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Krt4
Gene Detail
 Symbol
Name
ID
Krt4
keratin 4
MGI:96701
Synonyms K4, Krt-2.4, Krt2-4
Feature Type protein coding gene
Genetic Map
Chromosome 15
57.13 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr15:101918536-101924735 bp, - strand
From Ensembl annotation of GRCm38

  6200 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20523  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Gene Tree: Krt4

Human
homologs
Human Homolog KRT4, keratin 4
NCBI Gene ID 3851
Human Synonyms  CK4, CK-4, CYK4, K4, WSN1
Human Chr (Location)  12q13.13; chr12:52806543-52814116 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human KRT4
Alleles
and
phenotypes
All alleles(3) : Chemically induced (ENU)(1) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene display hyperplasia throughout the epithelium of the esophagus and tongue. Mice homozygous or heterozygous for a dominant mutation display oral leukoplakia and homozygotes display postnatal growth retardation.
 
Human Diseases Modeled Using Mouse Krt4 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(2)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process cytoskeleton organization, embryo development, ...
Component cell surface, intermediate filament, ...
Function protein heterodimerization activity, structural molecule activity
External Resources: FuncBase
Expression
Literature Summary: (11 records)
Data Summary: Results (107)    Tissues (33)    Images (21)
Theiler Stages: 20, 21, 22, 23, 24, 26, 28
Assay TypeResults
Immunohistochemistry 24
RNA in situ 81
Western blot 2
cDNA source data(23)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(28) Genomic(4) cDNA(24)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000059668 (Evidence)
Entrez Gene16682 (Evidence)
UniGene46425
DFCITC1580633
DoTSDT.101200047, DT.529371
NIA Mouse Gene IndexU036686
Consensus CDS ProjectCCDS37222.1
International Mouse Knockout Project StatusKrt4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000059668 Ensembl Gene Model | MGI Sequence Detail 6200 C57BL/6J ±  kb
transcript ENSMUST00000023797 Ensembl | MGI Sequence Detail 2132 Not Applicable 
polypeptide ENSMUSP00000023797 Ensembl | MGI Sequence Detail 525 Not Applicable 

For the selected sequences
All sequences(18) RefSeq(2) UniProt(1)
Polymorphisms SNPs within 2kb(44 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001664 Intermediate filament protein
InterPro IPR018039 Intermediate filament protein, conserved site
InterPro IPR003054 Type II keratin
Protein Ontology PR:000009479 keratin, type II cytoskeletal 4
References (Earliest) J:22955 Knapp B, et al., Nonepidermal members of the keratin multigene family: cDNA sequences and in situ localization of the mRNAs. Nucleic Acids Res. 1986 Jan 24;14(2):751-63
(Latest) J:203791 Kuracha MR, et al., Spry1 and Spry2 are necessary for eyelid closure. Dev Biol. 2013 Nov 15;383(2):227-38
All references(45)
Other
accession IDs
MGD-MRK-11636, MGD-MRK-11656, MGD-MRK-38408, MGI:109363, MGI:2146191

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory