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Kcnd1 Gene Detail
Summary
  • Symbol
    Kcnd1
  • Name
    potassium voltage-gated channel, Shal-related family, member 1
  • Synonyms
    1110037K09Rik, Kca2-1, Kv4.1, mShal1, Shal
  • Feature Type
    protein coding gene
  • IDs
    MGI:96671
    NCBI Gene: 16506
  • Gene Overview
    MyGene.info: KCND1
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:7688528-7704519 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome X, 3.53 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    38 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96671
protein coding gene ChrX:7686907-7704519 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035525
protein coding gene ChrX:2441367-2457275 (+)
A/J MGP_AJ_G0035503
protein coding gene ChrX:2403018-2419007 (+)
AKR/J MGP_AKRJ_G0035435
protein coding gene ChrX:2521133-2537780 (+)
BALB/cJ MGP_BALBcJ_G0035499
protein coding gene ChrX:2429399-2449881 (+)
C3H/HeJ MGP_C3HHeJ_G0035207
protein coding gene ChrX:2494491-2510432 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036023
protein coding gene ChrX:2531964-2549003 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032899
protein coding gene ChrX:1968207-1985058 (+)
CAST/EiJ MGP_CASTEiJ_G0034508
protein coding gene ChrX:2380892-2397275 (+)
CBA/J MGP_CBAJ_G0035177
protein coding gene ChrX:2647394-2663249 (+)
DBA/2J MGP_DBA2J_G0035334
protein coding gene ChrX:2430116-2446024 (+)
FVB/NJ MGP_FVBNJ_G0035281
protein coding gene ChrX:2389818-2405520 (+)
LP/J MGP_LPJ_G0035412
protein coding gene ChrX:2463231-2479089 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035321
protein coding gene ChrX:2621048-2637084 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036041
protein coding gene ChrX:2429891-2446187 (+)
PWK/PhJ MGP_PWKPhJ_G0034209
protein coding gene ChrX:2359340-2375054 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034047
protein coding gene ChrX:2406558-2424906 (+)
WSB/EiJ MGP_WSBEiJ_G0034631
protein coding gene ChrX:2437197-2453128 (+)



Homology
more
  • Human Ortholog
    KCND1, potassium voltage-gated channel subfamily D member 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KCND1, potassium voltage-gated channel subfamily D member 1
  • Synonyms
    KV4.1
  • Links
    NCBI Gene ID: 3750
    neXtProt AC: NX_Q9NSA2
    UniProt: Q9NSA2

  • Chr Location
    Xp11.23; chrX:48960983-48972099 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000009731 Ensembl Gene Model | MGI Sequence Detail 15992 C57BL/6J ±  kb
transcript ENSMUST00000009875 Ensembl | MGI Sequence Detail 5287 Not Applicable  
polypeptide ENSMUSP00000009875 Ensembl | MGI Sequence Detail 651 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000000784 voltage-gated potassium channel KCND1
  • InterPro Domains
    IPR000210 BTB/POZ domain
    IPR005821 Ion transport domain
    IPR003131 Potassium channel tetramerisation-type BTB domain
    IPR003968 Potassium channel, voltage dependent, Kv
    IPR003975 Potassium channel, voltage dependent, Kv4
    IPR004054 Potassium channel, voltage dependent, Kv4.1
    IPR024587 Potassium channel, voltage dependent, Kv4, C-terminal
    IPR021645 Shal-type voltage-gated potassium channels, N-terminal
    IPR011333 SKP1/BTB/POZ domain superfamily
    IPR027359 Voltage-dependent channel domain superfamily
    IPR028325 Voltage-gated potassium channel
Molecular
Reagents
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  • All nucleic 25
    Genomic 5
    cDNA 19
    Primer pair 1

    Microarray probesets 6
Other
Accession IDs
less
MGD-MRK-11557, MGD-MRK-11575, MGD-MRK-14398, MGI:1915999
References
more
  • Summaries
    All 43
    Developmental Gene Expression 3
    Gene Ontology 4
    Phenotypes 6
  • Earliest
    J:11182 Pak MD, et al., mShal, a subfamily of A-type K+ channel cloned from mammalian brain. Proc Natl Acad Sci U S A. 1991 May 15;88(10):4386-90
  • Latest
    J:255835 Hermanstyne TO, et al., Acute Knockdown of Kv4.1 Regulates Repetitive Firing Rates and Clock Gene Expression in the Suprachiasmatic Nucleus and Daily Rhythms in Locomotor Behavior. eNeuro. 2017 May-Jun;4(3)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
06/15/2021
MGI 6.17
The Jackson Laboratory