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Il7 Gene Detail
Summary
  • Symbol
    Il7
  • Name
    interleukin 7
  • Synonyms
    A630026I06Rik, hlb368, Il-7
  • Feature Type
    protein coding gene
  • IDs
    MGI:96561
    NCBI Gene: 16196
  • Gene Overview
    MyGene.info: IL7
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:7572028-7613760 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 2.02 cM
  • Mapping Data
    20 experiments
Strain
Comparison
more
  • SNPs within 2kb
    355 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96561
protein coding gene Chr3:7569994-7613760 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027051
protein coding gene Chr3:4406587-4445793 (-)
A/J MGP_AJ_G0027015
protein coding gene Chr3:4667993-4716351 (-)
AKR/J MGP_AKRJ_G0026985
protein coding gene Chr3:4470078-4511401 (-)
BALB/cJ MGP_BALBcJ_G0027024
protein coding gene Chr3:4384497-4429777 (-)
C3H/HeJ MGP_C3HHeJ_G0026764
protein coding gene Chr3:4760316-4809286 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027468
protein coding gene Chr3:4943525-4986511 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024830
protein coding gene Chr3:3728818-3773670 (-)
CAST/EiJ MGP_CASTEiJ_G0026222
protein coding gene Chr3:4749704-4805241 (-)
CBA/J MGP_CBAJ_G0026742
protein coding gene Chr3:4758412-4806477 (-)
DBA/2J MGP_DBA2J_G0026878
protein coding gene Chr3:4265081-4308589 (-)
FVB/NJ MGP_FVBNJ_G0026845
protein coding gene Chr3:4126871-4169137 (-)
LP/J MGP_LPJ_G0026988
protein coding gene Chr3:4894659-4936741 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026865
protein coding gene Chr3:5794590-5850708 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027528
protein coding gene Chr3:4338041-4378657 (-)
PWK/PhJ MGP_PWKPhJ_G0025957
protein coding gene Chr3:4438605-4485291 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025760
protein coding gene Chr3:4456840-4501179 (-)
WSB/EiJ MGP_WSBEiJ_G0026293
protein coding gene Chr3:4344801-4384284 (-)



Homology
more
  • Human Ortholog
    IL7, interleukin 7
  • Vertebrate Orthologs
    7
  • Human Ortholog
    IL7, interleukin 7
    Orthology source: HomoloGene, HGNC
  • Synonyms
    IL-7
  • Links
    NCBI Gene ID: 3574
    neXtProt AC: NX_P13232
    UniProt: P13232

  • Chr Location
    8q21.13; chr8:78675870-78805523 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    47 phenotypes from 8 alleles in 11 genetic backgrounds
    2 phenotypes from multigenic genotypes
    134 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mutant mice exhibit an increased white blood count.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16196 NCBI Gene Model | MGI Sequence Detail 41733 C57BL/6J ±  kb
    transcript NM_001313889 RefSeq | MGI Sequence Detail 3327 C57BL/6  
    polypeptide P10168 UniProt | EBI | MGI Sequence Detail 154 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 34
      Genomic 1
      cDNA 25
      Primer pair 7
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-11358, MGD-MRK-11394, MGI:2441812, MGI:3575125
    References
    more
    • Summaries
      All 315
      Developmental Gene Expression 21
      Gene Ontology 11
      Phenotypes 134
    • Earliest
      J:14594 Namen AE, et al., Stimulation of B-cell progenitors by cloned murine interleukin-7. Nature. 1988 Jun 9;333(6173):571-3
    • Latest
      J:267505 Fan MY, et al., Differential Roles of IL-2 Signaling in Developing versus Mature Tregs. Cell Rep. 2018 Oct 30;25(5):1204-1213.e4

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    Funding Information
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    last database update
    06/18/2019
    MGI 6.14
    The Jackson Laboratory