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Kcnc4
Gene Detail
Symbol

Name
ID
Kcnc4
potassium voltage gated channel, Shaw-related subfamily, member 4
MGI:96670
Synonyms
Kcr2-4, Kv3.4
Feature Type
protein coding gene
Genetic Map
Chromosome 3
46.83 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr3:107438303-107458898 bp, - strand
From Ensembl annotation of GRCm38

  20596 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68427  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: KCNC4
Protein SuperFamily: potassium voltage-gated channel, alpha subunit, subfamilies A/C/D/F/G/S
Gene Tree: Kcnc4

Human
homologs
KCNC4, potassium channel, voltage gated Shaw related subfamily C, member 4
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 3749
neXtProt AC: NX_Q03721

Human Synonyms: C1orf30, HKSHIIIC, KSHIIIC, KV3.4

Human Chr (Location): 1p21; chr1:110210714-110282617 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF , CvDC )
Interactions
Kcnc4 interacts with 256 markers (Mir7-2, Mir7b, Mir10b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process ion transport, potassium ion transmembrane transport, ...
Component axon terminus, integral component of membrane, ...
Function delayed rectifier potassium channel activity, ion channel activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (121)    Tissues (14)    Images (23)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 121
cDNA source data(9)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase kcnc4    NEW 
Molecular
reagents
All nucleic(12) Genomic(2) cDNA(10)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000027895 (Evidence)
Entrez Gene 99738 (Evidence)
UniGene 101976
DFCI TC1583205
DoTS DT.40161120
NIA Mouse Gene Index U024496
Consensus CDS Project CCDS17738.1
International Mouse Phenotyping Consortium Status Kcnc4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000027895 Ensembl Gene Model | MGI Sequence Detail 20596 C57BL/6J ±  kb
transcript ENSMUST00000009617 Ensembl | MGI Sequence Detail 3013 Not Applicable 
polypeptide ENSMUSP00000009617 Ensembl | MGI Sequence Detail 628 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(6) UniProt(2)
Polymorphisms
RFLP(2) : SNPs within 2kb(137 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011333 BTB/POZ fold
InterPro IPR000210 BTB/POZ-like
InterPro IPR005821 Ion transport domain
InterPro IPR003131 Potassium channel tetramerisation-type BTB domain
InterPro IPR003968 Potassium channel, voltage dependent, Kv
InterPro IPR003974 Potassium channel, voltage dependent, Kv3
InterPro IPR005405 Potassium channel, voltage dependent, Kv3.4
InterPro IPR021105 Potassium channel, voltage dependent, Kv3, inactivation domain
InterPro IPR003091 Voltage-dependent potassium channel
InterPro IPR027359 Voltage-dependent potassium channel, four helix bundle domain
Protein Ontology PR:000000783 voltage-gated potassium channel KCNC4
References
(Earliest) J:2312 Ghanshani S, et al., Genomic organization, nucleotide sequence, and cellular distribution of a Shaw-related potassium channel gene, Kv3.3, and mapping of Kv3.3 and Kv3.4 to human chromosomes 19 and 1. Genomics. 1992 Feb;12(2):190-6
(Latest) J:186741 Boda E, et al., Brain expression of Kv3 subunits during development, adulthood and aging and in a murine model of Alzheimer's disease. J Mol Neurosci. 2012 Mar;46(3):606-15
All references(34)
Other
accession IDs
MGD-MRK-11574, MGD-MRK-11582, MGI:2139819

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory