Kcnc4
Gene Detail

Symbol Name ID

Kcnc4 potassium voltage gated channel, Shaw-related subfamily, member 4 MGI:96670

Synonyms

Kcr2-4, Kv3.4

Feature Type

protein coding gene

Genetic Map

Chromosome 3

46.83 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr3:107438303-107458898 bp, - strand From NCBI annotation of GRCm38   20596 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:68427  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: potassium voltage-gated channel, alpha subunit, subfamilies A/C/D/F/G/S
Gene Tree: Kcnc4

Human homologs

Human Homolog		KCNC4, potassium voltage-gated channel, Shaw-related subfamily, member 4
NCBI Gene ID		3749
neXtProt AC		NX_Q03721
Human Synonyms		C1orf30, HKSHIIIC, KSHIIIC, KV3.4
Human Chr (Location)		1p21; chr1:110753336-110776674 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(2) : Targeted(2)

Gene Ontology (GO) classifications

All GO classifications: (23 annotations)

Process	ion transport, potassium ion transmembrane transport, ...
Component	axon terminus, integral to membrane, ...
Function	delayed rectifier potassium channel activity, ion channel activity, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (121)    Tissues (14)    Images (23)
Theiler Stages: 23

Assay Type	Results
RNA in situ	121

cDNA source data(9)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(12) Genomic(2) cDNA(10)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000027895 (Evidence)
Entrez Gene	99738 (Evidence)
UniGene	101976
DFCI	TC1583205
DoTS	DT.40161120
NIA Mouse Gene Index	U024496
Consensus CDS Project	CCDS17738.1
International Mouse Knockout Project Status	Kcnc4

Sequences

Length	Strain/Species
genomic	99738	NCBI Gene Model | MGI Sequence Detail	20596	C57BL/6J
transcript	NM_145922	RefSeq | MGI Sequence Detail	3013	C57BL/6
polypeptide	Q8R1C0	UniProt | EBI | MGI Sequence Detail	628	Not Applicable

All sequences(21) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(2) : SNPs(107 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR011333	BTB/POZ fold
InterPro	IPR000210	BTB/POZ-like
InterPro	IPR005821	Ion transport domain
InterPro	IPR003131	Potassium channel tetramerisation-type BTB domain
InterPro	IPR003968	Potassium channel, voltage dependent, Kv
InterPro	IPR003974	Potassium channel, voltage dependent, Kv3
InterPro	IPR005405	Potassium channel, voltage dependent, Kv3.4
InterPro	IPR021105	Potassium channel, voltage dependent, Kv3, inactivation domain
InterPro	IPR003091	Voltage-dependent potassium channel
Protein Ontology	PR:000000783	voltage-gated potassium channel KCNC4

Graphical View of Protein Domain Structure

References

(Earliest) J:2312 Ghanshani S, et al., Genomic organization, nucleotide sequence, and cellular distribution of a Shaw-related potassium channel gene, Kv3.3, and mapping of Kv3.3 and Kv3.4 to human chromosomes 19 and 1. Genomics. 1992 Feb;12(2):190-6
(Latest) J:186741 Boda E, et al., Brain expression of Kv3 subunits during development, adulthood and aging and in a murine model of Alzheimer's disease. J Mol Neurosci. 2012 Mar;46(3):606-15
All references(36)

Other accession IDs

MGD-MRK-11574, MGD-MRK-11582, MGI:2139819