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Kcna6 Gene Detail
Summary
  • Symbol
    Kcna6
  • Name
    potassium voltage-gated channel, shaker-related, subfamily, member 6
  • Synonyms
    Kv1.6, MK1.6
  • Feature Type
    protein coding gene
  • IDs
    MGI:96663
    NCBI Gene: 16494
Location & Maps
more
  • Sequence Map
    Chr6:126708329-126740662 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      32334 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    KCNA6, potassium channel, voltage gated shaker related subfamily A, member 6
  • Vertebrate Orthologs
    10
  • Human Ortholog
    KCNA6, potassium channel, voltage gated shaker related subfamily A, member 6
    Orthology source: HGNC, HomoloGene
  • Synonyms
    HBK2, KV1.6, PPP1R96
  • Links
    NCBI Gene ID: 3742
    neXtProt AC: NX_P17658

  • Chr Location
    12p13; chr12:4806885-4851114 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    3
  • Gene trapped
    1
  • Targeted
    2
Homozygous mutation of this gene results in an increased thermal nociceptive threshold and in females an increase in circulating triglyceride levels.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022444 VEGA Gene Model | MGI Sequence Detail 32334 C57BL/6J ±  kb
transcript OTTMUST00000053659 VEGA | MGI Sequence Detail 5827 Not Applicable  
polypeptide OTTMUSP00000025521 VEGA | MGI Sequence Detail 529 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    275 from dbSNP Build 137
  • RFLP
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000000813 voltage-gated potassium channel subunit KCNA6
  • InterPro Domains
    IPR000210 BTB/POZ domain
    IPR005821 Ion transport domain
    IPR003131 Potassium channel tetramerisation-type BTB domain
    IPR003968 Potassium channel, voltage dependent, Kv
    IPR003972 Potassium channel, voltage dependent, Kv1
    IPR004053 Potassium channel, voltage dependent, Kv1.6
    IPR011333 SKP1/BTB/POZ domain
    IPR027359 Voltage-dependent channel, four helix bundle domain
    IPR028325 Voltage-gated potassium channel
Molecular
Reagents
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  • All nucleic 13
    Genomic 5
    cDNA 5
    Primer pair 2
    Other 1

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-11567
References
more
  • Summaries
    All 37
    Developmental Gene Expression 4
    Gene Ontology 6
    Phenotypes 4
  • Earliest
    J:2710 Lesage F, et al., Developmental expression of voltage-sensitive K+ channels in mouse skeletal muscle and C2C12 cells. FEBS Lett. 1992 Sep 28;310(2):162-6
  • Latest
    J:178399 Roepke TK, et al., KCNE2 forms potassium channels with KCNA3 and KCNQ1 in the choroid plexus epithelium. FASEB J. 2011 Dec;25(12):4264-73

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory