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Il7 Gene Detail
Summary
  • Symbol
    Il7
  • Name
    interleukin 7
  • Synonyms
    A630026I06Rik, hlb368, Il-7
  • Feature Type
    protein coding gene
  • IDs
    MGI:96561
    NCBI Gene: 16196
  • Gene Overview
    MyGene.info: IL7
Location & Maps
more
  • Genetic Map
    Chromosome 3, 2.02 cM
  • Mapping Data
    20 experiments
Homology
more
  • Human Ortholog
    IL7, interleukin 7
  • Vertebrate Orthologs
    7
  • Human Ortholog
    IL7, interleukin 7
    Orthology source: HomoloGene, HGNC
  • Synonyms
    IL-7
  • Links
    NCBI Gene ID: 3574
    neXtProt AC: NX_P13232

  • Chr Location
    8q12-q13; chr8:78675872-78805523 (-)  GRCh38.p2
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    47 phenotypes from 8 alleles in 11 genetic backgrounds
    2 phenotypes from multigenic genotypes
    122 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    15
  • Chemically induced (ENU)
    2
  • Gene trapped
    3
  • Targeted
    8
  • Transgenic
    2
  • Incidental Mutations
    Mutagenetix , APF
Mutant mice exhibit an increased white blood count.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    24
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    88
  • Tissues
    39
  • cDNA Data
    21
  • Literature Summary
    20
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000051379 VEGA Gene Model | MGI Sequence Detail 43767 C57BL/6J ±  kb
transcript OTTMUST00000129912 VEGA | MGI Sequence Detail 4858 Not Applicable  
polypeptide OTTMUSP00000069723 VEGA | MGI Sequence Detail 154 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    376 from dbSNP Build 142
  • PCR
    2
  • RFLP
    3
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000001317 interleukin-7
  • InterPro Domains
    IPR001181 Interleukin-7
    IPR018049 Interleukin-7/Interleukin-9, conserved site
    IPR000226 Interleukin-7/interleukin-9 family
Molecular
Reagents
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  • All nucleic 33
    Genomic 1
    cDNA 24
    Primer pair 7
    Other 1

    Microarray probesets 5
Other
Accession IDs
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MGD-MRK-11358, MGD-MRK-11394, MGI:2441812, MGI:3575125
References
more
  • Summaries
    All 242
    Developmental Gene Expression 20
    Gene Ontology 10
    Phenotypes 122
  • Earliest
    J:14594 Namen AE, et al., Stimulation of B-cell progenitors by cloned murine interleukin-7. Nature. 1988 Jun 9;333(6173):571-3
  • Latest
    J:234398 Jung YW, et al., CCR7 expression alters memory CD8 T-cell homeostasis by regulating occupancy in IL-7- and IL-15-dependent niches. Proc Natl Acad Sci U S A. 2016 Jul 19;113(29):8278-83
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/13/2016
MGI 6.05 		The Jackson Laboratory