Krt15 MGI Mouse Gene Detail - MGI:96689

Symbol

Krt15
Name

keratin 15
Synonyms

K15, Krt1-15

Feature Type

protein coding gene
IDs

MGI:96689
NCBI Gene: 16665
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr11:100022584-100026754 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 63.41 cM
Mapping Data

9 experiments

SNPs within 2kb

81 from dbSNP Build 142
Strain Annotations

18
PCR

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_96689	protein coding gene	Chr11:100022584-100026775 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0019142	protein coding gene	Chr11:102880187-102884357 (-)
A/J	MGP_AJ_G0019110	protein coding gene	Chr11:98537461-98541652 (-)
AKR/J	MGP_AKRJ_G0019079	protein coding gene	Chr11:101582151-101586321 (-)
BALB/cJ	MGP_BALBcJ_G0019084	protein coding gene	Chr11:99053844-99058023 (-)
C3H/HeJ	MGP_C3HHeJ_G0018893	protein coding gene	Chr11:101779511-101783681 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0019533	protein coding gene	Chr11:106047742-106051912 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017160	protein coding gene	Chr11:95991746-95995922 (-)
CAST/EiJ	MGP_CASTEiJ_G0018447	protein coding gene	Chr11:102760931-102765106 (-)
CBA/J	MGP_CBAJ_G0018862	protein coding gene	Chr11:110482924-110487103 (-)
DBA/2J	MGP_DBA2J_G0018975	protein coding gene	Chr11:98112580-98116750 (-)
FVB/NJ	MGP_FVBNJ_G0018964	protein coding gene	Chr11:97613263-97617433 (-)
LP/J	MGP_LPJ_G0019043	protein coding gene	Chr11:103418748-103422918 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018995	protein coding gene	Chr11:110107272-110111442 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019571	protein coding gene	Chr11:101959569-101963747 (-)
PWK/PhJ	MGP_PWKPhJ_G0018210	protein coding gene	Chr11:99143467-99147749 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0018002	protein coding gene	Chr11:101659820-101663974 (-)
WSB/EiJ	MGP_WSBEiJ_G0018496	protein coding gene	Chr11:101926456-101930626 (-)

Human Ortholog

KRT15, keratin 15

Vertebrate Orthologs

12

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

KRT15, keratin 15
Synonyms

CK15, K15, K1CO
Links

HGNC:6421

NCBI Gene ID: 3866

neXtProt AC: NX_P19012

UniProt: P19012
Chr Location

17q21.2; chr17:41513745-41522529 (-) GRCh38

MGI Vertebrate Homology

Krt15 stringent orthology
1 human;1 mouse;1 rat;10 zebrafish
HCOP

vertebrate homology predictions: KRT15
Gene Tree

Krt15

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Endonuclease-mediated

4
Targeted

5
Genomic Mutations

2 involving Krt15
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

28 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Mice homozygous for a knock-out allele exhibit impaired esophageal epithelial regeneration with thicker epithelia due to enhanced basal cell proliferation.

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All GO Annotations

9
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

931
Tissues

73
cDNA Data

48
Literature Summary

70

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA KRT13

Xenbase krt15.1, krt15.2

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All Sequences

35
RefSeq

2
UniProt

2
CCDS

CCDS25410.2

Ensembl

ENSMUSG00000054146 (Evidence)
NCBI Gene

16665

			Length	Strain/Species	Flank
genomic	ENSMUSG00000054146	Ensembl Gene Model \| MGI Sequence Detail	4171	C57BL/6J	± kb
transcript	ENSMUST00000107411	Ensembl \| MGI Sequence Detail	1700	Not Applicable
polypeptide	ENSMUSP00000103034	Ensembl \| MGI Sequence Detail	456	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000009455 keratin, type I cytoskeletal 15

(term hierarchy)
InterPro Domains

IPR018039 Intermediate filament protein, conserved site

IPR039008 Intermediate filament, rod domain

IPR002957 Keratin, type I

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All nucleic 59

Genomic 5

cDNA 48

Primer pair 4

Other 2

Microarray probesets 3

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MGD-MRK-11644, MGI:2144217

Summaries

All 115

Developmental Gene Expression 70

Gene Ontology 5

Phenotypes 12
Earliest

J:16891 Nozaki M, et al., The complete sequence of the gene encoding mouse cytokeratin 15. Gene. 1994 Jan 28;138(1-2):197-200
Latest

J:337667 Ievlev V, et al., Krt14 and Krt15 differentially regulate regenerative properties and differentiation potential of airway basal cells. JCI Insight. 2023 Jan 24;8(2)

TSS for Krt15:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr110746	Chr11:100028594-100028613 (-)	-1,850 bp
Tssr110745	Chr11:100026875-100026913 (-)	-140 bp
Tssr110744	Chr11:100026765-100026780 (-)	-19 bp
Tssr110743	Chr11:100026327-100026354 (-)	413 bp
Tssr110742	Chr11:100025322-100025378 (-)	1,404 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23