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Cd74
Gene Detail
Symbol

Name
ID
Cd74
CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)
MGI:96534
STS
Synonyms
CLIP, Ii
Feature Type
protein coding gene
Genetic Map
Chromosome 18
34.41 cM
Detailed Genetic Map ± 1 cM


Mapping data(21)
Sequence Map
Chr18:60803848-60812646 bp, + strand
From Ensembl annotation of GRCm38

  8799 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3209  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog

Protein SuperFamily: HLA class II histocompatibility antigen, gamma subunit
Gene Tree: Cd74

Human
homologs
Human Homolog CD74, CD74 molecule, major histocompatibility complex, class II invariant chain
NCBI Gene ID 972
neXtProt AC  NX_P04233
Human Synonyms  DHLAG, HLADG, Ia-GAMMA, II
Human Chr (Location)  5q32; chr5:150401637-150412980 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations exhibit impaired transport of MHC class II molecules, poor antigen presentation, and deficiency of CD4+ T cell development and positive selection.
 
Human Diseases Modeled Using Mouse Cd74 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(1)
Interactions
Cd74 interacts with 65 markers (Mir22, Mir23a, Mir26a-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (83 annotations)
Process activation of MAPK activity, antigen processing and presentation, ...
Component cell surface, endoplasmic reticulum, ...
Function beta-amyloid binding, cytokine binding, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (5)    Tissues (1)    Images (5)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 5
cDNA source data(317)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(322) Genomic(3) cDNA(318) Primer pair(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000024610 (Evidence)
Entrez Gene16149 (Evidence)
UniGene439737
DFCITC1572060, TC1585360
DoTSDT.55101202, DT.97369989, DT.97370007, DT.99871560
NIA Mouse Gene IndexU018783
Consensus CDS ProjectCCDS37835.1, CCDS50299.1
International Mouse Knockout Project StatusCd74
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024610 Ensembl Gene Model | MGI Sequence Detail 8799 C57BL/6J ±  kb
transcript ENSMUST00000097563 Ensembl | MGI Sequence Detail 1410 Not Applicable 
polypeptide ENSMUSP00000095171 Ensembl | MGI Sequence Detail 279 Not Applicable 

For the selected sequences
All sequences(32) RefSeq(4) UniProt(3)
Polymorphisms
All PCR and RFLP(10) : PCR(2) RFLP(8) SNPs within 2kb(329 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR022339 MHC class II-associated invariant chain
InterPro IPR015386 MHC class II-associated invariant chain/CLIP, MHC II-interacting
InterPro IPR011988 MHC class II-associated invariant chain, trimerisation
InterPro IPR000716 Thyroglobulin type-1
Protein Ontology PR:000001822 MHC class II histocompatibility antigen gamma chain
References
(Earliest) J:6994 Day CE, et al., The gene encoding the Ia antigen-associated invariant chain (Ii) is not linked to the H-2 complex. Nature. 1983 Mar 10;302(5904):157-9
(Latest) J:213077 Sauler M, et al., Macrophage migration inhibitory factor deficiency in chronic obstructive pulmonary disease. Am J Physiol Lung Cell Mol Physiol. 2014 Mar 15;306(6):L487-96
All references(170)
Other
accession IDs
MGD-MRK-11344

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory