Kcna6
Gene Detail

Symbol Name ID

Kcna6 potassium voltage-gated channel, shaker-related, subfamily, member 6 MGI:96663

Synonyms

Kv1.6, MK1.6

Feature Type

protein coding gene

Genetic Map

Chromosome 6

61.72 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)

Sequence Map

Chr6:126708329-126740662 bp, - strand From VEGA annotation of GRCm38   32334 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Kcna6 ± 2 cM)

Protein SuperFamily: potassium voltage-gated channel, alpha subunit, subfamilies A/C/D/F/G/S
Gene Tree: Kcna6

Human ortholog

KCNA6 potassium voltage-gated channel, shaker-related subfamily, member 6 NCBI Gene ID 3742
Human Synonyms: HBK2, KV1.6
Human Chr12:4918342-4960278 bp, + strand Reference GRCh37.p2 Primary Assembly

Alleles and phenotypes

All alleles(3) : Targeted(2) Gene trapped(1)
 

Homozygous mutation of this gene results in an increased thermal nociceptive threshold and in females an increase in circulating triglyceride levels.

 

Gene Ontology (GO) classifications

All GO classifications: (19 annotations)

Process	ion transport, potassium ion transmembrane transport, ...
Component	integral to membrane, membrane, ...
Function	delayed rectifier potassium channel activity, ion channel activity, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (214)    Tissues (22)    Images (22)
Theiler Stages: 23, 25, 28

Assay Type	Results
RNA in situ	211
RT-PCR	3

cDNA source data(4)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(13) Genomic(5) cDNA(5) Primer pair(2) Other(1)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000022444 (Evidence)
Ensembl Gene Model	ENSMUSG00000038077 (Evidence)
Entrez Gene	16494 (Evidence)
DFCI	TC1585561, TC1591220, TC1605217, TC1614882
DoTS	DT.55128656, DT.55235195, DT.97357782
NIA Mouse Gene Index	U046768
Consensus CDS Project	CCDS20556.1
International Mouse Knockout Project Status	Kcna6

Sequences

Length	Strain/Species
genomic	OTTMUSG00000022444	VEGA Gene Model | MGI Sequence Detail	32334	C57BL/6J
transcript	OTTMUST00000061033	VEGA | MGI Sequence Detail	3464	Not Applicable
polypeptide	OTTMUSP00000029861	VEGA | MGI Sequence Detail	529	Not Applicable

All sequences(31) RefSeq(2) UniProt(1)

Polymorphisms

RFLP(2) : SNPs(20 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR011333	BTB/POZ fold
InterPro	IPR000210	BTB/POZ-like
InterPro	IPR005821	Ion transport domain
InterPro	IPR003131	Potassium channel tetramerisation-type BTB domain
InterPro	IPR003968	Potassium channel, voltage dependent, Kv
InterPro	IPR003972	Potassium channel, voltage dependent, Kv1
InterPro	IPR004053	Potassium channel, voltage dependent, Kv1.6
InterPro	IPR003091	Voltage-dependent potassium channel
Protein Ontology	PR:000000813	voltage-gated potassium channel subunit KCNA6

References

(Earliest) J:2710 Lesage F, et al., Developmental expression of voltage-sensitive K+ channels in mouse skeletal muscle and C2C12 cells. FEBS Lett. 1992 Sep 28;310(2):162-6
(Latest) J:178399 Roepke TK, et al., KCNE2 forms potassium channels with KCNA3 and KCNQ1 in the choroid plexus epithelium. FASEB J. 2011 Dec;25(12):4264-73
All references(39)

Other accession IDs

MGD-MRK-11567