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Junb
Gene Detail
 Symbol
Name
ID
Junb
jun B proto-oncogene
MGI:96647
Feature Type protein coding gene
Genetic Map
Chromosome 8
41.41 cM, cytoband C2-D1
Detailed Genetic Map ± 1 cM


Mapping data(30)
Sequence Map
Chr8:84976909-84978748 bp, - strand
From NCBI annotation of GRCm38

  1840 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7390  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog

Protein SuperFamily: transcription factor AP-1
Gene Tree: Junb

Human
homologs
Human Homolog JUNB, jun B proto-oncogene
NCBI Gene ID 3726
neXtProt AC  NX_P17275
Human Synonyms  AP-1
Human Chr (Location)  19p13.2; chr19:12791496-12793311 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(6) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mutants die between embryonic day 8.5-10 due to impaired placental development. Embryos are severely growth retarded, but cell proliferation is normal, reflecting a failure to establish vascular interactions with the maternal circulation.
 
Human Diseases Modeled Using Mouse Junb (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Junb interacts with 90 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (29 annotations)
Process cellular process, cellular response to calcium ion, ...
Component nucleus
Function DNA binding, double-stranded DNA binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (17 records)
Data Summary: Results (66)    Tissues (56)    Images (4)
Theiler Stages: 2, 3, 4, 5, 15, 21, 23, 25, 27, 28
Assay TypeResults
RNA in situ 56
RT-PCR 10
cDNA source data(147)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(158) Genomic(5) cDNA(150) Primer pair(2) Other(1)
Microarray probesets(2)
Other database
links
Ensembl Gene ModelENSMUSG00000052837 (Evidence)
Entrez Gene16477 (Evidence)
UniGene1167
DFCITC1573426
DoTSDT.101268143, DT.110869928, DT.94232238, DT.94299206, DT.94351207, DT.99865327
NIA Mouse Gene IndexU117162
Consensus CDS ProjectCCDS22488.1
International Mouse Knockout Project StatusJunb
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 16477 NCBI Gene Model | MGI Sequence Detail 1840 C57BL/6J ±  kb
transcript NM_008416 RefSeq | MGI Sequence Detail 1840 C57BL/6 
polypeptide P09450 UniProt | EBI | MGI Sequence Detail 344 Not Applicable 

For the selected sequences
All sequences(41) RefSeq(2) UniProt(5)
Polymorphisms RFLP(5) : SNPs within 2kb(43 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004827 Basic-leucine zipper domain
InterPro IPR008917 Eukaryotic transcription factor, Skn-1-like, DNA-binding
InterPro IPR005643 Jun-like transcription factor
InterPro IPR002112 Transcription factor Jun
Protein Ontology PR:000009233 transcription factor jun-B
Graphical View of Protein Domain Structure
References (Earliest) J:9056 Ryder K, et al., A gene activated by growth factors is related to the oncogene v-jun. Proc Natl Acad Sci U S A. 1988 Mar;85(5):1487-91
(Latest) J:209293 Schonthaler HB, et al., S100A8-S100A9 protein complex mediates psoriasis by regulating the expression of complement factor C3. Immunity. 2013 Dec 12;39(6):1171-81
All references(123)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-11539

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory