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Kcna3 Gene Detail
Summary
  • Symbol
    Kcna3
  • Name
    potassium voltage-gated channel, shaker-related subfamily, member 3
  • Synonyms
    Kca1-3, Kv1.3, Mk-3
  • Feature Type
    protein coding gene
  • IDs
    MGI:96660
    NCBI Gene: 16491
  • Gene Overview
    MyGene.info: KCNA3
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:107036169-107038070 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 46.59 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    5 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96660
protein coding gene Chr3:107036162-107038129 (.)
129S1/SvImJ MGP_129S1SvImJ_G0027739
protein coding gene Chr3:108501442-108503343 (+)
A/J MGP_AJ_G0027699
protein coding gene Chr3:105065051-105066952 (+)
AKR/J MGP_AKRJ_G0027664
protein coding gene Chr3:107637080-107638981 (+)
BALB/cJ MGP_BALBcJ_G0027711
protein coding gene Chr3:104762981-104764882 (+)
C3H/HeJ MGP_C3HHeJ_G0027441
protein coding gene Chr3:107969963-107974314 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028155
protein coding gene Chr3:112575453-112579095 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025493
protein coding gene Chr3:101222414-101224312 (+)
CAST/EiJ MGP_CASTEiJ_G0026897
protein coding gene Chr3:107335363-107337265 (+)
CBA/J MGP_CBAJ_G0027416
protein coding gene Chr3:116358784-116360685 (+)
DBA/2J MGP_DBA2J_G0027558
protein coding gene Chr3:104269087-104270988 (+)
FVB/NJ MGP_FVBNJ_G0027526
protein coding gene Chr3:102146967-102148868 (+)
LP/J MGP_LPJ_G0027665
protein coding gene Chr3:109922063-109923964 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027556
protein coding gene Chr3:122488396-122490297 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028210
protein coding gene Chr3:107217793-107219695 (+)
PWK/PhJ MGP_PWKPhJ_G0026623
protein coding gene Chr3:103988480-103990407 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026443
protein coding gene Chr3:105360165-105362067 (+)
WSB/EiJ MGP_WSBEiJ_G0026977
protein coding gene Chr3:107748177-107750078 (+)



Homology
more
  • Human Ortholog
    KCNA3, potassium voltage-gated channel subfamily A member 3
  • Vertebrate Orthologs
    11
  • Human Ortholog
    KCNA3, potassium voltage-gated channel subfamily A member 3
    Orthology source: HGNC, HomoloGene
  • Synonyms
    HGK5, HLK3, HPCN3, HUKIII, KV1.3, MK3, PCN3
  • Links
    NCBI Gene ID: 3738
    neXtProt AC: NX_P22001
    UniProt: P22001

  • Chr Location
    1p13.3; chr1:110653560-110675033 (-)  GRCh38.p7

Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 2 alleles in 2 genetic backgrounds
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele display no apparent immune system defects. Mice homozygous for a different knock-out allele show reduced body weight, increased basal metabolic rate, resistance to diet-induced obesity, increased insulin sensitivity, and altered peripheral glucose metabolism.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000047959 Ensembl Gene Model | MGI Sequence Detail 1902 C57BL/6J ±  kb
    transcript ENSMUST00000052718 Ensembl | MGI Sequence Detail 1902 Not Applicable  
    polypeptide ENSMUSP00000050680 Ensembl | MGI Sequence Detail 528 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 15
      Genomic 5
      cDNA 8
      Primer pair 1
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-11556, MGD-MRK-11564, MGD-MRK-12250
    References
    more
    • Summaries
      All 67
      Developmental Gene Expression 6
      Diseases 1
      Gene Ontology 6
      Phenotypes 19
    • Earliest
      J:10326 Chandy KG, et al., A family of three mouse potassium channel genes with intronless coding regions. Science. 1990 Feb 23;247(4945):973-5
    • Latest
      J:266138 Di Lucente J, et al., The voltage-gated potassium channel Kv1.3 is required for microglial pro-inflammatory activation in vivo. Glia. 2018 Sep;66(9):1881-1895

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory