About   Help   FAQ
Kcnc3 Gene Detail
Summary
  • Symbol
    Kcnc3
  • Name
    potassium voltage gated channel, Shaw-related subfamily, member 3
  • Synonyms
    Kcr2-3, KShIIID, Kv3.3
  • Feature Type
    protein coding gene
  • IDs
    MGI:96669
    NCBI Gene: 16504
  • Gene Overview
    MyGene.info: KCNC3
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:44590661-44604751 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 28.85 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    89 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96669
protein coding gene Chr7:44590661-44604754 (.)
129S1/SvImJ MGP_129S1SvImJ_G0032171
protein coding gene Chr7:44771103-44785612 (+)
A/J MGP_AJ_G0032150
protein coding gene Chr7:43950749-43964608 (+)
AKR/J MGP_AKRJ_G0032086
protein coding gene Chr7:45157503-45171504 (+)
BALB/cJ MGP_BALBcJ_G0032162
protein coding gene Chr7:43948019-43961879 (+)
C3H/HeJ MGP_C3HHeJ_G0031878
protein coding gene Chr7:45648072-45663038 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032654
protein coding gene Chr7:47029710-47043578 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029668
protein coding gene Chr7:46532120-46546090 (+)
CAST/EiJ MGP_CASTEiJ_G0031206
protein coding gene Chr7:37026864-37040748 (+)
CBA/J MGP_CBAJ_G0031842
protein coding gene Chr7:48580832-48594743 (+)
DBA/2J MGP_DBA2J_G0032000
protein coding gene Chr7:43622394-43636269 (+)
FVB/NJ MGP_FVBNJ_G0031951
protein coding gene Chr7:43368912-43384308 (+)
LP/J MGP_LPJ_G0032078
protein coding gene Chr7:45455158-45469083 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031988
protein coding gene Chr7:47312488-47338083 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032670
protein coding gene Chr7:44376843-44391453 (+)
PWK/PhJ MGP_PWKPhJ_G0030929
protein coding gene Chr7:36972752-36989328 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030766
protein coding gene Chr7:32383136-32396919 (+)
WSB/EiJ MGP_WSBEiJ_G0031323
protein coding gene Chr7:44843210-44857005 (+)



Homology
more
  • Human Ortholog
    KCNC3, potassium voltage-gated channel subfamily C member 3
  • Vertebrate Orthologs
    7
  • Human Ortholog
    KCNC3, potassium voltage-gated channel subfamily C member 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    KSHIIID, KV3.3, SCA13
  • Links
    NCBI Gene ID: 3748
    neXtProt AC: NX_Q14003
    UniProt: Q14003

  • Chr Location
    19q13.33; chr19:50311942-50333515 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human KCNC3 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    17 phenotypes from multigenic genotypes
    16 phenotype references
Homozgous null mice show no overt phenotype, though mutation of this locus in conjunction with mutations in another potassium channel results in alcohol hypersensitivty, increased locomotion, and spontaneous myoclonus.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 16504 NCBI Gene Model | MGI Sequence Detail 14091 C57BL/6J ±  kb
transcript NM_001290682 RefSeq | MGI Sequence Detail 5184 C57BL/6  
polypeptide Q63959 UniProt | EBI | MGI Sequence Detail 769 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    7 Sequences
  • InterPro Domains
    IPR000210 BTB/POZ domain
    IPR005821 Ion transport domain
    IPR003131 Potassium channel tetramerisation-type BTB domain
    IPR003968 Potassium channel, voltage dependent, Kv
    IPR003974 Potassium channel, voltage dependent, Kv3
    IPR005404 Potassium channel, voltage dependent, Kv3.3
    IPR021105 Potassium channel, voltage dependent, Kv3, inactivation domain
    IPR011333 SKP1/BTB/POZ domain superfamily
    IPR027359 Voltage-dependent channel domain superfamily
    IPR028325 Voltage-gated potassium channel
Molecular
Reagents
less
  • All nucleic 23
    Genomic 2
    cDNA 20
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-11573, MGD-MRK-11581
References
more
  • Summaries
    All 48
    Developmental Gene Expression 3
    Gene Ontology 8
    Phenotypes 16
  • Earliest
    J:2312 Ghanshani S, et al., Genomic organization, nucleotide sequence, and cellular distribution of a Shaw-related potassium channel gene, Kv3.3, and mapping of Kv3.3 and Kv3.4 to human chromosomes 19 and 1. Genomics. 1992 Feb;12(2):190-6
  • Latest
    J:234410 Zhang Y, et al., Kv3.3 Channels Bind Hax-1 and Arp2/3 to Assemble a Stable Local Actin Network that Regulates Channel Gating. Cell. 2016 Apr 7;165(2):434-48

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/06/2018
MGI 6.13
The Jackson Laboratory