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Kcna1
Gene Detail
 Symbol
Name
ID
Kcna1
potassium voltage-gated channel, shaker-related subfamily, member 1
MGI:96654
Synonyms Kv1.1, MBK1, mceph, Mk-1, mouse brain potassium channel protein-1, Shak
Feature Type protein coding gene
Genetic Map
Chromosome 6
61.57 cM, cytoband F1-F3
Detailed Genetic Map ± 1 cM


Mapping data(15)
Sequence Map
Chr6:126636463-126645801 bp, - strand
From NCBI annotation of GRCm38

  9339 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:183  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: potassium voltage-gated channel, alpha subunit, subfamilies A/C/D/F/G/S
Gene Tree: Kcna1

Human
homologs
Human Homolog KCNA1, potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)
NCBI Gene ID 3736
neXtProt AC  NX_Q09470
Human Synonyms  AEMK, EA1, HBK1, HUK1, KV1.1, MBK1, MK1, RBK1
Human Chr (Location)  12p13.32; chr12:4909907-4918256 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human KCNA1
Alleles
and
phenotypes
All alleles(4) : Targeted(3) Spontaneous(1)
 
Various mutations at this allele have diverse affects including behavioral abnormalities, megencephaly, and in one case, embryonic lethality.
 
Human Diseases Modeled Using Mouse Kcna1 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(3)
Gene Ontology
(GO)
classifications
All GO classifications: (23 annotations)
Process ion transport, potassium ion transmembrane transport, ...
Component apical plasma membrane, dendrite, ...
Function delayed rectifier potassium channel activity, ion channel activity, ...
External Resources: FuncBase
Expression
Literature Summary: (17 records)
Data Summary: Results (24)    Tissues (7)    Images (15)
Theiler Stages: 20, 23, 25, 28
Assay TypeResults
RNA in situ 21
RT-PCR 3
cDNA source data(15)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(42) Genomic(19) cDNA(16) Primer pair(3) Other(4)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000047976 (Evidence)
Entrez Gene16485 (Evidence)
DFCITC1575898, TC1592568, TC1633132
DoTSDT.101366112, DT.110500661, DT.60105256, DT.94233585
NIA Mouse Gene IndexU027876
Consensus CDS ProjectCCDS20555.1
International Mouse Knockout Project StatusKcna1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 16485 NCBI Gene Model | MGI Sequence Detail 9339 C57BL/6J ±  kb
transcript NM_010595 RefSeq | MGI Sequence Detail 8970 C57BL/6 
polypeptide P16388 UniProt | EBI | MGI Sequence Detail 495 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(2) UniProt(4)
Polymorphisms All PCR and RFLP(7) : PCR(2) RFLP(5) SNPs within 2kb(53 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011333 BTB/POZ fold
InterPro IPR000210 BTB/POZ-like
InterPro IPR005821 Ion transport domain
InterPro IPR003131 Potassium channel tetramerisation-type BTB domain
InterPro IPR003968 Potassium channel, voltage dependent, Kv
InterPro IPR003972 Potassium channel, voltage dependent, Kv1
InterPro IPR004048 Potassium channel, voltage dependent, Kv1.1
InterPro IPR003091 Voltage-dependent potassium channel
InterPro IPR027359 Voltage-dependent potassium channel, four helix bundle domain
Protein Ontology PR:000009250 voltage-gated potassium channel subunit KCNA1
Graphical View of Protein Domain Structure
References (Earliest) J:9129 Tempel BL, et al., Cloning of a probable potassium channel gene from mouse brain. Nature. 1988 Apr 28;332(6167):837-9
(Latest) J:206598 Simeone KA, et al., Targeting deficiencies in mitochondrial respiratory complex I and functional uncoupling exerts anti-seizure effects in a genetic model of temporal lobe epilepsy and in a model of acute temporal lobe seizures. Exp Neurol. 2014 Jan;251:84-90
All references(116)
Other
accession IDs
MGD-MRK-11554, MGD-MRK-11558, MGD-MRK-12133, MGD-MRK-12248, MGD-MRK-14397, MGI:2141481, MGI:96931

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory