About   Help   FAQ
Inhbb Gene Detail
Summary
  • Symbol
    Inhbb
  • Name
    inhibin beta-B
  • Synonyms
    activin beta-B
  • Feature Type
    protein coding gene
  • IDs
    MGI:96571
    NCBI Gene: 16324
  • Gene Overview
    MyGene.info: INHBB
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr1:119415465-119422248 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      6784 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 52.29 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    INHBB, inhibin subunit beta B
  • Vertebrate Orthologs
    7
  • Human Ortholog
    INHBB, inhibin subunit beta B
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 3625
    neXtProt AC: NX_P09529
    UniProt: P09529

  • Chr Location
    2q14.2; chr2:120346143-120351807 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 2 alleles in 3 genetic backgrounds
    15 phenotypes from multigenic genotypes
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Some homozygotes for targeted null mutations exhibit open eyes at birth and impaired maternal nuturing. Mutant females for one line exhibit extended gestation length, retarded mammary duct elongation and alveolar morphogenesis, and are unable to nurse their pups.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000034781 VEGA Gene Model | MGI Sequence Detail 6784 C57BL/6J ±  kb
    transcript OTTMUST00000088399 VEGA | MGI Sequence Detail 4255 Not Applicable  
    polypeptide OTTMUSP00000048169 VEGA | MGI Sequence Detail 411 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      27 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 88
      Genomic 7
      cDNA 76
      Primer pair 4
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-11408
    References
    more
    • Summaries
      All 114
      Developmental Gene Expression 42
      Gene Ontology 11
      Phenotypes 30
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:250696 Gherardi S, et al., Menin regulates Inhbb expression through an Akt/Ezh2-mediated H3K27 histone modification. Biochim Biophys Acta. 2017 Apr;1860(4):427-437

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory