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Itga4 Gene Detail
Summary
  • Symbol
    Itga4
  • Name
    integrin alpha 4
  • Synonyms
    VLA-4 receptor, alpha 4 subunit
  • Feature Type
    protein coding gene
  • IDs
    MGI:96603
    NCBI Gene: 16401
  • Gene Overview
    MyGene.info: ITGA4
  • Alliance
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:79255426-79333114 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 47.38 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    751 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96603
protein coding gene Chr2:79255426-79333123 (.)
129S1/SvImJ MGP_129S1SvImJ_G0025876
protein coding gene Chr2:79785375-79874887 (+)
A/J MGP_AJ_G0025853
protein coding gene Chr2:76708335-76786572 (+)
AKR/J MGP_AKRJ_G0025822
protein coding gene Chr2:78715383-78798316 (+)
BALB/cJ MGP_BALBcJ_G0025849
protein coding gene Chr2:76833002-76913242 (+)
C3H/HeJ MGP_C3HHeJ_G0025608
protein coding gene Chr2:78938365-79022662 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026295
protein coding gene Chr2:82148692-82241438 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023698
protein coding gene Chr2:73964094-74038811 (+)
CAST/EiJ MGP_CASTEiJ_G0025070
protein coding gene Chr2:79356984-79443700 (+)
CBA/J MGP_CBAJ_G0025589
protein coding gene Chr2:85092775-85186027 (+)
DBA/2J MGP_DBA2J_G0025720
protein coding gene Chr2:76260266-76339375 (+)
FVB/NJ MGP_FVBNJ_G0025682
protein coding gene Chr2:75631334-75707565 (+)
LP/J MGP_LPJ_G0025808
protein coding gene Chr2:79637817-79719448 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025713
protein coding gene Chr2:86951045-87038443 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026351
protein coding gene Chr2:78880294-78966347 (+)
PWK/PhJ MGP_PWKPhJ_G0024813
protein coding gene Chr2:76205797-76284427 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024619
protein coding gene Chr2:79145833-79229760 (+)
WSB/EiJ MGP_WSBEiJ_G0025139
protein coding gene Chr2:79504753-79593381 (+)



Homology
more
  • Human Ortholog
    ITGA4, integrin subunit alpha 4
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ITGA4, integrin subunit alpha 4
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CD49D, IA4
  • Links
    NCBI Gene ID: 3676
    neXtProt AC: NX_P13612
    UniProt: P13612

  • Chr Location
    2q31.3; chr2:181456892-181538928 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    32 phenotypes from 6 alleles in 7 genetic backgrounds
    44 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene exhibit embryonic lethality either due to failure of chorioallantoic fusion or cardiac abnormalities, including hemorrhage around the heart and defects in epicardium formation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16401 NCBI Gene Model | MGI Sequence Detail 77689 C57BL/6J ±  kb
    transcript NM_010576 RefSeq | MGI Sequence Detail 9832 C57BL/6  
    polypeptide Q00651 UniProt | EBI | MGI Sequence Detail 1039 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 112
      Genomic 16
      cDNA 90
      Primer pair 3
      Other 3

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGD-MRK-11482
    References
    more
    • Summaries
      All 196
      Developmental Gene Expression 63
      Gene Ontology 13
      Phenotypes 44
    • Earliest
      J:9952 Holzmann B, et al., Peyer's patch-specific lymphocyte homing receptors consist of a VLA-4-like alpha chain associated with either of two integrin beta chains, one of which is novel. EMBO J. 1989 Jun;8(6):1735-41
    • Latest
      J:258124 Caldeira-Dantas S, et al., The Chemokine Receptor CXCR3 Promotes CD8(+) T Cell Accumulation in Uninfected Salivary Glands but Is Not Necessary after Murine Cytomegalovirus Infection. J Immunol. 2018 Feb 1;200(3):1133-1145

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory