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Itpr3 Gene Detail
Summary
  • Symbol
    Itpr3
  • Name
    inositol 1,4,5-triphosphate receptor 3
  • Synonyms
    Ip3r3, Itpr-3, tf
  • Feature Type
    protein coding gene
  • IDs
    MGI:96624
    NCBI Gene: 16440
  • Gene Overview
    MyGene.info: ITPR3
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:27057304-27122223 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 13.68 cM
  • Mapping Data
    64 experiments
Strain
Comparison
more
  • SNPs within 2kb
    596 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96624
protein coding gene Chr17:27057261-27122223 (.)
129S1/SvImJ MGP_129S1SvImJ_G0023416
protein coding gene Chr17:26305425-26372717 (+)
A/J MGP_AJ_G0023373
protein coding gene Chr17:25494083-25566820 (+)
AKR/J MGP_AKRJ_G0023339
protein coding gene Chr17:25630176-25706573 (+)
BALB/cJ MGP_BALBcJ_G0023378
protein coding gene Chr17:25742591-25809740 (+)
C3H/HeJ MGP_C3HHeJ_G0023139
protein coding gene Chr17:26010751-26080956 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023821
protein coding gene Chr17:27417370-27490358 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021295
protein coding gene Chr17:22906092-22970034 (+)
CAST/EiJ MGP_CASTEiJ_G0022640
protein coding gene Chr17:25938888-26010439 (+)
CBA/J MGP_CBAJ_G0023113
protein coding gene Chr17:28361933-28443971 (+)
DBA/2J MGP_DBA2J_G0023245
protein coding gene Chr17:25058632-25128963 (+)
FVB/NJ MGP_FVBNJ_G0023214
protein coding gene Chr17:24839945-24907404 (+)
LP/J MGP_LPJ_G0023322
protein coding gene Chr17:26550551-26621024 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023232
protein coding gene Chr17:27886303-27958886 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023862
protein coding gene Chr17:26009128-26080939 (+)
PWK/PhJ MGP_PWKPhJ_G0022390
protein coding gene Chr17:23855557-23922732 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022208
protein coding gene Chr17:24040987-24125215 (+)
WSB/EiJ MGP_WSBEiJ_G0022703
protein coding gene Chr17:26034323-26107648 (+)



Homology
more
  • Human Ortholog
    ITPR3, inositol 1,4,5-trisphosphate receptor type 3
  • Vertebrate Orthologs
    8
  • Human Ortholog
    ITPR3, inositol 1,4,5-trisphosphate receptor type 3
    Orthology source: HGNC, HomoloGene
  • Synonyms
    IP3R, IP3R3
  • Links
    NCBI Gene ID: 3710
    neXtProt AC: NX_Q14573
    UniProt: Q14573

  • Chr Location
    6p21.31; chr6:33621333-33696574 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Itpr3 mouse models; 1 with human ITPR3 associations

Human Disease Mouse Models
      
IDs
View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    25 phenotypes from 5 alleles in 6 genetic backgrounds
    27 phenotypes from multigenic genotypes
    1 images
    73 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are viable and fertile and exhibit no apparent abnormalities in pancreatic and salivary secretion. However, one mutation in this gene results in alternating abnormal hair loss and normal hair growth throughout the life of the mouse and low sweet preference.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000042644 Ensembl Gene Model | MGI Sequence Detail 64920 C57BL/6J ±  kb
    transcript ENSMUST00000049308 Ensembl | MGI Sequence Detail 8990 Not Applicable  
    polypeptide ENSMUSP00000038150 Ensembl | MGI Sequence Detail 2670 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 98
      cDNA 97
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-11440, MGD-MRK-11507, MGD-MRK-11509, MGD-MRK-15043, MGI:98711
    References
    more
    • Summaries
      All 176
      Developmental Gene Expression 14
      Diseases 3
      Gene Ontology 19
      Phenotypes 73
    • Earliest
      J:273 Lyon MF, Hereditary hair loss in the tufted mutant of the house mouse. J Hered. 1956;47:101-3
    • Latest
      J:261524 Poitelon Y, et al., A dual role for Integrin alpha6beta4 in modulating hereditary neuropathy with liability to pressure palsies. J Neurochem. 2018 May;145(3):245-257

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    12/11/2018
    MGI 6.13
    The Jackson Laboratory