Itgb5
Gene Detail

Symbol Name ID

Itgb5 integrin beta 5 MGI:96614

Synonyms

[b]5, [b]-5, [b]5A, [b]5B, beta5, beta-5, ESTM23

Feature Type

protein coding gene

Genetic Map

Chromosome 16

24.22 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr16:33829665-33949153 bp, + strand From VEGA annotation of GRCm38   119489 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:20511  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: integrin, beta subunit
Gene Tree: Itgb5

Human homologs

Human Homolog		ITGB5, integrin, beta 5
NCBI Gene ID		3693
neXtProt AC		NX_P18084
Human Chr (Location)		3q21.2; chr3:124480795-124606500 (-)  GRCh37.p13

Alleles and phenotypes

All alleles(12) : Targeted(3) Gene trapped(9)
 

Homozygotes for a targeted null mutation do not appear to differ from normal in respect to development, reproduction, adenovirus infection, or wound healing. Mutant keratinocytes do show reduced migration on, and adhesion to, vitronectin in vitro.

 

Gene Ontology (GO) classifications

All GO classifications: (14 annotations)

Process	cell adhesion, integrin-mediated signaling pathway, ...
Component	cell leading edge, focal adhesion, ...
Function	integrin binding, receptor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (15 records)

Data Summary: Results (82)    Tissues (72)    Images (3)
Theiler Stages: 20, 21, 22, 23, 26, 28

Assay Type	Results
RNA in situ	36
RT-PCR	46

cDNA source data(15)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(16) cDNA(15) Primer pair(1)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000028487 (Evidence)
Ensembl Gene Model	ENSMUSG00000022817 (Evidence)
Entrez Gene	16419 (Evidence)
DFCI	TC1574091, TC1596610, TC1692818
DoTS	DT.101386411, DT.101737231, DT.87027408, DT.94405638, DT.94405642, DT.94405649, DT.94405666
NIA Mouse Gene Index	U017046, U183887
Consensus CDS Project	CCDS28135.1, CCDS49835.1
International Mouse Knockout Project Status	Itgb5

Sequences

Length	Strain/Species
genomic	OTTMUSG00000028487	VEGA Gene Model | MGI Sequence Detail	119489	C57BL/6J
transcript	OTTMUST00000070601	VEGA | MGI Sequence Detail	3056	Not Applicable
polypeptide	OTTMUSP00000036003	VEGA | MGI Sequence Detail	816	Not Applicable

All sequences(55) RefSeq(4) UniProt(4)

Polymorphisms

SNPs within 2kb(1049 from dbSNP Build 137)    SNPs within 2kb including multiple locations(1051)

Protein-related information

Resource	ID	Description
InterPro	IPR000742	Epidermal growth factor-like domain
InterPro	IPR027067	Integrin beta-5 subunit
InterPro	IPR015812	Integrin beta subunit
InterPro	IPR014836	Integrin beta subunit, cytoplasmic domain
InterPro	IPR002369	Integrin beta subunit, N-terminal
InterPro	IPR012896	Integrin beta subunit, tail
InterPro	IPR016201	Plexin-like fold
InterPro	IPR002035	von Willebrand factor, type A
Protein Ontology	PR:000009141	integrin beta-5

References

(Earliest) J:3170 Morse HC 3rd, Genetic nomenclature for loci controlling surface antigens of mouse hemopoietic cells [published erratum appears in J Immunol 1993 Mar 15;150(6):2563]. J Immunol. 1992 Nov 15;149(10):3129-34
(Latest) J:205525 Henderson NC, et al., Targeting of alphav integrin identifies a core molecular pathway that regulates fibrosis in several organs. Nat Med. 2013 Dec;19(12):1617-24
All references(73)

Other accession IDs

MGD-MRK-11493, MGI:1201382, MGI:2146516