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Il5ra Gene Detail
Summary
  • Symbol
    Il5ra
  • Name
    interleukin 5 receptor, alpha
  • Synonyms
    CD125, CDw125, Il5r, IL-5 receptor alpha chain
  • Feature Type
    protein coding gene
  • IDs
    MGI:96558
    NCBI Gene: 16192
Location & Maps
more
  • Sequence Map
    Chr6:106710357-106749037 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      38681 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 49.19 cM
  • Mapping Data
    23 experiments
Homology
more
  • Human Ortholog
    IL5RA, interleukin 5 receptor subunit alpha
  • Vertebrate Orthologs
    8
  • Human Ortholog
    IL5RA, interleukin 5 receptor subunit alpha
    Orthology source: HomoloGene
  • Synonyms
    CD125, CDw125, HSIL5R3, IL5R
  • Links
    NCBI Gene ID: 3568
    neXtProt AC: NX_Q01344

  • Chr Location
    3p26-p24; chr3:3066324-3110374 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotypes from 1 allele in 3 genetic backgrounds
    11 phenotypes from multigenic genotypes
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    3
  • Spontaneous
    1
  • Targeted
    2
  • Genomic Mutations
    1 involving Il5ra
  • Incidental Mutations
Mice homozygous for disruptions in this gene display a generally normal phenotype but with some immune system deficiencies. Mice homozygous for one knock-out allele exhibit increased metastasis of injected B16F10 melanoma cells.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000056402 VEGA Gene Model | MGI Sequence Detail 38681 C57BL/6J ±  kb
transcript OTTMUST00000139354 VEGA | MGI Sequence Detail 3575 Not Applicable  
polypeptide OTTMUSP00000073126 VEGA | MGI Sequence Detail 415 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    544 from dbSNP Build 142
  • PCR
  • RFLP
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000001867 interleukin-5 receptor subunit alpha
  • InterPro Domains
    IPR003961 Fibronectin type III
    IPR013783 Immunoglobulin-like fold
    IPR003532 Short hematopoietin receptor, family 2, conserved site
    IPR015321 Type I cytokine receptor, cytokine-binding domain
Molecular
Reagents
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  • All nucleic 18
    Genomic 5
    cDNA 11
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-11388, MGD-MRK-11389
References
more
  • Summaries
    All 65
    Developmental Gene Expression 2
    Gene Ontology 3
    Phenotypes 15
  • Earliest
    J:10912 Takaki S, et al., Molecular cloning and expression of the murine interleukin-5 receptor. EMBO J. 1990 Dec;9(13):4367-74
  • Latest
    J:180790 Ikutani M, et al., Identification of innate IL-5-producing cells and their role in lung eosinophil regulation and antitumor immunity. J Immunol. 2012 Jan 15;188(2):703-13

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory