Irf1
Gene Detail

Symbol Name ID

Irf1 interferon regulatory factor 1 MGI:96590

Synonyms

Irf-1

Feature Type

protein coding gene

Genetic Map

Chromosome 11

32.00 cM
Detailed Genetic Map ± 1 cM


Mapping data(10)

Sequence Map

Chr11:53770014-53778374 bp, + strand From VEGA annotation of GRCm38   8361 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1658  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: interferon regulatory factor, types 1/2
Gene Tree: Irf1

Human homologs

Human Homolog		IRF1, interferon regulatory factor 1
NCBI Gene ID		3659
neXtProt AC		NX_P10914
Human Synonyms		IRF-1, MAR
Human Chr (Location)		5q31.1; chr5:131817301-131826465 (-)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human IRF1

Alleles and phenotypes

All alleles(9) : Targeted(4) Gene trapped(4) Chemically induced(1)
 

Homozygous disruption of this gene leads to reduced CD8+ T cell number and altered response to viral infection and may cause alterations in cytokine levels, CD4+ cell subset homeostasis, blood vessel healing, DNA repair, and susceptibility to induced lymphomas, arthritis and autoimmune encephalitis.

 

Gene Ontology (GO) classifications

All GO classifications: (54 annotations)

Process	CD8-positive, alpha-beta T cell differentiation, cell cycle arrest, ...
Component	cytoplasm, nuclear chromatin, ...
Function	DNA binding, protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (8 records)
Data Summary: Results (100)    Tissues (68)    Images (29)
Theiler Stages: 1, 2, 3, 4, 5, 15, 16, 17, 18, 21, 23, 25, 28

Assay Type	Results
Immunohistochemistry	4
RNA in situ	74
Western blot	1
RT-PCR	21

cDNA source data(160)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(178) Genomic(12) cDNA(163) Primer pair(3)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000005648 (Evidence)
Ensembl Gene Model	ENSMUSG00000018899 (Evidence)
Entrez Gene	16362 (Evidence)
UniGene	105218
DFCI	TC1572848, TC1593050
DoTS	DT.101251199, DT.101325307, DT.533100, DT.94188575
NIA Mouse Gene Index	U012603
PDB	1IF1
Consensus CDS Project	CCDS24686.1, CCDS48796.1
International Mouse Knockout Project Status	Irf1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000005648	VEGA Gene Model | MGI Sequence Detail	8361	C57BL/6J
transcript	OTTMUST00000012563	VEGA | MGI Sequence Detail	2137	Not Applicable
polypeptide	OTTMUSP00000005820	VEGA | MGI Sequence Detail	329	Not Applicable

All sequences(76) RefSeq(6) UniProt(9)

Polymorphisms

RFLP(1) : SNPs(52 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017431	Interferon regulatory factor-1/2
InterPro	IPR019817	Interferon regulatory factor, conserved site
InterPro	IPR001346	Interferon regulatory factor DNA-binding domain
InterPro	IPR011991	Winged helix-turn-helix transcription repressor DNA-binding
Protein Ontology	PR:000002043	interferon regulatory factor 1

References

(Earliest) J:17555 Miyamoto M, et al., Regulated expression of a gene encoding a nuclear factor, IRF-1, that specifically binds to IFN-beta gene regulatory elements. Cell. 1988 Sep 9;54(6):903-13
(Latest) J:191206 Okamura D, et al., Cell cycle gene-specific control of transcription has a critical role in proliferation of primordial germ cells. Genes Dev. 2012 Nov 15;26(22):2477-82
All references(170)

Other accession IDs

MGD-MRK-11464, MGD-MRK-11465, MGI:2144403