Il7 MGI Mouse Gene Detail - MGI:96561

Symbol

Il7
Name

interleukin 7
Synonyms

A630026I06Rik, hlb368, Il-7

Feature Type

protein coding gene
IDs

MGI:96561
NCBI Gene: 16196
Gene Overview

MyGene.info: IL7
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr3:7572028-7613760 bp, - strand
From NCBI annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 2.02 cM
Mapping Data

20 experiments

SNPs within 2kb

355 from dbSNP Build 142
Strain Annotations

18
PCR

2
RFLP

3

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_96561	protein coding gene	Chr3:7569994-7613760 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0027051	protein coding gene	Chr3:4406587-4445793 (-)
A/J	MGP_AJ_G0027015	protein coding gene	Chr3:4667993-4716351 (-)
AKR/J	MGP_AKRJ_G0026985	protein coding gene	Chr3:4470078-4511401 (-)
BALB/cJ	MGP_BALBcJ_G0027024	protein coding gene	Chr3:4384497-4429777 (-)
C3H/HeJ	MGP_C3HHeJ_G0026764	protein coding gene	Chr3:4760316-4809286 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0027468	protein coding gene	Chr3:4943525-4986511 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024830	protein coding gene	Chr3:3728818-3773670 (-)
CAST/EiJ	MGP_CASTEiJ_G0026222	protein coding gene	Chr3:4749704-4805241 (-)
CBA/J	MGP_CBAJ_G0026742	protein coding gene	Chr3:4758412-4806477 (-)
DBA/2J	MGP_DBA2J_G0026878	protein coding gene	Chr3:4265081-4308589 (-)
FVB/NJ	MGP_FVBNJ_G0026845	protein coding gene	Chr3:4126871-4169137 (-)
LP/J	MGP_LPJ_G0026988	protein coding gene	Chr3:4894659-4936741 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026865	protein coding gene	Chr3:5794590-5850708 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027528	protein coding gene	Chr3:4338041-4378657 (-)
PWK/PhJ	MGP_PWKPhJ_G0025957	protein coding gene	Chr3:4438605-4485291 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0025760	protein coding gene	Chr3:4456840-4501179 (-)
WSB/EiJ	MGP_WSBEiJ_G0026293	protein coding gene	Chr3:4344801-4384284 (-)

Human Ortholog

IL7, interleukin 7

Vertebrate Orthologs

7

Human Ortholog

IL7, interleukin 7
Orthology source: HomoloGene, HGNC
Synonyms

IL-7
Links

HGNC:6023

NCBI Gene ID: 3574

neXtProt AC: NX_P13232

UniProt: P13232
Chr Location

8q21.13; chr8:78675870-78805523 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 680
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 macaque, rhesus
HCOP

human homology predictions: IL7
Protein SuperFamily

interleukin-7
Gene Tree

Il7

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Phenotype Summary

47 phenotypes from 8 alleles in 11 genetic backgrounds
2 phenotypes from multigenic genotypes
141 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

19
Chemically induced (ENU)

2
Endonuclease-mediated

1
Gene trapped

3
Targeted

11
Transgenic

2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

14 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

1

Mutant mice exhibit an increased white blood count.

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All GO Annotations

27
GO References

11

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

751
Tissues

56
cDNA Data

22
Literature Summary

22

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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Il7 interacts with 228 markers (Mir7-1, Mir7-2, Mir7b, ...) View All

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All Sequences

53
RefSeq

8
UniProt

4
CCDS

CCDS50859.1, CCDS84608.1
UniGene

3825

Ensembl

ENSMUSG00000040329 (Evidence)
NCBI Gene

16196

			Length	Strain/Species	Flank
genomic	16196	NCBI Gene Model \| MGI Sequence Detail	41733	C57BL/6J	± kb
transcript	NM_001313889	RefSeq \| MGI Sequence Detail	3327	C57BL/6
polypeptide	P10168	UniProt \| EBI \| MGI Sequence Detail	154	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000001317 interleukin-7

(term hierarchy)
InterPro Domains

IPR001181 Interleukin-7

IPR018049 Interleukin-7/Interleukin-9, conserved site

IPR038325 Interleukin-7 superfamily

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All nucleic 34

Genomic 1

cDNA 25

Primer pair 7

Other 1

Microarray probesets 5

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MGD-MRK-11358, MGD-MRK-11394, MGI:2441812, MGI:3575125

Summaries

All 326

Developmental Gene Expression 22

Gene Ontology 11

Phenotypes 141
Earliest

J:14594 Namen AE, et al., Stimulation of B-cell progenitors by cloned murine interleukin-7. Nature. 1988 Jun 9;333(6173):571-3
Latest

J:299441 Knop L, et al., IL-7 derived from lymph node fibroblastic reticular cells is dispensable for naive T cell homeostasis but crucial for central memory T cell survival. Eur J Immunol. 2020 Jun;50(6):846-857

TSS for Il7:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr32546	Chr3:7613771-7613785 (-)	-18 bp
Tssr32545	Chr3:7613738-7613765 (-)	8 bp
Tssr32544	Chr3:7613725-7613732 (-)	31 bp
Tssr32543	Chr3:7613694-7613704 (-)	61 bp
Tssr32542	Chr3:7613642-7613656 (-)	111 bp
Tssr32541	Chr3:7613577-7613592 (-)	175 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 03/30/2021 MGI 6.16