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Igll1
Gene Detail
 Symbol
Name
ID
Igll1
immunoglobulin lambda-like polypeptide 1
MGI:96529
Synonyms Igl-5, Igll, Lambda 5
Feature Type protein coding gene
Genetic Map
Chromosome 16
10.45 cM
Detailed Genetic Map ± 1 cM


Mapping data(9)
Sequence Map
Chr16:16860671-16863985 bp, - strand
From VEGA annotation of GRCm38

  3315 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:131669  Vertebrate Homology Class
2 human; 1 mouse; 1 rat; 2 chimpanzee; 1 rhesus macaque; 1 cattle; 4 dog

Protein SuperFamily: pre-B cell omega light chain
Gene Tree: Igll1

Human
homologs
Human Homolog IGLL1, immunoglobulin lambda-like polypeptide 1
NCBI Gene ID 3543
neXtProt AC  NX_P15814
Human Synonyms  14.1, AGM2, CD179b, IGL1, IGL5, IGLJ14.1, IGLL, IGO, IGVPB, VPREB2
Human Chr (Location)  22q11.23; chr22:23573125-23580308 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human IGLL1
Human Homolog IGLL5, immunoglobulin lambda-like polypeptide 5
NCBI Gene ID 100423062
neXtProt AC  NX_B9A064
Human Chr (Location)  22q11.22; chr22:22887780-22895834 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(51) : Gene trapped(47) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit spleen hypoplasia, a leaky blockade of B cell development at the pre-B stage, and decreased IgG levels in response to a T-cell dependent antigen.
 
Interactions
Igll1 interacts with 17 markers (Mir7-1, Mir137, Mir143, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (4 annotations)
Component extracellular region, extracellular vesicular exosome
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (65)    Tissues (48)   
Theiler Stages: 10, 13, 15, 16, 18, 19, 20, 21, 22, 23, 24, 25, 28
Assay TypeResults
Northern blot 4
RT-PCR 59
RNase protection 2
cDNA source data(7)
External Resources: GEO   Expression Atlas
Molecular
reagents
All nucleic(23) Genomic(9) cDNA(7) Primer pair(5) Other(2)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000025624 (Evidence)
Ensembl Gene ModelENSMUSG00000075370 (Evidence)
Entrez Gene16136 (Evidence)
UniGene184441
DFCITC1643679
DoTSDT.55163949, DT.94206365
NIA Mouse Gene IndexU060428
Consensus CDS ProjectCCDS49775.1
International Mouse Knockout Project StatusIgll1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025624 VEGA Gene Model | MGI Sequence Detail 3315 C57BL/6J ±  kb
transcript OTTMUST00000063035 VEGA | MGI Sequence Detail 702 Not Applicable 
polypeptide OTTMUSP00000031143 VEGA | MGI Sequence Detail 185 Not Applicable 

For the selected sequences
All sequences(26) RefSeq(2) UniProt(2)
Polymorphisms RFLP(2) : SNPs within 2kb(19 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003597 Immunoglobulin C1-set
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003006 Immunoglobulin/major histocompatibility complex, conserved site
Protein Ontology PR:000001859 immunoglobulin lambda-like polypeptide 1
References (Earliest) J:8478 Sakaguchi N, et al., Isolation of a cDNA copy of an RNA species expressed in murine pre-B cells. EMBO J. 1986 Sep;5(9):2139-47
(Latest) J:188886 Knoll M, et al., The non-Ig parts of the VpreB and lambda5 proteins of the surrogate light chain play opposite roles in the surface representation of the precursor B cell receptor. J Immunol. 2012 Jun 15;188(12):6010-7
All references(79)
Other
accession IDs
MGD-MRK-11335, MGD-MRK-11340, MGI:2146685

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory