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Irf1 Gene Detail
Summary
  • Symbol
    Irf1
  • Name
    interferon regulatory factor 1
  • Synonyms
    Irf-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:96590
    NCBI Gene: 16362
  • Gene Overview
    MyGene.info: IRF1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr11:53770014-53778374 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      8361 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 32.00 cM
  • Mapping Data
    10 experiments
Homology
more
  • Human Ortholog
    IRF1, interferon regulatory factor 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    IRF1, interferon regulatory factor 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    IRF-1, MAR
  • Links
    NCBI Gene ID: 3659
    neXtProt AC: NX_P10914
    UniProt: P10914

  • Chr Location
    5q31.1; chr5:132481609-132490789 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    2 with human IRF1 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    45 phenotypes from 3 alleles in 7 genetic backgrounds
    17 phenotypes from multigenic genotypes
    121 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous disruption of this gene leads to reduced CD8+ T cell number and altered response to viral infection and may cause alterations in cytokine levels, CD4+ cell subset homeostasis, blood vessel healing, DNA repair, and susceptibility to induced lymphomas, arthritis and autoimmune encephalitis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000005648 VEGA Gene Model | MGI Sequence Detail 8361 C57BL/6J ±  kb
    transcript OTTMUST00000012563 VEGA | MGI Sequence Detail 2137 Not Applicable  
    polypeptide OTTMUSP00000005820 VEGA | MGI Sequence Detail 329 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      86 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    • UniProt
      9 Sequences
    • Protein Ontology
      PR:000002043 interferon regulatory factor 1
    • PDB
    • InterPro Domains
      IPR031215 Interferon regulatory factor 1
      IPR017431 Interferon regulatory factor-1/2
      IPR019817 Interferon regulatory factor, conserved site
      IPR001346 Interferon regulatory factor DNA-binding domain
      IPR036390 Winged helix DNA-binding domain superfamily
      IPR036388 Winged helix-like DNA-binding domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 178
      Genomic 12
      cDNA 163
      Primer pair 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-11464, MGD-MRK-11465, MGI:2144403
    References
    more
    • Summaries
      All 215
      Developmental Gene Expression 10
      Gene Ontology 16
      Phenotypes 121
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:262477 Karki R, et al., IRF8 Regulates Transcription of Naips for NLRC4 Inflammasome Activation. Cell. 2018 May 3;173(4):920-933.e13

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    07/31/2018
    MGI 6.12
    The Jackson Laboratory