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Itgb5 Gene Detail
Summary
  • Symbol
    Itgb5
  • Name
    integrin beta 5
  • Synonyms
    [b]5, [b]-5, [b]5A, [b]5B, beta5, beta-5, ESTM23
  • Feature Type
    protein coding gene
  • IDs
    MGI:96614
    NCBI Gene: 16419
  • Alliance
    gene page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:33650035-33769708 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 24.22 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1049 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96614
 protein coding gene Chr16:33650021-33769708 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022759
 protein coding gene Chr16:32067244-32193061 (+)
A/J MGP_AJ_G0022724
 protein coding gene Chr16:30517931-30638374 (+)
AKR/J MGP_AKRJ_G0022697
 protein coding gene Chr16:31599073-31720462 (+)
BALB/cJ MGP_BALBcJ_G0022726
 protein coding gene Chr16:30635189-30755733 (+)
C3H/HeJ MGP_C3HHeJ_G0022491
 protein coding gene Chr16:31723953-31849267 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023175
 protein coding gene Chr16:32771600-32901745 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020693
 protein coding gene Chr16:30863868-30981832 (+)
CAST/EiJ MGP_CASTEiJ_G0022019
 protein coding gene Chr16:31898785-32031945 (+)
CBA/J MGP_CBAJ_G0022461
 protein coding gene Chr16:34091441-34239724 (+)
DBA/2J MGP_DBA2J_G0022594
 protein coding gene Chr16:30341442-30461666 (+)
FVB/NJ MGP_FVBNJ_G0022569
 protein coding gene Chr16:30332661-30453873 (+)
LP/J MGP_LPJ_G0022661
 protein coding gene Chr16:31788785-31914588 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022588
 protein coding gene Chr16:33449225-33582805 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023187
 protein coding gene Chr16:31605905-31734258 (+)
PWK/PhJ MGP_PWKPhJ_G0021760
 protein coding gene Chr16:30721602-30841449 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021589
 protein coding gene Chr16:31400428-31522172 (+)
WSB/EiJ MGP_WSBEiJ_G0022063
 protein coding gene Chr16:31570991-31693341 (+)



Homology
more
  • Human Ortholog
    ITGB5, integrin subunit beta 5
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ITGB5, integrin subunit beta 5
  • Links
    NCBI Gene ID: 3693
    neXtProt AC: NX_P18084
    UniProt: P18084

  • Chr Location
    3q21.2; chr3:124761948-124901418 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    2 phenotypes from multigenic genotypes
    34 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation do not appear to differ from normal in respect to development, reproduction, adenovirus infection, or wound healing. Mutant keratinocytes do show reduced migration on, and adhesion to, vitronectin in vitro.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    37
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    938
  • Tissues
    197
  • cDNA Data
    17
  • Literature Summary
    18
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022817 Ensembl Gene Model | MGI Sequence Detail 119674 C57BL/6J ±  kb
    transcript ENSMUST00000069345 Ensembl | MGI Sequence Detail 3056 Not Applicable  
    polypeptide ENSMUSP00000069416 Ensembl | MGI Sequence Detail 816 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 24
      cDNA 18
      Primer pair 1
      Other 5

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-11493, MGI:1201382, MGI:2146516
    References
    more
    • Summaries
      All 96
      Developmental Gene Expression 18
      Gene Ontology 11
      Phenotypes 34
    • Earliest
      J:3170 Morse HC 3rd, Genetic nomenclature for loci controlling surface antigens of mouse hemopoietic cells [published erratum appears in J Immunol 1993 Mar 15;150(6):2563]. J Immunol. 1992 Nov 15;149(10):3129-34
    • Latest
      J:345661 Datta R, et al., PTP1B mediates the inhibitory effect of MFGE8 on insulin signaling through the beta5 integrin. J Biol Chem. 2024 Jan 8;300(2):105631
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    04/16/2024
    MGI 6.23     		The Jackson Laboratory