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Irf1
Gene Detail
Symbol

Name
ID
Irf1
interferon regulatory factor 1
MGI:96590
Synonyms
Irf-1
Feature Type
protein coding gene
Genetic Map
Chromosome 11
32.00 cM
Detailed Genetic Map ± 1 cM


Mapping data(10)
Sequence Map
Chr11:53770014-53778374 bp, + strand
From VEGA annotation of GRCm38

  8361 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1658  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: interferon regulatory factor, types 1/2
Gene Tree: Irf1

Human
homologs
Human Homolog IRF1, interferon regulatory factor 1
NCBI Gene ID 3659
neXtProt AC  NX_P10914
Human Synonyms  IRF-1, MAR
Human Chr (Location)  5q31.1; chr5:132481609-132490773 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human IRF1
Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Chemically induced (ENU)(1) Gene trapped(4) Targeted(5)
Genomic Mutations involving Irf1 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous disruption of this gene leads to reduced CD8+ T cell number and altered response to viral infection and may cause alterations in cytokine levels, CD4+ cell subset homeostasis, blood vessel healing, DNA repair, and susceptibility to induced lymphomas, arthritis and autoimmune encephalitis.
 
Interactions
Irf1 interacts with 192 markers (Mir1b, Mir7-1, Mir15a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (55 annotations)
Process apoptotic process, CD8-positive, alpha-beta T cell differentiation, ...
Component cytoplasm, nuclear chromatin, ...
Function DNA binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (91)    Tissues (62)    Images (29)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 4
RNA in situ 74
Western blot 1
RT-PCR 12
cDNA source data(159)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(177) Genomic(12) cDNA(162) Primer pair(3)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000005648 (Evidence)
Ensembl Gene ModelENSMUSG00000018899 (Evidence)
Entrez Gene16362 (Evidence)
UniGene105218
DFCITC1572848, TC1593050
DoTSDT.101251199, DT.101325307, DT.533100, DT.94188575
NIA Mouse Gene IndexU012603
PDB1IF1
Consensus CDS ProjectCCDS24686.1, CCDS48796.1
International Mouse Knockout Project StatusIrf1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005648 VEGA Gene Model | MGI Sequence Detail 8361 C57BL/6J ±  kb
transcript OTTMUST00000012563 VEGA | MGI Sequence Detail 2137 Not Applicable 
polypeptide OTTMUSP00000005820 VEGA | MGI Sequence Detail 329 Not Applicable 

For the selected sequences
All sequences(78) RefSeq(8) UniProt(9)
Polymorphisms
RFLP(1) : SNPs within 2kb(84 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017431 Interferon regulatory factor-1/2
InterPro IPR019817 Interferon regulatory factor, conserved site
InterPro IPR001346 Interferon regulatory factor DNA-binding domain
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000002043 interferon regulatory factor 1
References
(Earliest) J:17555 Miyamoto M, et al., Regulated expression of a gene encoding a nuclear factor, IRF-1, that specifically binds to IFN-beta gene regulatory elements. Cell. 1988 Sep 9;54(6):903-13
(Latest) J:207189 Yang H, et al., Histone deacetylase sirtuin 1 deacetylates IRF1 protein and programs dendritic cells to control Th17 protein differentiation during autoimmune inflammation. J Biol Chem. 2013 Dec 27;288(52):37256-66
All references(178)
Other
accession IDs
MGD-MRK-11464, MGD-MRK-11465, MGI:2144403

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory