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Krt7 Gene Detail
Summary
  • Symbol
    Krt7
  • Name
    keratin 7
  • Synonyms
    Cytokeratin 7, D15Wsu77e, K7, Krt2-7
  • Feature Type
    protein coding gene
  • IDs
    MGI:96704
    NCBI Gene: 110310
  • Gene Overview
    MyGene.info: KRT7
Location & Maps
more
  • Sequence Map
    Chr15:101411043-101430313 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      19271 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 56.88 cM
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    KRT7, keratin 7
  • Vertebrate Orthologs
    9
  • Human Ortholog
    KRT7, keratin 7
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CK7, K2C7, K7, SCL
  • Links
    NCBI Gene ID: 3855
    neXtProt AC: NX_P08729

  • Chr Location
    12q13.13; chr12:52233170-52252667 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 4058
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog
  • HCOP
    human homology predictions: KRT7
  • Gene Tree
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    1 images
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Chemically induced (other)
    1
  • Radiation induced
    2
  • Targeted
    5
  • Genomic Mutations
    4 involving Krt7
  • Incidental Mutations
    APF , CvDC
Mice homozygous for a knock-out allele exhibit increased cell proliferation of urothelial cells without histological evidence of hyperplasia.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028023 VEGA Gene Model | MGI Sequence Detail 19271 C57BL/6J ±  kb
transcript OTTMUST00000069402 VEGA | MGI Sequence Detail 4094 Not Applicable  
polypeptide OTTMUSP00000035246 VEGA | MGI Sequence Detail 457 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    142 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 94
    Genomic 8
    cDNA 85
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-11659, MGD-MRK-34004, MGI:106312
References
more
  • Summaries
    All 64
    Developmental Gene Expression 28
    Diseases 1
    Gene Ontology 4
    Phenotypes 28
  • Earliest
    J:22245 Su L, et al., Protein and mRNA expression of simple epithelial keratins in normal, dysplastic, and malignant oral epithelia. Am J Pathol. 1994 Dec;145(6):1349-57
  • Latest
    J:229385 Teshima TH, et al., Apoptosis in Early Salivary Gland Duct Morphogenesis and Lumen Formation. J Dent Res. 2016 Mar;95(3):277-83

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory