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Il7
Gene Detail
Symbol

Name
ID
Il7
interleukin 7
MGI:96561
Synonyms
A630026I06Rik, hlb368, Il-7
Feature Type
protein coding gene
Genetic Map
Chromosome 3
2.02 cM
Detailed Genetic Map ± 1 cM


Mapping data(20)
Sequence Map
Chr3:7572077-7613427 bp, - strand
From Ensembl annotation of GRCm38

  41351 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:680  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: interleukin-7
Gene Tree: Il7

Human
homologs
Human Homolog IL7, interleukin 7
NCBI Gene ID 3574
neXtProt AC  NX_P13232
Human Synonyms  IL-7
Human Chr (Location)  8q12-q13; chr8:78732772-78805523 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Chemically induced (ENU)(2) Gene trapped(3) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Mutant mice exhibit an increased white blood count.
 
Interactions
Il7 interacts with 228 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (24 annotations)
Process bone resorption, cell-cell signaling, ...
Component extracellular region, extracellular space
Function cytokine activity, cytokine receptor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (19 records)
Data Summary: Results (88)    Tissues (39)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 83
Nuclease S1 5
cDNA source data(21)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(33) Genomic(1) cDNA(24) Primer pair(7) Other(1)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000040329 (Evidence)
Entrez Gene16196 (Evidence)
UniGene3825
DFCITC1581857, TC1688886
DoTSDT.101231566, DT.101299795, DT.40135866, DT.97396503
NIA Mouse Gene IndexU023811
Consensus CDS ProjectCCDS50859.1
International Mouse Knockout Project StatusIl7
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000040329 Ensembl Gene Model | MGI Sequence Detail 41351 C57BL/6J ±  kb
transcript ENSMUST00000168269 Ensembl | MGI Sequence Detail 2475 Not Applicable 
polypeptide ENSMUSP00000126219 Ensembl | MGI Sequence Detail 154 Not Applicable 

For the selected sequences
All sequences(34) RefSeq(4) UniProt(7)
Polymorphisms
All PCR and RFLP(5) : PCR(2) RFLP(3) SNPs within 2kb(359 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001181 Interleukin-7
InterPro IPR018049 Interleukin-7/-9, conserved site
InterPro IPR000226 Interleukin-7/interleukin-9
Protein Ontology PR:000001317 interleukin-7
References
(Earliest) J:14594 Namen AE, et al., Stimulation of B-cell progenitors by cloned murine interleukin-7. Nature. 1988 Jun 9;333(6173):571-3
(Latest) J:214094 Reeh KA, et al., Ectopic TBX1 suppresses thymic epithelial cell differentiation and proliferation during thymus organogenesis. Development. 2014 Aug;141(15):2950-8
All references(239)
Other
accession IDs
MGD-MRK-11358, MGD-MRK-11394, MGI:2441812, MGI:3575125

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory