence Detail 197 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 71
      Genomic 2
      cDNA 63
      Primer pair 1
      Other 5

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-11694, MGD-MRK-11726, MGI:1913365, MGI:1914919
    References
    more
    • Summaries
      All 55
      Developmental Gene Expression 1
      Gene Ontology 2
      Phenotypes 35
    • Earliest
      J:141526 Russell LB, et al., Analysis of the albino-locus region of the mouse. III. Time of death of prenatal lethals. Genetics. 1979 May;92(1):205-13
    • Latest
      J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    03/13/2019
    MGI 6.13
    The Jackson Laboratory