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Kcna5
Gene Detail
Symbol

Name
ID
Kcna5
potassium voltage-gated channel, shaker-related subfamily, member 5
MGI:96662
Synonyms
Kv1.5
Feature Type
protein coding gene
Genetic Map
Chromosome 6
61.35 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr6:126532551-126535555 bp, - strand
From NCBI annotation of GRCm38

  3005 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1683  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: KCNA5
Protein SuperFamily: potassium voltage-gated channel, alpha subunit, subfamilies A/C/D/F/G/S
Gene Tree: Kcna5

Human
homologs
KCNA5, potassium channel, voltage gated shaker related subfamily A, member 5
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 3741
neXtProt AC: NX_P22460

Human Synonyms: ATFB7, HCK1, HK2, HPCN1, KV1.5, PCN1

Human Chr (Location): 12p13; chr12:5043919-5046788 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human KCNA5

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit abnormal microglial proliferation and nitric oxide release after LPS treatment or facial nerve lesion. Mice homozygous for a knock-in allele exhibit impaired hypoxic pulmonary vasoconstriction, and resistance to drug-induced cardiac QT prolongation.
 
Interactions
Kcna5 interacts with 156 markers (Mir1a-1, Mir1a-2, Mir16-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (73 annotations)
Process atrial cardiac muscle cell action potential, ion transport, ...
Component cytosol, endoplasmic reticulum, ...
Function alpha-actinin binding, delayed rectifier potassium channel activity, ...
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (218)    Tissues (38)    Images (30)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 203
RT-PCR 15
cDNA source data(10)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase kcna5    NEW 
Molecular
reagents
All nucleic(22) Genomic(6) cDNA(12) Primer pair(3) Other(1)
Microarray probesets(5)
Other database
links
Ensembl Gene Model ENSMUSG00000045534 (Evidence)
Entrez Gene 16493 (Evidence)
UniGene 222831
DFCI TC1582403, TC1650801, TC1764739
DoTS DT.40139871, DT.99721054
NIA Mouse Gene Index U027874
Consensus CDS Project CCDS20554.1
International Mouse Phenotyping Consortium Status Kcna5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 16493 NCBI Gene Model | MGI Sequence Detail 3005 C57BL/6J ±  kb
transcript NM_145983 RefSeq | MGI Sequence Detail 3032 C57BL/6 
polypeptide Q61762 UniProt | EBI | MGI Sequence Detail 602 Not Applicable 

For the selected sequences
All sequences(20) RefSeq(2) UniProt(1)
Polymorphisms
RFLP(4) : SNPs within 2kb(33 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000210 BTB/POZ domain
InterPro IPR005821 Ion transport domain
InterPro IPR003091 Potassium channel
InterPro IPR003131 Potassium channel tetramerisation-type BTB domain
InterPro IPR003968 Potassium channel, voltage dependent, Kv
InterPro IPR003972 Potassium channel, voltage dependent, Kv1
InterPro IPR004052 Potassium channel, voltage dependent, Kv1.5
InterPro IPR011333 POZ domain
InterPro IPR027359 Voltage-dependent channel, four helix bundle domain
InterPro IPR028325 Voltage-gated potassium channel
Protein Ontology PR:000000812 voltage-gated potassium channel subunit KCNA5
Graphical View of Protein Domain Structure
References
(Earliest) J:2710 Lesage F, et al., Developmental expression of voltage-sensitive K+ channels in mouse skeletal muscle and C2C12 cells. FEBS Lett. 1992 Sep 28;310(2):162-6
(Latest) J:216917 Fouillade C, et al., Transcriptome analysis for Notch3 target genes identifies Grip2 as a novel regulator of myogenic response in the cerebrovasculature. Arterioscler Thromb Vasc Biol. 2013 Jan;33(1):76-86
All references(53)
Other
accession IDs
MGD-MRK-11566

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory