About   Help   FAQ
Cd74 Gene Detail
Summary
  • Symbol
    Cd74
  • Name
    CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)
  • Synonyms
    CLIP, Ii
  • Feature Type
    protein coding gene
  • IDs
    MGI:96534
    NCBI Gene: 16149
  • Gene Overview
    MyGene.info: CD74
Location & Maps
more
  • Sequence Map
    Chr18:60803848-60812646 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      8799 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    CD74, CD74 molecule
  • Vertebrate Orthologs
    8
  • Human Ortholog
    CD74, CD74 molecule
    Orthology source: HGNC, HomoloGene
  • Synonyms
    DHLAG, HLADG, Ia-GAMMA, II
  • Links
    NCBI Gene ID: 972
    neXtProt AC: NX_P04233

  • Chr Location
    5q32; chr5:150401637-150412936 (-)  GRCh38.p2

Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    31 phenotypes from 6 alleles in 12 genetic backgrounds
    40 phenotypes from multigenic genotypes
    1 images
    107 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    13
  • Targeted
    8
  • Transgenic
    5
  • Incidental Mutations
Homozygotes for targeted null mutations exhibit impaired transport of MHC class II molecules, poor antigen presentation, and deficiency of CD4+ T cell development and positive selection.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024610 Ensembl Gene Model | MGI Sequence Detail 8799 C57BL/6J ±  kb
transcript ENSMUST00000167610 Ensembl | MGI Sequence Detail 1345 Not Applicable  
polypeptide ENSMUSP00000126688 Ensembl | MGI Sequence Detail 279 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    251 from dbSNP Build 142
  • PCR
  • RFLP
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000001822 MHC class II histocompatibility antigen gamma chain
  • InterPro Domains
    IPR022339 MHC class II-associated invariant chain
    IPR015386 MHC class II-associated invariant chain/CLIP, MHC II-interacting
    IPR011988 MHC class II-associated invariant chain, trimerisation
    IPR000716 Thyroglobulin type-1
Molecular
Reagents
less
  • All nucleic 322
    Genomic 3
    cDNA 318
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-11344
References
more
  • Summaries
    All 171
    Developmental Gene Expression 3
    Diseases 1
    Gene Ontology 21
    Phenotypes 107
  • Earliest
    J:6994 Day CE, et al., The gene encoding the Ia antigen-associated invariant chain (Ii) is not linked to the H-2 complex. Nature. 1983 Mar 10;302(5904):157-9
  • Latest
    J:227623 Martin HL, et al., Evidence for a role of adaptive immune response in the disease pathogenesis of the MPTP mouse model of Parkinson's disease. Glia. 2016 Mar;64(3):386-95

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
04/26/2016
MGI 6.03
The Jackson Laboratory