Junb
Gene Detail

Symbol Name ID

Junb Jun-B oncogene MGI:96647

Feature Type

protein coding gene

Genetic Map

Chromosome 8

41.41 cM, cytoband C2-D1
Detailed Genetic Map ± 1 cM


Mapping data(30)

Sequence Map

Chr8:84976909-84978748 bp, - strand From NCBI annotation of GRCm38   1840 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:7390  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 2 zebrafish

Protein SuperFamily: transcription factor AP-1
Gene Tree: Junb

Human homologs

Human Homolog		JUNB, jun B proto-oncogene
NCBI Gene ID		3726
neXtProt AC		NX_P17275
Human Synonyms		AP-1
Human Chr (Location)		19p13.2; chr19:12902310-12904125 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(11) : Targeted(5) Gene trapped(6)
 

Homozygous null mutants die between embryonic day 8.5-10 due to impaired placental development. Embryos are severely growth retarded, but cell proliferation is normal, reflecting a failure to establish vascular interactions with the maternal circulation.

 
Human Diseases Modeled Using Mouse Junb (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (28 annotations)

Process	cellular process, cellular response to calcium ion, ...
Component	nucleus
Function	DNA binding, double-stranded DNA binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (17 records)
Data Summary: Results (73)    Tissues (61)    Images (4)
Theiler Stages: 2, 3, 4, 5, 15, 21, 23, 25, 28

Assay Type	Results
RNA in situ	56
RT-PCR	17

cDNA source data(23)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(34) Genomic(5) cDNA(26) Primer pair(2) Other(1)
Microarray probesets(2)

Other database links

Ensembl Gene Model	ENSMUSG00000052837 (Evidence)
Entrez Gene	16477 (Evidence)
DFCI	TC1573426
DoTS	DT.101268143, DT.110869928, DT.94232238, DT.94299206, DT.94351207, DT.99865327
NIA Mouse Gene Index	U117162
Consensus CDS Project	CCDS22488.1
International Mouse Knockout Project Status	Junb

Sequences

Length	Strain/Species
genomic	16477	NCBI Gene Model | MGI Sequence Detail	1840	C57BL/6J
transcript	NM_008416	RefSeq | MGI Sequence Detail	1840	C57BL/6
polypeptide	P09450	UniProt | EBI | MGI Sequence Detail	344	Not Applicable

All sequences(41) RefSeq(2) UniProt(5)

Polymorphisms

RFLP(5) : SNPs(21 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR004827	Basic-leucine zipper domain
InterPro	IPR008917	Eukaryotic transcription factor, Skn-1-like, DNA-binding
InterPro	IPR005643	Jun-like transcription factor
InterPro	IPR002112	Transcription factor Jun
Protein Ontology	PR:000009233	transcription factor jun-B

Graphical View of Protein Domain Structure

References

(Earliest) J:9056 Ryder K, et al., A gene activated by growth factors is related to the oncogene v-jun. Proc Natl Acad Sci U S A. 1988 Mar;85(5):1487-91
(Latest) J:194035 Kan A, et al., c-Jun is required for the specification of joint cell fates. Genes Dev. 2013 Mar 1;27(5):514-24
All references(119)

Other accession IDs

MGD-MRK-11539