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Ighg1 Gene Detail
Summary
  • Symbol
    Ighg1
  • Name
    immunoglobulin heavy constant gamma 1 (G1m marker)
  • Synonyms
    IgG1, Igh-4
  • Feature Type
    gene segment
  • IDs
    MGI:96446
    NCBI Gene: 16017
Location & Maps
more
  • Sequence Map
    Chr12:113325240-113330523 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      5284 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 62.10 cM
  • Mapping Data
    3 experiments
Homology
less
Human Diseases
less
  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 6 alleles in 4 genetic backgrounds
    62 phenotypes from multigenic genotypes
    1 images
    46 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    11
  • Targeted
    8
  • Transgenic
    3
Mutant mice are viable and fertile but show impaired primary and secondary Igh-4 immune responses.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
less
  • All Sequences
  • RefSeq
  • UniProt
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000051474 VEGA Gene Model | MGI Sequence Detail 5284 C57BL/6J ±  kb
transcript OTTMUST00000130065 VEGA | MGI Sequence Detail 2482 Not Applicable  
polypeptide OTTMUSP00000069779 VEGA | MGI Sequence Detail 393 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    5 from dbSNP Build 142
  • RFLP
Protein
Information
less
  • UniProt
    2 Sequences
  • InterPro Domains
    IPR003597 Immunoglobulin C1-set
    IPR007110 Immunoglobulin-like domain
    IPR013783 Immunoglobulin-like fold
Molecular
Reagents
less
  • All nucleic 34
    Genomic 20
    cDNA 12
    Other 2

    Microarray probesets 1
Other
Accession IDs
less
MGD-MRK-11243
References
more
  • Summaries
    All 108
    Developmental Gene Expression 1
    Diseases 2
    Gene Ontology 30
    Phenotypes 46
  • Earliest
    J:5041 Minna JD, et al., Identification of a gene locus for gamma-G-1 immunoglobulin H chains and its linkage to the H chain chromosome region in the mouse. Proc Natl Acad Sci U S A. 1967 Jul;58(1):188-94
  • Latest
    J:232623 Pone EJ, et al., B cell Rab7 mediates induction of activation-induced cytidine deaminase expression and class-switching in T-dependent and T-independent antibody responses. J Immunol. 2015 Apr 1;194(7):3065-78

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory