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Krt4
Gene Detail
Symbol

Name
ID
Krt4
keratin 4
MGI:96701
Synonyms
K4, Krt-2.4, Krt2-4
Feature Type
protein coding gene
Genetic Map
Chromosome 15
57.13 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr15:101918536-101924735 bp, - strand
From Ensembl annotation of GRCm38

  6200 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20523  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: KRT4
Gene Tree: Krt4

Human
homologs
KRT4, keratin 4, type II
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 3851

Human Synonyms: CK4, CK-4, CYK4, K4, WSN1

Human Chr (Location): 12q13.13; chr12:52806543-52814116 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human KRT4

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Chemically induced (ENU)(1) Radiation induced(1) Targeted(3)
Genomic Mutations involving Krt4 (2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene display hyperplasia throughout the epithelium of the esophagus and tongue. Mice homozygous or heterozygous for a dominant mutation display oral leukoplakia and homozygotes display postnatal growth retardation.
 
Human Diseases Modeled in Mice Using Krt4 (1)    Mutations Annotated to Human Diseases (1)    Phenotype Images(4)
Interactions
Krt4 interacts with 64 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process cytoskeleton organization, embryo development, ...
Component cell surface, intermediate filament, ...
Function protein heterodimerization activity, structural molecule activity
External Resources: FuncBase
Expression
Literature Summary: (13 records)
Data Summary: Results (107)    Tissues (33)    Images (21)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 24
RNA in situ 81
Western blot 2
cDNA source data(23)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA KRT4    NEW 
Molecular
reagents
All nucleic(28) Genomic(4) cDNA(24)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000059668 (Evidence)
Entrez Gene 16682 (Evidence)
UniGene 46425
DFCI TC1580633
DoTS DT.101200047, DT.529371
NIA Mouse Gene Index U036686
Consensus CDS Project CCDS37222.1
International Mouse Phenotyping Consortium Status Krt4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000059668 Ensembl Gene Model | MGI Sequence Detail 6200 C57BL/6J ±  kb
transcript ENSMUST00000023797 Ensembl | MGI Sequence Detail 2132 Not Applicable 
polypeptide ENSMUSP00000023797 Ensembl | MGI Sequence Detail 525 Not Applicable 

For the selected sequences
All sequences(18) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(44 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001664 Intermediate filament protein
InterPro IPR018039 Intermediate filament protein, conserved site
InterPro IPR003054 Keratin, type II
Protein Ontology PR:000009479 keratin, type II cytoskeletal 4
References
(Earliest) J:22955 Knapp B, et al., Nonepidermal members of the keratin multigene family: cDNA sequences and in situ localization of the mRNAs. Nucleic Acids Res. 1986 Jan 24;14(2):751-63
(Latest) J:215601 Gage PJ, et al., The homeodomain transcription factor PITX2 is required for specifying correct cell fates and establishing angiogenic privilege in the developing cornea. Dev Dyn. 2014 Nov;243(11):1391-400
All references(44)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-11636, MGD-MRK-11656, MGD-MRK-38408, MGI:109363, MGI:2146191

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory