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Inhbb
Gene Detail
Symbol

Name
ID
Inhbb
inhibin beta-B
MGI:96571
Synonyms
activin
Feature Type
protein coding gene
Genetic Map
Chromosome 1
52.29 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr1:119415465-119422248 bp, - strand
From VEGA annotation of GRCm38

  6784 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1654  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 chicken; 1 zebrafish

Protein SuperFamily: activin/inhibin, beta subunit
Gene Tree: Inhbb

Human
homologs
Human Homolog INHBB, inhibin, beta B
NCBI Gene ID 3625
neXtProt AC  NX_P09529
Human Chr (Location)  2cen-q13; chr2:120346143-120351807 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Some homozygotes for targeted null mutations exhibit open eyes at birth and impaired maternal nuturing. Mutant females for one line exhibit extended gestation length, retarded mammary duct elongation and alveolar morphogenesis, and are unable to nurse their pups.
 
Interactions
Inhbb interacts with 295 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (26 annotations)
Process activin receptor signaling pathway, cellular response to cholesterol, ...
Component extracellular region, extracellular space, ...
Function cytokine activity, growth factor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (34 records)
Data Summary: Results (156)    Tissues (119)    Images (43)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 103
Northern blot 14
RT-PCR 14
RNase protection 25
cDNA source data(67)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(87) Genomic(7) cDNA(76) Primer pair(3) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000034781 (Evidence)
Ensembl Gene ModelENSMUSG00000037035 (Evidence)
Entrez Gene16324 (Evidence)
UniGene3092
DFCITC1578320, TC1716376
DoTSDT.528513, DT.91351060, DT.91552222
NIA Mouse Gene IndexU021694
Consensus CDS ProjectCCDS15224.1
International Mouse Knockout Project StatusInhbb
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034781 VEGA Gene Model | MGI Sequence Detail 6784 C57BL/6J ±  kb
transcript OTTMUST00000088399 VEGA | MGI Sequence Detail 4255 Not Applicable 
polypeptide OTTMUSP00000048169 VEGA | MGI Sequence Detail 411 Not Applicable 

For the selected sequences
All sequences(24) RefSeq(2) UniProt(1)
Polymorphisms
RFLP(1) : SNPs within 2kb(27 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000381 Inhibin, beta B subunit
InterPro IPR017948 Transforming growth factor beta, conserved site
InterPro IPR001839 Transforming growth factor-beta, C-terminal
InterPro IPR001111 Transforming growth factor-beta, N-terminal
InterPro IPR015615 Transforming growth factor-beta-related
Protein Ontology PR:000000217 activin/inhibin beta B chain
References
(Earliest) J:8262 Mason AJ, et al., Structure of two human ovarian inhibins. Biochem Biophys Res Commun. 1986 Mar 28;135(3):957-64
(Latest) J:213791 Dutta DJ, et al., Combinatorial actions of Tgfbeta and Activin ligands promote oligodendrocyte development and CNS myelination. Development. 2014 Jun;141(12):2414-28
All references(97)
Other
accession IDs
MGD-MRK-11408

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory