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Kcnc4 Gene Detail
Summary
  • Symbol
    Kcnc4
  • Name
    potassium voltage gated channel, Shaw-related subfamily, member 4
  • Synonyms
    Kcr2-4, Kv3.4
  • Feature Type
    protein coding gene
  • IDs
    MGI:96670
    NCBI Gene: 99738
Location & Maps
more
  • Sequence Map
    Chr3:107438303-107459552 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      21250 bp   ±  kb flank

  • Genome Browsers
Homology
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  • Human Ortholog
    KCNC4, potassium channel, voltage gated Shaw related subfamily C, member 4
  • Vertebrate Orthologs
    10
  • Human Ortholog
    KCNC4, potassium channel, voltage gated Shaw related subfamily C, member 4
    Orthology source: HGNC, HomoloGene
  • Synonyms
    C1orf30, HKSHIIIC, KSHIIIC, KV3.4
  • Links
    NCBI Gene ID: 3749
    neXtProt AC: NX_Q03721

  • Chr Location
    1p21; chr1:110210714-110282617 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotype references
  • All Mutations and Alleles
    4
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    2
  • Genomic Mutations
    2 involving Kcnc4
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000052959 VEGA Gene Model | MGI Sequence Detail 21250 C57BL/6J ±  kb
transcript OTTMUST00000132513 VEGA | MGI Sequence Detail 3667 Not Applicable  
polypeptide OTTMUSP00000070648 VEGA | MGI Sequence Detail 628 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    141 from dbSNP Build 137
  • RFLP
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000000783 voltage-gated potassium channel KCNC4
  • InterPro Domains
    IPR000210 BTB/POZ domain
    IPR005821 Ion transport domain
    IPR003131 Potassium channel tetramerisation-type BTB domain
    IPR003968 Potassium channel, voltage dependent, Kv
    IPR003974 Potassium channel, voltage dependent, Kv3
    IPR005405 Potassium channel, voltage dependent, Kv3.4
    IPR021105 Potassium channel, voltage dependent, Kv3, inactivation domain
    IPR011333 SKP1/BTB/POZ domain
    IPR027359 Voltage-dependent channel, four helix bundle domain
    IPR028325 Voltage-gated potassium channel
Molecular
Reagents
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  • All nucleic 12
    Genomic 2
    cDNA 10

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-11574, MGD-MRK-11582, MGI:2139819
References
more
  • Summaries
    All 33
    Developmental Gene Expression 3
    Gene Ontology 5
    Phenotypes 6
  • Earliest
    J:2312 Ghanshani S, et al., Genomic organization, nucleotide sequence, and cellular distribution of a Shaw-related potassium channel gene, Kv3.3, and mapping of Kv3.3 and Kv3.4 to human chromosomes 19 and 1. Genomics. 1992 Feb;12(2):190-6
  • Latest
    J:186741 Boda E, et al., Brain expression of Kv3 subunits during development, adulthood and aging and in a murine model of Alzheimer's disease. J Mol Neurosci. 2012 Mar;46(3):606-15

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory