Cd47 MGI Mouse Gene Detail - MGI:96617 - CD47 antigen (Rh-related antigen, integrin-associated signal transducer)

Symbol

Cd47
Name

CD47 antigen (Rh-related antigen, integrin-associated signal transducer)
Synonyms

9130415E20Rik, B430305P08Rik, IAP, integrin-associated protein, Itgp

Feature Type

protein coding gene
IDs

MGI:96617
NCBI Gene: 16423
Alliance

genome feature page
Transcription Start Sites

9 TSS

Sequence Map

Chr16:49671691-49732799 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 16, 31.23 cM
Mapping Data

2 experiments

SNPs within 2kb

1481 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_96617	protein coding gene	Chr16:49620896-49735373 (+)
129S1/SvImJ	ENSMUSG00200020924	protein coding gene	Chr16:46506389-46621012 (+)
A/J	ENSMUSG00195003398	protein coding gene	Chr16:46108362-46221203 (+)
AKR/J	ENSMUSG00220021488	protein coding gene	Chr16:46461671-46574491 (+)
BALB/cJ	ENSMUSG00180028496	protein coding gene	Chr16:46312993-46425816 (+)
C3H/HeJ	ENSMUSG00175024321	protein coding gene	Chr16:46586885-46699866 (+)
C57BL/6NJ	ENSMUSG00215007886	protein coding gene	Chr16:46422504-46536987 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020801	protein coding gene	Chr16:46680827-46740506 (+)
CAST/EiJ	ENSTCUG00005012417	protein coding gene	Chr16:46722229-46836340 (+)
CBA/J	ENSMUSG00210016530	protein coding gene	Chr16:46623349-46736309 (+)
DBA/2J	ENSMUSG00185010445	protein coding gene	Chr16:46493173-46607658 (+)
FVB/NJ	ENSMUSG00205010362	protein coding gene	Chr16:46396886-46509908 (+)
JF1/MsJ	ENSUMUG00000022705	protein coding gene	Chr16:46723461-46836138 (+)
LP/J	ENSMUSG00230027509	protein coding gene	Chr16:49058683-49171764 (+)
NOD/ShiLtJ	ENSMUSG00190017392	protein coding gene	Chr16:46525669-46638484 (+)
NZO/HlLtJ	ENSMUSG00225025516	protein coding gene	Chr16:52150625-52265092 (+)
PWK/PhJ	ENSLUMG00010026468	protein coding gene	Chr16:46548037-46662531 (+)
SPRET/EiJ	ENSMSPG00010006879	protein coding gene	Chr16:46807647-46913766 (+)
WSB/EiJ	ENSIUOG00005012599	protein coding gene	Chr16:46700106-46814784 (+)

Human Ortholog

CD47, CD47 molecule

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CD47, CD47 molecule
Synonyms

IAP, MER6, OA3
Links

HGNC:1682

NCBI Gene ID: 961

UniProt: Q08722
Chr Location

3q13.12; chr3:108043091-108091862 (-) GRCh38

MGI Vertebrate Homology

Cd47 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: CD47
Gene Tree

Cd47

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Phenotype Summary

54 phenotypes from 1 allele in 5 genetic backgrounds
7 phenotypes from multigenic genotypes
141 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

27
Endonuclease-mediated

20
Targeted

7
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

35 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mutation of this gene results in a reduced CD3+ fraction of peripheral lymphocytes and inability to clear infection by E.coli. Mutant animals are otherwise normal in appearance, survival, and fertility.

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All GO Annotations

58
GO References

14

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

836
Tissues

88
cDNA Data

17
Literature Summary

13

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

92
RefSeq

24
UniProt

10
CCDS

CCDS28212.1, CCDS88938.1, CCDS88939.1

Ensembl

ENSMUSG00000055447 (Evidence)
NCBI Gene

16423

			Length	Strain/Species	Flank
genomic	16423	NCBI Gene Model \| MGI Sequence Detail	61109	C57BL/6J	± kb
transcript	NM_001368416	RefSeq \| MGI Sequence Detail	2710	C57BL/6
polypeptide	Q61735	UniProt \| EBI \| MGI Sequence Detail	303	Not Applicable

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UniProt

10 Sequences
Protein Ontology

PR:000001399 CD47 molecule

(term hierarchy)
InterPro Domains

IPR013270 CD47 immunoglobulin-like

IPR013147 CD47-like, transmembrane

IPR007110 Immunoglobulin-like domain

IPR013783 Immunoglobulin-like fold

IPR006704 Leukocyte surface antigen CD47

IPR037805 Leukocyte surface antigen CD47, IgV
GlyGen

Q61735 8 sites, 30 N-linked glycans (5 sites), 1 O-linked glycan (1 site)

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All nucleic 21

Genomic 1

cDNA 17

Primer pair 2

Other 1

Antibodies 1

Microarray probesets 8

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MGD-MRK-11496, MGI:1918837, MGI:1925789, MGI:2146333, MGI:2146503, MGI:2146621

Summaries

All 258

Developmental Gene Expression 13

Gene Ontology 14

Phenotypes 141
Earliest

J:3170 Morse HC 3rd, Genetic nomenclature for loci controlling surface antigens of mouse hemopoietic cells [published erratum appears in J Immunol 1993 Mar 15;150(6):2563]. J Immunol. 1992 Nov 15;149(10):3129-34
Latest

J:387176 Mochizuki-Ono C, et al., PLA2G12A-driven extracellular vesicle-lipid signaling amplifies pathogenic T cell responses in inflammatory diseases. Cell Rep. 2026 Jun 2;:117391

TSS for Cd47:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr138736	Chr16:49678243-49678253 (+)	6,557 bp
Tssr138737	Chr16:49688216-49688231 (+)	16,533 bp
Tssr138738	Chr16:49714570-49714583 (+)	42,886 bp
Tssr138739	Chr16:49725099-49725110 (+)	53,414 bp
Tssr138740	Chr16:49728725-49728731 (+)	57,037 bp
Tssr138741	Chr16:49729354-49729358 (+)	57,665 bp
Tssr138742	Chr16:49731817-49731839 (+)	60,137 bp
Tssr138743	Chr16:49732237-49732257 (+)	60,556 bp
Tssr138744	Chr16:49732348-49732371 (+)	60,669 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24