Krt2
Gene Detail

Symbol Name ID

Krt2 keratin 2 MGI:96699

Synonyms

Krt2-17, Krt2-2, Krt2e

Feature Type

protein coding gene

Genetic Map

Chromosome 15

57.03 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr15:101810689-101818169 bp, - strand From VEGA annotation of GRCm38   7481 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:30974  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Krt2

Human homologs

Human Homolog		KRT2, keratin 2
NCBI Gene ID		3849
neXtProt AC		NX_P35908
Human Synonyms		CK-2e, K2e, KRT2A, KRT2E, KRTE
Human Chr (Location)		12q13.13; chr12:53038342-53045959 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human KRT2

Alleles and phenotypes

All alleles(6) : Targeted(5) Chemically induced(1)
 

Mutant animals exhibit scaly skin and pigmentation defects affecting the tail, ears and feet.

 
Human Diseases Modeled Using Mouse Krt2 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (11 annotations)

Process	keratinization, keratinocyte activation, ...
Component	cytoplasm, Golgi apparatus, ...
Function	structural molecule activity

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (114)    Tissues (21)    Images (28)
Theiler Stages: 23, 24, 26, 28

Assay Type	Results
RNA in situ	106
RT-PCR	8

cDNA source data(9)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(15) Genomic(5) cDNA(9) Primer pair(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000033498 (Evidence)
Ensembl Gene Model	ENSMUSG00000064201 (Evidence)
Entrez Gene	16681 (Evidence)
UniGene	358616
DFCI	TC1586531
DoTS	DT.40140709, DT.55188522
Consensus CDS Project	CCDS37220.1
International Mouse Knockout Project Status	Krt2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000033498	VEGA Gene Model | MGI Sequence Detail	7481	C57BL/6J
transcript	OTTMUST00000084256	VEGA | MGI Sequence Detail	2613	Not Applicable
polypeptide	OTTMUSP00000045384	VEGA | MGI Sequence Detail	707	Not Applicable

All sequences(25) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(25 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR016044	Filament
InterPro	IPR001664	Intermediate filament protein
InterPro	IPR018039	Intermediate filament protein, conserved site
InterPro	IPR003054	Type II keratin
Protein Ontology	PR:000009460	keratin, type II cytoskeletal 2 epidermal

References

(Earliest) J:33289 Rentrop M, et al., An unusual type-II 70-kilodalton keratin protein of mouse epidermis exhibiting postnatal body-site specificity and sensitivity to hyperproliferation. Differentiation. 1987;34(3):189-200
(Latest) J:183911 Narhi K, et al., Sostdc1 defines the size and number of skin appendage placodes. Dev Biol. 2012 Apr 15;364(2):149-61
All references(34)

Other accession IDs

MGD-MRK-11654, MGI:2146252