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Il7
Gene Detail
Symbol

Name
ID
Il7
interleukin 7
MGI:96561
Synonyms
A630026I06Rik, hlb368, Il-7
Feature Type
protein coding gene
Genetic Map
Chromosome 3
2.02 cM
Detailed Genetic Map ± 1 cM


Mapping data(20)
Sequence Map
Chr3:7569994-7613760 bp, - strand
From VEGA annotation of GRCm38

  43767 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:680  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: IL7
Protein SuperFamily: interleukin-7
Gene Tree: Il7

Human
homologs
IL7, interleukin 7
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 3574
neXtProt AC: NX_P13232

Human Synonyms: IL-7

Human Chr (Location): 8q12-q13; chr8:78675872-78805523 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(14) : Chemically induced (ENU)(2) Gene trapped(3) Targeted(8) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF )
 
Mutant mice exhibit an increased white blood count.
 
Interactions
Il7 interacts with 228 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (24 annotations)
Process bone resorption, cell-cell signaling, ...
Component extracellular region, extracellular space
Function cytokine activity, cytokine receptor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (20 records)
Data Summary: Results (88)    Tissues (39)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 83
Nuclease S1 5
cDNA source data(21)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(33) Genomic(1) cDNA(24) Primer pair(7) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000051379 (Evidence)
Ensembl Gene Model ENSMUSG00000040329 (Evidence)
Entrez Gene 16196 (Evidence)
UniGene 3825
DFCI TC1581857, TC1688886
DoTS DT.101231566, DT.101299795, DT.40135866, DT.97396503
NIA Mouse Gene Index U023811
Consensus CDS Project CCDS50859.1
International Mouse Phenotyping Consortium Status Il7
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000051379 VEGA Gene Model | MGI Sequence Detail 43767 C57BL/6J ±  kb
transcript OTTMUST00000129912 VEGA | MGI Sequence Detail 4858 Not Applicable 
polypeptide OTTMUSP00000069723 VEGA | MGI Sequence Detail 154 Not Applicable 

For the selected sequences
All sequences(48) RefSeq(4) UniProt(4)
Polymorphisms
All PCR and RFLP(5) : PCR(2) RFLP(3) SNPs within 2kb(380 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001181 Interleukin-7
InterPro IPR018049 Interleukin-7/Interleukin-9, conserved site
InterPro IPR000226 Interleukin-7/interleukin-9 family
Protein Ontology PR:000001317 interleukin-7
References
(Earliest) J:14594 Namen AE, et al., Stimulation of B-cell progenitors by cloned murine interleukin-7. Nature. 1988 Jun 9;333(6173):571-3
(Latest) J:217502 Chojnowski JL, et al., Multiple roles for HOXA3 in regulating thymus and parathyroid differentiation and morphogenesis in mouse. Development. 2014 Oct;141(19):3697-708
All references(238)
Other
accession IDs
MGD-MRK-11358, MGD-MRK-11394, MGI:2441812, MGI:3575125

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory