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Krt9 Gene Detail
Summary
  • Symbol
    Krt9
  • Name
    keratin 9
  • Synonyms
    K9, Krt1-9
  • Feature Type
    protein coding gene
  • IDs
    MGI:96696
    NCBI Gene: 107656
  • Gene Overview
    MyGene.info: KRT9
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr11:100186781-100193246 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      6466 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 63.43 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    KRT9, keratin 9
  • Vertebrate Orthologs
    2
  • Human Ortholog
    KRT9, keratin 9
    Orthology source: HGNC
  • Synonyms
    CK-9, EPPK, K9
  • Links
    NCBI Gene ID: 3857
    neXtProt AC: NX_P35527
    UniProt: P35527

  • Chr Location
    17q21.2; chr17:41565841-41572058 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human KRT9 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    17 phenotypes from 2 alleles in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit hyperpigmented calluses on the footpad with acanthosis, hyperkeratosis, thick epidermis and increased keratinocyte proliferation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000002544 VEGA Gene Model | MGI Sequence Detail 6466 C57BL/6J ±  kb
    transcript OTTMUST00000004971 VEGA | MGI Sequence Detail 2580 Not Applicable  
    polypeptide OTTMUSP00000002395 VEGA | MGI Sequence Detail 743 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      60 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 2
      cDNA 2

      Microarray probesets 1
    Other
    Accession IDs
    less
    MGD-MRK-11651
    References
    more
    • Summaries
      All 35
      Developmental Gene Expression 4
      Gene Ontology 4
      Phenotypes 11
    • Earliest
      J:51113 Powell BC, et al., The role of keratin proteins and their genes in the growth, structure and properties of hair. EXS. 1997;78:59-148
    • Latest
      J:246066 Sundberg JP, et al., Systematic screening for skin, hair, and nail abnormalities in a large-scale knockout mouse program. PLoS One. 2017;12(7):e0180682

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    Funding Information
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    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory