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Kcna3 Gene Detail
Summary
  • Symbol
    Kcna3
  • Name
    potassium voltage-gated channel, shaker-related subfamily, member 3
  • Synonyms
    Kca1-3, Kv1.3, Mk-3
  • Feature Type
    protein coding gene
  • IDs
    MGI:96660
    NCBI Gene: 16491
  • Gene Overview
    MyGene.info: KCNA3
Location & Maps
more
  • Sequence Map
    Chr3:107036169-107038070 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      1902 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 46.59 cM
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    KCNA3, potassium voltage-gated channel subfamily A member 3
  • Vertebrate Orthologs
    11
  • Human Ortholog
    KCNA3, potassium voltage-gated channel subfamily A member 3
    Orthology source: HGNC, HomoloGene
  • Synonyms
    HGK5, HLK3, HPCN3, HUKIII, KV1.3, MK3, PCN3
  • Links
    NCBI Gene ID: 3738
    neXtProt AC: NX_P22001

  • Chr Location
    1p13.3; chr1:110653560-110675033 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 2 alleles in 2 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    2 involving Kcna3
  • Incidental Mutations
Mice homozygous for a knock-out allele display no apparent immune system defects. Mice homozygous for a different knock-out allele show reduced body weight, increased basal metabolic rate, resistance to diet-induced obesity, increased insulin sensitivity, and altered peripheral glucose metabolism.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000056409 VEGA Gene Model | MGI Sequence Detail 1902 C57BL/6J ±  kb
transcript OTTMUST00000139363 VEGA | MGI Sequence Detail 1902 Not Applicable  
polypeptide OTTMUSP00000073131 VEGA | MGI Sequence Detail 528 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    5 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000000811 voltage-gated potassium channel subunit KCNA3
  • InterPro Domains
    IPR000210 BTB/POZ domain
    IPR005821 Ion transport domain
    IPR003131 Potassium channel tetramerisation-type BTB domain
    IPR003968 Potassium channel, voltage dependent, Kv
    IPR003972 Potassium channel, voltage dependent, Kv1
    IPR004050 Potassium channel, voltage dependent, Kv1.3
    IPR011333 SKP1/BTB/POZ domain
    IPR027359 Voltage-dependent channel, four helix bundle domain
    IPR028325 Voltage-gated potassium channel
Molecular
Reagents
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  • All nucleic 14
    Genomic 5
    cDNA 7
    Primer pair 1
    Other 1

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-11556, MGD-MRK-11564, MGD-MRK-12250
References
more
  • Summaries
    All 49
    Developmental Gene Expression 4
    Gene Ontology 5
    Phenotypes 17
  • Earliest
    J:10326 Chandy KG, et al., A family of three mouse potassium channel genes with intronless coding regions. Science. 1990 Feb 23;247(4945):973-5
  • Latest
    J:211263 Thiebaud N, et al., Hyperlipidemic diet causes loss of olfactory sensory neurons, reduces olfactory discrimination, and disrupts odor-reversal learning. J Neurosci. 2014 May 14;34(20):6970-84

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory