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Ky
Gene Detail
 Symbol
Name
ID
Ky
kyphoscoliosis peptidase
MGI:96709
Synonyms D9Mgc44e
Feature Type protein coding gene
Genetic Map
Chromosome 9
54.54 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr9:102505750-102546239 bp, + strand
From VEGA annotation of GRCm38

  40490 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:11506  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 dog; 1 chicken; 1 western clawed frog

Gene Tree: Ky

Human
homologs
Human Homolog KY, kyphoscoliosis peptidase
NCBI Gene ID 339855
neXtProt AC  NX_Q8NBH2
Human Chr (Location)  3q22.2; chr3:134599923-134651680 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Spontaneous(1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a spontaneous mutation exhibit severe degenerative myopathy involving postural muscles, resulting in thoraco-lumbar kyphoscoliosis with degenerative changes in intervertebral discs. Body weight is reduced and breathing is irregular.
 
Interactions
Ky interacts with 336 markers (Mir1b, Mir7-1, Mir10a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process muscle organ development, neuromuscular junction development, ...
Component cytoplasm, cytoskeleton, ...
Function cysteine-type peptidase activity, hydrolase activity, ...
External Resources: FuncBase
Expression
cDNA source data(9)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(16) Genomic(5) cDNA(9) Primer pair(1) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000048441 (Evidence)
Ensembl Gene ModelENSMUSG00000035606 (Evidence)
Entrez Gene16716 (Evidence)
UniGene101692
DFCITC1588464, TC1589214
DoTSDT.87047366
NIA Mouse Gene IndexU010931
EC3.4.-.-
Consensus CDS ProjectCCDS23445.1
International Mouse Knockout Project StatusKy
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000048441 VEGA Gene Model | MGI Sequence Detail 40490 C57BL/6J ±  kb
transcript OTTMUST00000124158 VEGA | MGI Sequence Detail 5837 Not Applicable 
polypeptide OTTMUSP00000067600 VEGA | MGI Sequence Detail 661 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(6) UniProt(3)
Polymorphisms SNPs within 2kb(331 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002931 Transglutaminase-like
Protein Ontology PR:000009597 kyphoscoliosis peptidase
References (Earliest) J:5353 Dickinson AG, et al., Genetic kyphoscoliosis in mice. Lancet. 1973 May 26;1(813):1186
(Latest) J:162356 Baker J, et al., Identification of a Z-band associated protein complex involving KY, FLNC and IGFN1. Exp Cell Res. 2010 Jul 1;316(11):1856-70
All references(35)
Other
accession IDs
MGD-MRK-11667, MGI:1330308

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory