Itgb5 MGI Mouse Gene Detail - MGI:96614

Itgb5 Gene Detail

Symbol

Itgb5
Name

integrin beta 5
Synonyms

[b]5, [b]-5, [b]5A, [b]5B, beta5, beta-5, ESTM23

Feature Type

protein coding gene
IDs

MGI:96614
NCBI Gene: 16419

Sequence Map

Chr16:33829665-33949153 bp, + strand
From VEGA annotation of GRCm38

Mouse Genome Browser
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Sequence

119489 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 16, 24.22 cM
Mapping Data

1 experiment

Human Ortholog

ITGB5, integrin subunit beta 5

Vertebrate Orthologs

10

Human Ortholog

ITGB5, integrin subunit beta 5
Orthology source: HomoloGene, HGNC
Links

HGNC:6160

NCBI Gene ID: 3693

neXtProt AC: NX_P18084
Chr Location

3q21.2; chr3:124761948-124887538 (-) GRCh38.p2

HomoloGene

Vertebrate Homology Class 20511
1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
HCOP

human homology predictions: ITGB5
Protein SuperFamily

integrin, beta subunit
Gene Tree

Itgb5

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Phenotype Summary

6 phenotypes from 2 alleles in 2 genetic backgrounds
2 phenotypes from multigenic genotypes
24 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Gene trapped

9
Targeted

3
Incidental Mutations

Mutagenetix , APF

Homozygotes for a targeted null mutation do not appear to differ from normal in respect to development, reproduction, adenovirus infection, or wound healing. Mutant keratinocytes do show reduced migration on, and adhesion to, vitronectin in vitro.

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All GO Annotations

23
GO References

9

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

184
Tissues

158
cDNA Data

20
Literature Summary

17

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO
Other Vertebrate Links

Xenbase itgb5

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Itgb5 interacts with 51 markers (Mir15a, Mir22, Mir24-1, ...) View All

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All Sequences

42
RefSeq

4
UniProt

3
CCDS

CCDS28135.1, CCDS49835.1

			Length	Strain/Species	Flank
genomic	OTTMUSG00000028487	VEGA Gene Model \| MGI Sequence Detail	119489	C57BL/6J	± kb
transcript	OTTMUST00000070601	VEGA \| MGI Sequence Detail	3056	Not Applicable
polypeptide	OTTMUSP00000036003	VEGA \| MGI Sequence Detail	816	Not Applicable

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SNPs within 2kb

1046 from dbSNP Build 142

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UniProt

3 Sequences
Protein Ontology

PR:000009141 integrin beta-5
InterPro Domains

IPR027067 Integrin beta-5 subunit

IPR015812 Integrin beta subunit

IPR014836 Integrin beta subunit, cytoplasmic domain

IPR002369 Integrin beta subunit, N-terminal

IPR012896 Integrin beta subunit, tail

IPR032695 Integrin domain

IPR016201 Plexin-like fold

IPR002035 von Willebrand factor, type A

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All nucleic 22

cDNA 20

Primer pair 1

Other 1

Microarray probesets 6

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MGD-MRK-11493, MGI:1201382, MGI:2146516

Summaries

All 76

Developmental Gene Expression 17

Gene Ontology 9

Phenotypes 24
Earliest

J:3170 Morse HC 3rd, Genetic nomenclature for loci controlling surface antigens of mouse hemopoietic cells [published erratum appears in J Immunol 1993 Mar 15;150(6):2563]. J Immunol. 1992 Nov 15;149(10):3129-34
Latest

J:213636 Liu Y, et al., FERM domain-containing unconventional myosin VIIA interacts with integrin beta5 subunit and regulates alphavbeta5-mediated cell adhesion and migration. FEBS Lett. 2014 Aug 25;588(17):2859-66

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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