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Il3ra
Gene Detail
 Symbol
Name
ID
Il3ra
interleukin 3 receptor, alpha chain
MGI:96553
Synonyms CD123, IL-3 receptor alpha chain, SUT-1
Feature Type protein coding gene
Genetic Map
Chromosome 14
7.08 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr14:14346495-14355490 bp, + strand
From NCBI annotation of GRCm38

  8996 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:48088  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog

Gene Tree: Il3ra

Human
homologs
Human Homolog IL3RA, interleukin 3 receptor, alpha (low affinity)
NCBI Gene ID 3563
neXtProt AC  NX_P26951
Human Synonyms  CD123, hIL-3Ra, IL3R, IL3RAY, IL3RX, IL3RY
Human Chr (Location)  XYp22.3 or Yp11.3
Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Spontaneous(1)
Incidental mutations (data from Mutagenetix , APF )
 
A number of distantly related inbred mouse strains carrying an identical spontaneous deletion at the branch point in intron 7 exhibit a reduced capacity of bone marrow cells to form colonies in response to interleukin-3 in CFU-GM assays.
 
Interactions
Il3ra interacts with 5 markers (Mir210, Mir335, Mir503, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (5 annotations)
Component integral component of membrane, membrane, ...
Function cytokine receptor activity
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (3)    Tissues (3)   
Theiler Stages: 4, 14, 28
Assay TypeResults
RT-PCR 3
cDNA source data(14)
External Resources: GEO   Expression Atlas
Molecular
reagents
All nucleic(25) Genomic(7) cDNA(14) Primer pair(4)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000068758 (Evidence)
Entrez Gene16188 (Evidence)
UniGene425857
DFCITC1587384
DoTSDT.40144480, DT.94131084
NIA Mouse Gene IndexU015324
Consensus CDS ProjectCCDS26827.1
International Mouse Knockout Project StatusIl3ra
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 16188 NCBI Gene Model | MGI Sequence Detail 8996 C57BL/6J ±  kb
transcript NM_008369 RefSeq | MGI Sequence Detail 1394 B6.S 
polypeptide P26952 UniProt | EBI | MGI Sequence Detail 396 Not Applicable 

For the selected sequences
All sequences(57) RefSeq(40) UniProt(1)
Polymorphisms All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(133 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003961 Fibronectin, type III
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR015321 Interleukin-6 receptor alpha chain, binding
InterPro IPR003532 Short hematopoietin receptor, family 2, conserved site
Protein Ontology PR:000001865 interleukin-3 receptor class 2 alpha chain
Graphical View of Protein Domain Structure
References (Earliest) J:670 Hara T, et al., cDNA cloning of a mouse IL-3 receptor alpha subunit. FASEB J. 1992;6(5):A1606 (Abstr.)
(Latest) J:147898 Chen J, et al., A new isoform of interleukin-3 receptor {alpha} with novel differentiation activity and high affinity binding mode. J Biol Chem. 2009 Feb 27;284(9):5763-73
All references(35)
Other
accession IDs
MGD-MRK-11381

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory