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Krt2
Gene Detail
Symbol

Name
ID
Krt2
keratin 2
MGI:96699
Synonyms
Krt2-17, Krt2-2, Krt2e
Feature Type
protein coding gene
Genetic Map
Chromosome 15
57.03 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr15:101810689-101818169 bp, - strand
From VEGA annotation of GRCm38

  7481 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
Gene Tree: Krt2
Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Chemically induced (ENU)(1) Radiation induced(1) Targeted(7)
Genomic Mutations involving Krt2 (2)
Incidental mutations (data from Mutagenetix , APF )
 
Mutant animals exhibit scaly skin and pigmentation defects affecting the tail, ears and feet.
 
Human Diseases Modeled Using Mouse Krt2 (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Krt2 interacts with 86 markers (Mir10b, Mir23a, Mir23b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (5 annotations)
Process biological_process
Component intermediate filament, keratin filament
Function structural molecule activity
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (114)    Tissues (21)    Images (28)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 106
RT-PCR 8
cDNA source data(9)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(15) Genomic(5) cDNA(9) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000033498 (Evidence)
Ensembl Gene ModelENSMUSG00000064201 (Evidence)
Entrez Gene16681 (Evidence)
UniGene358616
DFCITC1586531
DoTSDT.40140709, DT.55188522
Consensus CDS ProjectCCDS37220.1
International Mouse Knockout Project StatusKrt2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033498 VEGA Gene Model | MGI Sequence Detail 7481 C57BL/6J ±  kb
transcript OTTMUST00000084256 VEGA | MGI Sequence Detail 2613 Not Applicable 
polypeptide OTTMUSP00000045384 VEGA | MGI Sequence Detail 707 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(4) UniProt(5)
Polymorphisms
SNPs within 2kb(39 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001664 Intermediate filament protein
InterPro IPR018039 Intermediate filament protein, conserved site
InterPro IPR003054 Type II keratin
Protein Ontology PR:000009460 keratin, type II cytoskeletal 2 epidermal
References
(Earliest) J:33289 Rentrop M, et al., An unusual type-II 70-kilodalton keratin protein of mouse epidermis exhibiting postnatal body-site specificity and sensitivity to hyperproliferation. Differentiation. 1987;34(3):189-200
(Latest) J:183911 Narhi K, et al., Sostdc1 defines the size and number of skin appendage placodes. Dev Biol. 2012 Apr 15;364(2):149-61
All references(35)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-11654, MGI:2146252

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory