Itih1 MGI Mouse Gene Detail - MGI:96618 - inter-alpha trypsin inhibitor, heavy chain 1

Symbol

Itih1
Name

inter-alpha trypsin inhibitor, heavy chain 1
Synonyms

inter-alpha (globulin) inhibitor, H1 polypeptide, Intin1, Itih-1

Feature Type

protein coding gene
IDs

MGI:96618
NCBI Gene: 16424
Alliance

genome feature page
Transcription Start Sites

2 TSS

Sequence Map

Chr14:30651137-30665246 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 19.09 cM, cytoband A2-C1
Mapping Data

1 experiment

SNPs within 2kb

462 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_96618	protein coding gene	Chr14:30651137-30665246 (-)
129S1/SvImJ	ENSMUSG00200036912	protein coding gene	Chr14:22472832-22486943 (-)
A/J	ENSMUSG00195012910	protein coding gene	Chr14:23548272-23562448 (-)
AKR/J	ENSMUSG00220032419	protein coding gene	Chr14:22660640-22674814 (-)
BALB/cJ	ENSMUSG00180021338	protein coding gene	Chr14:22636871-22651039 (-)
C3H/HeJ	ENSMUSG00175038090	protein coding gene	Chr14:22704183-22718351 (-)
C57BL/6NJ	ENSMUSG00215021472	protein coding gene	Chr14:22942620-22956729 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019059	protein coding gene	Chr14:23242562-23256996 (-)
CAST/EiJ	ENSTCUG00005023780	protein coding gene	Chr14:22782289-22796431 (-)
CBA/J	ENSMUSG00210036803	protein coding gene	Chr14:22947106-22961264 (-)
DBA/2J	ENSMUSG00185035301	protein coding gene	Chr14:27216614-27230720 (-)
FVB/NJ	ENSMUSG00205017123	protein coding gene	Chr14:22806151-22820325 (-)
JF1/MsJ	ENSUMUG00000034960	protein coding gene	Chr14:34475585-34489637 (-)
LP/J	ENSMUSG00230037099	protein coding gene	Chr14:34496854-34510966 (-)
NOD/ShiLtJ	ENSMUSG00190015602	protein coding gene	Chr14:22960719-22974875 (-)
NZO/HlLtJ	ENSMUSG00225036645	protein coding gene	Chr14:28835385-28849556 (-)
PWK/PhJ	ENSLUMG00010019864	protein coding gene	Chr14:11071267-11085339 (-)
SPRET/EiJ	ENSMSPG00010033040	protein coding gene	Chr14:24607841-24621999 (-)
WSB/EiJ	ENSIUOG00005011518	protein coding gene	Chr14:22765355-22779496 (-)

Human Ortholog

ITIH1, inter-alpha-trypsin inhibitor heavy chain 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ITIH1, inter-alpha-trypsin inhibitor heavy chain 1
Synonyms

H1P, IATIH, ITIH, ITI-HC1, SHAP
Links

HGNC:6166

NCBI Gene ID: 3697

UniProt: P19827
Chr Location

3p21.1; chr3:52777567-52792068 (+) GRCh38

MGI Vertebrate Homology

Itih1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: ITIH1
Gene Tree

Itih1

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Phenotype Summary

6 phenotype references

All Mutations and Alleles

7
Endonuclease-mediated

3
Targeted

4
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

56 strains or lines available

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All GO Annotations

10
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

652
Tissues

16
cDNA Data

49
Literature Summary

3

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

41
RefSeq

6
UniProt

4
CCDS

CCDS49435.1, CCDS79287.1

Ensembl

ENSMUSG00000006529 (Evidence)
NCBI Gene

16424

			Length	Strain/Species	Flank
genomic	16424	NCBI Gene Model \| MGI Sequence Detail	14110	C57BL/6J	± kb
transcript	NM_001306078	RefSeq \| MGI Sequence Detail	3089	C57BL/6
polypeptide	Q61702	UniProt \| EBI \| MGI Sequence Detail	907	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000009146 inter-alpha-trypsin inhibitor heavy chain H1

(term hierarchy)
InterPro Domains

IPR050934 Inter-alpha-trypsin inhibitor heavy chain

IPR010600 Inter-alpha-trypsin inhibitor heavy chain, C-terminal

IPR013694 VIT domain

IPR036465 von Willebrand factor A-like domain superfamily

IPR002035 von Willebrand factor, type A
GlyGen

Q61702 6 sites, 3 N-linked glycans (3 sites), 1 O-linked glycan (1 site)

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All nucleic 53

cDNA 52

Primer pair 1

Microarray probesets 3

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MGD-MRK-11434, MGD-MRK-11497, MGD-MRK-11500

Summaries

All 42

Developmental Gene Expression 3

Gene Ontology 7

Phenotypes 6
Earliest

J:2174 Salier JP, et al., Homologous chromosomal locations of the four genes for inter-alpha-inhibitor and pre-alpha-inhibitor family in human and mouse: assignment of the ancestral gene for the lipocalin superfamily. Genomics. 1992 Sep;14(1):83-8
Latest

J:265607 Naba A, et al., Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression. Sci Rep. 2017 Jan 10;7:40495

TSS for Itih1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr127905	Chr14:30665232-30665251 (-)	4 bp
Tssr127904	Chr14:30660025-30660047 (-)	5,210 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24