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Ighg1 Gene Detail
Summary
  • Symbol
    Ighg1
  • Name
    immunoglobulin heavy constant gamma 1 (G1m marker)
  • Synonyms
    IgG1, Igh-4
  • Feature Type
    gene segment
  • IDs
    MGI:96446
    NCBI Gene: 16017
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:113326544-113330523 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 62.10 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    5 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96446
gene segment Chr12:113325240-113330523 (-)
129S1/SvImJ MGP_129S1SvImJ_G0000007
gene segment Chr12:115880566-115885851 (-)
A/J MGP_AJ_G0000007
gene segment Chr12:111369341-111374626 (-)
AKR/J MGP_AKRJ_G0000006
gene segment Chr12:114624615-114629901 (-)
BALB/cJ MGP_BALBcJ_G0000007
gene segment Chr12:111825037-111830322 (-)
C3H/HeJ MGP_C3HHeJ_G0000007
gene segment Chr12:115103379-115108666 (-)
C57BL/6NJ MGP_C57BL6NJ_G0000007
gene segment Chr12:119381025-119386308 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0000006
gene segment Chr12:107773590-107778924 (-)
CAST/EiJ MGP_CASTEiJ_G0000008
gene segment Chr12:109996734-110002048 (-)
CBA/J MGP_CBAJ_G0000007
gene segment Chr12:123982041-123987328 (-)
DBA/2J MGP_DBA2J_G0000007
gene segment Chr12:110866638-110871925 (-)
FVB/NJ MGP_FVBNJ_G0000007
gene segment Chr12:109700343-109705636 (-)
LP/J MGP_LPJ_G0000007
gene segment Chr12:115681896-115687179 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0000006
gene segment Chr12:127082402-127087685 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0000007
gene segment Chr12:114114049-114119335 (-)
PWK/PhJ MGP_PWKPhJ_G0000007
gene segment Chr12:105547812-105553097 (-)
SPRET/EiJ MGP_SPRETEiJ_G0000006
gene segment Chr12:108303418-108308722 (-)
WSB/EiJ MGP_WSBEiJ_G0000007
gene segment Chr12:115052065-115057345 (-)



Homology
less
Human Diseases
less
  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 6 alleles in 4 genetic backgrounds
    62 phenotypes from multigenic genotypes
    2 images
    77 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mutant mice are viable and fertile but show impaired primary and secondary Igh-4 immune responses.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
less
  • All Sequences
  • RefSeq
  • UniProt
Representative SequencesLengthStrain/SpeciesFlank
genomic 16017 NCBI Gene Model | MGI Sequence Detail 3980 C57BL/6J ±  kb
transcript AK156019 GenBank | EMBL | DDBJ | MGI Sequence Detail 1565 NOD  
polypeptide P01869 UniProt | EBI | MGI Sequence Detail 393 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    3 Sequences
  • InterPro Domains
    IPR003597 Immunoglobulin C1-set
    IPR007110 Immunoglobulin-like domain
    IPR036179 Immunoglobulin-like domain superfamily
    IPR013783 Immunoglobulin-like fold
Molecular
Reagents
less
  • All nucleic 34
    Genomic 20
    cDNA 12
    Other 2

    Microarray probesets 1
Other
Accession IDs
less
MGD-MRK-11243
References
more
  • Summaries
    All 164
    Developmental Gene Expression 1
    Diseases 2
    Gene Ontology 32
    Phenotypes 77
  • Earliest
    J:5041 Minna JD, et al., Identification of a gene locus for gamma-G-1 immunoglobulin H chains and its linkage to the H chain chromosome region in the mouse. Proc Natl Acad Sci U S A. 1967 Jul;58(1):188-94
  • Latest
    J:274198 Ennishi D, et al., Molecular and Genetic Characterization of MHC Deficiency Identifies EZH2 as Therapeutic Target for Enhancing Immune Recognition. Cancer Discov. 2019 Apr;9(4):546-563

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/04/2019
MGI 6.14
The Jackson Laboratory