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Kcnc2 Gene Detail
Summary
  • Symbol
    Kcnc2
  • Name
    potassium voltage gated channel, Shaw-related subfamily, member 2
  • Synonyms
    KShIIIA, Kv3.2
  • Feature Type
    protein coding gene
  • IDs
    MGI:96668
    NCBI Gene: 268345
  • Gene Overview
    MyGene.info: KCNC2
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:112271121-112467024 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 60.30 cM
  • Mapping Data
    11 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1522 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96668
protein coding gene Chr10:112269121-112467024 (.)
129S1/SvImJ MGP_129S1SvImJ_G0017728
protein coding gene Chr10:114801641-114994205 (+)
A/J MGP_AJ_G0017705
protein coding gene Chr10:110438420-110625210 (+)
AKR/J MGP_AKRJ_G0017667
protein coding gene Chr10:113679970-113869667 (+)
BALB/cJ MGP_BALBcJ_G0017668
protein coding gene Chr10:110792386-110979153 (+)
C3H/HeJ MGP_C3HHeJ_G0017493
protein coding gene Chr10:113818327-114009244 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018125
protein coding gene Chr10:118784909-118970124 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015805
protein coding gene Chr10:105192613-105373239 (+)
CAST/EiJ MGP_CASTEiJ_G0017055
protein coding gene Chr10:114016716-114193644 (+)
CBA/J MGP_CBAJ_G0017462
protein coding gene Chr10:123484347-123673779 (+)
DBA/2J MGP_DBA2J_G0017567
protein coding gene Chr10:109593756-109772090 (+)
FVB/NJ MGP_FVBNJ_G0017562
protein coding gene Chr10:108547340-108731208 (+)
LP/J MGP_LPJ_G0017642
protein coding gene Chr10:115441900-115636912 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017591
protein coding gene Chr10:125997227-126202822 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018163
protein coding gene Chr10:113660930-113845260 (+)
PWK/PhJ MGP_PWKPhJ_G0016837
protein coding gene Chr10:109629114-109816021 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016627
protein coding gene Chr10:112430945-112616044 (+)
WSB/EiJ MGP_WSBEiJ_G0017115
protein coding gene Chr10:113842741-114046203 (+)



Homology
more
  • Human Ortholog
    KCNC2, potassium voltage-gated channel subfamily C member 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    KCNC2, potassium voltage-gated channel subfamily C member 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    KV3.2
  • Links
    NCBI Gene ID: 3747
    neXtProt AC: NX_Q96PR1
    UniProt: Q96PR1

  • Chr Location
    12q21.1; chr12:75040078-75209815 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 2 alleles in 2 genetic backgrounds
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele display impaired fast spiking in cortical interneurons, distorted cortical rhythmic activity, enhanced susceptibility to seizures, increased anxiety in the open field, and abnormal sleep patterns.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000035681 Ensembl Gene Model | MGI Sequence Detail 195904 C57BL/6J ±  kb
    transcript ENSMUST00000092175 Ensembl | MGI Sequence Detail 5046 Not Applicable  
    polypeptide ENSMUSP00000089814 Ensembl | MGI Sequence Detail 642 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • InterPro Domains
      IPR000210 BTB/POZ domain
      IPR005821 Ion transport domain
      IPR003131 Potassium channel tetramerisation-type BTB domain
      IPR003968 Potassium channel, voltage dependent, Kv
      IPR003974 Potassium channel, voltage dependent, Kv3
      IPR011333 SKP1/BTB/POZ domain superfamily
      IPR027359 Voltage-dependent channel domain superfamily
      IPR028325 Voltage-gated potassium channel
    Molecular
    Reagents
    less
    • All nucleic 15
      cDNA 13
      Primer pair 1
      Other 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-11572, MGI:2143797
    References
    more
    • Summaries
      All 61
      Developmental Gene Expression 8
      Gene Ontology 8
      Phenotypes 19
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:242531 Bedogni F, et al., Defects During Mecp2 Null Embryonic Cortex Development Precede the Onset of Overt Neurological Symptoms. Cereb Cortex. 2016 Jun;26(6):2517-2529

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/27/2018
    MGI 6.13
    The Jackson Laboratory