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Il10ra
Gene Detail
 Symbol
Name
ID
Il10ra
interleukin 10 receptor, alpha
MGI:96538
Synonyms CDw210, Il10r, mIL-10R
Feature Type protein coding gene
Genetic Map
Chromosome 9
24.84 cM
Detailed Genetic Map ± 1 cM


Mapping data(9)
Sequence Map
Chr9:45253837-45269149 bp, - strand
From VEGA annotation of GRCm38

  15313 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1196  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: interleukin-10 receptor, alpha chain
Gene Tree: Il10ra

Human
homologs
Human Homolog IL10RA, interleukin 10 receptor, alpha
NCBI Gene ID 3587
neXtProt AC  NX_Q13651
Human Synonyms  CD210, CD210a, CDW210A, HIL-10R, IL10R, IL-10R1
Human Chr (Location)  11q23; chr11:117986386-118001483 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human IL10RA
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Chemically induced (ENU)(1) Spontaneous(1) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for an ENU-generated null allele suffer from a severe inflammatory bowel syndrome. Mice heterozygote for an NZW variant allele have high sera levels of anti-chromatin antibodies. Mice homozygous for a knock-out allele exhibit increased susceptibility to induced colitis.
 
Interactions
Il10ra interacts with 255 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (6 annotations)
Process cytokine-mediated signaling pathway
Component integral component of membrane, membrane, ...
Function interleukin-10 binding, interleukin-10 receptor activity
External Resources: FuncBase
Expression
cDNA source data(20)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(23) cDNA(20) Primer pair(1) Other(2)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000042168 (Evidence)
Ensembl Gene ModelENSMUSG00000032089 (Evidence)
Entrez Gene16154 (Evidence)
UniGene379327
DFCITC1578204
DoTSDT.101386521, DT.40185631
NIA Mouse Gene IndexU030795
Consensus CDS ProjectCCDS23131.1
International Mouse Knockout Project StatusIl10ra
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000042168 VEGA Gene Model | MGI Sequence Detail 15313 C57BL/6J ±  kb
transcript OTTMUST00000110675 VEGA | MGI Sequence Detail 3498 Not Applicable 
polypeptide OTTMUSP00000061774 VEGA | MGI Sequence Detail 575 Not Applicable 

For the selected sequences
All sequences(40) RefSeq(2) UniProt(7)
Polymorphisms SNPs within 2kb(210 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003961 Fibronectin, type III
InterPro IPR013783 Immunoglobulin-like fold
Protein Ontology PR:000001365 interleukin-10 receptor subunit alpha
References (Earliest) J:16339 Ho AS, et al., A receptor for interleukin 10 is related to interferon receptors. Proc Natl Acad Sci U S A. 1993 Dec 1;90(23):11267-71
(Latest) J:207314 Kominsky DJ, et al., IFN-gamma-mediated induction of an apical IL-10 receptor on polarized intestinal epithelia. J Immunol. 2014 Feb 1;192(3):1267-76
All references(52)
Other
accession IDs
MGD-MRK-11362, MGI:2143329

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory