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Krt4 Gene Detail
Summary
  • Symbol
    Krt4
  • Name
    keratin 4
  • Synonyms
    K4, Krt-2.4, Krt2-4
  • Feature Type
    protein coding gene
  • IDs
    MGI:96701
    NCBI Gene: 16682
  • Gene Overview
    MyGene.info: KRT4
Location & Maps
more
  • Sequence Map
    Chr15:101918536-101924735 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      6200 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 57.13 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    KRT4, keratin 4
  • Vertebrate Orthologs
    9
  • Human Ortholog
    KRT4, keratin 4
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CK4, CK-4, CYK4, K4, WSN1
  • Links
    NCBI Gene ID: 3851

  • Chr Location
    12q13.13; chr12:52806543-52814116 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 20523
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog
  • HCOP
    human homology predictions: KRT4
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Krt4 mouse models; 1 with human KRT4 associations

Human Disease Mouse Models
       White Sponge Nevus 1; WSN1   OMIM: 193900 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 2 alleles in 2 genetic backgrounds
    2 images
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    1
  • Radiation induced
    2
  • Targeted
    3
  • Genomic Mutations
    4 involving Krt4
  • Incidental Mutations
Mice homozygous for disruptions in this gene display hyperplasia throughout the epithelium of the esophagus and tongue. Mice homozygous or heterozygous for a dominant mutation display oral leukoplakia and homozygotes display postnatal growth retardation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000059668 Ensembl Gene Model | MGI Sequence Detail 6200 C57BL/6J ±  kb
transcript ENSMUST00000023797 Ensembl | MGI Sequence Detail 2132 Not Applicable  
polypeptide ENSMUSP00000023797 Ensembl | MGI Sequence Detail 525 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    44 from dbSNP Build 142
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000009479 keratin, type II cytoskeletal 4
  • InterPro Domains
    IPR001664 Intermediate filament protein
    IPR018039 Intermediate filament protein, conserved site
    IPR003054 Keratin, type II
    IPR032444 Keratin type II head
Molecular
Reagents
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  • All nucleic 28
    Genomic 4
    cDNA 24

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-11636, MGD-MRK-11656, MGD-MRK-38408, MGI:109363, MGI:2146191
References
more
  • Summaries
    All 42
    Developmental Gene Expression 14
    Diseases 2
    Gene Ontology 4
    Phenotypes 25
  • Earliest
    J:22955 Knapp B, et al., Nonepidermal members of the keratin multigene family: cDNA sequences and in situ localization of the mRNAs. Nucleic Acids Res. 1986 Jan 24;14(2):751-63
  • Latest
    J:227725 Kaushal GS, et al., Fate of Prominin-1 Expressing Dermal Papilla Cells during Homeostasis, Wound Healing and Wnt Activation. J Invest Dermatol. 2015 Dec;135(12):2926-34

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory