About   Help   FAQ
Igkc
Gene Detail
Symbol

Name
ID
Igkc
immunoglobulin kappa constant
MGI:96495
Feature Type
gene segment
Genetic Map
Chromosome 6
32.04 cM, cytoband C
Detailed Genetic Map ± 1 cM


Mapping data(17)
Sequence Map
Chr6:70726435-70726966 bp, + strand
From VEGA annotation of GRCm38

  532 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
Gene Tree: Igkc
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Gene Ontology
(GO)
classifications
All GO classifications: (2 annotations)
Process B cell differentiation
Function metal ion binding
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (58)    Tissues (48)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
Northern blot 12
RT-PCR 46
cDNA source data(5)
Other mouse links: GEO   Expression Atlas
Other vertebrate links: Xenbase igkc    NEW 
Molecular
reagents
All nucleic(99) Genomic(61) cDNA(32) Primer pair(3) Other(3)
Microarray probesets(1)
Other database
links
VEGA Gene Model OTTMUSG00000053470 (Evidence)
Ensembl Gene Model ENSMUSG00000076609 (Evidence)
Entrez Gene 16071 (Evidence)
PDB 1CBV, 1CGS, 1F3D, 1LO0, 1M71, 1M7D, 1M7I, 1MNU, 1MPA, 1NBV, 1PLG, 1PZ5, 1QFU, 1T2Q, 1YNK, 1YNL, 1ZEA, 2A1W, 2CGR, 2DQT, 2DQU, 2DTM, 2IPT, 2IPU, 2IQ9, 2IQA, 2MPA, 2OJZ, 2OK0, 2R0W, 2R0Z, 3BAE, 3BKC, 3BKJ, 3BKM, 3BQU, 3EYS, 3EYU, 3UO1, 3UYR, 3V4U, 3V52, 3WE6, 4F37, 4HDI, 4OCX, 4OCY, 4P3D, 4Q0X
International Mouse Phenotyping Consortium Status Igkc
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000053470 VEGA Gene Model | MGI Sequence Detail 532 C57BL/6J ±  kb
transcript OTTMUST00000133385 VEGA | MGI Sequence Detail 532 Not Applicable 
polypeptide OTTMUSP00000070917 VEGA | MGI Sequence Detail 107 Not Applicable 

For the selected sequences
All sequences(18) RefSeq(1) UniProt(3)
Polymorphisms
All PCR and RFLP(5) : PCR(1) RFLP(4) SNPs within 2kb(65 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003597 Immunoglobulin C1-set
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003006 Immunoglobulin/major histocompatibility complex, conserved site
InterPro IPR013106 Immunoglobulin V-set domain
Protein Ontology PR:000008966 Ig kappa chain C region
References
(Earliest) J:6069 Seidman JG, et al., The arrangement and rearrangement of antibody genes. Nature. 1978 Dec 21-28;276(5690):790-5
(Latest) J:205764 Doyle-Cooper C, et al., Immune tolerance negatively regulates B cells in knock-in mice expressing broadly neutralizing HIV antibody 4E10. J Immunol. 2013 Sep 15;191(6):3186-91
All references(97)
Other
accession IDs
MGD-MRK-11293

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/25/2015
MGI 6.0
The Jackson Laboratory