Il7
Gene Detail

Symbol Name ID

Il7 interleukin 7 MGI:96561

Synonyms

A630026I06Rik, hlb368, Il-7

Feature Type

protein coding gene

Genetic Map

Chromosome 3

2.02 cM
Detailed Genetic Map ± 1 cM


Mapping data(20)

Sequence Map

Chr3:7572077-7613427 bp, - strand From NCBI annotation of GRCm38   41351 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:680  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog

Protein SuperFamily: interleukin-7
Gene Tree: Il7

Human homologs

Human Homolog		IL7, interleukin 7
NCBI Gene ID		3574
neXtProt AC		NX_P13232
Human Synonyms		IL-7
Human Chr (Location)		8q12-q13; chr8:78732772-78805523 (-)  GRCh38

Mutations, alleles, and phenotypes

All mutations/alleles(12) : Chemically induced (ENU)(2) Gene trapped(3) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 

Mutant mice exhibit an increased white blood count.

 

Interactions

Il7 interacts with 228 markers (Mir7-1, Mir7-2, Mir7b, ...)

View All

Gene Ontology (GO) classifications

All GO classifications: (21 annotations)

Process	bone resorption, homeostasis of number of cells within a tissue, ...
Component	extracellular region, extracellular space
Function	cytokine activity, cytokine receptor binding, ...

External Resources: FuncBase

Expression

Literature Summary: (18 records)

Data Summary: Results (88)    Tissues (35)    Images (2)
Theiler Stages: 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
RT-PCR	83
Nuclease S1	5

cDNA source data(21)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular reagents

All nucleic(33) Genomic(1) cDNA(24) Primer pair(7) Other(1)
Microarray probesets(5)

Other database links

Ensembl Gene Model	ENSMUSG00000040329 (Evidence)
Entrez Gene	16196 (Evidence)
UniGene	3825
DFCI	TC1581857, TC1688886
DoTS	DT.101231566, DT.101299795, DT.40135866, DT.97396503
NIA Mouse Gene Index	U023811
Consensus CDS Project	CCDS50859.1
International Mouse Knockout Project Status	Il7

Sequences

Length	Strain/Species
genomic	16196	NCBI Gene Model | MGI Sequence Detail	41351	C57BL/6J
transcript	NM_008371	RefSeq | MGI Sequence Detail	2475	C57BL/6
polypeptide	P10168	UniProt | EBI | MGI Sequence Detail	154	Not Applicable

All sequences(31) RefSeq(4) UniProt(4)

Polymorphisms

All PCR and RFLP(5) : PCR(2) RFLP(3) SNPs within 2kb(359 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR001181	Interleukin-7
InterPro	IPR018049	Interleukin-7/-9, conserved site
InterPro	IPR000226	Interleukin-7/interleukin-9
Protein Ontology	PR:000001317	interleukin-7

Graphical View of Protein Domain Structure

References

(Earliest) J:14594 Namen AE, et al., Stimulation of B-cell progenitors by cloned murine interleukin-7. Nature. 1988 Jun 9;333(6173):571-3
(Latest) J:204845 Ishigame H, et al., Truncated form of TGF-betaRII, but not its absence, induces memory CD8+ T cell expansion and lymphoproliferative disorder in mice. J Immunol. 2013 Jun 15;190(12):6340-50
All references(236)

Other accession IDs

MGD-MRK-11358, MGD-MRK-11394, MGI:2441812, MGI:3575125