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Il7r Gene Detail
Summary
  • Symbol
    Il7r
  • Name
    interleukin 7 receptor
  • Synonyms
    CD127, IL-7Ralpha, IL-7 receptor alpha chain
  • Feature Type
    protein coding gene
  • IDs
    MGI:96562
    NCBI Gene: 16197
  • Alliance
  • Transcription Start Sites
    18 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:9505874-9530262 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 15, 4.16 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    166 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96562
protein coding gene Chr15:9505874-9530270 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021716
protein coding gene Chr15:6597355-6622733 (-)
A/J MGP_AJ_G0021676
protein coding gene Chr15:6422479-6447746 (-)
AKR/J MGP_AKRJ_G0021654
protein coding gene Chr15:6583280-6606796 (-)
BALB/cJ MGP_BALBcJ_G0021683
protein coding gene Chr15:6340976-6367879 (-)
C3H/HeJ MGP_C3HHeJ_G0021459
protein coding gene Chr15:6524260-6554253 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022122
protein coding gene Chr15:6839450-6869294 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019659
protein coding gene Chr15:5940975-5964569 (-)
CAST/EiJ MGP_CASTEiJ_G0020975
protein coding gene Chr15:6599078-6622584 (-)
CBA/J MGP_CBAJ_G0021428
protein coding gene Chr15:7000950-7027540 (-)
DBA/2J MGP_DBA2J_G0021552
protein coding gene Chr15:6306854-6331479 (-)
FVB/NJ MGP_FVBNJ_G0021530
protein coding gene Chr15:6196927-6220560 (-)
LP/J MGP_LPJ_G0021620
protein coding gene Chr15:6517027-6549976 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021555
protein coding gene Chr15:7217986-7252275 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022145
protein coding gene Chr15:6560062-6583705 (-)
PWK/PhJ MGP_PWKPhJ_G0020718
protein coding gene Chr15:6444091-6467900 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020556
protein coding gene Chr15:6502334-6525719 (-)
WSB/EiJ MGP_WSBEiJ_G0021031
protein coding gene Chr15:6562808-6587374 (-)



Homology
more
  • Human Ortholog
    IL7R, interleukin 7 receptor
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IL7R, interleukin 7 receptor
  • Synonyms
    CD127, CDW127, IL7RA, IL7Ralpha, IL-7Ralpha, IL-7R-alpha, ILRA, IMD104, lnc-IL7R, sIL-7R
  • Links
    NCBI Gene ID: 3575
    neXtProt AC: NX_P16871
    UniProt: P16871

  • Chr Location
    5p13.2; chr5:35852695-35879603 (+)  GRCh38

Human Diseases
more
  • Diseases
    5 with human IL7R associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    38 phenotypes from 6 alleles in 9 genetic backgrounds
    7 phenotypes from multigenic genotypes
    246 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutations cause arrested T and B cell differentiation and severely reduced thymus and spleen cellularity. Mice homozygous for a knock-in allele show partial rescue of T cell numbers during late thymus development, and impaired CD8 T cell memory and CD4 T cell primary responses.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000003882 Ensembl Gene Model | MGI Sequence Detail 24389 C57BL/6J ±  kb
    transcript ENSMUST00000003981 Ensembl | MGI Sequence Detail 3540 Not Applicable  
    polypeptide ENSMUSP00000003981 Ensembl | MGI Sequence Detail 459 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 158
      Genomic 4
      cDNA 147
      Primer pair 7

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-11395
    References
    more
    • Summaries
      All 377
      Developmental Gene Expression 24
      Gene Ontology 13
      Phenotypes 246
    • Earliest
      J:10373 Goodwin RG, et al., Cloning of the human and murine interleukin-7 receptors: demonstration of a soluble form and homology to a new receptor superfamily. Cell. 1990 Mar 23;60(6):941-51
    • Latest
      J:340063 Roberts J, et al., Retinoic Acid-Related Orphan Receptor alpha Is Required for Generation of Th2 Cells in Type 2 Pulmonary Inflammation. J Immunol. 2023 Aug 15;211(4):626-632

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory