Phenotypes Associated with This Genotype

Genotype
MGI:3836922

• Allelic Composition: Cd4^tm1Mak/Cd4^tm1Mak; Igh-J^{tm2(3H9-VDJ*)Mwg}/Igh-J⁺
• Genetic Background: B6.Cg-Cd4^tm1Mak Igh-J^{tm2(3H9-VDJ*)Mwg}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased anti-double stranded DNA antibody level ( J:142389 )

• anti-dsDNA antibodies of IgG2a isotype are detected in the sera of mice at levels slightly less than that of 56R mice that have CD4 T cells present

• anti-dsDNA antibodies with IgM, IgG2b, IgG3 are also present in mice at 6 months of age though at levels less than those found in 56R mice with CD4 T cells

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
systemic lupus erythematosus		DOID:9074	OMIM:152700 OMIM:300809 OMIM:605480 OMIM:608437 OMIM:609903 OMIM:609939 OMIM:610065 OMIM:610066 OMIM:612254 OMIM:612378 OMIM:613145 OMIM:614420	J:142389