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Il3ra Gene Detail
Summary
  • Symbol
    Il3ra
  • Name
    interleukin 3 receptor, alpha chain
  • Synonyms
    CD123, IL-3 receptor alpha chain, SUT-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:96553
    NCBI Gene: 16188
  • Gene Overview
    MyGene.info: IL3RA
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:14346001-14355493 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 7.08 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    134 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96553
protein coding gene Chr14:14346001-14356011 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021009
protein coding gene Chr14:6866373-6875384 (+)
A/J MGP_AJ_G0020957
protein coding gene Chr14:6713141-6722133 (+)
AKR/J MGP_AKRJ_G0020934
protein coding gene Chr14:6818215-6827207 (+)
BALB/cJ MGP_BALBcJ_G0020960
protein coding gene Chr14:6723206-6732191 (+)
C3H/HeJ MGP_C3HHeJ_G0020744
protein coding gene Chr14:6906339-6915361 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021393
protein coding gene Chr14:7059336-7068331 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018962
protein coding gene Chr14:7390101-7399333 (+)
CAST/EiJ MGP_CASTEiJ_G0020266
protein coding gene Chr14:6857030-6866025 (+)
CBA/J MGP_CBAJ_G0020710
protein coding gene Chr14:7345525-7354501 (+)
DBA/2J MGP_DBA2J_G0020833
protein coding gene Chr14:6640655-6649684 (+)
FVB/NJ MGP_FVBNJ_G0020815
protein coding gene Chr14:6550157-6559152 (+)
LP/J MGP_LPJ_G0020909
protein coding gene Chr14:6897940-6907005 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020841
protein coding gene Chr14:7375180-7384175 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021426
protein coding gene Chr14:6778848-6787840 (+)
PWK/PhJ MGP_PWKPhJ_G0020018
protein coding gene Chr14:6631587-6640571 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019838
protein coding gene Chr14:6901449-6910486 (+)
WSB/EiJ MGP_WSBEiJ_G0020324
protein coding gene Chr14:6801398-6810383 (+)



Homology
more
  • Human Ortholog
    IL3RA, interleukin 3 receptor subunit alpha
  • Vertebrate Orthologs
    6
  • Human Ortholog
    IL3RA, interleukin 3 receptor subunit alpha
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CD123, hIL-3Ra, IL3R, IL3RAY, IL3RX, IL3RY
  • Links
    NCBI Gene ID: 3563
    neXtProt AC: NX_P26951
    UniProt: P26951

  • Chr Location
    XYp22.33 and Yp11.2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 10 genetic backgrounds
    3 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
A number of distantly related inbred mouse strains carrying an identical spontaneous deletion at the branch point in intron 7 exhibit a reduced capacity of bone marrow cells to form colonies in response to interleukin-3 in CFU-GM assays.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 16188 NCBI Gene Model | MGI Sequence Detail 9493 C57BL/6J ±  kb
transcript NM_008369 RefSeq | MGI Sequence Detail 1394 B6.S  
polypeptide P26952 UniProt | EBI | MGI Sequence Detail 396 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000001865 interleukin-3 receptor class 2 alpha chain
  • InterPro Domains
    IPR036116 Fibronectin type III superfamily
    IPR013783 Immunoglobulin-like fold
    IPR003532 Short hematopoietin receptor, family 2, conserved site
    IPR015321 Type I cytokine receptor, cytokine-binding domain
Molecular
Reagents
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  • All nucleic 26
    Genomic 7
    cDNA 14
    Primer pair 5

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-11381
References
more
  • Summaries
    All 37
    Developmental Gene Expression 4
    Gene Ontology 3
    Phenotypes 3
  • Earliest
    J:670 Hara T, et al., cDNA cloning of a mouse IL-3 receptor alpha subunit. FASEB J. 1992;6(5):A1606 (Abstr.)
  • Latest
    J:241037 Clarke M, et al., Transcriptional regulation of SPROUTY2 by MYB influences myeloid cell proliferation and stem cell properties by enhancing responsiveness to IL-3. Leukemia. 2017 Apr;31(4):957-966

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
06/11/2019
MGI 6.14
The Jackson Laboratory