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Krt2 Gene Detail
Summary
  • Symbol
    Krt2
  • Name
    keratin 2
  • Synonyms
    Krt2-17, Krt2-2, Krt2e
  • Feature Type
    protein coding gene
  • IDs
    MGI:96699
    NCBI Gene: 16681
  • Gene Overview
    MyGene.info: KRT2
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr15:101810689-101818169 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      7481 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 57.03 cM
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    KRT2, keratin 2
  • Human Ortholog
    KRT2, keratin 2
    Orthology source: HGNC
  • Synonyms
    CK-2e, K2e, KRT2A, KRT2E, KRTE
  • Links
    NCBI Gene ID: 3849
    neXtProt AC: NX_P35908
    UniProt: P35908

  • Chr Location
    12q13.13; chr12:52644558-52652175 (-)  GRCh38.p7

  • HCOP
    human homology predictions: KRT2
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Krt2 mouse models; 1 with human KRT2 associations

Human Disease Mouse Models
      
IDs
View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    19 phenotypes from 3 alleles in 5 genetic backgrounds
    5 phenotypes from multigenic genotypes
    33 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
ENU-induced mutant mice exhibit scaly skin and increased pigmentation in the tail, ears and feet. Mice homozygous for a knock-out allele show scaly skin, acanthosis, hyperkeratosis, increased water loss, ear skin inflammation, and aberrant aggregation of keratin 10 in suprabasal epidermal keratinocytes.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000033498 VEGA Gene Model | MGI Sequence Detail 7481 C57BL/6J ±  kb
    transcript OTTMUST00000084256 VEGA | MGI Sequence Detail 2613 Not Applicable  
    polypeptide OTTMUSP00000045384 VEGA | MGI Sequence Detail 707 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      39 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 16
      Genomic 6
      cDNA 9
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-11654, MGI:2146252
    References
    more
    • Summaries
      All 63
      Developmental Gene Expression 5
      Diseases 2
      Gene Ontology 4
      Phenotypes 33
    • Earliest
      J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
    • Latest
      J:252645 Fischer H, et al., Keratins K2 and K10 are essential for the epidermal integrity of plantar skin. J Dermatol Sci. 2016 Jan;81(1):10-6

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    10/09/2018
    MGI 6.12
    The Jackson Laboratory