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Igll1 Gene Detail
Summary
  • Symbol
    Igll1
  • Name
    immunoglobulin lambda-like polypeptide 1
  • Synonyms
    Igl-5, Igll, Lambda 5
  • Feature Type
    protein coding gene
  • IDs
    MGI:96529
    NCBI Gene: 16136
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
  • Candidate for QTL
    1 QTL
Location &
Maps
more
  • Sequence Map
    Chr16:16678535-16681849 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 10.45 cM
  • Mapping Data
    10 experiments
Strain
Comparison
more
  • SNPs within 2kb
    137 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96529
 protein coding gene Chr16:16678535-16681849 (-)
129S1/SvImJ ENSMUSG00200040442
 protein coding gene Chr16:13675062-13678376 (-)
A/J ENSMUSG00195031130
 protein coding gene Chr16:13232269-13235583 (-)
AKR/J ENSMUSG00220043397
 protein coding gene Chr16:13548592-13551906 (-)
BALB/cJ ENSMUSG00180030957
 protein coding gene Chr16:13473552-13476867 (-)
C3H/HeJ ENSMUSG00175048231
 protein coding gene Chr16:13618576-13621890 (-)
C57BL/6NJ ENSMUSG00215039869
 protein coding gene Chr16:13339705-13343019 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020496
 protein coding gene Chr16:13353895-13357203 (-)
CAST/EiJ ENSTCUG00005045228
 protein coding gene Chr16:13541496-13544799 (-)
CBA/J ENSMUSG00210033728
 protein coding gene Chr16:13634912-13638226 (-)
DBA/2J ENSMUSG00185026898
 protein coding gene Chr16:13581055-13584369 (-)
FVB/NJ ENSMUSG00205018977
 protein coding gene Chr16:13588620-13591934 (-)
JF1/MsJ ENSUMUG00000046926
 protein coding gene Chr16:13673167-13676481 (-)
LP/J ENSMUSG00230040808
 protein coding gene Chr16:16158984-16162298 (-)
NOD/ShiLtJ ENSMUSG00190048693
 protein coding gene Chr16:13721017-13724331 (-)
NZO/HlLtJ ENSMUSG00225030658
 protein coding gene Chr16:19404791-19408105 (-)
PWK/PhJ ENSLUMG00010039505
 protein coding gene Chr16:13555993-13559304 (-)
SPRET/EiJ ENSMSPG00010040487
 protein coding gene Chr16:13583461-13586704 (-)
WSB/EiJ ENSIUOG00005038757
 protein coding gene Chr16:13712448-13715761 (-)



Homology
more
  • Human Ortholog
    IGLL1, immunoglobulin lambda like polypeptide 1
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IGLL1, immunoglobulin lambda like polypeptide 1
  • Synonyms
    14.1, AGM2, CD179b, IGL1, IGL5, IGLJ14.1, IGLL, IGO, IGVPB, VPREB2
  • Links
    NCBI Gene ID: 3543
    UniProt: P15814

  • Chr Location
    22q11.23; chr22:23573125-23580302 (-)  GRCh38
  • Human Ortholog
    IGLL5, immunoglobulin lambda like polypeptide 5
  • Synonyms
    IGLV, VL-MAR
  • Links
    NCBI Gene ID: 100423062
    UniProt: B9A064

  • Chr Location
    22q11.22; chr22:22887780-22896111 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human IGLL1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 1 allele in 1 genetic background
    8 phenotypes from multigenic genotypes
    39 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit spleen hypoplasia, a leaky blockade of B cell development at the pre-B stage, and decreased IgG levels in response to a T-cell dependent antigen.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    696
  • Tissues
    82
  • cDNA Data
    7
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16136 NCBI Gene Model | MGI Sequence Detail 3315 C57BL/6J ±  kb
    transcript NM_001190325 RefSeq | MGI Sequence Detail 870 C57BL/6  
    polypeptide P20764 UniProt | EBI | MGI Sequence Detail 209 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 23
      Genomic 9
      cDNA 7
      Primer pair 5
      Other 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-11335, MGD-MRK-11340, MGI:2146685
    References
    more
    • Summaries
      All 90
      Developmental Gene Expression 9
      Gene Ontology 6
      Phenotypes 39
    • Earliest
      J:8478 Sakaguchi N, et al., Isolation of a cDNA copy of an RNA species expressed in murine pre-B cells. EMBO J. 1986 Sep;5(9):2139-47
    • Latest
      J:345215 Aranburu A, et al., Clonal relationships of memory B cell subsets in autoimmune mice. Front Immunol. 2023;14:1129234
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory