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Il10ra Gene Detail
Summary
  • Symbol
    Il10ra
  • Name
    interleukin 10 receptor, alpha
  • Synonyms
    CDw210, Il10r, mIL-10R
  • Feature Type
    protein coding gene
  • IDs
    MGI:96538
    NCBI Gene: 16154
Location & Maps
more
  • Sequence Map
    Chr9:45253837-45269149 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      15313 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 24.84 cM
  • Mapping Data
    9 experiments
Homology
more
  • Human Ortholog
    IL10RA, interleukin 10 receptor subunit alpha
  • Vertebrate Orthologs
    8
  • Human Ortholog
    IL10RA, interleukin 10 receptor subunit alpha
    Orthology source: HomoloGene
  • Synonyms
    CD210, CD210a, CDW210A, HIL-10R, IL10R, IL-10R1
  • Links
    NCBI Gene ID: 3587
    neXtProt AC: NX_Q13651

  • Chr Location
    11q23; chr11:117986391-118001483 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human IL10RA associations

Human Disease Mouse Models
       Inflammatory Bowel Disease 28, Autosomal Recessive; IBD28   OMIM: 613148
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    22 phenotypes from 5 alleles in 5 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Chemically induced (ENU)
    1
  • Spontaneous
    1
  • Targeted
    5
  • Incidental Mutations
Mice homozygous for an ENU-generated null allele suffer from a severe inflammatory bowel syndrome. Mice heterozygote for an NZW variant allele have high sera levels of anti-chromatin antibodies. Mice homozygous for a knock-out allele exhibit increased susceptibility to induced colitis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000042168 VEGA Gene Model | MGI Sequence Detail 15313 C57BL/6J ±  kb
transcript OTTMUST00000110675 VEGA | MGI Sequence Detail 3498 Not Applicable  
polypeptide OTTMUSP00000061774 VEGA | MGI Sequence Detail 575 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    210 from dbSNP Build 142
Protein
Information
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  • UniProt
    7 Sequences
  • Protein Ontology
    PR:000001365 interleukin-10 receptor subunit alpha
  • InterPro Domains
    IPR003961 Fibronectin type III
    IPR013783 Immunoglobulin-like fold
Molecular
Reagents
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  • All nucleic 23
    cDNA 20
    Primer pair 1
    Other 2

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-11362, MGI:2143329
References
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  • Summaries
    All 52
    Gene Ontology 3
    Phenotypes 15
  • Earliest
    J:16339 Ho AS, et al., A receptor for interleukin 10 is related to interferon receptors. Proc Natl Acad Sci U S A. 1993 Dec 1;90(23):11267-71
  • Latest
    J:209608 Norden DM, et al., TGFbeta produced by IL-10 redirected astrocytes attenuates microglial activation. Glia. 2014 Jun;62(6):881-95

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory