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Itgb5 Gene Detail
Summary
  • Symbol
    Itgb5
  • Name
    integrin beta 5
  • Synonyms
    [b]5, [b]-5, [b]5A, [b]5B, beta5, beta-5, ESTM23
  • Feature Type
    protein coding gene
  • IDs
    MGI:96614
    NCBI Gene: 16419
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr16:33829665-33949153 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      119489 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 24.22 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    ITGB5, integrin subunit beta 5
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ITGB5, integrin subunit beta 5
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 3693
    neXtProt AC: NX_P18084
    UniProt: P18084

  • Chr Location
    3q21.2; chr3:124761948-124901411 (-)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    2 phenotypes from multigenic genotypes
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation do not appear to differ from normal in respect to development, reproduction, adenovirus infection, or wound healing. Mutant keratinocytes do show reduced migration on, and adhesion to, vitronectin in vitro.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    32
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    184
  • Tissues
    158
  • cDNA Data
    17
  • Literature Summary
    18
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000028487 VEGA Gene Model | MGI Sequence Detail 119489 C57BL/6J ±  kb
    transcript OTTMUST00000070601 VEGA | MGI Sequence Detail 3056 Not Applicable  
    polypeptide OTTMUSP00000036003 VEGA | MGI Sequence Detail 816 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      1046 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 22
      cDNA 17
      Primer pair 1
      Other 4

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-11493, MGI:1201382, MGI:2146516
    References
    more
    • Summaries
      All 86
      Developmental Gene Expression 18
      Gene Ontology 12
      Phenotypes 25
    • Earliest
      J:3170 Morse HC 3rd, Genetic nomenclature for loci controlling surface antigens of mouse hemopoietic cells [published erratum appears in J Immunol 1993 Mar 15;150(6):2563]. J Immunol. 1992 Nov 15;149(10):3129-34
    • Latest
      J:265062 Kumawat AK, et al., Expression and characterization of alphavbeta5 integrin on intestinal macrophages. Eur J Immunol. 2018 Jul;48(7):1181-1187
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    10/09/2018
    MGI 6.12     		The Jackson Laboratory