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Kcnc4
Gene Detail
 Symbol
Name
ID
Kcnc4
potassium voltage gated channel, Shaw-related subfamily, member 4
MGI:96670
Synonyms Kcr2-4, Kv3.4
Feature Type protein coding gene
Genetic Map
Chromosome 3
46.83 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr3:107438303-107458898 bp, - strand
From NCBI annotation of GRCm38

  20596 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68427  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: potassium voltage-gated channel, alpha subunit, subfamilies A/C/D/F/G/S
Gene Tree: Kcnc4

Human
homologs
Human Homolog KCNC4, potassium voltage-gated channel, Shaw-related subfamily, member 4
NCBI Gene ID 3749
neXtProt AC  NX_Q03721
Human Synonyms  C1orf30, HKSHIIIC, KSHIIIC, KV3.4
Human Chr (Location)  1p21; chr1:110210714-110282631 (+)  GRCh38
Alleles
and
phenotypes
All alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process ion transport, potassium ion transmembrane transport, ...
Component axon terminus, integral component of membrane, ...
Function delayed rectifier potassium channel activity, ion channel activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (121)    Tissues (14)    Images (23)
Theiler Stages: 23
Assay TypeResults
RNA in situ 121
cDNA source data(9)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress
Molecular
reagents
All nucleic(12) Genomic(2) cDNA(10)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000027895 (Evidence)
Entrez Gene99738 (Evidence)
UniGene101976
DFCITC1583205
DoTSDT.40161120
NIA Mouse Gene IndexU024496
Consensus CDS ProjectCCDS17738.1
International Mouse Knockout Project StatusKcnc4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 99738 NCBI Gene Model | MGI Sequence Detail 20596 C57BL/6J ±  kb
transcript NM_145922 RefSeq | MGI Sequence Detail 3013 C57BL/6 
polypeptide Q8R1C0 UniProt | EBI | MGI Sequence Detail 628 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(6) UniProt(2)
Polymorphisms RFLP(2) : SNPs within 2kb(137 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011333 BTB/POZ fold
InterPro IPR000210 BTB/POZ-like
InterPro IPR005821 Ion transport domain
InterPro IPR003131 Potassium channel tetramerisation-type BTB domain
InterPro IPR003968 Potassium channel, voltage dependent, Kv
InterPro IPR003974 Potassium channel, voltage dependent, Kv3
InterPro IPR005405 Potassium channel, voltage dependent, Kv3.4
InterPro IPR021105 Potassium channel, voltage dependent, Kv3, inactivation domain
InterPro IPR003091 Voltage-dependent potassium channel
InterPro IPR027359 Voltage-dependent potassium channel, four helix bundle domain
Protein Ontology PR:000000783 voltage-gated potassium channel KCNC4
Graphical View of Protein Domain Structure
References (Earliest) J:2312 Ghanshani S, et al., Genomic organization, nucleotide sequence, and cellular distribution of a Shaw-related potassium channel gene, Kv3.3, and mapping of Kv3.3 and Kv3.4 to human chromosomes 19 and 1. Genomics. 1992 Feb;12(2):190-6
(Latest) J:186741 Boda E, et al., Brain expression of Kv3 subunits during development, adulthood and aging and in a murine model of Alzheimer's disease. J Mol Neurosci. 2012 Mar;46(3):606-15
All references(36)
Other
accession IDs
MGD-MRK-11574, MGD-MRK-11582, MGI:2139819

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory