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Kcnc3
Gene Detail
 Symbol
Name
ID
Kcnc3
potassium voltage gated channel, Shaw-related subfamily, member 3
MGI:96669
Synonyms Kcr2-3, KShIIID, Kv3.3
Feature Type protein coding gene
Genetic Map
Chromosome 7
28.85 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr7:44590664-44604754 bp, + strand
From VEGA annotation of GRCm38

  14091 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3650  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle; 2 zebrafish

Protein SuperFamily: potassium voltage-gated channel, alpha subunit, subfamilies A/C/D/F/G/S
Gene Tree: Kcnc3

Human
homologs
Human Homolog KCNC3, potassium voltage-gated channel, Shaw-related subfamily, member 3
NCBI Gene ID 3748
neXtProt AC  NX_Q14003
Human Synonyms  KSHIIID, KV3.3, SCA13
Human Chr (Location)  19q13.33; chr19:50314937-50329377 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human KCNC3
Alleles
and
phenotypes
All alleles(3) : Targeted(1) Gene trapped(2)
 
Homozgous null mice show no overt phenotype, though mutation of this locus in conjunction with mutations in another potassium channel results in alcohol hypersensitivty, increased locomotion, and spontaneous myoclonus.
 
Gene Ontology
(GO)
classifications
All GO classifications: (25 annotations)
Process ion transport, potassium ion transmembrane transport, ...
Component axolemma, axon terminus, ...
Function delayed rectifier potassium channel activity, ion channel activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (11)    Tissues (4)    Images (5)
Theiler Stages: 23
Assay TypeResults
RNA in situ 11
cDNA source data(17)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(22) Genomic(2) cDNA(19) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000021883 (Evidence)
Ensembl Gene ModelENSMUSG00000062785 (Evidence)
Entrez Gene16504 (Evidence)
UniGene40312
DFCITC1678494, TC1695335, TC1696481, TC1719763
DoTSDT.101365468, DT.60103900, DT.87073852, DT.97360836
NIA Mouse Gene IndexU008046
Consensus CDS ProjectCCDS39942.1
International Mouse Knockout Project StatusKcnc3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021883 VEGA Gene Model | MGI Sequence Detail 14091 C57BL/6J ±  kb
transcript OTTMUST00000051948 VEGA | MGI Sequence Detail 5062 Not Applicable 
polypeptide OTTMUSP00000024529 VEGA | MGI Sequence Detail 770 Not Applicable 

For the selected sequences
All sequences(74) RefSeq(33) UniProt(5)
Polymorphisms RFLP(1) : SNPs within 2kb(91 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011333 BTB/POZ fold
InterPro IPR000210 BTB/POZ-like
InterPro IPR005821 Ion transport domain
InterPro IPR003131 Potassium channel tetramerisation-type BTB domain
InterPro IPR003968 Potassium channel, voltage dependent, Kv
InterPro IPR003974 Potassium channel, voltage dependent, Kv3
InterPro IPR005404 Potassium channel, voltage dependent, Kv3.3
InterPro IPR003091 Voltage-dependent potassium channel
InterPro IPR027359 Voltage-dependent potassium channel, four helix bundle domain
Protein Ontology PR:000009254 voltage-gated potassium channel KCNC3
References (Earliest) J:2312 Ghanshani S, et al., Genomic organization, nucleotide sequence, and cellular distribution of a Shaw-related potassium channel gene, Kv3.3, and mapping of Kv3.3 and Kv3.4 to human chromosomes 19 and 1. Genomics. 1992 Feb;12(2):190-6
(Latest) J:191347 Bocksteins E, et al., Kv3 channels contribute to the delayed rectifier current in small cultured mouse dorsal root ganglion neurons. Am J Physiol Cell Physiol. 2012 Aug 15;303(4):C406-15
All references(45)
Other
accession IDs
MGD-MRK-11573, MGD-MRK-11581

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory