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Kcnb1 Gene Detail
Summary
  • Symbol
    Kcnb1
  • Name
    potassium voltage gated channel, Shab-related subfamily, member 1
  • Synonyms
    Kcr1-1, Kv2.1, Shab
  • Feature Type
    protein coding gene
  • IDs
    MGI:96666
    NCBI Gene: 16500
  • Gene Overview
    MyGene.info: KCNB1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr2:167095969-167190155 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      94187 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 87.22 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    KCNB1, potassium voltage-gated channel subfamily B member 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    KCNB1, potassium voltage-gated channel subfamily B member 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DRK1, Kv2.1
  • Links
    NCBI Gene ID: 3745
    neXtProt AC: NX_Q14721
    UniProt: Q14721

  • Chr Location
    20q13.13; chr20:49363877-49484033 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 2 alleles in 2 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele show reduced fasting glucose levels, hyperinsulinemia, improved glucose tolerance, altered glucose-induced electrical activity of pancreatic beta cells, and enhanced insulin secretion.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000001150 VEGA Gene Model | MGI Sequence Detail 94187 C57BL/6J ±  kb
    transcript OTTMUST00000002242 VEGA | MGI Sequence Detail 11153 Not Applicable  
    polypeptide OTTMUSP00000001091 VEGA | MGI Sequence Detail 857 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      479 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 12
      Genomic 1
      cDNA 9
      Primer pair 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-11570, MGD-MRK-11579, MGD-MRK-14396
    References
    more
    • Summaries
      All 60
      Developmental Gene Expression 9
      Gene Ontology 9
      Phenotypes 16
    • Earliest
      J:10462 Wei A, et al., K+ current diversity is produced by an extended gene family conserved in Drosophila and mouse. Science. 1990 May 4;248(4955):599-603
    • Latest
      J:260051 Yu W, et al., Oxidation of KCNB1 potassium channels triggers apoptotic integrin signaling in the brain. Cell Death Dis. 2017 Apr 6;8(4):e2737

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    07/31/2018
    MGI 6.12
    The Jackson Laboratory