Il7r
Gene Detail

Symbol Name ID

Il7r interleukin 7 receptor MGI:96562

Synonyms

CD127, IL-7Ralpha, IL-7 receptor alpha chain

Feature Type

protein coding gene

Genetic Map

Chromosome 15

4.16 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)

Sequence Map

Chr15:9506161-9529876 bp, - strand From Ensembl annotation of GRCm38   23716 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1646  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: interleukin-7 receptor
Gene Tree: Il7r

Human homologs

Human Homolog		IL7R, interleukin 7 receptor
NCBI Gene ID		3575
neXtProt AC		NX_P16871
Human Synonyms		CD127, CDW127, IL7RA, IL-7R-alpha, ILRA
Human Chr (Location)		5p13; chr5:35856977-35879705 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human IL7R

Alleles and phenotypes

All alleles(7) : Targeted(7)
 

Homozygous null mutations cause arrested T and B cell differentiation and severely reduced thymus and spleen cellularity. Mice homozygous for a knock-in allele show partial rescue of T cell numbers during late thymus development, and impaired CD8 T cell memory and CD4 T cell primary responses.

 

Gene Ontology (GO) classifications

All GO classifications: (19 annotations)

Process	B cell proliferation, cell growth, ...
Component	external side of plasma membrane, integral to membrane, ...
Function	cytokine receptor activity

External Resources: FuncBase

Expression

Literature Summary: (22 records)
Data Summary: Results (28)    Tissues (14)    Images (12)
Theiler Stages: 4, 14, 21, 22, 23, 24, 25, 28

Assay Type	Results
RNA in situ	12
RT-PCR	16

cDNA source data(145)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(158) Genomic(4) cDNA(148) Primer pair(6)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000003882 (Evidence)
Entrez Gene	16197 (Evidence)
UniGene	389
DFCI	TC1574987, TC1753212
DoTS	DT.101138300, DT.521789, DT.87068859, DT.94230833
NIA Mouse Gene Index	U036001
Consensus CDS Project	CCDS27376.1
International Mouse Knockout Project Status	Il7r

Sequences

Length	Strain/Species
genomic	ENSMUSG00000003882	Ensembl Gene Model | MGI Sequence Detail	23716	C57BL/6J
transcript	ENSMUST00000003981	Ensembl | MGI Sequence Detail	3208	Not Applicable
polypeptide	ENSMUSP00000003981	Ensembl | MGI Sequence Detail	459	Not Applicable

All sequences(28) RefSeq(2) UniProt(4)

Polymorphisms

RFLP(1) : SNPs(150 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR003961	Fibronectin, type III
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR003531	Short hematopoietin receptor, family 1, conserved site
Protein Ontology	PR:000001869	interleukin-7 receptor subunit alpha

References

(Earliest) J:10373 Goodwin RG, et al., Cloning of the human and murine interleukin-7 receptors: demonstration of a soluble form and homology to a new receptor superfamily. Cell. 1990 Mar 23;60(6):941-51
(Latest) J:193283 Tani-ichi S, et al., Interleukin-7 receptor controls development and maturation of late stages of thymocyte subpopulations. Proc Natl Acad Sci U S A. 2013 Jan 8;110(2):612-7
All references(209)

Other accession IDs

MGD-MRK-11395