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Krt12 Gene Detail
Summary
  • Symbol
    Krt12
  • Name
    keratin 12
  • Synonyms
    K12, Krt1-12
  • Feature Type
    protein coding gene
  • IDs
    MGI:96687
    NCBI Gene: 268482
  • Gene Overview
    MyGene.info: KRT12
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:99415666-99422259 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 62.92 cM
  • Mapping Data
    9 experiments
Strain
Comparison
more
  • SNPs within 2kb
    120 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96687
protein coding gene Chr11:99415664-99422593 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019092
protein coding gene Chr11:102081014-102087593 (-)
A/J MGP_AJ_G0019060
protein coding gene Chr11:97783245-97789814 (-)
AKR/J MGP_AKRJ_G0019030
protein coding gene Chr11:100818047-100824631 (-)
BALB/cJ MGP_BALBcJ_G0019034
protein coding gene Chr11:98292842-98299411 (-)
C3H/HeJ MGP_C3HHeJ_G0018847
protein coding gene Chr11:100969209-100975779 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019485
protein coding gene Chr11:105220731-105227324 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017117
protein coding gene Chr11:95345288-95351846 (-)
CAST/EiJ MGP_CASTEiJ_G0018402
protein coding gene Chr11:101966860-101973462 (-)
CBA/J MGP_CBAJ_G0018818
protein coding gene Chr11:109606044-109612623 (-)
DBA/2J MGP_DBA2J_G0018926
protein coding gene Chr11:97350481-97357047 (-)
FVB/NJ MGP_FVBNJ_G0018915
protein coding gene Chr11:96860982-96867560 (-)
LP/J MGP_LPJ_G0018996
protein coding gene Chr11:102548582-102555159 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018942
protein coding gene Chr11:109276535-109283148 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019525
protein coding gene Chr11:101176931-101183507 (-)
PWK/PhJ MGP_PWKPhJ_G0018173
protein coding gene Chr11:98422911-98429488 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017961
protein coding gene Chr11:100934183-100940643 (-)
WSB/EiJ MGP_WSBEiJ_G0018450
protein coding gene Chr11:101153327-101159897 (-)



Homology
more
  • Human Ortholog
    KRT12, keratin 12
  • Vertebrate Orthologs
    9
  • Human Ortholog
    KRT12, keratin 12
    Orthology source: HomoloGene, HGNC
  • Synonyms
    K12
  • Links
    NCBI Gene ID: 3859
    neXtProt AC: NX_Q99456
    UniProt: Q99456

  • Chr Location
    17q21.2; chr17:40861178-40867210 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 188
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: KRT12
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human KRT12 associations

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    4 phenotypes from multigenic genotypes
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mutants display abnormal and fragile corneal epithelium.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020912 Ensembl Gene Model | MGI Sequence Detail 6594 C57BL/6J ±  kb
    transcript ENSMUST00000017741 Ensembl | MGI Sequence Detail 1852 Not Applicable  
    polypeptide ENSMUSP00000017741 Ensembl | MGI Sequence Detail 487 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 23
      Genomic 5
      cDNA 16
      Primer pair 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-11642, MGI:2144270
    References
    more
    • Summaries
      All 94
      Developmental Gene Expression 41
      Diseases 1
      Gene Ontology 3
      Phenotypes 28
    • Earliest
      J:16837 Liu CY, et al., Cornea-specific expression of K12 keratin during mouse development. Curr Eye Res. 1993 Nov;12(11):963-74
    • Latest
      J:271683 Tiwari A, et al., KLF4 Regulates Corneal Epithelial Cell Cycle Progression by Suppressing Canonical TGF-beta Signaling and Upregulating CDK Inhibitors P16 and P27. Invest Ophthalmol Vis Sci. 2019 Feb 1;60(2):731-740

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    Funding Information
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    last database update
    02/11/2020
    MGI 6.14
    The Jackson Laboratory