Il10ra
Gene Detail

Symbol Name ID

Il10ra interleukin 10 receptor, alpha MGI:96538

Synonyms

CDw210, Il10r, mIL-10R

Feature Type

protein coding gene

Genetic Map

Chromosome 9

24.84 cM
Detailed Genetic Map ± 1 cM


Mapping data(9)

Sequence Map

Chr9:45253837-45269149 bp, - strand From VEGA annotation of GRCm38   15313 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1196  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: interleukin-10 receptor, alpha chain
Gene Tree: Il10ra

Human homologs

Human Homolog		IL10RA, interleukin 10 receptor, alpha
NCBI Gene ID		3587
neXtProt AC		NX_Q13651
Human Synonyms		CD210, CD210a, CDW210A, HIL-10R, IL10R, IL-10R1
Human Chr (Location)		11q23; chr11:117857106-117872198 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human IL10RA

Alleles and phenotypes

All alleles(6) : Targeted(4) Spontaneous(1) Chemically induced(1)
 

Mice homozygous for an ENU-generated null allele suffer from a severe inflammatory bowel syndrome. Mice heterozygote for an NZW variant allele have high sera levels of anti-chromatin antibodies. Mice homozygous for a knock-out allele exhibit increased susceptibility to induced colitis.

 

Gene Ontology (GO) classifications

All GO classifications: (5 annotations)

Component	cytoplasm, integral to membrane, ...
Function	interleukin-10 binding, interleukin-10 receptor activity

External Resources: FuncBase

Expression

cDNA source data(20)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(23) cDNA(20) Primer pair(1) Other(2)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000042168 (Evidence)
Ensembl Gene Model	ENSMUSG00000032089 (Evidence)
Entrez Gene	16154 (Evidence)
UniGene	379327
DFCI	TC1578204
DoTS	DT.101386521, DT.40185631
NIA Mouse Gene Index	U030795
Consensus CDS Project	CCDS23131.1
International Mouse Knockout Project Status	Il10ra

Sequences

Length	Strain/Species
genomic	OTTMUSG00000042168	VEGA Gene Model | MGI Sequence Detail	15313	C57BL/6J
transcript	OTTMUST00000110675	VEGA | MGI Sequence Detail	3498	Not Applicable
polypeptide	OTTMUSP00000061774	VEGA | MGI Sequence Detail	575	Not Applicable

All sequences(40) RefSeq(2) UniProt(7)

Polymorphisms

SNPs(68 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR003961	Fibronectin, type III
InterPro	IPR013783	Immunoglobulin-like fold
Protein Ontology	PR:000001365	interleukin-10 receptor alpha chain

References

(Earliest) J:16339 Ho AS, et al., A receptor for interleukin 10 is related to interferon receptors. Proc Natl Acad Sci U S A. 1993 Dec 1;90(23):11267-71
(Latest) J:189844 Nguyen HH, et al., IL-10 acts as a developmental switch guiding monocyte differentiation to macrophages during a murine peritoneal infection. J Immunol. 2012 Sep 15;189(6):3112-20
All references(47)

Other accession IDs

MGD-MRK-11362, MGI:2143329