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Krt9 Gene Detail
Summary
  • Symbol
    Krt9
  • Name
    keratin 9
  • Synonyms
    K9, Krt1-9
  • Feature Type
    protein coding gene
  • IDs
    MGI:96696
    NCBI Gene: 107656
  • Gene Overview
    MyGene.info: KRT9
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:100186781-100193246 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 63.43 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    60 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96696
protein coding gene Chr11:100186781-100193246 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019144
protein coding gene Chr11:102937319-102945199 (-)
A/J MGP_AJ_G0019112
protein coding gene Chr11:98594609-98600792 (-)
AKR/J MGP_AKRJ_G0019081
protein coding gene Chr11:101636901-101643204 (-)
BALB/cJ MGP_BALBcJ_G0019086
protein coding gene Chr11:99108327-99115243 (-)
C3H/HeJ MGP_C3HHeJ_G0018895
protein coding gene Chr11:101841830-101849486 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019535
protein coding gene Chr11:106104764-106112645 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017162
protein coding gene Chr11:96046613-96052895 (-)
CAST/EiJ MGP_CASTEiJ_G0018449
protein coding gene Chr11:102823543-102830127 (-)
CBA/J MGP_CBAJ_G0018864
protein coding gene Chr11:110539187-110545538 (-)
DBA/2J MGP_DBA2J_G0018977
protein coding gene Chr11:98167943-98174318 (-)
FVB/NJ MGP_FVBNJ_G0018966
protein coding gene Chr11:97670383-97676702 (-)
LP/J MGP_LPJ_G0019045
protein coding gene Chr11:103477133-103485463 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018997
protein coding gene Chr11:110162301-110168466 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019573
protein coding gene Chr11:102014134-102020461 (-)
PWK/PhJ MGP_PWKPhJ_G0018212
protein coding gene Chr11:99195626-99202141 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018004
protein coding gene Chr11:101722674-101729316 (-)
WSB/EiJ MGP_WSBEiJ_G0018498
protein coding gene Chr11:101982323-101988669 (-)



Homology
more
  • Human Ortholog
    KRT9, keratin 9
  • Vertebrate Orthologs
    2
  • Human Ortholog
    KRT9, keratin 9
    Orthology source: HGNC
  • Synonyms
    CK-9, EPPK, K9
  • Links
    NCBI Gene ID: 3857
    neXtProt AC: NX_P35527
    UniProt: P35527

  • Chr Location
    17q21.2; chr17:41565841-41572058 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human KRT9 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 2 alleles in 2 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit hyperpigmented calluses on the footpad with acanthosis, hyperkeratosis, thick epidermis and increased keratinocyte proliferation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 107656 NCBI Gene Model | MGI Sequence Detail 6466 C57BL/6J ±  kb
    transcript NM_201255 RefSeq | MGI Sequence Detail 2580 Not Specified  
    polypeptide Q6RHW0 UniProt | EBI | MGI Sequence Detail 743 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 3
      cDNA 3

      Microarray probesets 1
    Other
    Accession IDs
    less
    MGD-MRK-11651
    References
    more
    • Summaries
      All 38
      Developmental Gene Expression 6
      Gene Ontology 4
      Phenotypes 13
    • Earliest
      J:51113 Powell BC, et al., The role of keratin proteins and their genes in the growth, structure and properties of hair. EXS. 1997;78:59-148
    • Latest
      J:277277 Zieman AG, et al., Altered keratinocyte differentiation is an early driver of keratin mutation-based palmoplantar keratoderma. Hum Mol Genet. 2019 Jul 1;28(13):2255-2270

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    Funding Information
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    last database update
    09/10/2019
    MGI 6.14
    The Jackson Laboratory