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Ina Gene Detail
Summary
  • Symbol
    Ina
  • Name
    internexin neuronal intermediate filament protein, alpha
  • Synonyms
    MGC:25352, NF66, NF-66
  • Feature Type
    protein coding gene
  • IDs
    MGI:96568
    NCBI Gene: 226180
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:47014698-47025327 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 39.07 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    160 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96568
protein coding gene Chr19:47014681-47025327 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025219
protein coding gene Chr19:46784275-46794874 (+)
A/J MGP_AJ_G0025195
protein coding gene Chr19:44446122-44457015 (+)
AKR/J MGP_AKRJ_G0025164
protein coding gene Chr19:45903530-45914470 (+)
BALB/cJ MGP_BALBcJ_G0025190
protein coding gene Chr19:44497285-44508159 (+)
C3H/HeJ MGP_C3HHeJ_G0024950
protein coding gene Chr19:46084442-46096297 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025633
protein coding gene Chr19:47909981-47921698 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023047
protein coding gene Chr19:43691724-43702102 (+)
CAST/EiJ MGP_CASTEiJ_G0024415
protein coding gene Chr19:45896365-45907125 (+)
CBA/J MGP_CBAJ_G0024930
protein coding gene Chr19:50334377-50346879 (+)
DBA/2J MGP_DBA2J_G0025062
protein coding gene Chr19:44258868-44269775 (+)
FVB/NJ MGP_FVBNJ_G0025023
protein coding gene Chr19:44053372-44064191 (+)
LP/J MGP_LPJ_G0025148
protein coding gene Chr19:46679910-46690550 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025054
protein coding gene Chr19:49629839-49640669 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025691
protein coding gene Chr19:46018963-46029828 (+)
PWK/PhJ MGP_PWKPhJ_G0024164
protein coding gene Chr19:44225116-44236066 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023968
protein coding gene Chr19:44669496-44680123 (+)
WSB/EiJ MGP_WSBEiJ_G0024485
protein coding gene Chr19:46166786-46177676 (+)



Homology
more
  • Human Ortholog
    INA, internexin neuronal intermediate filament protein alpha
  • Vertebrate Orthologs
    8
  • Human Ortholog
    INA, internexin neuronal intermediate filament protein alpha
    Orthology source: HomoloGene, HGNC
  • Synonyms
    NEF5, NF-66, TXBP-1
  • Links
    NCBI Gene ID: 9118
    neXtProt AC: NX_Q16352
    UniProt: Q16352

  • Chr Location
    10q24.33; chr10:103277163-103290351 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 10433
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: INA
  • Gene Tree
    Ina
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    9 phenotype references
Homozygous mice are healthy and viable, and do not exhibit any obvious abnormalities; no defects in the nervous system were detected, including brain development, axon outgrowth, or guidance.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000034336 Ensembl Gene Model | MGI Sequence Detail 10630 C57BL/6J ±  kb
transcript ENSMUST00000037636 Ensembl | MGI Sequence Detail 3240 Not Applicable  
polypeptide ENSMUSP00000041347 Ensembl | MGI Sequence Detail 501 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 9
    Genomic 1
    cDNA 7
    Other 1

    Microarray probesets 7
Other
Accession IDs
less
MGD-MRK-11403, MGI:2147669
References
more
  • Summaries
    All 55
    Developmental Gene Expression 17
    Gene Ontology 11
    Phenotypes 9
  • Earliest
    J:11497 Ching GY, et al., Structure of the gene for the neuronal intermediate filament protein alpha-internexin and functional analysis of its promoter. J Biol Chem. 1991 Oct 15;266(29):19459-68
  • Latest
    J:267504 Kiyama T, et al., Essential roles of mitochondrial biogenesis regulator Nrf1 in retinal development and homeostasis. Mol Neurodegener. 2018 Oct 17;13(1):56

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
11/26/2019
MGI 6.14
The Jackson Laboratory