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Itgb5 Gene Detail
Summary
  • Symbol
    Itgb5
  • Name
    integrin beta 5
  • Synonyms
    [b]5, [b]-5, [b]5A, [b]5B, beta5, beta-5, ESTM23
  • Feature Type
    protein coding gene
  • IDs
    MGI:96614
    NCBI Gene: 16419
Location & Maps
more
  • Sequence Map
    Chr16:33829665-33949153 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      119489 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 24.22 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    ITGB5, integrin subunit beta 5
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ITGB5, integrin subunit beta 5
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 3693
    neXtProt AC: NX_P18084
    UniProt: P18084

  • Chr Location
    3q21.2; chr3:124761948-124901411 (-)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    2 phenotypes from multigenic genotypes
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation do not appear to differ from normal in respect to development, reproduction, adenovirus infection, or wound healing. Mutant keratinocytes do show reduced migration on, and adhesion to, vitronectin in vitro.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    23
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    184
  • Tissues
    158
  • cDNA Data
    16
  • Literature Summary
    17
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028487 VEGA Gene Model | MGI Sequence Detail 119489 C57BL/6J ±  kb
transcript OTTMUST00000070601 VEGA | MGI Sequence Detail 3056 Not Applicable  
polypeptide OTTMUSP00000036003 VEGA | MGI Sequence Detail 816 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    1046 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 21
    cDNA 16
    Primer pair 1
    Other 4

    Microarray probesets 6
Other
Accession IDs
less
MGD-MRK-11493, MGI:1201382, MGI:2146516
References
more
  • Summaries
    All 77
    Developmental Gene Expression 17
    Gene Ontology 9
    Phenotypes 24
  • Earliest
    J:3170 Morse HC 3rd, Genetic nomenclature for loci controlling surface antigens of mouse hemopoietic cells [published erratum appears in J Immunol 1993 Mar 15;150(6):2563]. J Immunol. 1992 Nov 15;149(10):3129-34
  • Latest
    J:239007 Tanaka S, et al., Periostin supports hematopoietic progenitor cells and niche-dependent myeloblastoma cells in vitro. Biochem Biophys Res Commun. 2016 Sep 30;478(4):1706-12
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/19/2017
MGI 6.10 		The Jackson Laboratory