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Kcna5
Gene Detail
Symbol

Name
ID
Kcna5
potassium voltage-gated channel, shaker-related subfamily, member 5
MGI:96662
Synonyms
Kv1.5
Feature Type
protein coding gene
Genetic Map
Chromosome 6
61.35 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr6:126532551-126535555 bp, - strand
From NCBI annotation of GRCm38

  3005 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1683  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: potassium voltage-gated channel, alpha subunit, subfamilies A/C/D/F/G/S
Gene Tree: Kcna5

Human
homologs
Human Homolog KCNA5, potassium voltage-gated channel, shaker-related subfamily, member 5
NCBI Gene ID 3741
neXtProt AC  NX_P22460
Human Synonyms  ATFB7, HCK1, HK2, HPCN1, KV1.5, PCN1
Human Chr (Location)  12p13; chr12:5043919-5046788 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human KCNA5
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit abnormal microglial proliferation and nitric oxide release after LPS treatment or facial nerve lesion. Mice homozygous for a knock-in allele exhibit impaired hypoxic pulmonary vasoconstriction, and resistance to drug-induced cardiac QT prolongation.
 
Interactions
Kcna5 interacts with 156 markers (Mir1a-1, Mir1a-2, Mir16-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (62 annotations)
Process atrial cardiac muscle cell action potential, ion transport, ...
Component cytosol, endoplasmic reticulum, ...
Function alpha-actinin binding, delayed rectifier potassium channel activity, ...
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (218)    Tissues (38)    Images (30)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 203
RT-PCR 15
cDNA source data(10)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(22) Genomic(6) cDNA(12) Primer pair(3) Other(1)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000045534 (Evidence)
Entrez Gene16493 (Evidence)
UniGene222831
DFCITC1582403, TC1650801, TC1764739
DoTSDT.40139871, DT.99721054
NIA Mouse Gene IndexU027874
Consensus CDS ProjectCCDS20554.1
International Mouse Knockout Project StatusKcna5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 16493 NCBI Gene Model | MGI Sequence Detail 3005 C57BL/6J ±  kb
transcript NM_145983 RefSeq | MGI Sequence Detail 3032 C57BL/6 
polypeptide Q61762 UniProt | EBI | MGI Sequence Detail 602 Not Applicable 

For the selected sequences
All sequences(20) RefSeq(2) UniProt(1)
Polymorphisms
RFLP(4) : SNPs within 2kb(33 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011333 BTB/POZ fold
InterPro IPR000210 BTB/POZ-like
InterPro IPR005821 Ion transport domain
InterPro IPR003131 Potassium channel tetramerisation-type BTB domain
InterPro IPR003968 Potassium channel, voltage dependent, Kv
InterPro IPR003972 Potassium channel, voltage dependent, Kv1
InterPro IPR004052 Potassium channel, voltage dependent, Kv1.5
InterPro IPR003091 Voltage-dependent potassium channel
InterPro IPR027359 Voltage-dependent potassium channel, four helix bundle domain
Protein Ontology PR:000000812 voltage-gated potassium channel subunit KCNA5
Graphical View of Protein Domain Structure
References
(Earliest) J:2710 Lesage F, et al., Developmental expression of voltage-sensitive K+ channels in mouse skeletal muscle and C2C12 cells. FEBS Lett. 1992 Sep 28;310(2):162-6
(Latest) J:211437 de la Rosa AJ, et al., Functional suppression of Kcnq1 leads to early sodium channel remodelling and cardiac conduction system dysmorphogenesis. Cardiovasc Res. 2013 Jun 1;98(3):504-14
All references(52)
Other
accession IDs
MGD-MRK-11566

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory