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Ky Gene Detail
Summary
  • Symbol
    Ky
  • Name
    kyphoscoliosis peptidase
  • Synonyms
    D9Mgc44e
  • Feature Type
    protein coding gene
  • IDs
    MGI:96709
    NCBI Gene: 16716
Location & Maps
more
  • Sequence Map
    Chr9:102505750-102546239 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      40490 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 54.54 cM
  • Mapping Data
    7 experiments
Homology
more
  • Human Ortholog
    KY, kyphoscoliosis peptidase
  • Vertebrate Orthologs
    7
  • Human Ortholog
    KY, kyphoscoliosis peptidase
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 339855
    neXtProt AC: NX_Q8NBH2

  • Chr Location
    3q22.2; chr3:134599923-134651677 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    23 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a spontaneous mutation exhibit severe degenerative myopathy involving postural muscles, resulting in thoraco-lumbar kyphoscoliosis with degenerative changes in intervertebral discs. Body weight is reduced and breathing is irregular.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000048441 VEGA Gene Model | MGI Sequence Detail 40490 C57BL/6J ±  kb
transcript OTTMUST00000124158 VEGA | MGI Sequence Detail 5837 Not Applicable  
polypeptide OTTMUSP00000067600 VEGA | MGI Sequence Detail 661 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    331 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 16
    Genomic 5
    cDNA 9
    Primer pair 1
    Other 1

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-11667, MGI:1330308
References
more
  • Summaries
    All 31
    Gene Ontology 4
    Phenotypes 9
  • Earliest
    J:5353 Dickinson AG, et al., Genetic kyphoscoliosis in mice. Lancet. 1973 May 26;1(813):1186
  • Latest
    J:162356 Baker J, et al., Identification of a Z-band associated protein complex involving KY, FLNC and IGFN1. Exp Cell Res. 2010 Jul 1;316(11):1856-70

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory