Itgam
Gene Detail

Symbol Name ID

Itgam integrin alpha M MGI:96607

Synonyms

Cd11b, CD11b/CD18, CD11B (p170), complement component receptor 3 alpha, complement receptor type 3, CR3, F730045J24Rik, Ly-40, Mac-1, Mac-1a, Mac-1 alpha

Feature Type

protein coding gene

Genetic Map

Chromosome 7

69.93 cM, cytoband F4
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr7:128062640-128128160 bp, + strand From VEGA annotation of GRCm38   65521 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:526  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: integrin alpha with I domain
Gene Tree: Itgam

Human homologs

Human Homolog		ITGAM, integrin, alpha M (complement component 3 receptor 3 subunit)
NCBI Gene ID		3684
neXtProt AC		NX_P11215
Human Synonyms		CD11B, CR3A, MAC-1, MAC1A, MO1A, SLEB6
Human Chr (Location)		16p11.2; chr16:31271288-31344213 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human ITGAM

Alleles and phenotypes

All alleles(5) : Targeted(4) Gene trapped(1)
 

Homozygous null mice exhibit reduced staphylococcal enterotoxin- induced T cell proliferation, reduced neutrophil adhesion to fibrinogen, and defective homotypic aggregation and reduced degranulation of neutrophils.

 

Gene Ontology (GO) classifications

All GO classifications: (22 annotations)

Process	activated T cell proliferation, cell adhesion, ...
Component	cell surface, external side of plasma membrane, ...
Function	glycoprotein binding, heparan sulfate proteoglycan binding, ...

External Resources: FuncBase

Expression

Literature Summary: (35 records)
Data Summary: Results (14)    Tissues (4)   
Theiler Stages: 17, 20, 24, 28

Assay Type	Results
Immunohistochemistry	1
RT-PCR	13

cDNA source data(35)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(42) Genomic(3) cDNA(35) Primer pair(4)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000030928 (Evidence)
Ensembl Gene Model	ENSMUSG00000030786 (Evidence)
Entrez Gene	16409 (Evidence)
UniGene	262106
DFCI	TC1578386, TC1590713
DoTS	DT.101241831, DT.101330060, DT.101400713, DT.110981637, DT.110981748, DT.99859177, DT.99859178, DT.99869669
NIA Mouse Gene Index	U008827
Consensus CDS Project	CCDS21889.1, CCDS40149.1
International Mouse Knockout Project Status	Itgam

Sequences

Length	Strain/Species
genomic	OTTMUSG00000030928	VEGA Gene Model | MGI Sequence Detail	65521	C57BL/6J
transcript	OTTMUST00000076530	VEGA | MGI Sequence Detail	4803	Not Applicable
polypeptide	OTTMUSP00000040303	VEGA | MGI Sequence Detail	1232	Not Applicable

All sequences(90) RefSeq(4) UniProt(17)

Polymorphisms

All PCR and RFLP(3) : PCR(2) RFLP(1) SNPs(200 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR013517	FG-GAP repeat
InterPro	IPR013649	Integrin alpha-2
InterPro	IPR013519	Integrin alpha beta-propellor
InterPro	IPR000413	Integrin alpha chain
InterPro	IPR018184	Integrin alpha chain, C-terminal cytoplasmic region, conserved site
InterPro	IPR001854	Ribosomal protein L29
InterPro	IPR002035	von Willebrand factor, type A
Protein Ontology	PR:000001012	integrin alpha-M

References

(Earliest) J:6186 Springer T, et al., Mac-1: a macrophage differentiation antigen identified by monoclonal antibody. Eur J Immunol. 1979 Apr;9(4):301-6
(Latest) J:194534 Chang CY, et al., NFIB is a governor of epithelial-melanocyte stem cell behaviour in a shared niche. Nature. 2013 Mar 7;495(7439):98-102
All references(247)

Other accession IDs

MGD-MRK-11486, MGD-MRK-11982, MGD-MRK-12094, MGI:2444489