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Igll1
Gene Detail
Symbol

Name
ID
Igll1
immunoglobulin lambda-like polypeptide 1
MGI:96529
Synonyms
Igl-5, Igll, Lambda 5
Feature Type
protein coding gene
Genetic Map
Chromosome 16
10.45 cM
Detailed Genetic Map ± 1 cM


Mapping data(9)
Sequence Map
Chr16:16860671-16863985 bp, - strand
From VEGA annotation of GRCm38

  3315 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:131669  Vertebrate Homology Class
2 human; 1 mouse; 1 rat; 2 chimpanzee; 1 rhesus macaque; 1 cattle; 4 dog; 1 western clawed frog

HCOP human homology predictions: IGLL1, IGLL5
Protein SuperFamily: pre-B cell omega light chain
Gene Tree: Igll1

Human
homologs
IGLL1, immunoglobulin lambda-like polypeptide 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 3543
neXtProt AC: NX_P15814

Human Synonyms: 14.1, AGM2, CD179b, IGL1, IGL5, IGLJ14.1, IGLL, IGO, IGVPB, VPREB2

Human Chr (Location): 22q11.23; chr22:23573125-23580472 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human IGLL1

  1 More Homolog(s):
Mutations,
alleles, and
phenotypes
All mutations/alleles(51) : Gene trapped(47) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit spleen hypoplasia, a leaky blockade of B cell development at the pre-B stage, and decreased IgG levels in response to a T-cell dependent antigen.
 
Interactions
Igll1 interacts with 17 markers (Mir7-1, Mir137, Mir143, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (5 annotations)
Component extracellular exosome, extracellular region
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (65)    Tissues (47)    Tissue x Stage Matrix (view)
Assay TypeResults
Northern blot 4
RT-PCR 59
RNase protection 2
cDNA source data(7)
Other mouse links: GEO   Expression Atlas
Molecular
reagents
All nucleic(23) Genomic(9) cDNA(7) Primer pair(5) Other(2)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000025624 (Evidence)
Ensembl Gene Model ENSMUSG00000075370 (Evidence)
Entrez Gene 16136 (Evidence)
UniGene 184441
DFCI TC1643679
DoTS DT.55163949, DT.94206365
NIA Mouse Gene Index U060428
Consensus CDS Project CCDS49775.1
International Mouse Phenotyping Consortium Status Igll1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025624 VEGA Gene Model | MGI Sequence Detail 3315 C57BL/6J ±  kb
transcript OTTMUST00000063035 VEGA | MGI Sequence Detail 702 Not Applicable 
polypeptide OTTMUSP00000031143 VEGA | MGI Sequence Detail 185 Not Applicable 

For the selected sequences
All sequences(26) RefSeq(2) UniProt(2)
Polymorphisms
RFLP(2) : SNPs within 2kb(19 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003597 Immunoglobulin C1-set
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003006 Immunoglobulin/major histocompatibility complex, conserved site
Protein Ontology PR:000001859 immunoglobulin lambda-like polypeptide 1
References
(Earliest) J:8478 Sakaguchi N, et al., Isolation of a cDNA copy of an RNA species expressed in murine pre-B cells. EMBO J. 1986 Sep;5(9):2139-47
(Latest) J:188886 Knoll M, et al., The non-Ig parts of the VpreB and lambda5 proteins of the surrogate light chain play opposite roles in the surface representation of the precursor B cell receptor. J Immunol. 2012 Jun 15;188(12):6010-7
All references(77)
Other
accession IDs
MGD-MRK-11335, MGD-MRK-11340, MGI:2146685

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory