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Il7r
Gene Detail
Symbol

Name
ID
Il7r
interleukin 7 receptor
MGI:96562
Synonyms
CD127, IL-7Ralpha, IL-7 receptor alpha chain
Feature Type
protein coding gene
Genetic Map
Chromosome 15
4.16 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr15:9506161-9529876 bp, - strand
From Ensembl annotation of GRCm38

  23716 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1646  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: interleukin-7 receptor
Gene Tree: Il7r

Human
homologs
Human Homolog IL7R, interleukin 7 receptor
NCBI Gene ID 3575
neXtProt AC  NX_P16871
Human Synonyms  CD127, CDW127, IL7RA, IL-7R-alpha, ILRA
Human Chr (Location)  5p13; chr5:35856875-35879603 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human IL7R
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mutations cause arrested T and B cell differentiation and severely reduced thymus and spleen cellularity. Mice homozygous for a knock-in allele show partial rescue of T cell numbers during late thymus development, and impaired CD8 T cell memory and CD4 T cell primary responses.
 
Interactions
Il7r interacts with 247 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process B cell proliferation, cell growth, ...
Component external side of plasma membrane, integral component of membrane, ...
Function cytokine receptor activity
External Resources: FuncBase
Expression
Literature Summary: (22 records)
Data Summary: Results (27)    Tissues (14)    Images (12)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 12
RT-PCR 15
cDNA source data(143)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(156) Genomic(4) cDNA(146) Primer pair(6)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000003882 (Evidence)
Entrez Gene16197 (Evidence)
UniGene389
DFCITC1574987, TC1753212
DoTSDT.101138300, DT.521789, DT.87068859, DT.94230833
NIA Mouse Gene IndexU036001
PDB4NN5, 4NN6, 4NN7
Consensus CDS ProjectCCDS27376.1
International Mouse Knockout Project StatusIl7r
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000003882 Ensembl Gene Model | MGI Sequence Detail 23716 C57BL/6J ±  kb
transcript ENSMUST00000003981 Ensembl | MGI Sequence Detail 3208 Not Applicable 
polypeptide ENSMUSP00000003981 Ensembl | MGI Sequence Detail 459 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(2) UniProt(7)
Polymorphisms
RFLP(1) : SNPs within 2kb(165 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003961 Fibronectin, type III
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003531 Short hematopoietin receptor, family 1, conserved site
Protein Ontology PR:000001869 interleukin-7 receptor subunit alpha
References
(Earliest) J:10373 Goodwin RG, et al., Cloning of the human and murine interleukin-7 receptors: demonstration of a soluble form and homology to a new receptor superfamily. Cell. 1990 Mar 23;60(6):941-51
(Latest) J:211053 Miller ML, et al., Basal NF-kappaB controls IL-7 responsiveness of quiescent naive T cells. Proc Natl Acad Sci U S A. 2014 May 20;111(20):7397-402
All references(220)
Other
accession IDs
MGD-MRK-11395

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/21/2014
MGI 5.20
The Jackson Laboratory