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Kcnc2
Gene Detail
Symbol

Name
ID
Kcnc2
potassium voltage gated channel, Shaw-related subfamily, member 2
MGI:96668
Synonyms
KShIIIA, Kv3.2
Feature Type
protein coding gene
Genetic Map
Chromosome 10
60.30 cM
Detailed Genetic Map ± 1 cM


Mapping data(11)
Sequence Map
Chr10:112271123-112466304 bp, + strand
From Ensembl annotation of GRCm38

  195182 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:71199  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: potassium voltage-gated channel, alpha subunit, subfamilies A/C/D/F/G/S
Gene Tree: Kcnc2

Human
homologs
Human Homolog KCNC2, potassium voltage-gated channel, Shaw-related subfamily, member 2
NCBI Gene ID 3747
neXtProt AC  NX_Q96PR1
Human Synonyms  KV3.2
Human Chr (Location)  12q14.1; chr12:75040078-75209804 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele display impaired fast spiking in cortical interneurons, distorted cortical rhythmic activity, enhanced susceptibility to seizures, increased anxiety in the open field, and abnormal sleep patterns.
 
Interactions
Kcnc2 interacts with 413 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process action potential, ion transport, ...
Component integral component of membrane, membrane, ...
Function delayed rectifier potassium channel activity, ion channel activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (3)    Tissues (3)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 3
cDNA source data(9)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(12) cDNA(10) Primer pair(1) Other(1)
Microarray probesets(2)
Other database
links
Ensembl Gene ModelENSMUSG00000035681 (Evidence)
Entrez Gene268345 (Evidence)
DFCITC1597660, TC1607925, TC1612704
DoTSDT.101235377, DT.101725427, DT.87048176
NIA Mouse Gene IndexU012015
Consensus CDS ProjectCCDS24173.1
International Mouse Knockout Project StatusKcnc2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000035681 Ensembl Gene Model | MGI Sequence Detail 195182 C57BL/6J ±  kb
transcript ENSMUST00000092175 Ensembl | MGI Sequence Detail 6196 Not Applicable 
polypeptide ENSMUSP00000089814 Ensembl | MGI Sequence Detail 639 Not Applicable 

For the selected sequences
All sequences(50) RefSeq(24) UniProt(5)
Polymorphisms
RFLP(2) : SNPs within 2kb(1520 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011333 BTB/POZ fold
InterPro IPR000210 BTB/POZ-like
InterPro IPR013099 Ion transport 2
InterPro IPR005821 Ion transport domain
InterPro IPR003131 Potassium channel tetramerisation-type BTB domain
InterPro IPR003968 Potassium channel, voltage dependent, Kv
InterPro IPR003974 Potassium channel, voltage dependent, Kv3
InterPro IPR003091 Voltage-dependent potassium channel
InterPro IPR027359 Voltage-dependent potassium channel, four helix bundle domain
Protein Ontology PR:000000782 voltage-gated potassium channel KCNC2
References
(Earliest) J:2312 Ghanshani S, et al., Genomic organization, nucleotide sequence, and cellular distribution of a Shaw-related potassium channel gene, Kv3.3, and mapping of Kv3.3 and Kv3.4 to human chromosomes 19 and 1. Genomics. 1992 Feb;12(2):190-6
(Latest) J:205051 Miller JA, et al., Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates. Development. 2013 Nov;140(22):4633-44
All references(49)
Other
accession IDs
MGD-MRK-11572, MGI:2143797

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory