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Igll1 Gene Detail
Summary
  • Symbol
    Igll1
  • Name
    immunoglobulin lambda-like polypeptide 1
  • Synonyms
    Igl-5, Igll, Lambda 5
  • Feature Type
    protein coding gene
  • IDs
    MGI:96529
    NCBI Gene: 16136
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:16860671-16863985 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 10.45 cM
  • Mapping Data
    10 experiments
Strain
Comparison
more
  • SNPs within 2kb
    19 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96529
protein coding gene Chr16:16860671-16863985 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022561
protein coding gene Chr16:13951665-13954979 (-)
A/J MGP_AJ_G0022522
protein coding gene Chr16:13269252-13272561 (-)
AKR/J MGP_AKRJ_G0022499
protein coding gene Chr16:13812148-13815462 (-)
BALB/cJ MGP_BALBcJ_G0022527
protein coding gene Chr16:13423009-13426707 (-)
C3H/HeJ MGP_C3HHeJ_G0022294
protein coding gene Chr16:13918328-13921642 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022976
protein coding gene Chr16:14173916-14177230 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020496
protein coding gene Chr16:13353895-13357203 (-)
CAST/EiJ MGP_CASTEiJ_G0021821
protein coding gene Chr16:13848880-13852183 (-)
CBA/J MGP_CBAJ_G0022263
protein coding gene Chr16:14835271-14838585 (-)
DBA/2J MGP_DBA2J_G0022395
protein coding gene Chr16:13209615-13212929 (-)
FVB/NJ MGP_FVBNJ_G0022370
protein coding gene Chr16:13231171-13234485 (-)
LP/J MGP_LPJ_G0022462
protein coding gene Chr16:13741804-13745118 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022392
protein coding gene Chr16:14543932-14547247 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022989
protein coding gene Chr16:13721991-13725305 (-)
PWK/PhJ MGP_PWKPhJ_G0021563
protein coding gene Chr16:13445985-13449296 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021391
protein coding gene Chr16:13723531-13726838 (-)
WSB/EiJ MGP_WSBEiJ_G0021869
protein coding gene Chr16:13729753-13733066 (-)



Homology
more
  • Human Ortholog
    IGLL1, immunoglobulin lambda like polypeptide 1
  • Vertebrate Orthologs
    13
  • Human Ortholog
    IGLL1, immunoglobulin lambda like polypeptide 1
    Orthology source: HomoloGene
  • Synonyms
    14.1, AGM2, CD179b, IGL1, IGL5, IGLJ14.1, IGLL, IGO, IGVPB, VPREB2
  • Links
    NCBI Gene ID: 3543
    neXtProt AC: NX_P15814
    UniProt: P15814

  • Chr Location
    22q11.23; chr22:23573125-23580548 (-)  GRCh38.p7

  • Human Ortholog
    IGLL5, immunoglobulin lambda like polypeptide 5
    Orthology source: HomoloGene
  • Synonyms
    IGL, IGLV, VL-MAR
  • Links
    NCBI Gene ID: 100423062
    neXtProt AC: NX_B9A064
    UniProt: B9A064

  • Chr Location
    22q11.22; chr22:22887780-22895834 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human IGLL1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 1 allele in 1 genetic background
    8 phenotypes from multigenic genotypes
    31 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit spleen hypoplasia, a leaky blockade of B cell development at the pre-B stage, and decreased IgG levels in response to a T-cell dependent antigen.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16136 NCBI Gene Model | MGI Sequence Detail 3315 C57BL/6J ±  kb
    transcript NM_001190325 RefSeq | MGI Sequence Detail 870 C57BL/6  
    polypeptide P20764 UniProt | EBI | MGI Sequence Detail 209 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • InterPro Domains
      IPR003597 Immunoglobulin C1-set
      IPR007110 Immunoglobulin-like domain
      IPR036179 Immunoglobulin-like domain superfamily
      IPR013783 Immunoglobulin-like fold
      IPR003006 Immunoglobulin/major histocompatibility complex, conserved site
    Molecular
    Reagents
    less
    • All nucleic 23
      Genomic 9
      cDNA 7
      Primer pair 5
      Other 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-11335, MGD-MRK-11340, MGI:2146685
    References
    more
    • Summaries
      All 78
      Developmental Gene Expression 8
      Gene Ontology 5
      Phenotypes 31
    • Earliest
      J:8478 Sakaguchi N, et al., Isolation of a cDNA copy of an RNA species expressed in murine pre-B cells. EMBO J. 1986 Sep;5(9):2139-47
    • Latest
      J:259780 Khass M, et al., VpreB serves as an invariant surrogate antigen for selecting immunoglobulin antigen-binding sites. Sci Immunol. 2016 Jul 14;1(1):aaf6628

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory