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Itih2 Gene Detail
Summary
  • Symbol
    Itih2
  • Name
    inter-alpha trypsin inhibitor, heavy chain 2
  • Synonyms
    Intin2, Itih-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:96619
    NCBI Gene: 16425
  • Gene Overview
    MyGene.info: ITIH2
Location & Maps
more
  • Sequence Map
    Chr2:10094593-10131396 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      36804 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 6.89 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    ITIH2, inter-alpha-trypsin inhibitor heavy chain 2
  • Vertebrate Orthologs
    7
  • Human Ortholog
    ITIH2, inter-alpha-trypsin inhibitor heavy chain 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    H2P, SHAP
  • Links
    NCBI Gene ID: 3698
    neXtProt AC: NX_P19823

  • Chr Location
    10p15; chr10:7703273-7749520 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype reference
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000011191 VEGA Gene Model | MGI Sequence Detail 36804 C57BL/6J ±  kb
transcript OTTMUST00000026267 VEGA | MGI Sequence Detail 3100 Not Applicable  
polypeptide OTTMUSP00000012019 VEGA | MGI Sequence Detail 950 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    233 from dbSNP Build 142
  • RFLP
Protein
Information
less
  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000009147 inter-alpha-trypsin inhibitor heavy chain H2
  • InterPro Domains
    IPR010600 Inter-alpha-trypsin inhibitor heavy chain, C-terminal
    IPR013694 VIT domain
    IPR002035 von Willebrand factor, type A
Molecular
Reagents
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  • All nucleic 65
    cDNA 64
    Other 1

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-11435, MGD-MRK-11498, MGD-MRK-11501, MGI:2139047
References
more
  • Summaries
    All 30
    Developmental Gene Expression 5
    Gene Ontology 3
    Phenotypes 1
  • Earliest
    J:2174 Salier JP, et al., Homologous chromosomal locations of the four genes for inter-alpha-inhibitor and pre-alpha-inhibitor family in human and mouse: assignment of the ancestral gene for the lipocalin superfamily. Genomics. 1992 Sep;14(1):83-8
  • Latest
    J:172805 Wang Q, et al., Recent acquisition of imprinting at the rodent Sfmbt2 locus correlates with insertion of a large block of miRNAs. BMC Genomics. 2011;12:204

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory