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Igkc Gene Detail
Summary
  • Symbol
    Igkc
  • Name
    immunoglobulin kappa constant
  • Feature Type
    gene segment
  • IDs
    MGI:96495
    NCBI Gene: 16071
Location & Maps
more
Homology
less
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    14 phenotypes from 4 alleles in 3 genetic backgrounds
    25 phenotypes from multigenic genotypes
    41 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Targeted
    6
Homozygous inactivation of this gene prevents the expression of rearranged kappa genes, leading to exclusive production of lambda chain-expressing B cells and alterations in immunization titers, germinal center development, and somatic hypermutation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
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  • All Sequences
  • RefSeq
  • UniProt
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000053470 VEGA Gene Model | MGI Sequence Detail 532 C57BL/6J ±  kb
transcript OTTMUST00000133385 VEGA | MGI Sequence Detail 532 Not Applicable  
polypeptide OTTMUSP00000070917 VEGA | MGI Sequence Detail 107 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    65 from dbSNP Build 142
  • PCR
  • RFLP
Protein
Information
less
Molecular
Reagents
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  • All nucleic 99
    Genomic 61
    cDNA 32
    Primer pair 3
    Other 3

    Microarray probesets 1
Other
Accession IDs
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MGD-MRK-11293
References
more
  • Summaries
    All 97
    Developmental Gene Expression 2
    Gene Ontology 2
    Phenotypes 41
  • Earliest
    J:6069 Seidman JG, et al., The arrangement and rearrangement of antibody genes. Nature. 1978 Dec 21-28;276(5690):790-5
  • Latest
    J:225367 Vettermann C, et al., The proximal J kappa germline-transcript promoter facilitates receptor editing through control of ordered recombination. PLoS One. 2015;10(1):e0113824

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory