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Il7r
Gene Detail
Symbol

Name
ID
Il7r
interleukin 7 receptor
MGI:96562
Synonyms
CD127, IL-7Ralpha, IL-7 receptor alpha chain
Feature Type
protein coding gene
Genetic Map
Chromosome 15
4.16 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr15:9506161-9529876 bp, - strand
From Ensembl annotation of GRCm38

  23716 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1646  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

HCOP human homology predictions: IL7R
Protein SuperFamily: interleukin-7 receptor
Gene Tree: Il7r

Human
homologs
IL7R, interleukin 7 receptor
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 3575
neXtProt AC: NX_P16871

Human Synonyms: CD127, CDW127, IL7RA, IL-7R-alpha, ILRA

Human Chr (Location): 5p13; chr5:35856875-35879603 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human IL7R

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Targeted(7) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mutations cause arrested T and B cell differentiation and severely reduced thymus and spleen cellularity. Mice homozygous for a knock-in allele show partial rescue of T cell numbers during late thymus development, and impaired CD8 T cell memory and CD4 T cell primary responses.
 
Interactions
Il7r interacts with 246 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process B cell proliferation, cell growth, ...
Component external side of plasma membrane, integral component of membrane, ...
Function cytokine receptor activity
External Resources: FuncBase
Expression
Literature Summary: (23 records)
Data Summary: Results (31)    Tissues (17)    Images (12)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 4
RNA in situ 12
RT-PCR 15
cDNA source data(143)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN il7r    NEW 
Molecular
reagents
All nucleic(156) Genomic(4) cDNA(146) Primer pair(6)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000003882 (Evidence)
Entrez Gene 16197 (Evidence)
UniGene 389
DFCI TC1574987, TC1753212
DoTS DT.101138300, DT.521789, DT.87068859, DT.94230833
NIA Mouse Gene Index U036001
PDB 4NN5, 4NN6, 4NN7
Consensus CDS Project CCDS27376.1
International Mouse Phenotyping Consortium Status Il7r
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000003882 Ensembl Gene Model | MGI Sequence Detail 23716 C57BL/6J ±  kb
transcript ENSMUST00000003981 Ensembl | MGI Sequence Detail 3208 Not Applicable 
polypeptide ENSMUSP00000003981 Ensembl | MGI Sequence Detail 459 Not Applicable 

For the selected sequences
All sequences(28) RefSeq(2) UniProt(4)
Polymorphisms
RFLP(1) : SNPs within 2kb(165 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003961 Fibronectin, type III
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003531 Short hematopoietin receptor, family 1, conserved site
Protein Ontology PR:000001869 interleukin-7 receptor subunit alpha
References
(Earliest) J:10373 Goodwin RG, et al., Cloning of the human and murine interleukin-7 receptors: demonstration of a soluble form and homology to a new receptor superfamily. Cell. 1990 Mar 23;60(6):941-51
(Latest) J:219556 Miyazaki M, et al., The E-Id protein axis modulates the activities of the PI3K-AKT-mTORC1-Hif1a and c-myc/p19Arf pathways to suppress innate variant TFH cell development, thymocyte expansion, and lymphomagenesis. Genes Dev. 2015 Feb 15;29(4):409-25
All references(225)
Other
accession IDs
MGD-MRK-11395

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory