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Itgax Gene Detail
Summary
  • Symbol
    Itgax
  • Name
    integrin alpha X
  • Synonyms
    Cd11c, CD11C (p150) alpha polypeptide
  • Feature Type
    protein coding gene
  • IDs
    MGI:96609
    NCBI Gene: 16411
  • Gene Overview
    MyGene.info: ITGAX
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:128129547-128150657 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 69.98 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    261 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96609
protein coding gene Chr7:128129530-128150657 (.)
129S1/SvImJ MGP_129S1SvImJ_G0033072
protein coding gene Chr7:132534286-132556840 (+)
A/J MGP_AJ_G0033055
protein coding gene Chr7:128971104-128992074 (+)
AKR/J MGP_AKRJ_G0032987
protein coding gene Chr7:132331839-132354128 (+)
BALB/cJ MGP_BALBcJ_G0033056
protein coding gene Chr7:128634892-128655981 (+)
C3H/HeJ MGP_C3HHeJ_G0032770
protein coding gene Chr7:132224092-132252015 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033566
protein coding gene Chr7:137695220-137723576 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030538
protein coding gene Chr7:130154871-130180812 (+)
CAST/EiJ MGP_CASTEiJ_G0032099
protein coding gene Chr7:124012700-124040361 (+)
CBA/J MGP_CBAJ_G0032743
protein coding gene Chr7:142390585-142416227 (+)
DBA/2J MGP_DBA2J_G0032895
protein coding gene Chr7:126954708-126977304 (+)
FVB/NJ MGP_FVBNJ_G0032848
protein coding gene Chr7:126821412-126842562 (+)
LP/J MGP_LPJ_G0032989
protein coding gene Chr7:134006805-134030896 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032880
protein coding gene Chr7:143442129-143465452 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033585
protein coding gene Chr7:131306805-131330050 (+)
PWK/PhJ MGP_PWKPhJ_G0031806
protein coding gene Chr7:119960797-119983253 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031652
protein coding gene Chr7:118106312-118127928 (+)
WSB/EiJ MGP_WSBEiJ_G0032211
protein coding gene Chr7:132279083-132300580 (+)



Homology
more
  • Human Ortholog
    ITGAX, integrin subunit alpha X
  • Vertebrate Orthologs
    5
  • Human Ortholog
    ITGAX, integrin subunit alpha X
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CD11C, SLEB6
  • Links
    NCBI Gene ID: 3687
    neXtProt AC: NX_P20702
    UniProt: P20702

  • Chr Location
    16p11.2; chr16:31355134-31382997 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 3 alleles in 4 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased susceptibility to bacterial infection, decreased susceptibility to experimental autoimmune encephalomyelitis (EAE), increased T cell proliferation, and an abnormal pattern of cytokine production during EAE.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000030789 Ensembl Gene Model | MGI Sequence Detail 21111 C57BL/6J ±  kb
transcript ENSMUST00000033053 Ensembl | MGI Sequence Detail 4046 Not Applicable  
polypeptide ENSMUSP00000033053 Ensembl | MGI Sequence Detail 1169 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    7 Sequences
  • InterPro Domains
    IPR013517 FG-GAP repeat
    IPR013649 Integrin alpha-2
    IPR013519 Integrin alpha beta-propellor
    IPR000413 Integrin alpha chain
    IPR018184 Integrin alpha chain, C-terminal cytoplasmic region, conserved site
    IPR028994 Integrin alpha, N-terminal
    IPR032695 Integrin domain superfamily
    IPR036465 von Willebrand factor A-like domain superfamily
    IPR002035 von Willebrand factor, type A
Molecular
Reagents
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  • All nucleic 27
    Genomic 1
    cDNA 25
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-11488, MGI:2141963
References
more
  • Summaries
    All 123
    Developmental Gene Expression 21
    Gene Ontology 13
    Phenotypes 15
  • Earliest
    J:10461 Metlay JP, et al., The distinct leukocyte integrins of mouse spleen dendritic cells as identified with new hamster monoclonal antibodies. J Exp Med. 1990 May 1;171(5):1753-71
  • Latest
    J:263963 Wu J, et al., Critical role of integrin CD11c in splenic dendritic cell capture of missing-self CD47 cells to induce adaptive immunity. Proc Natl Acad Sci U S A. 2018 Jun 26;115(26):6786-6791

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/04/2018
MGI 6.13
The Jackson Laboratory