Il5ra
Gene Detail

Symbol Name ID

Il5ra interleukin 5 receptor, alpha MGI:96558

Synonyms

CD125, CDw125, Il5r, IL-5 receptor alpha chain

Feature Type

protein coding gene

Genetic Map

Chromosome 6

49.19 cM
Detailed Genetic Map ± 1 cM


Mapping data(23)

Sequence Map

Chr6:106711975-106745109 bp, - strand From Ensembl annotation of GRCm38   33135 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:473  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: interleukin-5 receptor, alpha chain
Gene Tree: Il5ra

Human homologs

Human Homolog		IL5RA, interleukin 5 receptor, alpha
NCBI Gene ID		3568
neXtProt AC		NX_Q01344
Human Synonyms		CD125, CDw125, HSIL5R3, IL5R
Human Chr (Location)		3p26-p24; chr3:3108008-3152058 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(2) : Targeted(2)
 

Mice homozygous for disruptions in this gene display a generally normal phenotype but with some immune system deficiencies. Mice homozygous for one knock-out allele exhibit increased metastasis of injected B16F10 melanoma cells.

 

Gene Ontology (GO) classifications

All GO classifications: (7 annotations)

Process	cellular response to organic substance, inflammatory response to antigenic stimulus, ...
Component	integral to membrane, membrane
Function	cytokine receptor activity

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (2)    Tissues (2)   
Theiler Stages: 4

Assay Type	Results
RT-PCR	2

cDNA source data(11)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(18) Genomic(5) cDNA(11) Primer pair(2)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000005364 (Evidence)
Entrez Gene	16192 (Evidence)
UniGene	3448
DFCI	TC1595935
DoTS	DT.110499356, DT.55123970
NIA Mouse Gene Index	U027700
Consensus CDS Project	CCDS20396.1
International Mouse Knockout Project Status	Il5ra

Sequences

Length	Strain/Species
genomic	ENSMUSG00000005364	Ensembl Gene Model | MGI Sequence Detail	33135	C57BL/6J
transcript	ENSMUST00000167925	Ensembl | MGI Sequence Detail	1704	Not Applicable
polypeptide	ENSMUSP00000129781	Ensembl | MGI Sequence Detail	415	Not Applicable

All sequences(17) RefSeq(2) UniProt(3)

Polymorphisms

All PCR and RFLP(3) : PCR(1) RFLP(2) SNPs(334 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR003961	Fibronectin, type III
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR015321	Interleukin-6 receptor alpha chain, binding
InterPro	IPR003532	Short hematopoietin receptor, family 2, conserved site
Protein Ontology	PR:000001867	interleukin-5 receptor subunit alpha

References

(Earliest) J:10912 Takaki S, et al., Molecular cloning and expression of the murine interleukin-5 receptor. EMBO J. 1990 Dec;9(13):4367-74
(Latest) J:180790 Ikutani M, et al., Identification of innate IL-5-producing cells and their role in lung eosinophil regulation and antitumor immunity. J Immunol. 2012 Jan 15;188(2):703-13
All references(69)

Other accession IDs

MGD-MRK-11388, MGD-MRK-11389