About   Help   FAQ
Itga5
Gene Detail
Symbol

Name
ID
Itga5
integrin alpha 5 (fibronectin receptor alpha)
MGI:96604
Synonyms
Cd49e, Fnra
Feature Type
protein coding gene
Genetic Map
Chromosome 15
58.90 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr15:103344286-103366748 bp, - strand
From NCBI annotation of GRCm38

  22463 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20508  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ITGA5
Protein SuperFamily: integrin alpha, VLA protein type
Gene Tree: Itga5

Human
homologs
ITGA5, integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 3678
neXtProt AC: NX_P08648

Human Synonyms: CD49e, FNRA, VLA-5, VLA5A

Human Chr (Location): 12q11-q13; chr12:54395261-54419266 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(22) : Gene trapped(16) Targeted(6)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygotes for a targeted null mutation exhibit severe defects in posterior trunk and yolk sac mesodermal structures, lack of epithelialization of somites, reduced numbers of Schwann cells, and lethality around embryonic day 10-11.
 
Interactions
Itga5 interacts with 243 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (38 annotations)
Process cell adhesion, cell-cell adhesion mediated by integrin, ...
Component cell-cell junction, cell surface, ...
Function cell adhesion molecule binding, epidermal growth factor receptor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (47 records)
Data Summary: Results (145)    Tissues (87)    Images (49)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 27
RNA in situ 64
Western blot 4
RT-PCR 50
cDNA source data(68)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase itga5 ; ZFIN itga5    NEW 
Molecular
reagents
All nucleic(77) Genomic(2) cDNA(70) Primer pair(3) Other(2)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000000555 (Evidence)
Entrez Gene 16402 (Evidence)
UniGene 16234
DFCI TC1578518, TC1632950, TC1775195
DoTS DT.101391200, DT.110804620, DT.110804642, DT.490671, DT.91447455, DT.94399981
NIA Mouse Gene Index U036713
Consensus CDS Project CCDS27903.1
International Mouse Phenotyping Consortium Status Itga5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 16402 NCBI Gene Model | MGI Sequence Detail 22463 C57BL/6J ±  kb
transcript NM_010577 RefSeq | MGI Sequence Detail 4397 C57BL/6 
polypeptide P11688 UniProt | EBI | MGI Sequence Detail 1053 Not Applicable 

For the selected sequences
All sequences(51) RefSeq(2) UniProt(3)
Polymorphisms
RFLP(2) : SNPs within 2kb(93 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013517 FG-GAP repeat
InterPro IPR013649 Integrin alpha-2
InterPro IPR013519 Integrin alpha beta-propellor
InterPro IPR000413 Integrin alpha chain
InterPro IPR018184 Integrin alpha chain, C-terminal cytoplasmic region, conserved site
Protein Ontology PR:000009130 integrin alpha-5
Graphical View of Protein Domain Structure
References
(Earliest) J:31505 Holers VM, et al., Molecular cloning of a murine fibronectin receptor and its expression during inflammation. Expression of VLA-5 is increased in activated peritoneal macrophages in a manner discordant from major histocompatibility complex class II. J Exp Med. 1989 May 1;169(5):1589-605
(Latest) J:218158 Turner CJ, et al., alpha5 and alphav integrins cooperate to regulate vascular smooth muscle and neural crest functions in vivo. Development. 2015 Feb 15;142(4):797-808
All references(142)
Other
accession IDs
MGD-MRK-11483, MGD-MRK-9851

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/25/2015
MGI 6.0
The Jackson Laboratory