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Inhbb Gene Detail
Summary
  • Symbol
    Inhbb
  • Name
    inhibin beta-B
  • Synonyms
    activin beta-B
  • Feature Type
    protein coding gene
  • IDs
    MGI:96571
    NCBI Gene: 16324
  • Gene Overview
    MyGene.info: INHBB
Location & Maps
more
  • Sequence Map
    Chr1:119415465-119422248 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      6784 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    INHBB, inhibin beta B
  • Vertebrate Orthologs
    7
  • Human Ortholog
    INHBB, inhibin beta B
    Orthology source: HomoloGene
  • Links
    NCBI Gene ID: 3625
    neXtProt AC: NX_P09529

  • Chr Location
    2cen-q13; chr2:120346143-120351807 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    20 phenotypes from 2 alleles in 3 genetic backgrounds
    15 phenotypes from multigenic genotypes
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    9
  • Chemically induced (other)
    2
  • Radiation induced
    1
  • Targeted
    6
  • Genomic Mutations
    3 involving Inhbb
  • Incidental Mutations
Some homozygotes for targeted null mutations exhibit open eyes at birth and impaired maternal nuturing. Mutant females for one line exhibit extended gestation length, retarded mammary duct elongation and alveolar morphogenesis, and are unable to nurse their pups.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034781 VEGA Gene Model | MGI Sequence Detail 6784 C57BL/6J ±  kb
transcript OTTMUST00000088399 VEGA | MGI Sequence Detail 4255 Not Applicable  
polypeptide OTTMUSP00000048169 VEGA | MGI Sequence Detail 411 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    27 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000000217 activin/inhibin beta B chain
  • InterPro Domains
    IPR029034 Cystine-knot cytokine
    IPR000381 Inhibin, beta B subunit
    IPR017948 Transforming growth factor beta, conserved site
    IPR001839 Transforming growth factor-beta, C-terminal
    IPR001111 Transforming growth factor-beta, N-terminal
    IPR015615 Transforming growth factor-beta-related
Molecular
Reagents
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  • All nucleic 87
    Genomic 7
    cDNA 76
    Primer pair 3
    Other 1

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-11408
References
more
  • Summaries
    All 97
    Developmental Gene Expression 40
    Gene Ontology 10
    Phenotypes 27
  • Earliest
    J:8262 Mason AJ, et al., Structure of two human ovarian inhibins. Biochem Biophys Res Commun. 1986 Mar 28;135(3):957-64
  • Latest
    J:225731 Nicol B, et al., Gonadal Identity in the Absence of Pro-Testis Factor SOX9 and Pro-Ovary Factor Beta-Catenin in Mice. Biol Reprod. 2015 Aug;93(2):35

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory