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Itgax
Gene Detail
 Symbol
Name
ID
Itgax
integrin alpha X
MGI:96609
Synonyms Cd11c, CD11C (p150) alpha polypeptide
Feature Type protein coding gene
Genetic Map
Chromosome 7
69.98 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:128129568-128150657 bp, + strand
From NCBI annotation of GRCm38

  21090 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55493  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 dog

Protein SuperFamily: integrin alpha with I domain
Gene Tree: Itgax

Human
homologs
Human Homolog ITGAX, integrin, alpha X (complement component 3 receptor 4 subunit)
NCBI Gene ID 3687
neXtProt AC  NX_P20702
Human Synonyms  CD11C, SLEB6
Human Chr (Location)  16p11.2; chr16:31355134-31382997 (+)  GRCh38
Alleles
and
phenotypes
All alleles(5) : Targeted(5)
 
Mice homozygous for a knock-out allele exhibit increased susceptibility to bacterial infection, decreased susceptibility to experimental autoimmune encephalomyelitis (EAE), increased T cell proliferation, and an abnormal pattern of cytokine production during EAE.
 
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process cell adhesion, defense response to virus, ...
Component external side of plasma membrane, integral component of membrane, ...
Function metal ion binding
External Resources: FuncBase
Expression
Literature Summary: (16 records)
Data Summary: Results (8)    Tissues (2)   
Theiler Stages: 22, 24
Assay TypeResults
Immunohistochemistry 8
cDNA source data(24)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(26) Genomic(1) cDNA(24) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000030789 (Evidence)
Entrez Gene16411 (Evidence)
UniGene22378
DFCITC1571898, TC1592386
DoTSDT.101131598, DT.110981365, DT.99865171
NIA Mouse Gene IndexU008828
Consensus CDS ProjectCCDS40150.1
International Mouse Knockout Project StatusItgax
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 16411 NCBI Gene Model | MGI Sequence Detail 21090 C57BL/6J ±  kb
transcript NM_021334 RefSeq | MGI Sequence Detail 4025 C57BL/6 
polypeptide Q9QXH4 UniProt | EBI | MGI Sequence Detail 1169 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(3) UniProt(6)
Polymorphisms SNPs within 2kb(269 from dbSNP Build 137)    SNPs within 2kb including multiple locations(287)
Protein-related
information
ResourceIDDescription
InterPro IPR013517 FG-GAP repeat
InterPro IPR013649 Integrin alpha-2
InterPro IPR013519 Integrin alpha beta-propellor
InterPro IPR000413 Integrin alpha chain
InterPro IPR018184 Integrin alpha chain, C-terminal cytoplasmic region, conserved site
InterPro IPR002035 von Willebrand factor, type A
Protein Ontology PR:000001013 integrin alpha-X
Graphical View of Protein Domain Structure
References (Earliest) J:10461 Metlay JP, et al., The distinct leukocyte integrins of mouse spleen dendritic cells as identified with new hamster monoclonal antibodies. J Exp Med. 1990 May 1;171(5):1753-71
(Latest) J:194055 Bose TO, et al., CD11a Regulates Effector CD8 T Cell Differentiation and Central Memory Development in Response to Infection with Listeria monocytogenes. Infect Immun. 2013 Apr;81(4):1140-51
All references(80)
Other
accession IDs
MGD-MRK-11488, MGI:2141963

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory