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Il7
Gene Detail
 Symbol
Name
ID
Il7
interleukin 7
MGI:96561
Synonyms A630026I06Rik, hlb368, Il-7
Feature Type protein coding gene
Genetic Map
Chromosome 3
2.02 cM
Detailed Genetic Map ± 1 cM


Mapping data(20)
Sequence Map
Chr3:7572077-7613427 bp, - strand
From NCBI annotation of GRCm38

  41351 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:680  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog

Protein SuperFamily: interleukin-7
Gene Tree: Il7

Human
homologs
Human Homolog IL7, interleukin 7
NCBI Gene ID 3574
neXtProt AC  NX_P13232
Human Synonyms  IL-7
Human Chr (Location)  8q12-q13; chr8:78732772-78805523 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Chemically induced (ENU)(2) Gene trapped(3) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Mutant mice exhibit an increased white blood count.
 
Interactions
Il7 interacts with 228 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process bone resorption, homeostasis of number of cells within a tissue, ...
Component extracellular region, extracellular space
Function cytokine activity, cytokine receptor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (18 records)
Data Summary: Results (88)    Tissues (35)    Images (2)
Theiler Stages: 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
RT-PCR 83
Nuclease S1 5
cDNA source data(21)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(33) Genomic(1) cDNA(24) Primer pair(7) Other(1)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000040329 (Evidence)
Entrez Gene16196 (Evidence)
UniGene3825
DFCITC1581857, TC1688886
DoTSDT.101231566, DT.101299795, DT.40135866, DT.97396503
NIA Mouse Gene IndexU023811
Consensus CDS ProjectCCDS50859.1
International Mouse Knockout Project StatusIl7
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 16196 NCBI Gene Model | MGI Sequence Detail 41351 C57BL/6J ±  kb
transcript NM_008371 RefSeq | MGI Sequence Detail 2475 C57BL/6 
polypeptide P10168 UniProt | EBI | MGI Sequence Detail 154 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(4) UniProt(4)
Polymorphisms All PCR and RFLP(5) : PCR(2) RFLP(3) SNPs within 2kb(359 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001181 Interleukin-7
InterPro IPR018049 Interleukin-7/-9, conserved site
InterPro IPR000226 Interleukin-7/interleukin-9
Protein Ontology PR:000001317 interleukin-7
Graphical View of Protein Domain Structure
References (Earliest) J:14594 Namen AE, et al., Stimulation of B-cell progenitors by cloned murine interleukin-7. Nature. 1988 Jun 9;333(6173):571-3
(Latest) J:204845 Ishigame H, et al., Truncated form of TGF-betaRII, but not its absence, induces memory CD8+ T cell expansion and lymphoproliferative disorder in mice. J Immunol. 2013 Jun 15;190(12):6340-50
All references(236)
Other
accession IDs
MGD-MRK-11358, MGD-MRK-11394, MGI:2441812, MGI:3575125

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory