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Itga4 Gene Detail
Summary
  • Symbol
    Itga4
  • Name
    integrin alpha 4
  • Synonyms
    VLA-4 receptor, alpha 4 subunit
  • Feature Type
    protein coding gene
  • IDs
    MGI:96603
    NCBI Gene: 16401
  • Alliance
  • Transcription Start Sites
    34 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:79085770-79163467 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 2, 47.38 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    751 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96603
protein coding gene Chr2:79084767-79163467 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025876
protein coding gene Chr2:79785375-79874887 (+)
A/J MGP_AJ_G0025853
protein coding gene Chr2:76708335-76786572 (+)
AKR/J MGP_AKRJ_G0025822
protein coding gene Chr2:78715383-78798316 (+)
BALB/cJ MGP_BALBcJ_G0025849
protein coding gene Chr2:76833002-76913242 (+)
C3H/HeJ MGP_C3HHeJ_G0025608
protein coding gene Chr2:78938365-79022662 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026295
protein coding gene Chr2:82148692-82241438 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023698
protein coding gene Chr2:73964094-74038811 (+)
CAST/EiJ MGP_CASTEiJ_G0025070
protein coding gene Chr2:79356984-79443700 (+)
CBA/J MGP_CBAJ_G0025589
protein coding gene Chr2:85092775-85186027 (+)
DBA/2J MGP_DBA2J_G0025720
protein coding gene Chr2:76260266-76339375 (+)
FVB/NJ MGP_FVBNJ_G0025682
protein coding gene Chr2:75631334-75707565 (+)
LP/J MGP_LPJ_G0025808
protein coding gene Chr2:79637817-79719448 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025713
protein coding gene Chr2:86951045-87038443 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026351
protein coding gene Chr2:78880294-78966347 (+)
PWK/PhJ MGP_PWKPhJ_G0024813
protein coding gene Chr2:76205797-76284427 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024619
protein coding gene Chr2:79145833-79229760 (+)
WSB/EiJ MGP_WSBEiJ_G0025139
protein coding gene Chr2:79504753-79593381 (+)



Homology
more
  • Human Ortholog
    ITGA4, integrin subunit alpha 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ITGA4, integrin subunit alpha 4
  • Synonyms
    CD49D, IA4
  • Links
    NCBI Gene ID: 3676
    neXtProt AC: NX_P13612
    UniProt: P13612

  • Chr Location
    2q31.3; chr2:181457202-181538940 (+)  GRCh38

Human Diseases
more
  • Diseases
    2 with human ITGA4 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    26 phenotypes from 4 alleles in 5 genetic backgrounds
    7 phenotypes from multigenic genotypes
    64 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene exhibit embryonic lethality either due to failure of chorioallantoic fusion or cardiac abnormalities, including hemorrhage around the heart and defects in epicardium formation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000027009 Ensembl Gene Model | MGI Sequence Detail 77698 C57BL/6J ±  kb
    transcript ENSMUST00000099972 Ensembl | MGI Sequence Detail 9767 Not Applicable  
    polypeptide ENSMUSP00000099718 Ensembl | MGI Sequence Detail 1032 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 114
      Genomic 16
      cDNA 91
      Primer pair 4
      Other 3

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGD-MRK-11482
    References
    more
    • Summaries
      All 228
      Developmental Gene Expression 69
      Gene Ontology 13
      Phenotypes 64
    • Earliest
      J:9952 Holzmann B, et al., Peyer's patch-specific lymphocyte homing receptors consist of a VLA-4-like alpha chain associated with either of two integrin beta chains, one of which is novel. EMBO J. 1989 Jun;8(6):1735-41
    • Latest
      J:345312 Mak S, et al., Canonical and Non-Canonical Localization of Tight Junction Proteins during Early Murine Cranial Development. Int J Mol Sci. 2024 Jan 24;25(3)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory