About   Help   FAQ
Junb Gene Detail
Summary
  • Symbol
    Junb
  • Name
    jun B proto-oncogene
  • Feature Type
    protein coding gene
  • IDs
    MGI:96647
    NCBI Gene: 16477
  • Gene Overview
    MyGene.info: JUNB
Location & Maps
more
  • Sequence Map
    Chr8:84976909-84978748 bp, - strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      1840 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    JUNB, jun B proto-oncogene
  • Vertebrate Orthologs
    8
  • Human Ortholog
    JUNB, jun B proto-oncogene
    Orthology source: HGNC, HomoloGene
  • Synonyms
    AP-1
  • Links
    NCBI Gene ID: 3726
    neXtProt AC: NX_P17275

  • Chr Location
    19p13.2; chr19:12791496-12793311 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Junb mouse models

Human Disease Mouse Models
       Systemic Lupus Erythematosus; SLE   OMIM: 152700 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    36 phenotypes from 1 allele in 3 genetic backgrounds
    27 phenotypes from multigenic genotypes
    61 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    14
  • Chemically induced (other)
    1
  • Gene trapped
    6
  • Radiation induced
    1
  • Targeted
    5
  • Transgenic
    1
  • Genomic Mutations
    2 involving Junb
  • Incidental Mutations
Homozygous null mutants die between embryonic day 8.5-10 due to impaired placental development. Embryos are severely growth retarded, but cell proliferation is normal, reflecting a failure to establish vascular interactions with the maternal circulation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 16477 NCBI Gene Model | MGI Sequence Detail 1840 C57BL/6J ±  kb
transcript NM_008416 RefSeq | MGI Sequence Detail 1840 C57BL/6  
polypeptide P09450 UniProt | EBI | MGI Sequence Detail 344 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    42 from dbSNP Build 142
  • RFLP
Protein
Information
less
  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000009233 transcription factor jun-B
  • InterPro Domains
    IPR004827 Basic-leucine zipper domain
    IPR005643 Jun-like transcription factor
    IPR002112 Transcription factor Jun
    IPR029822 Transcription factor JunB
    IPR008917 Transcription factor, Skn-1-like, DNA-binding domain
Molecular
Reagents
less
  • All nucleic 158
    Genomic 5
    cDNA 150
    Primer pair 2
    Other 1

    Microarray probesets 2
Other
Accession IDs
less
MGD-MRK-11539
References
more
  • Summaries
    All 125
    Developmental Gene Expression 19
    Diseases 1
    Gene Ontology 18
    Phenotypes 61
  • Earliest
    J:9056 Ryder K, et al., A gene activated by growth factors is related to the oncogene v-jun. Proc Natl Acad Sci U S A. 1988 Mar;85(5):1487-91
  • Latest
    J:227211 Zhang Y, et al., Maternal bile acid transporter deficiency promotes neonatal demise. Nat Commun. 2015;6:8186

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
04/19/2016
MGI 6.03
The Jackson Laboratory