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Irf1 Gene Detail
Summary
  • Symbol
    Irf1
  • Name
    interferon regulatory factor 1
  • Synonyms
    Irf-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:96590
    NCBI Gene: 16362
  • Gene Overview
    MyGene.info: IRF1
Location & Maps
more
  • Sequence Map
    Chr11:53770014-53778374 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      8361 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 32.00 cM
  • Mapping Data
    10 experiments
Homology
more
  • Human Ortholog
    IRF1, interferon regulatory factor 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    IRF1, interferon regulatory factor 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    IRF-1, MAR
  • Links
    NCBI Gene ID: 3659
    neXtProt AC: NX_P10914

  • Chr Location
    5q31.1; chr5:132481609-132490777 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    2 with human IRF1 associations

Human Disease Mouse Models
       Gastric Cancer   OMIM: 613659
Lung Cancer   OMIM: 211980
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    50 phenotypes from 4 alleles in 8 genetic backgrounds
    17 phenotypes from multigenic genotypes
    109 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    12
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    1
  • Gene trapped
    4
  • Targeted
    5
  • Transgenic
    1
  • Genomic Mutations
    2 involving Irf1
  • Incidental Mutations
Homozygous disruption of this gene leads to reduced CD8+ T cell number and altered response to viral infection and may cause alterations in cytokine levels, CD4+ cell subset homeostasis, blood vessel healing, DNA repair, and susceptibility to induced lymphomas, arthritis and autoimmune encephalitis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005648 VEGA Gene Model | MGI Sequence Detail 8361 C57BL/6J ±  kb
transcript OTTMUST00000012563 VEGA | MGI Sequence Detail 2137 Not Applicable  
polypeptide OTTMUSP00000005820 VEGA | MGI Sequence Detail 329 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    86 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    9 Sequences
  • Protein Ontology
    PR:000002043 interferon regulatory factor 1
  • PDB
  • InterPro Domains
    IPR031215 Interferon regulatory factor 1
    IPR017431 Interferon regulatory factor-1/2
    IPR019817 Interferon regulatory factor, conserved site
    IPR001346 Interferon regulatory factor DNA-binding domain
    IPR011991 Winged helix-turn-helix DNA-binding domain
Molecular
Reagents
less
  • All nucleic 177
    Genomic 12
    cDNA 162
    Primer pair 3

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-11464, MGD-MRK-11465, MGI:2144403
References
more
  • Summaries
    All 179
    Developmental Gene Expression 9
    Gene Ontology 16
    Phenotypes 109
  • Earliest
    J:17555 Miyamoto M, et al., Regulated expression of a gene encoding a nuclear factor, IRF-1, that specifically binds to IFN-beta gene regulatory elements. Cell. 1988 Sep 9;54(6):903-13
  • Latest
    J:222327 Maruyama S, et al., A novel function of interferon regulatory factor-1: inhibition of Th2 cells by down-regulating the Il4 gene during Listeria infection. Int Immunol. 2015 Mar;27(3):143-52

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory