Itgax
Gene Detail

Symbol Name ID

Itgax integrin alpha X MGI:96609

Synonyms

Cd11c, CD11C (p150) alpha polypeptide

Feature Type

protein coding gene

Genetic Map

Chromosome 7

69.98 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr7:128129568-128150657 bp, + strand From NCBI annotation of GRCm38   21090 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:55493  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 dog

Protein SuperFamily: integrin alpha with I domain
Gene Tree: Itgax

Human homologs

Human Homolog		ITGAX, integrin, alpha X (complement component 3 receptor 4 subunit)
NCBI Gene ID		3687
neXtProt AC		NX_P20702
Human Synonyms		CD11C, SLEB6
Human Chr (Location)		16p11.2; chr16:31366509-31394318 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(5) : Targeted(5)
 

Mice homozygous for a knock-out allele exhibit increased susceptibility to bacterial infection, decreased susceptibility to experimental autoimmune encephalomyelitis (EAE), increased T cell proliferation, and an abnormal pattern of cytokine production during EAE.

 

Gene Ontology (GO) classifications

All GO classifications: (10 annotations)

Process	cell adhesion, defense response to virus, ...
Component	external side of plasma membrane, integral to membrane, ...
Function	metal ion binding

External Resources: FuncBase

Expression

Literature Summary: (16 records)
Data Summary: Results (8)    Tissues (2)   
Theiler Stages: 22, 24

Assay Type	Results
Immunohistochemistry	8

cDNA source data(24)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(26) Genomic(1) cDNA(24) Other(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000030789 (Evidence)
Entrez Gene	16411 (Evidence)
UniGene	22378
DFCI	TC1571898, TC1592386
DoTS	DT.101131598, DT.110981365, DT.99865171
NIA Mouse Gene Index	U008828
Consensus CDS Project	CCDS40150.1
International Mouse Knockout Project Status	Itgax

Sequences

Length	Strain/Species
genomic	16411	NCBI Gene Model | MGI Sequence Detail	21090	C57BL/6J
transcript	NM_021334	RefSeq | MGI Sequence Detail	4025	C57BL/6
polypeptide	Q9QXH4	UniProt | EBI | MGI Sequence Detail	1169	Not Applicable

All sequences(29) RefSeq(2) UniProt(6)

Polymorphisms

SNPs(196 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR013517	FG-GAP repeat
InterPro	IPR013649	Integrin alpha-2
InterPro	IPR013519	Integrin alpha beta-propellor
InterPro	IPR000413	Integrin alpha chain
InterPro	IPR018184	Integrin alpha chain, C-terminal cytoplasmic region, conserved site
InterPro	IPR002035	von Willebrand factor, type A
Protein Ontology	PR:000001013	integrin alpha-X

Graphical View of Protein Domain Structure

References

(Earliest) J:10461 Metlay JP, et al., The distinct leukocyte integrins of mouse spleen dendritic cells as identified with new hamster monoclonal antibodies. J Exp Med. 1990 May 1;171(5):1753-71
(Latest) J:194055 Bose TO, et al., CD11a Regulates Effector CD8 T Cell Differentiation and Central Memory Development in Response to Infection with Listeria monocytogenes. Infect Immun. 2013 Apr;81(4):1140-51
All references(80)

Other accession IDs

MGD-MRK-11488, MGI:2141963