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Itga4
Gene Detail
 Symbol
Name
ID
Itga4
integrin alpha 4
MGI:96603
Synonyms VLA-4 receptor, alpha 4 subunit
Feature Type protein coding gene
Genetic Map
Chromosome 2
47.38 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr2:79255426-79333123 bp, + strand
From VEGA annotation of GRCm38

  77698 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37364  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: integrin alpha, VLA protein type
Gene Tree: Itga4

Human
homologs
Human Homolog ITGA4, integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
NCBI Gene ID 3676
neXtProt AC  NX_P13612
Human Synonyms  CD49D, IA4
Human Chr (Location)  2q31.3; chr2:181456892-181537747 (+)  GRCh38
Alleles
and
phenotypes
All alleles(9) : Gene trapped(1) Targeted(8)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene exhibit embryonic lethality either due to failure of chorioallantoic fusion or cardiac abnormalities, including hemorrhage around the heart and defects in epicardium formation.
 
Gene Ontology
(GO)
classifications
All GO classifications: (31 annotations)
Process blood vessel remodeling, cell adhesion, ...
Component cell-cell junction, cell surface, ...
Function cell adhesion molecule binding, fibronectin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (51 records)
Data Summary: Results (528)    Tissues (389)    Images (115)
Theiler Stages: 1, 3, 4, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 69
RNA in situ 399
RT-PCR 60
cDNA source data(80)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(106) Genomic(16) cDNA(86) Primer pair(3) Other(1)
Microarray probesets(9)
Other database
links
VEGA Gene ModelOTTMUSG00000013313 (Evidence)
Ensembl Gene ModelENSMUSG00000027009 (Evidence)
Entrez Gene16401 (Evidence)
UniGene31903
NIA Mouse Gene IndexU042318, U120584
Consensus CDS ProjectCCDS16168.1
International Mouse Knockout Project StatusItga4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000013313 VEGA Gene Model | MGI Sequence Detail 77698 C57BL/6J ±  kb
transcript OTTMUST00000032190 VEGA | MGI Sequence Detail 9767 Not Applicable 
polypeptide OTTMUSP00000014305 VEGA | MGI Sequence Detail 1032 Not Applicable 

For the selected sequences
All sequences(71) RefSeq(2) UniProt(9)
Polymorphisms SNPs within 2kb(756 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013649 Integrin alpha-2
InterPro IPR013519 Integrin alpha beta-propellor
InterPro IPR000413 Integrin alpha chain
InterPro IPR018184 Integrin alpha chain, C-terminal cytoplasmic region, conserved site
Protein Ontology PR:000009129 integrin alpha-4
References (Earliest) J:9952 Holzmann B, et al., Peyer's patch-specific lymphocyte homing receptors consist of a VLA-4-like alpha chain associated with either of two integrin beta chains, one of which is novel. EMBO J. 1989 Jun;8(6):1735-41
(Latest) J:201578 Hung WC, et al., Distinct signaling mechanisms regulate migration in unconfined versus confined spaces. J Cell Biol. 2013 Sep 2;202(5):807-24
All references(149)
Other
accession IDs
MGD-MRK-11482

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory