Krt12
Gene Detail

Symbol Name ID

Krt12 keratin 12 MGI:96687

Synonyms

K12, Krt1-12

Feature Type

protein coding gene

Genetic Map

Chromosome 11

62.92 cM
Detailed Genetic Map ± 1 cM


Mapping data(9)

Sequence Map

Chr11:99415666-99422259 bp, - strand From VEGA annotation of GRCm38   6594 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:188  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Gene Tree: Krt12

Human homologs

Human Homolog		KRT12, keratin 12
NCBI Gene ID		3859
neXtProt AC		NX_Q99456
Human Synonyms		K12
Human Chr (Location)		17q12; chr17:39017430-39023462 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human KRT12

Alleles and phenotypes

All alleles(5) : Targeted(5)
 

Homozygous null mutants display abnormal and fragile corneal epithelium.

 

Gene Ontology (GO) classifications

All GO classifications: (5 annotations)

Process	cornea development in camera-type eye, epithelium development
Component	intermediate filament
Function	structural molecule activity

External Resources: FuncBase

Expression

Literature Summary: (26 records)
Data Summary: Results (60)    Tissues (19)    Images (6)
Theiler Stages: 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	42
RNA in situ	16
Western blot	2

cDNA source data(14)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(20) Genomic(5) cDNA(14) Primer pair(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000004989 (Evidence)
Ensembl Gene Model	ENSMUSG00000020912 (Evidence)
Entrez Gene	268482 (Evidence)
UniGene	436651
DFCI	TC1578522
DoTS	DT.40172308
NIA Mouse Gene Index	U046595
Consensus CDS Project	CCDS36306.1
International Mouse Knockout Project Status	Krt12

Sequences

Length	Strain/Species
genomic	OTTMUSG00000004989	VEGA Gene Model | MGI Sequence Detail	6594	C57BL/6J
transcript	OTTMUST00000011067	VEGA | MGI Sequence Detail	1852	Not Applicable
polypeptide	OTTMUSP00000005172	VEGA | MGI Sequence Detail	487	Not Applicable

All sequences(20) RefSeq(2) UniProt(1)

Polymorphisms

RFLP(1) : SNPs(84 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR016044	Filament
InterPro	IPR001664	Intermediate filament protein
InterPro	IPR018039	Intermediate filament protein, conserved site
InterPro	IPR002957	Keratin, type I
Protein Ontology	PR:000009452	keratin, type I cytoskeletal 12

References

(Earliest) J:16837 Liu CY, et al., Cornea-specific expression of K12 keratin during mouse development. Curr Eye Res. 1993 Nov;12(11):963-74
(Latest) J:189493 Terai K, et al., Crosstalk between TGF-beta and MAPK signaling during corneal wound healing. Invest Ophthalmol Vis Sci. 2011 Oct;52(11):8208-15
All references(66)

Other accession IDs

MGD-MRK-11642, MGI:2144270