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Itgax
Gene Detail
Symbol

Name
ID
Itgax
integrin alpha X
MGI:96609
Synonyms
Cd11c, CD11C (p150) alpha polypeptide
Feature Type
protein coding gene
Genetic Map
Chromosome 7
69.98 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:128129547-128150656 bp, + strand
From Ensembl annotation of GRCm38

  21110 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55493  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 dog

Protein SuperFamily: integrin alpha with I domain
Gene Tree: Itgax

Human
homologs
Human Homolog ITGAX, integrin, alpha X (complement component 3 receptor 4 subunit)
NCBI Gene ID 3687
neXtProt AC  NX_P20702
Human Synonyms  CD11C, SLEB6
Human Chr (Location)  16p11.2; chr16:31355134-31382997 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit increased susceptibility to bacterial infection, decreased susceptibility to experimental autoimmune encephalomyelitis (EAE), increased T cell proliferation, and an abnormal pattern of cytokine production during EAE.
 
Interactions
Itgax interacts with 98 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process cell adhesion, defense response to virus, ...
Component cell surface, external side of plasma membrane, ...
Function metal ion binding
External Resources: FuncBase
Expression
Literature Summary: (16 records)
Data Summary: Results (8)    Tissues (2)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 8
cDNA source data(24)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(26) Genomic(1) cDNA(24) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000030789 (Evidence)
Entrez Gene16411 (Evidence)
UniGene22378
DFCITC1571898, TC1592386
DoTSDT.101131598, DT.110981365, DT.99865171
NIA Mouse Gene IndexU008828
Consensus CDS ProjectCCDS40150.1
International Mouse Knockout Project StatusItgax
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000030789 Ensembl Gene Model | MGI Sequence Detail 21110 C57BL/6J ±  kb
transcript ENSMUST00000033053 Ensembl | MGI Sequence Detail 4045 Not Applicable 
polypeptide ENSMUSP00000033053 Ensembl | MGI Sequence Detail 1169 Not Applicable 

For the selected sequences
All sequences(35) RefSeq(3) UniProt(11)
Polymorphisms
SNPs within 2kb(269 from dbSNP Build 137)    SNPs within 2kb including multiple locations(287)
Protein-related
information
ResourceIDDescription
InterPro IPR013517 FG-GAP repeat
InterPro IPR013649 Integrin alpha-2
InterPro IPR013519 Integrin alpha beta-propellor
InterPro IPR000413 Integrin alpha chain
InterPro IPR018184 Integrin alpha chain, C-terminal cytoplasmic region, conserved site
InterPro IPR002035 von Willebrand factor, type A
Protein Ontology PR:000001013 integrin alpha-X
References
(Earliest) J:10461 Metlay JP, et al., The distinct leukocyte integrins of mouse spleen dendritic cells as identified with new hamster monoclonal antibodies. J Exp Med. 1990 May 1;171(5):1753-71
(Latest) J:194055 Bose TO, et al., CD11a Regulates Effector CD8 T Cell Differentiation and Central Memory Development in Response to Infection with Listeria monocytogenes. Infect Immun. 2013 Apr;81(4):1140-51
All references(81)
Other
accession IDs
MGD-MRK-11488, MGI:2141963

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory