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Itgb5
Gene Detail
 Symbol
Name
ID
Itgb5
integrin beta 5
MGI:96614
Synonyms [b]5, [b]-5, [b]5A, [b]5B, beta5, beta-5, ESTM23
Feature Type protein coding gene
Genetic Map
Chromosome 16
24.22 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr16:33829665-33949153 bp, + strand
From VEGA annotation of GRCm38

  119489 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20511  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: integrin, beta subunit
Gene Tree: Itgb5

Human
homologs
Human Homolog ITGB5, integrin, beta 5
NCBI Gene ID 3693
neXtProt AC  NX_P18084
Human Chr (Location)  3q21.2; chr3:124761948-124887653 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Gene trapped(9) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a targeted null mutation do not appear to differ from normal in respect to development, reproduction, adenovirus infection, or wound healing. Mutant keratinocytes do show reduced migration on, and adhesion to, vitronectin in vitro.
 
Interactions
Itgb5 interacts with 51 markers (Mir15a, Mir22, Mir24-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process cell adhesion, integrin-mediated signaling pathway, ...
Component cell leading edge, extracellular vesicular exosome, ...
Function integrin binding, receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (16 records)
Data Summary: Results (82)    Tissues (72)    Images (3)
Theiler Stages: 20, 21, 22, 23, 26, 28
Assay TypeResults
RNA in situ 36
RT-PCR 46
cDNA source data(15)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(16) cDNA(15) Primer pair(1)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000028487 (Evidence)
Ensembl Gene ModelENSMUSG00000022817 (Evidence)
Entrez Gene16419 (Evidence)
DFCITC1574091, TC1596610, TC1692818
DoTSDT.101386411, DT.101737231, DT.87027408, DT.94405638, DT.94405642, DT.94405649, DT.94405666
NIA Mouse Gene IndexU017046, U183887
Consensus CDS ProjectCCDS28135.1, CCDS49835.1
International Mouse Knockout Project StatusItgb5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028487 VEGA Gene Model | MGI Sequence Detail 119489 C57BL/6J ±  kb
transcript OTTMUST00000070601 VEGA | MGI Sequence Detail 3056 Not Applicable 
polypeptide OTTMUSP00000036003 VEGA | MGI Sequence Detail 816 Not Applicable 

For the selected sequences
All sequences(55) RefSeq(4) UniProt(4)
Polymorphisms SNPs within 2kb(1049 from dbSNP Build 137)    SNPs within 2kb including multiple locations(1051)
Protein-related
information
ResourceIDDescription
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR027067 Integrin beta-5 subunit
InterPro IPR015812 Integrin beta subunit
InterPro IPR014836 Integrin beta subunit, cytoplasmic domain
InterPro IPR002369 Integrin beta subunit, N-terminal
InterPro IPR012896 Integrin beta subunit, tail
InterPro IPR016201 Plexin-like fold
InterPro IPR002035 von Willebrand factor, type A
Protein Ontology PR:000009141 integrin beta-5
References (Earliest) J:3170 Morse HC 3rd, Genetic nomenclature for loci controlling surface antigens of mouse hemopoietic cells [published erratum appears in J Immunol 1993 Mar 15;150(6):2563]. J Immunol. 1992 Nov 15;149(10):3129-34
(Latest) J:206863 Khalifeh-Soltani A, et al., Mfge8 promotes obesity by mediating the uptake of dietary fats and serum fatty acids. Nat Med. 2014 Feb;20(2):175-83
All references(77)
Other
accession IDs
MGD-MRK-11493, MGI:1201382, MGI:2146516

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory