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Cd74 Gene Detail
Summary
  • Symbol
    Cd74
  • Name
    CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)
  • Synonyms
    CLIP, Ii
  • Feature Type
    protein coding gene
  • IDs
    MGI:96534
    NCBI Gene: 16149
  • Gene Overview
    MyGene.info: CD74
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr18:60803848-60812646 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      8799 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 18, 34.41 cM
  • Mapping Data
    21 experiments
  • Sequence Tag
Homology
more
  • Human Ortholog
    CD74, CD74 molecule
  • Vertebrate Orthologs
    8
  • Human Ortholog
    CD74, CD74 molecule
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DHLAG, HLADG, Ia-GAMMA, II
  • Links
    NCBI Gene ID: 972
    neXtProt AC: NX_P04233
    UniProt: P04233

  • Chr Location
    5q33.1; chr5:150401637-150412936 (-)  GRCh38.p7

Human Diseases
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  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    31 phenotypes from 6 alleles in 12 genetic backgrounds
    44 phenotypes from multigenic genotypes
    1 images
    110 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit impaired transport of MHC class II molecules, poor antigen presentation, and deficiency of CD4+ T cell development and positive selection.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024610 Ensembl Gene Model | MGI Sequence Detail 8799 C57BL/6J ±  kb
    transcript ENSMUST00000097563 Ensembl | MGI Sequence Detail 1410 Not Applicable  
    polypeptide ENSMUSP00000095171 Ensembl | MGI Sequence Detail 279 Not Applicable  
    For the selected sequence
    Polymorphisms
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    • SNPs within 2kb
      251 from dbSNP Build 142
    • PCR
    • RFLP
    Protein
    Information
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    • UniProt
      3 Sequences
    • InterPro Domains
      IPR022339 MHC class II-associated invariant chain
      IPR015386 MHC class II-associated invariant chain/CLIP, MHC II-interacting
      IPR011988 MHC class II-associated invariant chain, trimerisation
      IPR036613 MHC class II-associated invariant chain, trimerisation domain superfamily
      IPR000716 Thyroglobulin type-1
      IPR036857 Thyroglobulin type-1 superfamily
    Molecular
    Reagents
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    • All nucleic 322
      Genomic 3
      cDNA 318
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-11344
    References
    more
    • Summaries
      All 189
      Developmental Gene Expression 4
      Diseases 2
      Gene Ontology 22
      Phenotypes 110
    • Earliest
      J:6994 Day CE, et al., The gene encoding the Ia antigen-associated invariant chain (Ii) is not linked to the H-2 complex. Nature. 1983 Mar 10;302(5904):157-9
    • Latest
      J:250653 Schneppenheim J, et al., The Influence of MHC Class II on B Cell Defects Induced by Invariant Chain/CD74 N-Terminal Fragments. J Immunol. 2017 Jul 1;199(1):172-185

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory