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Igll1 Gene Detail
Summary
  • Symbol
    Igll1
  • Name
    immunoglobulin lambda-like polypeptide 1
  • Synonyms
    Igl-5, Igll, Lambda 5
  • Feature Type
    protein coding gene
  • IDs
    MGI:96529
    NCBI Gene: 16136
Location & Maps
more
  • Sequence Map
    Chr16:16860671-16863985 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3315 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    IGLL1, immunoglobulin lambda like polypeptide 1
  • Vertebrate Orthologs
    13
  • Human Ortholog
    IGLL1, immunoglobulin lambda like polypeptide 1
    Orthology source: HomoloGene
  • Synonyms
    14.1, AGM2, CD179b, IGL1, IGL5, IGLJ14.1, IGLL, IGO, IGVPB, VPREB2
  • Links
    NCBI Gene ID: 3543
    neXtProt AC: NX_P15814

  • Chr Location
    22q11.23; chr22:23573125-23580472 (-)  GRCh38.p2

  • Human Ortholog
    IGLL5, immunoglobulin lambda like polypeptide 5
    Orthology source: HomoloGene
  • Synonyms
    IGL, IGLV, VL-MAR
  • Links
    NCBI Gene ID: 100423062
    neXtProt AC: NX_B9A064

  • Chr Location
    22q11.22; chr22:22887780-22895834 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human IGLL1 associations

Human Disease Mouse Models
       Agammaglobulinemia 2, Autosomal Recessive; AGM2   OMIM: 613500
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 1 allele in 1 genetic background
    8 phenotypes from multigenic genotypes
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    51
  • Gene trapped
    47
  • Targeted
    4
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit spleen hypoplasia, a leaky blockade of B cell development at the pre-B stage, and decreased IgG levels in response to a T-cell dependent antigen.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025624 VEGA Gene Model | MGI Sequence Detail 3315 C57BL/6J ±  kb
transcript OTTMUST00000063035 VEGA | MGI Sequence Detail 702 Not Applicable  
polypeptide OTTMUSP00000031143 VEGA | MGI Sequence Detail 185 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    19 from dbSNP Build 137
  • RFLP
Protein
Information
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  • UniProt
    2 Sequences
  • InterPro Domains
    IPR003597 Immunoglobulin C1-set
    IPR007110 Immunoglobulin-like domain
    IPR013783 Immunoglobulin-like fold
    IPR003006 Immunoglobulin/major histocompatibility complex, conserved site
Molecular
Reagents
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  • All nucleic 23
    Genomic 9
    cDNA 7
    Primer pair 5
    Other 2

    Microarray probesets 5
Other
Accession IDs
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MGD-MRK-11335, MGD-MRK-11340, MGI:2146685
References
more
  • Summaries
    All 75
    Developmental Gene Expression 8
    Gene Ontology 5
    Phenotypes 29
  • Earliest
    J:8478 Sakaguchi N, et al., Isolation of a cDNA copy of an RNA species expressed in murine pre-B cells. EMBO J. 1986 Sep;5(9):2139-47
  • Latest
    J:222120 Ratliff M, et al., In aged mice, low surrogate light chain promotes pro-B-cell apoptotic resistance, compromises the PreBCR checkpoint, and favors generation of autoreactive, phosphorylcholine-specific B cells. Aging Cell. 2015 Jun;14(3):382-90

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory