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Il5ra
Gene Detail
 Symbol
Name
ID
Il5ra
interleukin 5 receptor, alpha
MGI:96558
Synonyms CD125, CDw125, Il5r, IL-5 receptor alpha chain
Feature Type protein coding gene
Genetic Map
Chromosome 6
49.19 cM
Detailed Genetic Map ± 1 cM


Mapping data(23)
Sequence Map
Chr6:106711975-106745109 bp, - strand
From Ensembl annotation of GRCm38

  33135 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:473  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: interleukin-5 receptor, alpha chain
Gene Tree: Il5ra

Human
homologs
Human Homolog IL5RA, interleukin 5 receptor, alpha
NCBI Gene ID 3568
neXtProt AC  NX_Q01344
Human Synonyms  CD125, CDw125, HSIL5R3, IL5R
Human Chr (Location)  3p26-p24; chr3:3066324-3110374 (-)  GRCh38
Alleles
and
phenotypes
All alleles(2) : Targeted(2)
 
Mice homozygous for disruptions in this gene display a generally normal phenotype but with some immune system deficiencies. Mice homozygous for one knock-out allele exhibit increased metastasis of injected B16F10 melanoma cells.
 
Gene Ontology
(GO)
classifications
All GO classifications: (7 annotations)
Process cellular response to organic substance, inflammatory response to antigenic stimulus, ...
Component integral component of membrane, membrane
Function cytokine receptor activity
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (2)    Tissues (2)   
Theiler Stages: 4
Assay TypeResults
RT-PCR 2
cDNA source data(11)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(18) Genomic(5) cDNA(11) Primer pair(2)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000005364 (Evidence)
Entrez Gene16192 (Evidence)
UniGene3448
DFCITC1595935
DoTSDT.110499356, DT.55123970
NIA Mouse Gene IndexU027700
Consensus CDS ProjectCCDS20396.1
International Mouse Knockout Project StatusIl5ra
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000005364 Ensembl Gene Model | MGI Sequence Detail 33135 C57BL/6J ±  kb
transcript ENSMUST00000167925 Ensembl | MGI Sequence Detail 1704 Not Applicable 
polypeptide ENSMUSP00000129781 Ensembl | MGI Sequence Detail 415 Not Applicable 

For the selected sequences
All sequences(19) RefSeq(4) UniProt(3)
Polymorphisms All PCR and RFLP(3) : PCR(1) RFLP(2) SNPs within 2kb(530 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003961 Fibronectin, type III
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR015321 Interleukin-6 receptor alpha chain, binding
InterPro IPR003532 Short hematopoietin receptor, family 2, conserved site
Protein Ontology PR:000001867 interleukin-5 receptor subunit alpha
References (Earliest) J:10912 Takaki S, et al., Molecular cloning and expression of the murine interleukin-5 receptor. EMBO J. 1990 Dec;9(13):4367-74
(Latest) J:180790 Ikutani M, et al., Identification of innate IL-5-producing cells and their role in lung eosinophil regulation and antitumor immunity. J Immunol. 2012 Jan 15;188(2):703-13
All references(69)
Other
accession IDs
MGD-MRK-11388, MGD-MRK-11389

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory