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Itga5
Gene Detail
 Symbol
Name
ID
Itga5
integrin alpha 5 (fibronectin receptor alpha)
MGI:96604
Synonyms Cd49e, Fnra
Feature Type protein coding gene
Genetic Map
Chromosome 15
58.90 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr15:103344286-103366748 bp, - strand
From NCBI annotation of GRCm38

  22463 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20508  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: integrin alpha, VLA protein type
Gene Tree: Itga5

Human
homologs
Human Homolog ITGA5, integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
NCBI Gene ID 3678
neXtProt AC  NX_P08648
Human Synonyms  CD49e, FNRA, VLA5A
Human Chr (Location)  12q11-q13; chr12:54395261-54419266 (-)  GRCh38
Alleles
and
phenotypes
All alleles(22) : Gene trapped(16) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a targeted null mutation exhibit severe defects in posterior trunk and yolk sac mesodermal structures, lack of epithelialization of somites, reduced numbers of Schwann cells, and lethality around embryonic day 10-11.
 
Gene Ontology
(GO)
classifications
All GO classifications: (29 annotations)
Process cell adhesion, cell-cell adhesion mediated by integrin, ...
Component cell-cell junction, cell surface, ...
Function cell adhesion molecule binding, epidermal growth factor receptor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (43 records)
Data Summary: Results (145)    Tissues (87)    Images (49)
Theiler Stages: 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 27
RNA in situ 64
Western blot 4
RT-PCR 50
cDNA source data(68)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(77) Genomic(2) cDNA(70) Primer pair(3) Other(2)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000000555 (Evidence)
Entrez Gene16402 (Evidence)
UniGene16234
DFCITC1578518, TC1632950, TC1775195
DoTSDT.101391200, DT.110804620, DT.110804642, DT.490671, DT.91447455, DT.94399981
NIA Mouse Gene IndexU036713
Consensus CDS ProjectCCDS27903.1
International Mouse Knockout Project StatusItga5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 16402 NCBI Gene Model | MGI Sequence Detail 22463 C57BL/6J ±  kb
transcript NM_010577 RefSeq | MGI Sequence Detail 4397 C57BL/6 
polypeptide P11688 UniProt | EBI | MGI Sequence Detail 1053 Not Applicable 

For the selected sequences
All sequences(51) RefSeq(2) UniProt(3)
Polymorphisms RFLP(2) : SNPs within 2kb(93 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013517 FG-GAP repeat
InterPro IPR013649 Integrin alpha-2
InterPro IPR013519 Integrin alpha beta-propellor
InterPro IPR000413 Integrin alpha chain
InterPro IPR018184 Integrin alpha chain, C-terminal cytoplasmic region, conserved site
Protein Ontology PR:000009130 integrin alpha-5
Graphical View of Protein Domain Structure
References (Earliest) J:31505 Holers VM, et al., Molecular cloning of a murine fibronectin receptor and its expression during inflammation. Expression of VLA-5 is increased in activated peritoneal macrophages in a manner discordant from major histocompatibility complex class II. J Exp Med. 1989 May 1;169(5):1589-605
(Latest) J:208230 Overstreet MG, et al., Inflammation-induced interstitial migration of effector CD4(+) T cells is dependent on integrin alphaV. Nat Immunol. 2013 Sep;14(9):949-58
All references(133)
Other
accession IDs
MGD-MRK-11483, MGD-MRK-9851

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory