Itgb5
Gene Detail

Symbol

Name
ID

Itgb5
integrin beta 5
MGI:96614

Synonyms

[b]5, [b]-5, [b]5A, [b]5B, beta5, beta-5, ESTM23

Feature Type

protein coding gene

Genetic Map

Chromosome 16
24.22 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr16:33829665-33949153 bp, + strand From VEGA annotation of GRCm38   119489 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:20511  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: integrin, beta subunit
Gene Tree: Itgb5

Human
homologs

Human Homolog		ITGB5, integrin, beta 5
NCBI Gene ID		3693
neXtProt AC		NX_P18084
Human Chr (Location)		3q21.2; chr3:124761948-124887653 (-)  GRCh38

Mutations,
alleles, and
phenotypes

All mutations/alleles(12) : Gene trapped(9) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 

Homozygotes for a targeted null mutation do not appear to differ from normal in respect to development, reproduction, adenovirus infection, or wound healing. Mutant keratinocytes do show reduced migration on, and adhesion to, vitronectin in vitro.

 

Interactions

Itgb5 interacts with 51 markers (Mir15a, Mir22, Mir24-1, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (25 annotations)

Process	cell adhesion, cell-matrix adhesion, ...
Component	cell leading edge, cell surface, ...
Function	integrin binding, protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (16 records)

Data Summary: Results (82)    Tissues (72)    Images (3)    Tissue x Stage Matrix (view)

Assay Type	Results
RNA in situ	36
RT-PCR	46

cDNA source data(15)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(16) cDNA(15) Primer pair(1)
Microarray probesets(6)

Other database
links

VEGA Gene Model	OTTMUSG00000028487 (Evidence)
Ensembl Gene Model	ENSMUSG00000022817 (Evidence)
Entrez Gene	16419 (Evidence)
DFCI	TC1574091, TC1596610, TC1692818
DoTS	DT.101386411, DT.101737231, DT.87027408, DT.94405638, DT.94405642, DT.94405649, DT.94405666
NIA Mouse Gene Index	U017046, U183887
Consensus CDS Project	CCDS28135.1, CCDS49835.1
International Mouse Knockout Project Status	Itgb5

Sequences

Length	Strain/Species
genomic	OTTMUSG00000028487	VEGA Gene Model | MGI Sequence Detail	119489	C57BL/6J
transcript	OTTMUST00000070601	VEGA | MGI Sequence Detail	3056	Not Applicable
polypeptide	OTTMUSP00000036003	VEGA | MGI Sequence Detail	816	Not Applicable

All sequences(56) RefSeq(4) UniProt(5)

Polymorphisms

SNPs within 2kb(1049 from dbSNP Build 137)    SNPs within 2kb including multiple locations(1051)

Protein-related
information

Resource	ID	Description
InterPro	IPR000742	Epidermal growth factor-like domain
InterPro	IPR027067	Integrin beta-5 subunit
InterPro	IPR015812	Integrin beta subunit
InterPro	IPR014836	Integrin beta subunit, cytoplasmic domain
InterPro	IPR002369	Integrin beta subunit, N-terminal
InterPro	IPR012896	Integrin beta subunit, tail
InterPro	IPR016201	Plexin-like fold
InterPro	IPR002035	von Willebrand factor, type A
Protein Ontology	PR:000009141	integrin beta-5

References

(Earliest) J:3170 Morse HC 3rd, Genetic nomenclature for loci controlling surface antigens of mouse hemopoietic cells [published erratum appears in J Immunol 1993 Mar 15;150(6):2563]. J Immunol. 1992 Nov 15;149(10):3129-34
(Latest) J:213636 Liu Y, et al., FERM domain-containing unconventional myosin VIIA interacts with integrin beta5 subunit and regulates alphavbeta5-mediated cell adhesion and migration. FEBS Lett. 2014 Aug 25;588(17):2859-66
All references(79)

Other
accession IDs

MGD-MRK-11493, MGI:1201382, MGI:2146516