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Itgam Gene Detail
Summary
  • Symbol
    Itgam
  • Name
    integrin alpha M
  • Synonyms
    Cd11b, CD11b/CD18, CD11B (p170), complement component receptor 3 alpha, complement receptor type 3, CR3, F730045J24Rik, Ly-40, Mac-1, Mac-1a, Mac-1 alpha
  • Feature Type
    protein coding gene
  • IDs
    MGI:96607
    NCBI Gene: 16409
  • Gene Overview
    MyGene.info: ITGAM
Location & Maps
more
  • Sequence Map
    Chr7:128062640-128118491 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      55852 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 69.93 cM, cytoband F4
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    ITGAM, integrin subunit alpha M
  • Vertebrate Orthologs
    11
  • Human Ortholog
    ITGAM, integrin subunit alpha M
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CD11B, CR3A, MAC-1, MAC1A, MO1A, SLEB6
  • Links
    NCBI Gene ID: 3684
    neXtProt AC: NX_P11215
    UniProt: P11215

  • Chr Location
    16p11.2; chr16:31259967-31332892 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human ITGAM associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    29 phenotypes from 4 alleles in 8 genetic backgrounds
    1 phenotype from multigenic genotypes
    144 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit reduced staphylococcal enterotoxin- induced T cell proliferation, reduced neutrophil adhesion to fibrinogen, and defective homotypic aggregation and reduced degranulation of neutrophils.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 16409 NCBI Gene Model | MGI Sequence Detail 55852 C57BL/6J ±  kb
transcript NM_001082960 RefSeq | MGI Sequence Detail 4682 C57BL/6  
polypeptide P05555 UniProt | EBI | MGI Sequence Detail 1153 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    287 from dbSNP Build 142
  • PCR
  • RFLP
Protein
Information
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Molecular
Reagents
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  • All nucleic 44
    Genomic 3
    cDNA 36
    Primer pair 5

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-11486, MGD-MRK-11982, MGD-MRK-12094, MGI:2444489
References
more
  • Summaries
    All 289
    Developmental Gene Expression 44
    Gene Ontology 30
    Phenotypes 144
  • Earliest
    J:6186 Springer T, et al., Mac-1: a macrophage differentiation antigen identified by monoclonal antibody. Eur J Immunol. 1979 Apr;9(4):301-6
  • Latest
    J:239929 Gobel K, et al., Blood coagulation factor XII drives adaptive immunity during neuroinflammation via CD87-mediated modulation of dendritic cells. Nat Commun. 2016 May 18;7:11626

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/18/2017
MGI 6.08
The Jackson Laboratory