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Kcne1
Gene Detail
Symbol

Name
ID
Kcne1
potassium voltage-gated channel, Isk-related subfamily, member 1
MGI:96673
Synonyms
Isk, MinK, nmf190
Feature Type
protein coding gene
Genetic Map
Chromosome 16
53.57 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr16:92346001-92359468 bp, - strand
From NCBI annotation of GRCm38

  13468 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:185  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog

Protein SuperFamily: potassium voltage-gated channel subfamily E member 1
Gene Tree: Kcne1

Human
homologs
Human Homolog LOC102723475, potassium voltage-gated channel subfamily E member 1-like
NCBI Gene ID 102723475
neXtProt AC  NX_A8MWV9
Human Chr (Location)  chr21:7789203-7829632 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Chemically induced (ENU)(1) Spontaneous(1) Targeted(8)
Genomic Mutations involving Kcne1 (3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted and spontaneous null mutations exhibit head-shaking, circling, ataxia, and severe deafness associated with inner ear defects. Older mutants show increased numbers of T cells. Study of cardiac myocytes in one line revealed physiologic defects.
 
Human Diseases Modeled Using Mouse Kcne1 (1)    Alleles Annotated to Human Diseases(2)    Phenotype Images(2)
Interactions
Kcne1 interacts with 185 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (17 records)
Data Summary: Results (257)    Tissues (181)    Images (17)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 129
In situ reporter (knock in) 68
Northern blot 30
RT-PCR 30
cDNA source data(19)
External Resources: GEO   Expression Atlas
Molecular
reagents
All nucleic(25) Genomic(1) cDNA(20) Primer pair(4)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000039639 (Evidence)
Entrez Gene16509 (Evidence)
UniGene299425
DFCITC1586801, TC1625112
DoTSDT.101333265, DT.91335557
NIA Mouse Gene IndexU037312
Consensus CDS ProjectCCDS28336.1
International Mouse Knockout Project StatusKcne1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 16509 NCBI Gene Model | MGI Sequence Detail 13468 C57BL/6J ±  kb
transcript NM_008424 RefSeq | MGI Sequence Detail 3155 C57BL/6 
polypeptide P23299 UniProt | EBI | MGI Sequence Detail 129 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(4) UniProt(2)
Polymorphisms
SNPs within 2kb(110 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000369 Potassium channel, voltage-dependent, beta subunit, KCNE
InterPro IPR005424 Potassium channel, voltage-dependent, beta subunit, KCNE1
Protein Ontology PR:000009255 potassium voltage-gated channel subfamily E member 1
Graphical View of Protein Domain Structure
References
(Earliest) J:11462 Honore E, et al., Cloning, expression, pharmacology and regulation of a delayed rectifier K+ channel in mouse heart. EMBO J. 1991 Oct;10(10):2805-11
(Latest) J:189403 Neal AM, et al., Renal defects in KCNE1 knockout mice are mimicked by chromanol 293B in vivo: identification of a KCNE1-regulated K+ conductance in the proximal tubule. J Physiol. 2011 Jul 15;589(Pt 14):3595-609
All references(76)
Disease annotation references (3)
Other
accession IDs
MGD-MRK-11577, MGI:2678336

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory