Kcna3
Gene Detail

Symbol Name ID

Kcna3 potassium voltage-gated channel, shaker-related subfamily, member 3 MGI:96660

Synonyms

Kca1-3, Kv1.3, Mk-3

Feature Type

protein coding gene

Genetic Map

Chromosome 3

46.59 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr3:107036162-107038129 bp, + strand From NCBI annotation of GRCm38   1968 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:128570  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: potassium voltage-gated channel, alpha subunit, subfamilies A/C/D/F/G/S
Gene Tree: Kcna3

Human homologs

Human Homolog		KCNA3, potassium voltage-gated channel, shaker-related subfamily, member 3
NCBI Gene ID		3738
neXtProt AC		NX_P22001
Human Synonyms		HGK5, HLK3, HPCN3, HUKIII, KV1.3, MK3, PCN3
Human Chr (Location)		1p13.3; chr1:111214310-111217655 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Mice homozygous for a knock-out allele display no apparent immune system defects. Mice homozygous for a different knock-out allele show reduced body weight, increased basal metabolic rate, resistance to diet-induced obesity, increased insulin sensitivity, and altered peripheral glucose metabolism.

 

Gene Ontology (GO) classifications

All GO classifications: (27 annotations)

Process	ion transmembrane transport, ion transport, ...
Component	integral to membrane, membrane, ...
Function	delayed rectifier potassium channel activity, ion channel activity, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (8)    Tissues (3)    Images (5)
Theiler Stages: 23, 25, 28

Assay Type	Results
RNA in situ	5
RT-PCR	3

cDNA source data(6)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(13) Genomic(5) cDNA(6) Primer pair(1) Other(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000047959 (Evidence)
Entrez Gene	16491 (Evidence)
UniGene	30640
DFCI	TC1651806
DoTS	DT.94220444
NIA Mouse Gene Index	U043920
Consensus CDS Project	CCDS17730.1
International Mouse Knockout Project Status	Kcna3

Sequences

Length	Strain/Species
genomic	16491	NCBI Gene Model | MGI Sequence Detail	1968	C57BL/6J
transcript	NM_008418	RefSeq | MGI Sequence Detail	1968	C57BL/6
polypeptide	P16390	UniProt | EBI | MGI Sequence Detail	528	Not Applicable

All sequences(15) RefSeq(2) UniProt(1)

Polymorphisms

RFLP(1) : SNPs(2 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR011333	BTB/POZ fold
InterPro	IPR000210	BTB/POZ-like
InterPro	IPR005821	Ion transport domain
InterPro	IPR003131	Potassium channel tetramerisation-type BTB domain
InterPro	IPR003968	Potassium channel, voltage dependent, Kv
InterPro	IPR003972	Potassium channel, voltage dependent, Kv1
InterPro	IPR004050	Potassium channel, voltage dependent, Kv1.3
InterPro	IPR003091	Voltage-dependent potassium channel
Protein Ontology	PR:000000811	voltage-gated potassium channel subunit KCNA3

Graphical View of Protein Domain Structure

References

(Earliest) J:10326 Chandy KG, et al., A family of three mouse potassium channel genes with intronless coding regions. Science. 1990 Feb 23;247(4945):973-5
(Latest) J:190721 Pennington MW, et al., A C-terminally amidated analogue of ShK is a potent and selective blocker of the voltage-gated potassium channel Kv1.3. FEBS Lett. 2012 Nov 16;586(22):3996-4001
All references(45)

Other accession IDs

MGD-MRK-11556, MGD-MRK-11564, MGD-MRK-12250