Il7 MGI Mouse Gene Detail - MGI:96561

Il7 Gene Detail

Symbol

Il7
Name

interleukin 7
Synonyms

A630026I06Rik, hlb368, Il-7

Feature Type

protein coding gene
IDs

MGI:96561
NCBI Gene: 16196
Gene Overview

MyGene.info: IL7
Alliance

gene page

Sequence Map

Chr3:7569994-7613760 bp, - strand
From VEGA annotation of GRCm38

Mouse Genome Browser
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Sequence

43767 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 2.02 cM
Mapping Data

20 experiments

Human Ortholog

IL7, interleukin 7

Vertebrate Orthologs

7

Human Ortholog

IL7, interleukin 7
Orthology source: HomoloGene, HGNC
Synonyms

IL-7
Links

HGNC:6023

NCBI Gene ID: 3574

neXtProt AC: NX_P13232

UniProt: P13232
Chr Location

8q21.13; chr8:78675870-78805523 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 680
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 macaque, rhesus
HCOP

human homology predictions: IL7
Protein SuperFamily

interleukin-7
Gene Tree

Il7

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Phenotype Summary

47 phenotypes from 8 alleles in 11 genetic backgrounds
2 phenotypes from multigenic genotypes
123 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

15
Chemically induced (ENU)

2
Gene trapped

3
Targeted

8
Transgenic

2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

22 strains or lines available

Mutant mice exhibit an increased white blood count.

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All GO Annotations

21
GO References

9

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

118
Tissues

55
cDNA Data

21
Literature Summary

20

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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Il7 interacts with 228 markers (Mir7-1, Mir7-2, Mir7b, ...) View All

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All Sequences

45
RefSeq

8
UniProt

4
CCDS

CCDS50859.1, CCDS84608.1
UniGene

3825

			Length	Strain/Species	Flank
genomic	OTTMUSG00000051379	VEGA Gene Model \| MGI Sequence Detail	43767	C57BL/6J	± kb
transcript	OTTMUST00000129912	VEGA \| MGI Sequence Detail	4858	Not Applicable
polypeptide	OTTMUSP00000069723	VEGA \| MGI Sequence Detail	154	Not Applicable

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SNPs within 2kb

376 from dbSNP Build 142

PCR

2
RFLP

3

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UniProt

4 Sequences
Protein Ontology

PR:000001317 interleukin-7

(term hierarchy)
InterPro Domains

IPR001181 Interleukin-7

IPR018049 Interleukin-7/Interleukin-9, conserved site

IPR000226 Interleukin-7/interleukin-9 family

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All nucleic 33

Genomic 1

cDNA 24

Primer pair 7

Other 1

Microarray probesets 5

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MGD-MRK-11358, MGD-MRK-11394, MGI:2441812, MGI:3575125

Summaries

All 253

Developmental Gene Expression 20

Gene Ontology 9

Phenotypes 123
Earliest

J:14594 Namen AE, et al., Stimulation of B-cell progenitors by cloned murine interleukin-7. Nature. 1988 Jun 9;333(6173):571-3
Latest

J:239080 von Muenchow L, et al., Permissive roles of cytokines interleukin-7 and Flt3 ligand in mouse B-cell lineage commitment. Proc Natl Acad Sci U S A. 2016 Dec 13;113(50):E8122-E8130

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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