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Itga4 Gene Detail
Summary
  • Symbol
    Itga4
  • Name
    integrin alpha 4
  • Synonyms
    VLA-4 receptor, alpha 4 subunit
  • Feature Type
    protein coding gene
  • IDs
    MGI:96603
    NCBI Gene: 16401
  • Gene Overview
    MyGene.info: ITGA4
Location & Maps
more
  • Sequence Map
    Chr2:79255426-79333123 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      77698 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 47.38 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    ITGA4, integrin subunit alpha 4
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ITGA4, integrin subunit alpha 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CD49D, IA4
  • Links
    NCBI Gene ID: 3676
    neXtProt AC: NX_P13612

  • Chr Location
    2q31.3; chr2:181456892-181537747 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    32 phenotypes from 6 alleles in 7 genetic backgrounds
    39 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    12
  • Chemically induced (other)
    1
  • Gene trapped
    1
  • Targeted
    10
  • Genomic Mutations
    3 involving Itga4
  • Incidental Mutations
Mice homozygous for disruptions in this gene exhibit embryonic lethality either due to failure of chorioallantoic fusion or cardiac abnormalities, including hemorrhage around the heart and defects in epicardium formation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000013313 VEGA Gene Model | MGI Sequence Detail 77698 C57BL/6J ±  kb
transcript OTTMUST00000032190 VEGA | MGI Sequence Detail 9767 Not Applicable  
polypeptide OTTMUSP00000014305 VEGA | MGI Sequence Detail 1032 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    751 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 107
    Genomic 16
    cDNA 86
    Primer pair 3
    Other 2

    Microarray probesets 9
Other
Accession IDs
less
MGD-MRK-11482
References
more
  • Summaries
    All 155
    Developmental Gene Expression 55
    Gene Ontology 13
    Phenotypes 39
  • Earliest
    J:9952 Holzmann B, et al., Peyer's patch-specific lymphocyte homing receptors consist of a VLA-4-like alpha chain associated with either of two integrin beta chains, one of which is novel. EMBO J. 1989 Jun;8(6):1735-41
  • Latest
    J:229483 Borok MJ, et al., Unique functions of Gata4 in mouse liver induction and heart development. Dev Biol. 2016 Feb 15;410(2):213-22

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory