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Il10ra
Gene Detail
Symbol

Name
ID
Il10ra
interleukin 10 receptor, alpha
MGI:96538
Synonyms
CDw210, Il10r, mIL-10R
Feature Type
protein coding gene
Genetic Map
Chromosome 9
24.84 cM
Detailed Genetic Map ± 1 cM


Mapping data(9)
Sequence Map
Chr9:45253837-45269149 bp, - strand
From VEGA annotation of GRCm38

  15313 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1196  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

HCOP human homology predictions: IL10RA
Protein SuperFamily: interleukin-10 receptor, alpha chain
Gene Tree: Il10ra

Human
homologs
IL10RA, interleukin 10 receptor, alpha
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 3587
neXtProt AC: NX_Q13651

Human Synonyms: CD210, CD210a, CDW210A, HIL-10R, IL10R, IL-10R1

Human Chr (Location): 11q23; chr11:117986391-118001483 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human IL10RA

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Chemically induced (ENU)(1) Spontaneous(1) Targeted(4)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for an ENU-generated null allele suffer from a severe inflammatory bowel syndrome. Mice heterozygote for an NZW variant allele have high sera levels of anti-chromatin antibodies. Mice homozygous for a knock-out allele exhibit increased susceptibility to induced colitis.
 
Interactions
Il10ra interacts with 254 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process cytokine-mediated signaling pathway
Component integral component of membrane, membrane, ...
Function interleukin-10 binding, interleukin-10 receptor activity
External Resources: FuncBase
Expression
cDNA source data(20)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase il10ra ; ZFIN il10ra    NEW 
Molecular
reagents
All nucleic(23) cDNA(20) Primer pair(1) Other(2)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000042168 (Evidence)
Ensembl Gene Model ENSMUSG00000032089 (Evidence)
Entrez Gene 16154 (Evidence)
UniGene 379327
DFCI TC1578204
DoTS DT.101386521, DT.40185631
NIA Mouse Gene Index U030795
Consensus CDS Project CCDS23131.1
International Mouse Phenotyping Consortium Status Il10ra
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000042168 VEGA Gene Model | MGI Sequence Detail 15313 C57BL/6J ±  kb
transcript OTTMUST00000110675 VEGA | MGI Sequence Detail 3498 Not Applicable 
polypeptide OTTMUSP00000061774 VEGA | MGI Sequence Detail 575 Not Applicable 

For the selected sequences
All sequences(42) RefSeq(4) UniProt(7)
Polymorphisms
SNPs within 2kb(210 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003961 Fibronectin type III
InterPro IPR013783 Immunoglobulin-like fold
Protein Ontology PR:000001365 interleukin-10 receptor subunit alpha
References
(Earliest) J:16339 Ho AS, et al., A receptor for interleukin 10 is related to interferon receptors. Proc Natl Acad Sci U S A. 1993 Dec 1;90(23):11267-71
(Latest) J:209608 Norden DM, et al., TGFbeta produced by IL-10 redirected astrocytes attenuates microglial activation. Glia. 2014 Jun;62(6):881-95
All references(54)
Other
accession IDs
MGD-MRK-11362, MGI:2143329

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory