Kcnc2
Gene Detail

Symbol Name ID

Kcnc2 potassium voltage gated channel, Shaw-related subfamily, member 2 MGI:96668

Synonyms

KShIIIA, Kv3.2

Feature Type

protein coding gene

Genetic Map

Chromosome 10

60.30 cM
Detailed Genetic Map ± 1 cM


Mapping data(11)

Sequence Map

Chr10:112271123-112466304 bp, + strand From NCBI annotation of GRCm38   195182 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:71199  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: potassium voltage-gated channel, alpha subunit, subfamilies A/C/D/F/G/S
Gene Tree: Kcnc2

Human homologs

Human Homolog		KCNC2, potassium voltage-gated channel, Shaw-related subfamily, member 2
NCBI Gene ID		3747
neXtProt AC		NX_Q96PR1
Human Synonyms		KV3.2
Human Chr (Location)		12q14.1; chr12:75433858-75603528 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Mice homozygous for a knock-out allele display impaired fast spiking in cortical interneurons, distorted cortical rhythmic activity, enhanced susceptibility to seizures, increased anxiety in the open field, and abnormal sleep patterns.

 

Gene Ontology (GO) classifications

All GO classifications: (20 annotations)

Process	ion transport, potassium ion transmembrane transport, ...
Component	integral to membrane, membrane, ...
Function	delayed rectifier potassium channel activity, ion channel activity, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (3)    Tissues (2)   
Theiler Stages: 25, 28

Assay Type	Results
RT-PCR	3

cDNA source data(9)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(12) cDNA(10) Primer pair(1) Other(1)
Microarray probesets(2)

Other database links

Ensembl Gene Model	ENSMUSG00000035681 (Evidence)
Entrez Gene	268345 (Evidence)
DFCI	TC1597660, TC1607925, TC1612704
DoTS	DT.101235377, DT.101725427, DT.87048176
NIA Mouse Gene Index	U012015
Consensus CDS Project	CCDS24173.1
International Mouse Knockout Project Status	Kcnc2

Sequences

Length	Strain/Species
genomic	268345	NCBI Gene Model | MGI Sequence Detail	195182	C57BL/6J
transcript	NM_001025581	RefSeq | MGI Sequence Detail	6196	C57BL/6
polypeptide	Q14B80	UniProt | EBI | MGI Sequence Detail	642	Not Applicable

All sequences(26) RefSeq(2) UniProt(3)

Polymorphisms

RFLP(2) : SNPs(1182 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR011333	BTB/POZ fold
InterPro	IPR000210	BTB/POZ-like
InterPro	IPR013099	Ion transport 2
InterPro	IPR005821	Ion transport domain
InterPro	IPR003131	Potassium channel tetramerisation-type BTB domain
InterPro	IPR003968	Potassium channel, voltage dependent, Kv
InterPro	IPR003974	Potassium channel, voltage dependent, Kv3
InterPro	IPR003091	Voltage-dependent potassium channel
Protein Ontology	PR:000000782	voltage-gated potassium channel KCNC2

Graphical View of Protein Domain Structure

References

(Earliest) J:2312 Ghanshani S, et al., Genomic organization, nucleotide sequence, and cellular distribution of a Shaw-related potassium channel gene, Kv3.3, and mapping of Kv3.3 and Kv3.4 to human chromosomes 19 and 1. Genomics. 1992 Feb;12(2):190-6
(Latest) J:191347 Bocksteins E, et al., Kv3 channels contribute to the delayed rectifier current in small cultured mouse dorsal root ganglion neurons. Am J Physiol Cell Physiol. 2012 Aug 15;303(4):C406-15
All references(47)

Other accession IDs

MGD-MRK-11572, MGI:2143797