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Il7 Gene Detail
Summary
  • Symbol
    Il7
  • Name
    interleukin 7
  • Synonyms
    A630026I06Rik, hlb368, Il-7
  • Feature Type
    protein coding gene
  • IDs
    MGI:96561
    NCBI Gene: 16196
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:7637088-7678820 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 2.02 cM
  • Mapping Data
    20 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2688 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    2
  • RFLP
    3
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96561
 protein coding gene Chr3:7635054-7678820 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027051
 protein coding gene Chr3:4406587-4445793 (-)
A/J MGP_AJ_G0027015
 protein coding gene Chr3:4667993-4716351 (-)
AKR/J MGP_AKRJ_G0026985
 protein coding gene Chr3:4470078-4511401 (-)
BALB/cJ MGP_BALBcJ_G0027024
 protein coding gene Chr3:4384497-4429777 (-)
C3H/HeJ MGP_C3HHeJ_G0026764
 protein coding gene Chr3:4760316-4809286 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027468
 protein coding gene Chr3:4943525-4986511 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024830
 protein coding gene Chr3:3728818-3773670 (-)
CAST/EiJ MGP_CASTEiJ_G0026222
 protein coding gene Chr3:4749704-4805241 (-)
CBA/J MGP_CBAJ_G0026742
 protein coding gene Chr3:4758412-4806477 (-)
DBA/2J MGP_DBA2J_G0026878
 protein coding gene Chr3:4265081-4308589 (-)
FVB/NJ MGP_FVBNJ_G0026845
 protein coding gene Chr3:4126871-4169137 (-)
LP/J MGP_LPJ_G0026988
 protein coding gene Chr3:4894659-4936741 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026865
 protein coding gene Chr3:5794590-5850708 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027528
 protein coding gene Chr3:4338041-4378657 (-)
PWK/PhJ MGP_PWKPhJ_G0025957
 protein coding gene Chr3:4438605-4485291 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025760
 protein coding gene Chr3:4456840-4501179 (-)
WSB/EiJ MGP_WSBEiJ_G0026293
 protein coding gene Chr3:4344801-4384284 (-)



Homology
more
  • Human Ortholog
    IL7, interleukin 7
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IL7, interleukin 7
  • Synonyms
    IL-7, IMD130
  • Links
    NCBI Gene ID: 3574
    UniProt: P13232

  • Chr Location
    8q21.13; chr8:78675044-78805523 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human IL7 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    47 phenotypes from 8 alleles in 11 genetic backgrounds
    2 phenotypes from multigenic genotypes
    152 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mutant mice exhibit an increased white blood count.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    51
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    830
  • Tissues
    57
  • cDNA Data
    22
  • Literature Summary
    24
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16196 NCBI Gene Model | MGI Sequence Detail 41733 C57BL/6J ±  kb
    transcript NM_001313889 RefSeq | MGI Sequence Detail 3327 ZRU/MplStud  
    polypeptide P10168 UniProt | EBI | MGI Sequence Detail 154 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 39
      Genomic 1
      cDNA 25
      Primer pair 9
      Other 4

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-11358, MGD-MRK-11394, MGI:2441812, MGI:3575125
    References
    more
    • Summaries
      All 354
      Developmental Gene Expression 24
      Gene Ontology 15
      Phenotypes 152
    • Earliest
      J:14594 Namen AE, et al., Stimulation of B-cell progenitors by cloned murine interleukin-7. Nature. 1988 Jun 9;333(6173):571-3
    • Latest
      J:358070 Shim JA, et al., NFAT1 and NFkappaB regulates expression of the common gamma-chain cytokine receptor in activated T cells. Cell Commun Signal. 2023 Oct 30;21(1):309
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    03/25/2025
    MGI 6.24     		The Jackson Laboratory