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Kcna6
Gene Detail
Symbol

Name
ID
Kcna6
potassium voltage-gated channel, shaker-related, subfamily, member 6
MGI:96663
Synonyms
Kv1.6, MK1.6
Feature Type
protein coding gene
Genetic Map
Chromosome 6
61.72 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr6:126708329-126740662 bp, - strand
From VEGA annotation of GRCm38

  32334 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1684  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: KCNA6
Protein SuperFamily: potassium voltage-gated channel, alpha subunit, subfamilies A/C/D/F/G/S
Gene Tree: Kcna6

Human
homologs
KCNA6, potassium channel, voltage gated shaker related subfamily A, member 6
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 3742
neXtProt AC: NX_P17658

Human Synonyms: HBK2, KV1.6, PPP1R96

Human Chr (Location): 12p13; chr12:4806885-4851114 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Gene trapped(1) Targeted(2)
 
Homozygous mutation of this gene results in an increased thermal nociceptive threshold and in females an increase in circulating triglyceride levels.
 
Interactions
Kcna6 interacts with 308 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (28 annotations)
Process ion transport, potassium ion transmembrane transport, ...
Component axon, axon terminus, ...
Function delayed rectifier potassium channel activity, ion channel activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (214)    Tissues (23)    Images (22)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 211
RT-PCR 3
cDNA source data(4)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN kcna6a    NEW 
Molecular
reagents
All nucleic(13) Genomic(5) cDNA(5) Primer pair(2) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000022444 (Evidence)
Ensembl Gene Model ENSMUSG00000038077 (Evidence)
Entrez Gene 16494 (Evidence)
DFCI TC1585561, TC1591220, TC1605217, TC1614882
DoTS DT.55128656, DT.55235195, DT.97357782
NIA Mouse Gene Index U046768
Consensus CDS Project CCDS20556.1
International Mouse Phenotyping Consortium Status Kcna6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022444 VEGA Gene Model | MGI Sequence Detail 32334 C57BL/6J ±  kb
transcript OTTMUST00000053659 VEGA | MGI Sequence Detail 5827 Not Applicable 
polypeptide OTTMUSP00000025521 VEGA | MGI Sequence Detail 529 Not Applicable 

For the selected sequences
All sequences(39) RefSeq(8) UniProt(1)
Polymorphisms
RFLP(2) : SNPs within 2kb(275 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011333 BTB/POZ fold
InterPro IPR000210 BTB/POZ-like
InterPro IPR005821 Ion transport domain
InterPro IPR003131 Potassium channel tetramerisation-type BTB domain
InterPro IPR003968 Potassium channel, voltage dependent, Kv
InterPro IPR003972 Potassium channel, voltage dependent, Kv1
InterPro IPR004053 Potassium channel, voltage dependent, Kv1.6
InterPro IPR003091 Voltage-dependent potassium channel
InterPro IPR027359 Voltage-dependent potassium channel, four helix bundle domain
Protein Ontology PR:000000813 voltage-gated potassium channel subunit KCNA6
References
(Earliest) J:2710 Lesage F, et al., Developmental expression of voltage-sensitive K+ channels in mouse skeletal muscle and C2C12 cells. FEBS Lett. 1992 Sep 28;310(2):162-6
(Latest) J:178399 Roepke TK, et al., KCNE2 forms potassium channels with KCNA3 and KCNQ1 in the choroid plexus epithelium. FASEB J. 2011 Dec;25(12):4264-73
All references(40)
Other
accession IDs
MGD-MRK-11567

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory