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Kcnb1
Gene Detail
Symbol

Name
ID
Kcnb1
potassium voltage gated channel, Shab-related subfamily, member 1
MGI:96666
Synonyms
Kcr1-1, Kv2.1, Shab
Feature Type
protein coding gene
Genetic Map
Chromosome 2
87.22 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr2:167103378-167190155 bp, - strand
From VEGA annotation of GRCm38

  86778 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37988  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: KCNB1
Protein SuperFamily: potassium voltage-gated channel, subfamily B
Gene Tree: Kcnb1

Human
homologs
KCNB1, potassium channel, voltage gated Shab related subfamily B, member 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 3745
neXtProt AC: NX_Q14721

Human Synonyms: DRK1, EIEE26, h-DRK1, KV2.1

Human Chr (Location): 20q13.2; chr20:49363877-49484042 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human KCNB1

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(2) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele show reduced fasting glucose levels, hyperinsulinemia, improved glucose tolerance, altered glucose-induced electrical activity of pancreatic beta cells, and enhanced insulin secretion.
 
Interactions
Kcnb1 interacts with 113 markers (Mir7-1, Mir15b, Mir24-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (72 annotations)
Process action potential, cellular response to glucose stimulus, ...
Component axon, cell junction, ...
Function delayed rectifier potassium channel activity, ion channel activity, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (12)    Tissues (7)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 12
cDNA source data(6)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase LOC100489405    NEW 
Molecular
reagents
All nucleic(10) Genomic(1) cDNA(7) Primer pair(2)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000001150 (Evidence)
Ensembl Gene Model ENSMUSG00000050556 (Evidence)
Entrez Gene 16500 (Evidence)
NIA Mouse Gene Index U023673, U130917
Consensus CDS Project CCDS17096.1
International Mouse Phenotyping Consortium Status Kcnb1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000001150 VEGA Gene Model | MGI Sequence Detail 86778 C57BL/6J ±  kb
transcript OTTMUST00000002242 VEGA | MGI Sequence Detail 3725 Not Applicable 
polypeptide OTTMUSP00000001091 VEGA | MGI Sequence Detail 857 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(4) UniProt(4)
Polymorphisms
RFLP(2) : SNPs within 2kb(474 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011333 BTB/POZ fold
InterPro IPR000210 BTB/POZ-like
InterPro IPR005821 Ion transport domain
InterPro IPR003131 Potassium channel tetramerisation-type BTB domain
InterPro IPR003968 Potassium channel, voltage dependent, Kv
InterPro IPR003973 Potassium channel, voltage dependent, Kv2
InterPro IPR004350 Potassium channel, voltage dependent, Kv2.1
InterPro IPR003971 Potassium channel, voltage dependent, Kv9
InterPro IPR003091 Voltage-dependent potassium channel
InterPro IPR027359 Voltage-dependent potassium channel, four helix bundle domain
Protein Ontology PR:000000722 voltage-gated potassium channel KCNB1
References
(Earliest) J:10462 Wei A, et al., K+ current diversity is produced by an extended gene family conserved in Drosophila and mouse. Science. 1990 May 4;248(4955):599-603
(Latest) J:219665 Sukma Rita R, et al., Partial blockade of Kv2.1 channel potentiates GLP-1's insulinotropic effects in islets and reduces its dose required for improving glucose tolerance in type 2 diabetic male mice. Endocrinology. 2015 Jan;156(1):114-23
All references(47)
Other
accession IDs
MGD-MRK-11570, MGD-MRK-11579, MGD-MRK-14396

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory