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Igh-J Complex/Cluster/Region Detail
Summary
  • Symbol
    Igh-J
  • Name
    immunoglobulin heavy chain, joining region
  • Synonyms
    Jh
  • Feature Type
    complex/cluster/region
  • IDs
    MGI:96461
    NCBI Gene: 16033
Location & Maps
more
  • Sequence Map
    Genome coordinates not available
  • Genetic Map
    Chromosome 12, Syntenic
  • Mapping Data
    1 experiment
Human Diseases
more
  • Diseases
    1 with Igh-J mouse models

Human Disease Mouse Models
      
IDs
View 4 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    42 phenotypes from 14 alleles in 13 genetic backgrounds
    58 phenotypes from multigenic genotypes
    266 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for targeting alleles exhibit altered immune system morphology and function.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • Literature Summary
  • Comparison Matrix
    Sequences &
    Gene Models
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    • All Sequences
    Representative SequencesLengthStrain/SpeciesFlank
    genomic X63164 GenBank | EMBL | DDBJ | MGI Sequence Detail 1342 A/J ±  kb
    For the selected sequence
    Polymorphisms
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    Molecular
    Reagents
    less
    • All nucleic 325
      Genomic 178
      cDNA 144
      Primer pair 1
      Other 2
    Other
    Accession IDs
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    MGD-MRK-11258
    References
    more
    • Summaries
      All 374
      Developmental Gene Expression 1
      Diseases 4
      Phenotypes 266
    • Earliest
      J:6108 Early PW, et al., Immunoglobulin heavy chain gene organization in mice: analysis of a myeloma genomic clone containing variable and alpha constant regions. Proc Natl Acad Sci U S A. 1979 Feb;76(2):857-61
    • Latest
      J:261352 Liu Y, et al., T-bet(+)CD11c(+) B cells are critical for antichromatin immunoglobulin G production in the development of lupus. Arthritis Res Ther. 2017 Oct 5;19(1):225

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    Funding Information
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    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory