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Ighd Gene Detail
Summary
  • Symbol
    Ighd
  • Name
    immunoglobulin heavy constant delta
  • Synonyms
    IgD
Location &
Maps
more
  • Sequence Map
    Chr12:113371155-113379944 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 62.10 cM
Strain
Comparison
more
  • SNPs within 2kb
    136 from dbSNP Build 142
  • Strain Annotations
    21
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96447
 gene segment Chr12:113370224-113379944 (-)
129S1/SvImJ ENSMUSG00200027651
 gene segment Chr12:105156532-105166195 (-)
A/J ENSMUSG00195047975
 gene segment Chr12:107654901-107664630 (-)
A/J ENSMUSG00195041044
 protein coding gene Chr12:107654901-107664634 (-)
AKR/J ENSMUSG00220037184
 gene segment Chr12:105583552-105593234 (-)
BALB/cJ ENSMUSG00180050812
 gene segment Chr12:106925127-106934788 (-)
C3H/HeJ ENSMUSG00175047302
 gene segment Chr12:109506831-109516474 (-)
C57BL/6NJ ENSMUSG00215048591
 gene segment Chr12:106191224-106200938 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0000008
 gene segment Chr12:107845069-107854634 (-)
CAST/EiJ ENSTCUG00005041529
 gene segment Chr12:105826271-105835998 (-)
CBA/J ENSMUSG00210034618
 gene segment Chr12:106563278-106572926 (-)
DBA/2J ENSMUSG00185035097
 gene segment Chr12:108380632-108390307 (-)
FVB/NJ ENSMUSG00205039876
 gene segment Chr12:105594992-105604635 (-)
JF1/MsJ ENSUMUG00000033810
 gene segment Chr12:113167022-113176774 (-)
LP/J ENSMUSG00230045304
 gene segment Chr12:115419258-115428960 (-)
NOD/ShiLtJ ENSMUSG00190029552
 gene segment Chr12:105002308-105012014 (-)
NZO/HlLtJ ENSMUSG00225044360
 gene segment Chr12:117162049-117171740 (-)
PWK/PhJ ENSLUMG00010046592
 gene segment Chr12:106626791-106636506 (-)
SPRET/EiJ ENSMSPG00010020784
 gene segment Chr12:108874658-108884414 (-)
SPRET/EiJ ENSMSPG00010016128
 protein coding gene Chr12:108874658-108884418 (-)
WSB/EiJ ENSIUOG00005036953
 gene segment Chr12:105882291-105892001 (-)



Homology
more
  • Human Ortholog
    IGHD, immunoglobulin heavy constant delta
  • Vertebrate Orthologs
    1
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IGHD, immunoglobulin heavy constant delta
  • Links
    NCBI Gene ID: 3495
    UniProt: P01880

  • Chr Location
    14q32.33; chr14:105836765-105845677 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 5 alleles in 5 genetic backgrounds
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a null allele show delayed antibody affinity maturation and reduced IgE levels. Homozygotes for another null allele show 30-50% less B cells in spleen and lymph nodes, reduced IgG2b levels, and increased IgA levels. Homozygotes for an ENU-induced allele show shifted IgD expression.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    3
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    • All Sequences
      32
    • RefSeq
      1
    • UniProt
      2
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 380797 NCBI Gene Model | MGI Sequence Detail 8790 C57BL/6J ±  kb
    transcript V00790 GenBank | ENA | DDBJ | MGI Sequence Detail 206 Not Specified  
    polypeptide A0A0A6YW14 UniProt | EBI | MGI Sequence Detail 291 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • InterPro Domains
      IPR050380 Immune Recognition and Response Modulators
      IPR003597 Immunoglobulin C1-set
      IPR007110 Immunoglobulin-like domain
      IPR036179 Immunoglobulin-like domain superfamily
      IPR013783 Immunoglobulin-like fold
      IPR003006 Immunoglobulin/major histocompatibility complex, conserved site
    Molecular
    Reagents
    less
    • All nucleic 13
      Genomic 10
      cDNA 3

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-11244
    References
    more
    • Summaries
      All 61
      Developmental Gene Expression 1
      Gene Ontology 16
      Phenotypes 24
    • Earliest
      J:5903 Goding JW, et al., Genetics, cellular expression and function of IgD and IgM receptors. Immunol Rev. 1977;37:152-86
    • Latest
      J:362914 Li R, et al., Oxidative phosphorylation regulates B cell effector cytokines and promotes inflammation in multiple sclerosis. Sci Immunol. 2024 May 3;9(95):eadk0865
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory