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Krt12
Gene Detail
Symbol

Name
ID
Krt12
keratin 12
MGI:96687
Synonyms
K12, Krt1-12
Feature Type
protein coding gene
Genetic Map
Chromosome 11
62.92 cM
Detailed Genetic Map ± 1 cM


Mapping data(9)
Sequence Map
Chr11:99415666-99422259 bp, - strand
From VEGA annotation of GRCm38

  6594 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:188  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Gene Tree: Krt12

Human
homologs
Human Homolog KRT12, keratin 12
NCBI Gene ID 3859
neXtProt AC  NX_Q99456
Human Synonyms  K12
Human Chr (Location)  17q12; chr17:40861178-40867210 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human KRT12
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mutants display abnormal and fragile corneal epithelium.
 
Interactions
Krt12 interacts with 44 markers (Mir18, Mir18b, Mir26b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (28 records)
Data Summary: Results (69)    Tissues (21)    Images (12)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 44
RNA in situ 23
Western blot 2
cDNA source data(15)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(22) Genomic(5) cDNA(15) Primer pair(2)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000004989 (Evidence)
Ensembl Gene ModelENSMUSG00000020912 (Evidence)
Entrez Gene268482 (Evidence)
UniGene436651
DFCITC1578522
DoTSDT.40172308
NIA Mouse Gene IndexU046595
Consensus CDS ProjectCCDS36306.1
International Mouse Knockout Project StatusKrt12
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000004989 VEGA Gene Model | MGI Sequence Detail 6594 C57BL/6J ±  kb
transcript OTTMUST00000011067 VEGA | MGI Sequence Detail 1852 Not Applicable 
polypeptide OTTMUSP00000005172 VEGA | MGI Sequence Detail 487 Not Applicable 

For the selected sequences
All sequences(24) RefSeq(4) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(120 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001664 Intermediate filament protein
InterPro IPR018039 Intermediate filament protein, conserved site
InterPro IPR002957 Keratin, type I
InterPro IPR009053 Prefoldin
Protein Ontology PR:000009452 keratin, type I cytoskeletal 12
References
(Earliest) J:16837 Liu CY, et al., Cornea-specific expression of K12 keratin during mouse development. Curr Eye Res. 1993 Nov;12(11):963-74
(Latest) J:204591 Yamben IF, et al., Scrib is required for epithelial cell identity and prevents epithelial to mesenchymal transition in the mouse. Dev Biol. 2013 Dec 1;384(1):41-52
All references(69)
Other
accession IDs
MGD-MRK-11642, MGI:2144270

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory