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Itgam
Gene Detail
 Symbol
Name
ID
Itgam
integrin alpha M
MGI:96607
Synonyms Cd11b, CD11b/CD18, CD11B (p170), complement component receptor 3 alpha, complement receptor type 3, CR3, F730045J24Rik, Ly-40, Mac-1, Mac-1a, Mac-1 alpha
Feature Type protein coding gene
Genetic Map
Chromosome 7
69.93 cM, cytoband F4
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr7:128062640-128128160 bp, + strand
From VEGA annotation of GRCm38

  65521 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:526  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: integrin alpha with I domain
Gene Tree: Itgam

Human
homologs
Human Homolog ITGAM, integrin, alpha M (complement component 3 receptor 3 subunit)
NCBI Gene ID 3684
neXtProt AC  NX_P11215
Human Synonyms  CD11B, CR3A, MAC-1, MAC1A, MO1A, SLEB6
Human Chr (Location)  16p11.2; chr16:31259967-31332892 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human ITGAM
Alleles
and
phenotypes
All alleles(5) : Targeted(4) Gene trapped(1)
 
Homozygous null mice exhibit reduced staphylococcal enterotoxin- induced T cell proliferation, reduced neutrophil adhesion to fibrinogen, and defective homotypic aggregation and reduced degranulation of neutrophils.
 
Gene Ontology
(GO)
classifications
All GO classifications: (23 annotations)
Process activated T cell proliferation, cell adhesion, ...
Component cell surface, external side of plasma membrane, ...
Function glycoprotein binding, heparan sulfate proteoglycan binding, ...
External Resources: FuncBase
Expression
Literature Summary: (39 records)
Data Summary: Results (14)    Tissues (4)   
Theiler Stages: 17, 20, 24, 28
Assay TypeResults
Immunohistochemistry 1
RT-PCR 13
cDNA source data(36)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(43) Genomic(3) cDNA(36) Primer pair(4)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000030928 (Evidence)
Ensembl Gene ModelENSMUSG00000030786 (Evidence)
Entrez Gene16409 (Evidence)
UniGene262106
DFCITC1578386, TC1590713
DoTSDT.101241831, DT.101330060, DT.101400713, DT.110981637, DT.110981748, DT.99859177, DT.99859178, DT.99869669
NIA Mouse Gene IndexU008827
Consensus CDS ProjectCCDS21889.1, CCDS40149.1
International Mouse Knockout Project StatusItgam
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030928 VEGA Gene Model | MGI Sequence Detail 65521 C57BL/6J ±  kb
transcript OTTMUST00000076530 VEGA | MGI Sequence Detail 4803 Not Applicable 
polypeptide OTTMUSP00000040303 VEGA | MGI Sequence Detail 1232 Not Applicable 

For the selected sequences
All sequences(90) RefSeq(4) UniProt(17)
Polymorphisms All PCR and RFLP(3) : PCR(2) RFLP(1) SNPs within 2kb(372 from dbSNP Build 137)    SNPs within 2kb including multiple locations(374)
Protein-related
information
ResourceIDDescription
InterPro IPR013517 FG-GAP repeat
InterPro IPR013649 Integrin alpha-2
InterPro IPR013519 Integrin alpha beta-propellor
InterPro IPR000413 Integrin alpha chain
InterPro IPR018184 Integrin alpha chain, C-terminal cytoplasmic region, conserved site
InterPro IPR001854 Ribosomal protein L29
InterPro IPR002035 von Willebrand factor, type A
Protein Ontology PR:000001012 integrin alpha-M
References (Earliest) J:6186 Springer T, et al., Mac-1: a macrophage differentiation antigen identified by monoclonal antibody. Eur J Immunol. 1979 Apr;9(4):301-6
(Latest) J:207099 Gorina R, et al., beta2 integrin-mediated crawling on endothelial ICAM-1 and ICAM-2 is a prerequisite for transcellular neutrophil diapedesis across the inflamed blood-brain barrier. J Immunol. 2014 Jan 1;192(1):324-37
All references(260)
Other
accession IDs
MGD-MRK-11486, MGD-MRK-11982, MGD-MRK-12094, MGI:2444489

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory