Igll1
Gene Detail

Symbol Name ID

Igll1 immunoglobulin lambda-like polypeptide 1 MGI:96529

Synonyms

Igl-5, Igll, Lambda 5

Feature Type

protein coding gene

Genetic Map

Chromosome 16

10.45 cM
Detailed Genetic Map ± 1 cM


Mapping data(9)

Sequence Map

Chr16:16860671-16863985 bp, - strand From VEGA annotation of GRCm38   3315 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Igll1 ± 2 cM)

Protein SuperFamily: pre-B cell omega light chain
Gene Tree: Igll1

Human ortholog

IGLL1 immunoglobulin lambda-like polypeptide 1 NCBI Gene ID 3543
Human Synonyms: 14.1, AGM2, CD179b, IGL1, IGL5, IGLJ14.1, IGLL, IGO, IGVPB, VPREB2
Human Chr22:23915312-23922495 bp, - strand Reference GRCh37.p2 Primary Assembly
Human Diseases Associated with Human IGLL1 (1)

Alleles and phenotypes

All alleles(51) : Targeted(4) Gene trapped(47)
 

Mice homozygous for a knock-out allele exhibit spleen hypoplasia, a leaky blockade of B cell development at the pre-B stage, and decreased IgG levels in response to a T-cell dependent antigen.

 

Gene Ontology (GO) classifications

All GO classifications: (3 annotations)

Component	extracellular region
Function	protein binding

External Resources: FuncBase

Expression

Literature Summary: (8 records)
Data Summary: Results (65)    Tissues (47)   
Theiler Stages: 10, 13, 15, 16, 18, 19, 20, 21, 22, 23, 24, 25, 28

Assay Type	Results
Northern blot	4
RT-PCR	59
RNase protection	2

cDNA source data(7)
External Resources: GEO   ArrayExpress

Molecular reagents

All nucleic(23) Genomic(9) cDNA(7) Primer pair(5) Other(2)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000025624 (Evidence)
Ensembl Gene Model	ENSMUSG00000075370 (Evidence)
Entrez Gene	16136 (Evidence)
UniGene	184441
DFCI	TC1643679
DoTS	DT.55163949, DT.94206365
NIA Mouse Gene Index	U060428
Consensus CDS Project	CCDS49775.1
International Mouse Knockout Project Status	Igll1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000025624	VEGA Gene Model | MGI Sequence Detail	3315	C57BL/6J
transcript	OTTMUST00000063035	VEGA | MGI Sequence Detail	702	Not Applicable
polypeptide	OTTMUSP00000031143	VEGA | MGI Sequence Detail	185	Not Applicable

All sequences(26) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(2) : SNPs(0 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR003597	Immunoglobulin C1-set
InterPro	IPR007110	Immunoglobulin-like
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR003006	Immunoglobulin/major histocompatibility complex, conserved site
Protein Ontology	PR:000001859	immunoglobulin lambda-like polypeptide 1

References

(Earliest) J:8478 Sakaguchi N, et al., Isolation of a cDNA copy of an RNA species expressed in murine pre-B cells. EMBO J. 1986 Sep;5(9):2139-47
(Latest) J:188886 Knoll M, et al., The non-Ig parts of the VpreB and lambda5 proteins of the surrogate light chain play opposite roles in the surface representation of the precursor B cell receptor. J Immunol. 2012 Jun 15;188(12):6010-7
All references(78)

Other accession IDs

MGD-MRK-11335, MGD-MRK-11340, MGI:2146685