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Itga1
Gene Detail
Symbol

Name
ID
Itga1
integrin alpha 1
MGI:96599
Synonyms
CD49A, E130012M19Rik, Vla1
Feature Type
protein coding gene
Genetic Map
Chromosome 13
64.61 cM
Detailed Genetic Map ± 1 cM


Mapping data(11)
Sequence Map
Chr13:114958079-115101964 bp, - strand
From NCBI annotation of GRCm38

  143886 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:57137  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ITGA1
Protein SuperFamily: integrin alpha with I domain
Gene Tree: Itga1

Human
homologs
ITGA1, integrin, alpha 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 3672
neXtProt AC: NX_P56199

Human Synonyms: CD49a, VLA1

Human Chr (Location): 5q11.2; chr5:52788302-52953655 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Gene trapped(1) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene are essentially normal although their kidneys are smaller and more succeptible to injury.
 
Mutations Annotated to Human Diseases (1)   
Interactions
Itga1 interacts with 320 markers (Mir1b, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (36 annotations)
Process activation of MAPK activity, cell adhesion, ...
Component acrosomal vesicle, basal part of cell, ...
Function collagen binding, collagen binding involved in cell-matrix adhesion, ...
External Resources: FuncBase
Expression
Literature Summary: (13 records)
Data Summary: Results (15)    Tissues (11)    Images (11)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 6
RNA in situ 8
RT-PCR 1
cDNA source data(37)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase itga1    NEW 
Molecular
reagents
All nucleic(48) Genomic(1) cDNA(43) Primer pair(1) Other(3)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000042284 (Evidence)
Entrez Gene 109700 (Evidence)
UniGene 317280
DFCI TC1582867, TC1599640
DoTS DT.101341280, DT.87038868, DT.91305336, DT.91373438, DT.94210013
Consensus CDS Project CCDS36788.1
International Mouse Phenotyping Consortium Status Itga1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 109700 NCBI Gene Model | MGI Sequence Detail 143886 C57BL/6J ±  kb
transcript NM_001033228 RefSeq | MGI Sequence Detail 5984 C57BL/6 
polypeptide Q3V3R4 UniProt | EBI | MGI Sequence Detail 1179 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(2) UniProt(5)
Polymorphisms
RFLP(7) : SNPs within 2kb(1920 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013517 FG-GAP repeat
InterPro IPR013649 Integrin alpha-2
InterPro IPR013519 Integrin alpha beta-propellor
InterPro IPR000413 Integrin alpha chain
InterPro IPR018184 Integrin alpha chain, C-terminal cytoplasmic region, conserved site
InterPro IPR002035 von Willebrand factor, type A
Protein Ontology PR:000001007 integrin alpha-1
Graphical View of Protein Domain Structure
References
(Earliest) J:10663 Eicher EM, et al., The NXSM recombinant inbred strains of mice: genetic profile for 58 loci including the Mtv proviral loci. Genetics. 1990 Jun;125(2):431-46
(Latest) J:219330 Williams AS, et al., Integrin alpha1-null Mice Exhibit Improved Fatty Liver When Fed a High Fat Diet Despite Severe Hepatic Insulin Resistance. J Biol Chem. 2015 Mar 6;290(10):6546-57
All references(100)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-11478, MGD-MRK-19432, MGI:2444353

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory