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Kcna3
Gene Detail
 Symbol
Name
ID
Kcna3
potassium voltage-gated channel, shaker-related subfamily, member 3
MGI:96660
Synonyms Kca1-3, Kv1.3, Mk-3
Feature Type protein coding gene
Genetic Map
Chromosome 3
46.59 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr3:107036162-107038129 bp, + strand
From NCBI annotation of GRCm38

  1968 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:128570  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: potassium voltage-gated channel, alpha subunit, subfamilies A/C/D/F/G/S
Gene Tree: Kcna3

Human
homologs
Human Homolog KCNA3, potassium voltage-gated channel, shaker-related subfamily, member 3
NCBI Gene ID 3738
neXtProt AC  NX_P22001
Human Synonyms  HGK5, HLK3, HPCN3, HUKIII, KV1.3, MK3, PCN3
Human Chr (Location)  1p13.3; chr1:110653560-110675033 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele display no apparent immune system defects. Mice homozygous for a different knock-out allele show reduced body weight, increased basal metabolic rate, resistance to diet-induced obesity, increased insulin sensitivity, and altered peripheral glucose metabolism.
 
Interactions
Kcna3 interacts with 45 markers (Mir18b, Mir128-2, Mir147, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process ion transport, potassium ion transmembrane transport, ...
Component integral component of membrane, membrane, ...
Function delayed rectifier potassium channel activity, ion channel activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (8)    Tissues (4)    Images (5)
Theiler Stages: 23, 25, 27, 28
Assay TypeResults
RNA in situ 5
RT-PCR 3
cDNA source data(6)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(13) Genomic(5) cDNA(6) Primer pair(1) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000047959 (Evidence)
Entrez Gene16491 (Evidence)
UniGene30640
DFCITC1651806
DoTSDT.94220444
NIA Mouse Gene IndexU043920
Consensus CDS ProjectCCDS17730.1
International Mouse Knockout Project StatusKcna3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 16491 NCBI Gene Model | MGI Sequence Detail 1968 C57BL/6J ±  kb
transcript NM_008418 RefSeq | MGI Sequence Detail 1968 C57BL/6 
polypeptide P16390 UniProt | EBI | MGI Sequence Detail 528 Not Applicable 

For the selected sequences
All sequences(15) RefSeq(2) UniProt(1)
Polymorphisms RFLP(1) : SNPs within 2kb(5 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011333 BTB/POZ fold
InterPro IPR000210 BTB/POZ-like
InterPro IPR005821 Ion transport domain
InterPro IPR003131 Potassium channel tetramerisation-type BTB domain
InterPro IPR003968 Potassium channel, voltage dependent, Kv
InterPro IPR003972 Potassium channel, voltage dependent, Kv1
InterPro IPR004050 Potassium channel, voltage dependent, Kv1.3
InterPro IPR003091 Voltage-dependent potassium channel
InterPro IPR027359 Voltage-dependent potassium channel, four helix bundle domain
Protein Ontology PR:000000811 voltage-gated potassium channel subunit KCNA3
Graphical View of Protein Domain Structure
References (Earliest) J:10326 Chandy KG, et al., A family of three mouse potassium channel genes with intronless coding regions. Science. 1990 Feb 23;247(4945):973-5
(Latest) J:211263 Thiebaud N, et al., Hyperlipidemic diet causes loss of olfactory sensory neurons, reduces olfactory discrimination, and disrupts odor-reversal learning. J Neurosci. 2014 May 14;34(20):6970-84
All references(51)
Other
accession IDs
MGD-MRK-11556, MGD-MRK-11564, MGD-MRK-12250

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory