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Cd47 Gene Detail
Summary
  • Symbol
    Cd47
  • Name
    CD47 antigen (Rh-related antigen, integrin-associated signal transducer)
  • Synonyms
    9130415E20Rik, B430305P08Rik, IAP, integrin-associated protein, Itgp
  • Feature Type
    protein coding gene
  • IDs
    MGI:96617
    NCBI Gene: 16423
  • Gene Overview
    MyGene.info: CD47
  • Alliance
  • Transcription Start Sites
    19 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:49855253-49912424 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 31.23 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    317 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96617
protein coding gene Chr16:49800533-49915010 (.)
129S1/SvImJ MGP_129S1SvImJ_G0022874
protein coding gene Chr16:48739547-48806548 (+)
A/J MGP_AJ_G0022841
protein coding gene Chr16:46601229-46662708 (+)
AKR/J MGP_AKRJ_G0022813
protein coding gene Chr16:48156699-48218311 (+)
BALB/cJ MGP_BALBcJ_G0022841
protein coding gene Chr16:46673057-46733475 (+)
C3H/HeJ MGP_C3HHeJ_G0022604
protein coding gene Chr16:48226930-48288684 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023289
protein coding gene Chr16:49991813-50054221 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020801
protein coding gene Chr16:46680827-46740506 (+)
CAST/EiJ MGP_CASTEiJ_G0022130
protein coding gene Chr16:48551841-48616952 (+)
CBA/J MGP_CBAJ_G0022577
protein coding gene Chr16:51955997-52020372 (+)
DBA/2J MGP_DBA2J_G0022709
protein coding gene Chr16:46339378-46399134 (+)
FVB/NJ MGP_FVBNJ_G0022684
protein coding gene Chr16:46205063-46264677 (+)
LP/J MGP_LPJ_G0022776
protein coding gene Chr16:48530375-48592005 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022702
protein coding gene Chr16:51710136-51775214 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023304
protein coding gene Chr16:48198325-48261941 (+)
PWK/PhJ MGP_PWKPhJ_G0021870
protein coding gene Chr16:46683823-46745543 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021700
protein coding gene Chr16:48021951-48088744 (+)
WSB/EiJ MGP_WSBEiJ_G0022175
protein coding gene Chr16:48216629-48279941 (+)



Homology
more
  • Human Ortholog
    CD47, CD47 molecule
  • Vertebrate Orthologs
    8
  • Human Ortholog
    CD47, CD47 molecule
    Orthology source: HGNC, HomoloGene
  • Synonyms
    IAP, MER6, OA3
  • Links
    NCBI Gene ID: 961
    neXtProt AC: NX_Q08722
    UniProt: Q08722

  • Chr Location
    3q13.12; chr3:108043094-108094200 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    54 phenotypes from 1 allele in 5 genetic backgrounds
    7 phenotypes from multigenic genotypes
    70 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in a reduced CD3+ fraction of peripheral lymphocytes and inability to clear infection by E.coli. Mutant animals are otherwise normal in appearance, survival, and fertility.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16423 NCBI Gene Model | MGI Sequence Detail 57172 C57BL/6J ±  kb
    transcript NM_010581 RefSeq | MGI Sequence Detail 1928 Not Specified  
    polypeptide Q61735 UniProt | EBI | MGI Sequence Detail 303 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 18
      Genomic 1
      cDNA 16
      Primer pair 1

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGD-MRK-11496, MGI:1918837, MGI:1925789, MGI:2146333, MGI:2146503, MGI:2146621
    References
    more
    • Summaries
      All 139
      Developmental Gene Expression 9
      Gene Ontology 9
      Phenotypes 70
    • Earliest
      J:3170 Morse HC 3rd, Genetic nomenclature for loci controlling surface antigens of mouse hemopoietic cells [published erratum appears in J Immunol 1993 Mar 15;150(6):2563]. J Immunol. 1992 Nov 15;149(10):3129-34
    • Latest
      J:263963 Wu J, et al., Critical role of integrin CD11c in splenic dendritic cell capture of missing-self CD47 cells to induce adaptive immunity. Proc Natl Acad Sci U S A. 2018 Jun 26;115(26):6786-6791

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory