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Itgax
Gene Detail
Symbol

Name
ID
Itgax
integrin alpha X
MGI:96609
Synonyms
Cd11c, CD11C (p150) alpha polypeptide
Feature Type
protein coding gene
Genetic Map
Chromosome 7
69.98 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:128129547-128150656 bp, + strand
From Ensembl annotation of GRCm38

  21110 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55493  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 dog

HCOP human homology predictions: ITGAX
Protein SuperFamily: integrin alpha with I domain
Gene Tree: Itgax

Human
homologs
ITGAX, integrin, alpha X (complement component 3 receptor 4 subunit)
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 3687
neXtProt AC: NX_P20702

Human Synonyms: CD11C, SLEB6

Human Chr (Location): 16p11.2; chr16:31355134-31382997 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a knock-out allele exhibit increased susceptibility to bacterial infection, decreased susceptibility to experimental autoimmune encephalomyelitis (EAE), increased T cell proliferation, and an abnormal pattern of cytokine production during EAE.
 
Interactions
Itgax interacts with 98 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process cell adhesion, defense response to virus, ...
Component cell surface, external side of plasma membrane, ...
Function metal ion binding
External Resources: FuncBase
Expression
Literature Summary: (17 records)
Data Summary: Results (16)    Tissues (10)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 15
RT-PCR 1
cDNA source data(24)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(27) Genomic(1) cDNA(24) Primer pair(1) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000030789 (Evidence)
Entrez Gene 16411 (Evidence)
UniGene 22378
DFCI TC1571898, TC1592386
DoTS DT.101131598, DT.110981365, DT.99865171
NIA Mouse Gene Index U008828
Consensus CDS Project CCDS40150.1
International Mouse Phenotyping Consortium Status Itgax
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000030789 Ensembl Gene Model | MGI Sequence Detail 21110 C57BL/6J ±  kb
transcript ENSMUST00000033053 Ensembl | MGI Sequence Detail 4045 Not Applicable 
polypeptide ENSMUSP00000033053 Ensembl | MGI Sequence Detail 1169 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(3) UniProt(6)
Polymorphisms
SNPs within 2kb(269 from dbSNP Build 137)    SNPs within 2kb including multiple locations(287)
Protein-related
information
ResourceIDDescription
InterPro IPR013517 FG-GAP repeat
InterPro IPR013649 Integrin alpha-2
InterPro IPR013519 Integrin alpha beta-propellor
InterPro IPR000413 Integrin alpha chain
InterPro IPR018184 Integrin alpha chain, C-terminal cytoplasmic region, conserved site
InterPro IPR002035 von Willebrand factor, type A
Protein Ontology PR:000001013 integrin alpha-X
References
(Earliest) J:10461 Metlay JP, et al., The distinct leukocyte integrins of mouse spleen dendritic cells as identified with new hamster monoclonal antibodies. J Exp Med. 1990 May 1;171(5):1753-71
(Latest) J:216439 Lee KM, et al., The chemokine receptors ACKR2 and CCR2 reciprocally regulate lymphatic vessel density. EMBO J. 2014 Nov 3;33(21):2564-80
All references(80)
Other
accession IDs
MGD-MRK-11488, MGI:2141963

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory