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Itga1 Gene Detail
Summary
  • Symbol
    Itga1
  • Name
    integrin alpha 1
  • Synonyms
    CD49A, E130012M19Rik, Vla1
  • Feature Type
    protein coding gene
  • IDs
    MGI:96599
    NCBI Gene: 109700
  • Gene Overview
    MyGene.info: ITGA1
  • Alliance
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:114958079-115101964 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 64.61 cM
  • Mapping Data
    11 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1917 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96599
protein coding gene Chr13:114953096-115101964 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020959
protein coding gene Chr13:117707112-117868022 (-)
A/J MGP_AJ_G0020909
protein coding gene Chr13:112925709-113076535 (-)
AKR/J MGP_AKRJ_G0020884
protein coding gene Chr13:116325002-116471272 (-)
BALB/cJ MGP_BALBcJ_G0020909
protein coding gene Chr13:113648010-113797220 (-)
C3H/HeJ MGP_C3HHeJ_G0020698
protein coding gene Chr13:116155957-116308153 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021345
protein coding gene Chr13:121136839-121295330 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018914
protein coding gene Chr13:108194682-108342535 (-)
CAST/EiJ MGP_CASTEiJ_G0020217
protein coding gene Chr13:115829379-115991033 (-)
CBA/J MGP_CBAJ_G0020660
protein coding gene Chr13:125765915-125938827 (-)
DBA/2J MGP_DBA2J_G0020783
protein coding gene Chr13:112637214-112785238 (-)
FVB/NJ MGP_FVBNJ_G0020767
protein coding gene Chr13:111285087-111432616 (-)
LP/J MGP_LPJ_G0020859
protein coding gene Chr13:117696763-117849677 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020795
protein coding gene Chr13:126038452-126194619 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021381
protein coding gene Chr13:115816206-115973175 (-)
PWK/PhJ MGP_PWKPhJ_G0019970
protein coding gene Chr13:111425023-111579731 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019792
protein coding gene Chr13:112158742-112296723 (-)
WSB/EiJ MGP_WSBEiJ_G0020275
protein coding gene Chr13:116451918-116606099 (-)



Homology
more
  • Human Ortholog
    ITGA1, integrin subunit alpha 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ITGA1, integrin subunit alpha 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CD49a, VLA1
  • Links
    NCBI Gene ID: 3672
    neXtProt AC: NX_P56199
    UniProt: P56199

  • Chr Location
    5q11.2; chr5:52788302-52953655 (+)  GRCh38.p7

Human Diseases
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  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 1 allele in 1 genetic background
    18 phenotypes from multigenic genotypes
    33 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene are essentially normal although their kidneys are smaller and more succeptible to injury.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic 109700 NCBI Gene Model | MGI Sequence Detail 143886 C57BL/6J ±  kb
    transcript NM_001033228 RefSeq | MGI Sequence Detail 5984 C57BL/6  
    polypeptide Q3V3R4 UniProt | EBI | MGI Sequence Detail 1179 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 50
      Genomic 1
      cDNA 44
      Primer pair 2
      Other 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-11478, MGD-MRK-19432, MGI:2444353
    References
    more
    • Summaries
      All 103
      Developmental Gene Expression 14
      Diseases 1
      Gene Ontology 12
      Phenotypes 33
    • Earliest
      J:10663 Eicher EM, et al., The NXSM recombinant inbred strains of mice: genetic profile for 58 loci including the Mtv proviral loci. Genetics. 1990 Jun;125(2):431-46
    • Latest
      J:243182 Wang H, et al., Embryonic Lethality Due to Arrested Cardiac Development in Psip1/Hdgfrp2 Double-Deficient Mice. PLoS One. 2015;10(9):e0137797

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory