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Krt9 Gene Detail
Summary
  • Symbol
    Krt9
  • Name
    keratin 9
  • Synonyms
    K9, Krt1-9
  • Feature Type
    protein coding gene
  • IDs
    MGI:96696
    NCBI Gene: 107656
  • Gene Overview
    MyGene.info: KRT9
Location & Maps
more
  • Sequence Map
    Chr11:100186781-100193246 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      6466 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 63.43 cM
  • Detailed Genetic Map ± 1 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    KRT9, keratin 9
  • Vertebrate Orthologs
    2
  • Human Ortholog
    KRT9, keratin 9
    Orthology source: HGNC
  • Synonyms
    CK-9, EPPK, K9
  • Links
    NCBI Gene ID: 3857
    neXtProt AC: NX_P35527

  • Chr Location
    17q21.2; chr17:41565841-41572058 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human KRT9 associations

Human Disease Mouse Models
       Palmoplantar Keratoderma, Epidermolytic; EPPK   OMIM: 144200
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    3
  • Targeted
    3
  • Genomic Mutations
    1 involving Krt9
  • Incidental Mutations
    APF
Mice homozygous for a knock-out allele exhibit hyperpigmented calluses on the footpad with acanthosis, hyperkeratosis, thick epidermis and increased keratinocyte proliferation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000002544 VEGA Gene Model | MGI Sequence Detail 6466 C57BL/6J ±  kb
transcript OTTMUST00000004971 VEGA | MGI Sequence Detail 2580 Not Applicable  
polypeptide OTTMUSP00000002395 VEGA | MGI Sequence Detail 743 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    60 from dbSNP Build 142
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000009503 keratin, type I cytoskeletal 9
  • InterPro Domains
    IPR001664 Intermediate filament protein
    IPR002957 Keratin, type I
Molecular
Reagents
less
  • All nucleic 3
    cDNA 2
    Other 1

    Microarray probesets 1
Other
Accession IDs
less
MGD-MRK-11651
References
more
  • Summaries
    All 27
    Developmental Gene Expression 3
    Gene Ontology 4
    Phenotypes 8
  • Earliest
    J:51113 Powell BC, et al., The role of keratin proteins and their genes in the growth, structure and properties of hair. EXS. 1997;78:59-148
  • Latest
    J:228563 Koscielny G, et al., The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Nucleic Acids Res. 2014 Jan;42(Database issue):D802-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory